38 results about "Sensory Functions" patented technology

The invention relates to a fully-bionic brain-like intelligent electro-mechanical exoskeleton for hands and a comprehensive control system thereof. The electro-mechanical exoskeleton is characterized by comprising finger tip bushes, middle phalanx exoskeletons, proximal phalanx exoskeletons, metacarpal bone exoskeletons, a finger stretching mechanical driving device, a finger bending mechanical driving device, finger stretching artificial tendons, finger bending artificial tendons, finger tip pressure and temperature sensors, force assistance sensors and joint angle sensors. The system comprises a multifunctional human brain computer interface helmet and a movement sensory system, and the multifunctional human brain computer interface helmet is connected with the fully-bionic brain-like intelligent electro-mechanical exoskeleton for the hands through the movement sensory system. With the control system, the electro-mechanical exoskeleton can be directly controlled to generate all kinds of action according to the intention of a human brain, and the electro-mechanical exoskeleton stably operates in balance by means of various methods, and can be widely applied to the fields of rehabilitation, life assistance and the like for people with limb movement and limb sensory function disturbance caused by neural system injury.

Provided is a deep brain stimulation (DBS) device using a wireless power transmission mechanism to wirelessly receive microwaves from a power transmission antenna installed at a hat put on a patient, transform the microwaves into power, and drive electrodes implanted into a brain of the patient using the power so as to correct abnormal motor and sensory functions of the patient using power which is wirelessly transmitted from an outside into a body of the patient. The DBS device includes: a hat module which is installed at a hat put on a head of the patient to transmit microwaves; and an implantation module which is implanted through a skull under a scalp to contact the cerebral nerve of the patient, receives the microwaves from the hat module, transforms the microwaves into direct current (DC) power, and stimulates the cerebral nerve using the DC power.

PCT No. PCT/JP97/00954 Sec. 371 Date Jan. 21, 1999 Sec. 102(e) Date Jan. 21, 1999 PCT Filed Mar. 24, 1997 PCT Pub. No. WO97/35577 PCT Pub. Date Oct. 2, 1997(+)-N,N'-Propylene dinicotinamide or pharmaceutically acceptable salts thereof are outstanding drugs of high safety that can heal or ameliorate spinal cord injuries, prevent the transition from an incomplete cord injury to a complete injury, and minimize the consequences of spinal cord injuries including neurological disorders such as quadriplegia, paralysis of the respiratory muscle, damage to sensory functions and impairment of reflex functions, as well as impaired urinating or defecating functions.

The present invention relates to a silk nanofiber nerve conduit characterized in that fibroin nanofibers having a diameter of 200 to 400 nm, originated from silk fiber, are stacked layer upon layer to form a porous conduit-shape; and a method for producing thereof, more specifically, to a method for producing a silk nanofiber nerve conduit comprising: (Step 1) preparing a fibrous spinning solution; (Step 2) producing a silk nanofiber of conduit-shape by electrospinning the fibrous spinning solution prepared in step 1 into the cylindrical collecting part coated with polyethyleneoxide; and (Step 3) separating a silk nanofiber of conduit-shape produced in step 2 from the collecting part. The silk nanofiber nerve conduit of the present invention has excellent biocompatibility; allows the body fluid to be exchanged inter in and out of conduit through pores of the conduit, as well; has a proper elasticity, tensile strength, and tear strength. Due to these properties, the silk nanofiber nerve conduit of the present invention helps the regeneration of the nerve injury to recover a motor skill and a sensory function, and thus shows an excellent effect of nerve regeneration. Therefore, the silk nanofiber nerve conduit of the present invention can be used in treating a nerve injury instead of an existing synthetic polymeric nerve conduit.

This invention relates to the engineering of animal cells, preferably mammalian, more preferably rat, that are deficient due to the disruption of gene(s) or gene product(s) resulting in altered nervous system function. In one aspect, the altered function results in pain in the mammal. In another aspect, the nervous system dysfunction results in prolonged hyperalgesia, allo dynia, and loss of sensory function. In another aspect, the invention relates to genetically modified rats, as well as the descendants and ancestors of such animals, which are animal models of altered nervous system function mediated pain and methods of their use. In another aspect, the genetically modified rats, as well as the descendants and ancestors of such animals, are animal models of nervous system dysfunction resulting in prolonged hyperalgesia, allodynia, and loss of sensory function and methods of their use. In another aspect, the present invention provides a method of identifying a compound useful for the treatment or prevention of pain.

The present invention is directed to a method of improving functional recovery following a central nervous system contusion injury. The method includes administering a therapeutically effective amount of glycosaminoglycan degrading enzyme. The glycosaminoglycan degrading enzyme may be dermatan sulfate or chondroitin sulfate degrading enzymes. The central nervous system contusion injury may include a traumatic brain injury or a spinal cord injury. The functional recovery may include autonomic functions, sensory functions, motor functions or the like.

Provided is a neural electronic interface (NEI) device for motor and sensory controls of a human body, into which wireless technology, a smart micro-sensor, and a nano probe pin device (PPD) are integrated and which is implanted into a brain of a patient having abnormal motor and sensory functions to monitor activities of a cerebral nerve or stimulate a cerebral nerve. The NEI device includes: a deep brain monitoring and stimulation (DBMS) module which is implanted through a skull to contact the cerebral nerve of the patient; and a hat module which is installed at a hat put on a head of the patient, wirelessly supplies power to the DBMS module, and performs a wireless communication with the DBMS module to transmit a control signal to control the DBMS module according to nervous system data monitored and fed back from the DBMS module.

The invention discloses a method for reconstructing sensory nerve functions of amputation upper limbs and a method for reconstructing sensory nerve and artificial limb interfaces.The method for reconstructing the sensory nerve functions of the amputation upper limbs includes steps of separating sensory branches of various nerve bundles of remaining brachial plexus nerves of amputation patients and connecting the nerve sensory branches with sensory nerves in target sensory regions; adding different sensory sensors into nerve artificial limbs, timely transmitting external stimulation in contact with the artificial limbs to the target sensory regions of the limbs of the amputees by the aid of a stimulation input process and further transmitting the external stimulation in contact with the artificial limbs to sensory center regions of the brains of the amputees by the aid of the reconstructed target sensory regions of the limbs.The methods have the advantages that the brachial plexus nerves remained after the upper limbs of the amputation patients are amputated are connected into the selected target sensory regions, sensory innervation regions of the limbs can be reconstructed in the target sensory regions by the brachial plexus nerves, the limb sensory functions lost due to amputation can be reconstructed, and accordingly interfaces functions of remaining limb sensory and multifunctional nerve artificial limb sensory can be implemented.

The present invention belongs to the field of pharmacy, and relates to a new drug use of quercetin. According to the present invention, results of a series of the whole animal experiments show that the quercetin can enhance intrinsic regenerative capacity of the peripheral nerve and delay the degeneration process of the distal side stump so as to finally promote regeneration of the peripheral nerve, and make the recovery of movement and sensory functions be improved. In addition, experiment results prove that the quercetin can be used as the treatment drug for treating peripheral nerve injury and promoting function recovery of nerve after nerve injury.

The invention discloses a method for preparing functional oil by segmented solid state fermentation of mixed fungus, and belongs to the field of processing of edible oil. According to the invention, soybeans are utilized as main fermentation substrates, and are collocated with other oil seeds according to the demand for different functional nutrients, and the segmented solid state fermentation ofthe fungus is utilized and combined with a supercritical extraction fractionation technology, so that the aims of improving the aftertaste of soybean oil and producing different flavors are achieved,and the nutritional value of the oil is improved at the same time. According to the segmented solid state fermentation of the fungus disclosed by the invention, the oil extraction rate is increased; the composition of fatty acids of the oil is improved; the contents of the main flavor substances such as pyrazines, alcohols and phenols are increased; and the sensory functions such as flavor and color of the oil are more in line with the demand of consumers for innovative products. The fermented oil seed meal can be further processed for producing by-products such as functional peptides, and sustainable green development is realized.

Methods, apparatus, compositions and kits for inhibiting a disorder in a human patient, including non-cerebral neurovascular disorder or muscular headache pain, or loss of motor or sensory function, sympathetic tone or range or fluidity of motion that affect a nerve pathway at more than one locus associated with the disorder to inhibit the disorder. Alternatively or in addition, neuropathy associated with a disorder is treatable by palpating to determine a Keystone nerve essential to the neuropathy, applying pressure to determine a point of maximum discomfort or trigger of increased symptoms to identify a Levin Sign as a locus of initial intervention, and intervening to treat the neuropathy at the location of the Levin Sign by administering a pharmaceutically active agent, internal implanted or external neuro stimulation affecting the nerve pathway to inhibit the neuropathy.

The invention relates to the field of medicaments, in particular relates to a medicament for treating overactive bladder caused by bladder outlet obstruction, and specifically relates to application of an M3 receptor inhibitor and an alpha1-A receptor inhibitor in preparation of a medicament for treating overactive bladder caused by bladder outlet obstruction. The medicament for treating the bladder outlet obstruction consists of the following components in parts by weight: 15 to 20 parts of M3 receptor inhibitor, and 0.5 to 2 parts of alpha1-A receptor inhibitor. By investigating the indexes of bladder sensory function, bladder detrusor pressure, highest urine flow rate, vesical neck pressure, functional urethral length, urethral closing area and the like, the M3 receptor inhibitor and the alpha1-A receptor inhibitor applied to treatment of the overactive bladder caused by the bladder outlet obstruction have a good effect.

The invention provides a neural function evaluation and training system for a central nervous system disease experiment rat model, and belongs to the technical field of medical tracking evaluation, the system comprises an evaluation system, a training system and a scoring system; the evaluation system aims at three aspects of a motion function, a sensory function and a brain cognitive function; the training system comprises motion function training, sensory function training and brain cognitive function training; and the scoring system designs a scoring table according to the reliability validity evaluation, and calculates each score and a total score by using the scoring table. The method is characterized in that the dysfunction of the central nervous system disease rat model can be comprehensively evaluated. Both evaluation and training can be carried out. Comprising a central nervous system dysfunction evaluation system and a central nervous system dysfunction training system. The system is reasonable in design, convenient to arrange and easy to master, and has good popularization and use values.

The invention discloses a multimedia teaching system for spinal cord injury sensory function assessment teaching, which comprises a teaching device and a control system for driving the teaching device to operate, and is characterized in that the teaching device comprises a support frame, a display screen is installed outside the support frame, a placement box is arranged outside the display screen, and a spinal cord model is placed in the placement box; the spinal cord model is internally provided with a plurality of optical fiber sensors, the optical fiber sensors are sequentially arranged in the spinal cord model, and problems existing in the acupuncture process can be pointed out and guided through a correction module, a guiding module and a feeling judgment module in the comment system. The acupuncture sense and the light touch sense of acupuncture points in the acupuncture process are judged through the feeling judgment module, errors existing in the acupuncture process are indicated through the guide module and the correction module, and the errors are displayed through the display screen, so that demonstration can be conveniently carried out on students who learn, and the evaluation method of the spinal cord injury sensory function can be better mastered.

A system and method for enhancing sensory function of an individual are disclosed. The system comprises a generalized brain-skin interface (GBSI), configured to enable the individual to experience senses. The system further comprises a sensor, a processor, and an epidermal neuro-oscillating patch (ENOP). The sensor is configured to receive environmental data surrounding the individual. The processor in communication with the sensor is configured to receive environmental data from the sensor and convert it into an analog vibration pattern. The epidermal neuro-oscillating patch (ENOP) is removably fastened to the skin of the individual, configured to produce a sequence of vibrations based on the analog vibration pattern received from the processor and directly transmit it to the skin for stimulating the nerves of the individual, thereby effectively training the brain of the individual to learn and equate the sequence of vibrations for experiencing senses of the physical environment of the individual.

The invention discloses a patient-self-adjustment nipple-retraction orthopedic device. The patient-self-adjustment nipple-retraction orthopedic device comprises a hollow cylinder, a chassis, a rotating disc and a T-shaped rod. The base is arranged at the bottom of the hollow cylinder, an internal thread is tapped inside the hollow cylinder, the rotating disc is installed on the thread inside the hollow cylinder, four groups of rotating-disc small holes are formed in the rotating disc, a rotating-disc center hole is also formed in the center of the rotating disc, and the T-shaped rod is installed on the rotating-disc center hole through threads. The patient-self-adjustment nipple-retraction orthopedic device is simple in structure; a patient can adjust the height of a nipple by herself according to blood circulation of the nipple and patient bearing conditions, time and cost of the patient are saved, an orthopedic effect is good, and influences on the life and work of the patient are small; the patient-self-adjustment nipple-retraction orthopedic device can be conveniently adjusted by the patient, is small in wound and rapid in recovery, can be adjusted by the patient by herself, and is easy and convenient to operate; blood circulation obstacles of the nipple are avoided, the sensory function has no abnormal risk, incision scars are avoided, pain of the patient is greatly reduced, and a recurrence rate is also lower.

The invention discloses a portable pain assessment system combining electrical stimulation with big data analysis. The system comprises an electrical stimulation device, a data acquisition device, a display assessment device, a data transmission device and a cloud data processing device, wherein the electrical stimulation device processes an input voltage value, outputs corresponding current and applies the output current to skin of a normal human body sensory function area through an electrode slice, so that a generated subjective pain score is input into the display assessment device. According to the portable pain assessment system combining electrical stimulation with big data analysis, the subjective pain score of a current patient is assessed in a mode of combining the subjective pain score with an objective pain score, so that corresponding pain assessment is obtained, and the disease severity degree of the patient and the pain self-scoring objective degree of the patient are further assessed.

An apparatus for reducing symptoms associated with neuropathy such as pain or other sensation deficits and sensation dysfunction in the lower extremity of a patient includes a platform having a base and a top plate supported by the base and configured to allow a patient to place their feet thereon. A vibrational actuator is carried by the base and connected to the top plate and configured to vibrate the top plate when a patient stands thereon or while seated with their feet placed on top of the plate. A controller is connected to the vibrational actuator and configured to operate the vibrational actuator to impart a vibrating force to the top plate when a patient has their feet thereon and stimulate the Pacini corpuscles to impart a neurological feedback response that dilates blood vessels of the feet and legs.

The invention discloses a teaching aid with a sensory integration ability training function. The utility model relates to the technical field of infant sensory integration ability development or training, in particular to an infant sensory integration ability training device which mainly comprises a training walkway for infants to walk, the training walkway comprises a module group with a sensorystimulation function, and the sensory stimulation function refers to at least one of a gradient stimulation function and a color stimulation function. The basic module, the feeling module and the connecting module are combined to form the training walkway or only the basic module and the connecting module are used to form the training walkway, an infant can be subjected to walking training on thetraining walkway under nursing or protection, especially for infants of 6-36 months old, the gradient can be used for stimulating sensory functions such as sense of balance and sense of space and colors can be used for stimulating sensory functions such as sense of visual perception and sense of dizziness, and therefore the requirements for autonomous prevention and self-judgment of sensory integration ability development of the infants are met.

The invention discloses a portable hand trainer for nursing elderly patients. Firstly, the portable hand trainer is suitable for general old people, acts on meridian points of the old people, can stimulate cerebral cortex, improve cerebral blood flow, enable the brain to form a new stimulant point, improve muscle strength and cognitive function of the old people and delay cerebral neurodegeneration, and is beneficial to improving understanding and memory functions of the old people; and secondly, the portable hand trainer is suitable for early rehabilitation training of stroke patients, the cerebral apoplexy patient loses the control of the high-order center of the brain on the low-order center due to cerebral lesions, so that the sensory function is abnormal. When the portable hand trainer is used by a stroke patient in the early stage, the hand feeling function of the patient can be improved, and then the cognitive function is improved; and thirdly, the portable hand trainer is suitable for old rheumatoid patients, and can increase muscle strength, preserve joint movement capacity and prevent joint contracture, ankylosis and muscular atrophy.