34 results about "Autonomic function" patented technology

Embodiments of the invention concern methods and apparatuses for deriving respiratory data from both single lead and multi-lead ECG data recordings. Other embodiments of the invention address the assessment of respiration rate from respiratory data such as respiratory data derived from ECG data. Still other embodiments of the invention address methods and apparatuses for the assessment of autonomic function. These last embodiments involve the derivation of respiratory data from ECG data, comparing the respiration rate to key threshold values, and the final derivation of one or more HRV parameters from the ECG data. The embodiments of the invention have implementations applicable to data previously recorded data as well as data recorded and processed in a real-time manner.

A pain measurement and diagnostic system (PMD) for bioanalytical analysis of pain matrix activity and the autonomic nervous system to diagnose and validate patient treatments, health status and outcomes. The PMD is implemented using medical devices for measuring and reporting objective measurements of pain through patient monitoring and analyzing related biological, psychological, social, environmental, and demographic factors that may contribute to and effect physiological outcomes for patients and through the integrated and iterative analysis improve diagnosis of pain, the evaluation of related disease states, health status, and treatment options.

The present invention relates to novel inhibitors of glutaminyl cyclase and combinations thereof for the treatment of neuronal disorders, especially Alzheimer's disease, Down Syndrome, Parkinson disease, Chorea Huntington, pathogenic psychotic conditions, schizophrenia, impaired food intake, sleep-wakefulness, impaired homeostatic regulation of energy metabolism, impaired autonomic function, impaired hormonal balance, impaired regulation, body fluids, hypertension, fever, sleep dysregulation, anorexia, anxiety related disorders including depression, seizures including epilepsy, drug withdrawal and alcoholism, neurodegenerative disorders including cognitive dysfunction and dementia.

The present invention provides methods and apparatuses to assess vascular stiffness of a subject, and to assess diabetes or hypertension from the assessment of vascular stiffness. Example embodiments comprise determining arrival at a peripheral site of a blood pressure wave as a function of time relative to the cardiac cycle of the subject at a plurality of measurement conditions, wherein at least two of the conditions are characterized by at least one of: (a) different central transmural pressure, (b) different peripheral transmural pressure; assessing vascular stiffness from the determinations at the plurality of measurement conditions.

The invention analyzes relationships between factors, within a patient population, to identify autonomic dysfunction patterns. Patient test results are then compared with the identified patterns to determine the patient's autonomic function. The invention can continually amend the patient population with new test results to create increasingly accurate normative data sets from which a patient's autonomic function can be more accurately assessed. The invention may apply this concept in an application service provider model. An embodiment of the invention may use a novel method of identifying ECG R-waves. The method locates R-waves by searching for maximum slope values, in signals, that exceed threshold values. Another embodiment of the invention entails utilizing data from a non-provocative HRV test and a provocative HRV test in an assessment tool to assess a patient's autonomic function.

The invention analyzes relationships between factors, within a patient population, to identify autonomic dysfunction patterns. Patient test results are then compared with the identified patterns to determine the patient's autonomic function. The invention can continually amend the patient population with new test results to create increasingly accurate normative data sets from which a patient's autonomic function can be more accurately assessed. The invention may apply this concept in an application service provider model. An embodiment of the invention may use a novel method of identifying ECG R-waves. The method locates R-waves by searching for maximum slope values, in signals, that exceed threshold values. Another embodiment of the invention entails a non-provocative HRV test whereby certain time domain and frequency domain factors are analyzed to determine a patient's autonomic function.

The disclosure provides an implantable bioartificial active secretion system for providing a physiological regulating secretion such as insulin necessary for functionality of a physiologic activity such as glucose metabolism of a living-being host. The system includes a housing implantable within the host, in fluidic communication with tissue fluid indicative of a physiological regulating secretion need. A chamber within the housing contains a plurality of physiologically active, autonomously functioning, live secretory cells for producing the physiological regulating secretion. A continually operating two pump apparatus moves tissue fluid into contact with the secretory cells for pick up of the physiological regulating secretion for subsequent physiologically-effective dispensing into the host, while avoiding immunorejection of the host body or of the host to the secretory cells.

A method of energetic medicine wherein a practitioner corrects faults in various functional categories of the system that controls vegetative functions in the body of the subject. The method is comprised of the steps of applying specific clinical algorithms consisting of queries and corrective statements to assess and then train this system toward optimal function. The medium by which this is achieved is verbal and/or other than conscious communications from the practitioner to subject, as well as application of physical stimuli. Communication from subject to the practitioner is determined by monitoring an indicator of autonomic function.

Methods and systems for stimulating a gastrointestinal system and for modifying a stimulation signal based on an indicator of autonomic nervous system function are described. One indicator of autonomic nervous system described is cardiac activity, including heart rate variability. Methods for selecting candidate patients for gastrointestinal stimulation therapy based on an indicator of autonomic nervous system function and methods of treating patients at risk of or suffering from gastrointestinal disorders by modifying therapy based on an indicator of autonomic function are also discussed.

The present invention provides a method and system of auditory evoked heart rate variability analysis having advantage of simply analytical process and portability. The disclosed method mainly includes the following steps of: stimulating the auditory system of a person by a sound through a sound transmission device, capturing an electrocardiogram signal of the person, performing analog-to-digital conversion of the electrocardiogram signal, selecting the peaks of the electrocardiogram signal and transforming the qualified peaks to a consecutive peak signal, and performing spectrum analysis to the peak signal in frequency domain, and obtaining the difference of the spectral parameters before and after the evoked sounds. Moreover, the sound further is selected from the group consisting of noise, short tone burst, click, and any other sound with the intensity of 30 dB to 100 dB. By comparing the heart rate variability analysis before or after sound stimulation in order to get the differences, the disclosed method and system of auditory evoked heart rate variability analysis can evaluate a changing index of stimulated autonomic functions.

The present invention is an article of manufacture and method for using same, comprising at least two sensors having a paired offset potential of below about +/−1.0 mV; and a data gathering device connected to the sensors capable of measuring the voltage difference between the sensors. The sensors preferably are AgCl coated Silver.

The present invention is directed to a method of improving functional recovery following a central nervous system contusion injury. The method includes administering a therapeutically effective amount of glycosaminoglycan degrading enzyme. The glycosaminoglycan degrading enzyme may be dermatan sulfate or chondroitin sulfate degrading enzymes. The central nervous system contusion injury may include a traumatic brain injury or a spinal cord injury. The functional recovery may include autonomic functions, sensory functions, motor functions or the like.

To provide a stent which holds various performances such as deliverability, prevention of restenosis, flexible shape conformability, and so on and is therefore adaptable not only to a bile duct but also to a blood vessel system such as a tortuous coronary artery substantially without causing restenosis.

A stent with an autonomic function is made of a Ti—Ni based shape memory alloy and has a maximum expanding force at a center portion in its lengthwise direction.