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34 results about "Autonomic function" patented technology
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Autonomic Function Your brain stem, located at the base of your brain, controls your autonomic body functions. ... Autonomic function are those that you have no control over, such as breathing, heart rate and digestive processes. Your brain sends signals to the muscles and tissues of the lungs, telling them to inhale and exhale at a rate that best serves the oxygenation needs of the body during exercise.
Apparatus for autonomic neuromodulation for the treatment of systemic disease
InactiveUS20100241183A1Delay is slowPreserving and prolonging effect of modulationSpinal electrodesUltrasound therapyNervous systemEfferent
A method, apparatus, and surgical technique for the modulation of autonomic function, for the purpose of treating any of several conditions and diseases, including obesity, metabolic disorders, endocrine disorders, diabetes, respiratory disease, asthma, inflammatory disease, immunological disease, infection, cancer, cardiac disease, cardiovascular disease, cerebrovascular disease, stroke, vasospasm, vascular disease, psychiatric disease, depression, affective disorders, anxiety disorders, and other conditions. This includes neural and tissue modulators, including implanted devices, used to modulate efferent and afferent autonomic neurons to influence or control autonomic or other neural function, including modulation of sympathetic and parasympathetic nervous system components as well as their combination.
Owner:DILORENZO BIOMEDICAL
Method and apparatus for processing respiration data and assessing autonomic function
PendingUS20050251056A1High signal fidelityAccurate representationMedical data miningElectrocardiographyAutonomic functionSingle lead
Embodiments of the invention concern methods and apparatuses for deriving respiratory data from both single lead and multi-lead ECG data recordings. Other embodiments of the invention address the assessment of respiration rate from respiratory data such as respiratory data derived from ECG data. Still other embodiments of the invention address methods and apparatuses for the assessment of autonomic function. These last embodiments involve the derivation of respiratory data from ECG data, comparing the respiration rate to key threshold values, and the final derivation of one or more HRV parameters from the ECG data. The embodiments of the invention have implementations applicable to data previously recorded data as well as data recorded and processed in a real-time manner.
Owner:MEDDORNA
Inhibitors of glutaminyl cyclase
The present invention relates to novel inhibitors of glutaminyl cyclase and combinations thereof for the treatment of neuronal disorders, especially Alzheimer's disease, Down Syndrome, Parkinson disease, Chorea Huntington, pathogenic psychotic conditions, schizophrenia, impaired food intake, sleep-wakefulness, impaired homeostatic regulation of energy metabolism, impaired autonomic function, impaired hormonal balance, impaired regulation, body fluids, hypertension, fever, sleep dysregulation, anorexia, anxiety related disorders including depression, seizures including epilepsy, drug withdrawal and alcoholism, neurodegenerative disorders including cognitive dysfunction and dementia.
Owner:VIVORYON THERAPEUTICS NV
High density epidural stimulation for facilitation of locomotion, posture, voluntary movement, and recovery of autonomic, sexual, vasomotor, and cognitive function after neurological injury
ActiveUS20140163640A1Easy to controlPromote recoverySpinal electrodesChiropractic devicesDiseaseImpaired proprioception
Methods of enabling locomotor control, postural control, voluntary control of body movements (e.g., in non-weight bearing conditions), and / or autonomic functions in a human subject having spinal cord injury, brain injury, or neurological neuromotor disease. In certain embodiments, the methods involve stimulating the spinal cord of the subject using an epidurally placed electrode array, subjecting the subject to physical training thereby generating proprioceptive and / or supraspinal signals, and optionally administering pharmacological agents to the subject. The combination of stimulation, physical training, and optional pharmacological agents modulate in real time electrophysiological properties of spinal circuits in the subject so they are activated by supraspinal information and / or proprioceptive information derived from the region of the subject where locomotor activity is to be facilitated.
Owner:CALIFORNIA INST OF TECH +2
Method and apparatus for the measurement of autonomic function for the diagnosis and validation of patient treatments and outcomes
A pain measurement and diagnostic system (PMD) for bioanalytical analysis of pain matrix activity and the autonomic nervous system to diagnose and validate patient treatments, health status and outcomes. The PMD is implemented using medical devices for measuring and reporting objective measurements of pain through patient monitoring and analyzing related biological, psychological, social, environmental, and demographic factors that may contribute to and effect physiological outcomes for patients and through the integrated and iterative analysis improve diagnosis of pain, the evaluation of related disease states, health status, and treatment options.
Owner:DULLEN DEBORAH
Method and apparatus for detecting physiologic signals
InactiveUS7381185B2Accurate assessmentMedical data miningElectrocardiographyTime domainAutonomic function
The invention analyzes relationships between factors, within a patient population, to identify autonomic dysfunction patterns. Patient test results are then compared with the identified patterns to determine the patient's autonomic function. The invention can continually amend the patient population with new test results to create increasingly accurate normative data sets from which a patient's autonomic function can be more accurately assessed. The invention may apply this concept in an application service provider model. An embodiment of the invention may use a novel method of identifying certain components on physiological signals such as the R-wave for an ECG. The method locates R-waves by searching for maximum slope values and cycle lengths that satisfy certain threshold values. Another embodiment of the invention entails a non-provocative HRV test whereby certain time domain and frequency domain factors are analyzed to determine a patient's autonomic function.
Owner:MEDDORNA
Novel inhibitors of glutaminyl cyclase
ActiveUS20050215573A1Facilitated DiffusionOrganic active ingredientsBiocideHuntingtons choreaDrug withdrawal
The present invention relates to novel inhibitors of glutaminyl cyclase and combinations thereof for the treatment of neuronal disorders, especially Alzheimer's disease, Down Syndrome, Parkinson disease, Chorea Huntington, pathogenic psychotic conditions, schizophrenia, impaired food intake, sleep-wakefulness, impaired homeostatic regulation of energy metabolism, impaired autonomic function, impaired hormonal balance, impaired regulation, body fluids, hypertension, fever, sleep dysregulation, anorexia, anxiety related disorders including depression, seizures including epilepsy, drug withdrawal and alcoholism, neurodegenerative disorders including cognitive dysfunction and dementia.
Owner:VIVORYON THERAPEUTICS NV
Diabetes and Hypertension Screening by Assessment of Arterial Stiffness and Autonomic Function
InactiveUS20170079533A1Reliable and convenient and cost-effectiveHealth-index calculationDiagnostics using spectroscopyDiabetes mellitusAutonomic function
The present invention provides methods and apparatuses to assess vascular stiffness of a subject, and to assess diabetes or hypertension from the assessment of vascular stiffness. Example embodiments comprise determining arrival at a peripheral site of a blood pressure wave as a function of time relative to the cardiac cycle of the subject at a plurality of measurement conditions, wherein at least two of the conditions are characterized by at least one of: (a) different central transmural pressure, (b) different peripheral transmural pressure; assessing vascular stiffness from the determinations at the plurality of measurement conditions.
Owner:MEDICI TECH LLC
High density epidural stimulation for facilitation of locomotion, posture, voluntary movement, and recovery of autonomic, sexual, vasomotor, and cognitive function after neurological injury
ActiveUS9101769B2Easy to controlPromote recoverySpinal electrodesChiropractic devicesDiseaseImpaired proprioception
Methods of enabling locomotor control, postural control, voluntary control of body movements (e.g., in non-weight bearing conditions), and / or autonomic functions in a human subject having spinal cord injury, brain injury, or neurological neuromotor disease. In certain embodiments, the methods involve stimulating the spinal cord of the subject using an epidurally placed electrode array, subjecting the subject to physical training thereby generating proprioceptive and / or supraspinal signals, and optionally administering pharmacological agents to the subject. The combination of stimulation, physical training, and optional pharmacological agents modulate in real time electrophysiological properties of spinal circuits in the subject so they are activated by supraspinal information and / or proprioceptive information derived from the region of the subject where locomotor activity is to be facilitated.
Owner:CALIFORNIA INST OF TECH +2
Method and apparatus for assessing autonomic function
InactiveUS20050251051A1Improve accuracyGreat health issueElectrocardiographySurgeryAutonomic functionAutonomic bladder dysfunction
The invention analyzes relationships between factors, within a patient population, to identify autonomic dysfunction patterns. Patient test results are then compared with the identified patterns to determine the patient's autonomic function. The invention can continually amend the patient population with new test results to create increasingly accurate normative data sets from which a patient's autonomic function can be more accurately assessed. The invention may apply this concept in an application service provider model. An embodiment of the invention may use a novel method of identifying ECG R-waves. The method locates R-waves by searching for maximum slope values, in signals, that exceed threshold values. Another embodiment of the invention entails utilizing data from a non-provocative HRV test and a provocative HRV test in an assessment tool to assess a patient's autonomic function.
Owner:MEDDORNA
Method and apparatus for measurement of autonomic nervous system function
InactiveUS20050251054A1Improve accuracyImprove assessmentMedical data miningElectrocardiographyTime domainAutonomic bladder dysfunction
The invention analyzes relationships between factors, within a patient population, to identify autonomic dysfunction patterns. Patient test results are then compared with the identified patterns to determine the patient's autonomic function. The invention can continually amend the patient population with new test results to create increasingly accurate normative data sets from which a patient's autonomic function can be more accurately assessed. The invention may apply this concept in an application service provider model. An embodiment of the invention may use a novel method of identifying ECG R-waves. The method locates R-waves by searching for maximum slope values, in signals, that exceed threshold values. Another embodiment of the invention entails a non-provocative HRV test whereby certain time domain and frequency domain factors are analyzed to determine a patient's autonomic function.
Owner:MEDDORNA
Implantable bioartificial perfusion system
ActiveUS20130289540A1High densityEnhanced interactionMedical devicesPharmaceutical delivery mechanismAutonomic functionTissue fluid
The disclosure provides an implantable bioartificial active secretion system for providing a physiological regulating secretion such as insulin necessary for functionality of a physiologic activity such as glucose metabolism of a living-being host. The system includes a housing implantable within the host, in fluidic communication with tissue fluid indicative of a physiological regulating secretion need. A chamber within the housing contains a plurality of physiologically active, autonomously functioning, live secretory cells for producing the physiological regulating secretion. A continually operating two pump apparatus moves tissue fluid into contact with the secretory cells for pick up of the physiological regulating secretion for subsequent physiologically-effective dispensing into the host, while avoiding immunorejection of the host body or of the host to the secretory cells.
Owner:ZELTSER GREGORY +1
Compositions and methods for the treatment of CNS injuries
InactiveUS20140248253A1High degree of recoveryPromotes neurologicalOrganic active ingredientsNervous disorderAutonomic functionMedicine
The present invention is directed to a method of improving functional recovery following a central nervous system contusion injury. The method includes administering a therapeutically effective amount of glycosaminoglycan degrading enzyme. The glycosaminoglycan degrading enzyme may be dermatan sulfate or chondroitin sulfate degrading enzymes. The central nervous system contusion injury may include a traumatic brain injury or a spinal cord injury. The functional recovery may include autonomic functions, sensory functions, motor functions or the like.
Owner:ACORDA THERAPEUTICS INC
Method of neuromodulation therapy
InactiveUS20050056290A1Thoroughly assessedEasy to controlSurgeryEvaluation of blood vesselsAutonomic functionMedicine
A method of energetic medicine wherein a practitioner corrects faults in various functional categories of the system that controls vegetative functions in the body of the subject. The method is comprised of the steps of applying specific clinical algorithms consisting of queries and corrective statements to assess and then train this system toward optimal function. The medium by which this is achieved is verbal and / or other than conscious communications from the practitioner to subject, as well as application of physical stimuli. Communication from subject to the practitioner is determined by monitoring an indicator of autonomic function.
Owner:FEINBERG LESLIE S
Heart rate variability control of gastric electrical stimulator
InactiveUS20070203531A9Improvement in autonomic functionInternal electrodesDiagnostic recording/measuringAutonomic functionNervous system
Methods and systems for stimulating a gastrointestinal system and for modifying a stimulation signal based on an indicator of autonomic nervous system function are described. One indicator of autonomic nervous system described is cardiac activity, including heart rate variability. Methods for selecting candidate patients for gastrointestinal stimulation therapy based on an indicator of autonomic nervous system function and methods of treating patients at risk of or suffering from gastrointestinal disorders by modifying therapy based on an indicator of autonomic function are also discussed.
Owner:MEDTRONIC INC
Method and system of auditory evoked heart rate variability analysis
InactiveUS20100268104A1High precisionSimplify analytical processingElectrocardiographyCatheterFrequency spectrumSOUND STIMULATION
The present invention provides a method and system of auditory evoked heart rate variability analysis having advantage of simply analytical process and portability. The disclosed method mainly includes the following steps of: stimulating the auditory system of a person by a sound through a sound transmission device, capturing an electrocardiogram signal of the person, performing analog-to-digital conversion of the electrocardiogram signal, selecting the peaks of the electrocardiogram signal and transforming the qualified peaks to a consecutive peak signal, and performing spectrum analysis to the peak signal in frequency domain, and obtaining the difference of the spectral parameters before and after the evoked sounds. Moreover, the sound further is selected from the group consisting of noise, short tone burst, click, and any other sound with the intensity of 30 dB to 100 dB. By comparing the heart rate variability analysis before or after sound stimulation in order to get the differences, the disclosed method and system of auditory evoked heart rate variability analysis can evaluate a changing index of stimulated autonomic functions.
Owner:NATIONAL YANG MING UNIVERSITY
Measurement of autonomic function
The present invention is an article of manufacture and method for using same, comprising at least two sensors having a paired offset potential of below about + / −1.0 mV; and a data gathering device connected to the sensors capable of measuring the voltage difference between the sensors. The sensors preferably are AgCl coated Silver.
Owner:BIOGRAPHS
Compositions and methods for the treatment of CNS injuries
InactiveUS20080025963A1Recovery functionHigh degree of recoveryOrganic active ingredientsNervous disorderAutonomic functionMedicine
The present invention is directed to a method of improving functional recovery following a central nervous system contusion injury. The method includes administering a therapeutically effective amount of glycosaminoglycan degrading enzyme. The glycosaminoglycan degrading enzyme may be dermatan sulfate or chondroitin sulfate degrading enzymes. The central nervous system contusion injury may include a traumatic brain injury or a spinal cord injury. The functional recovery may include autonomic functions, sensory functions, motor functions or the like.
Owner:ACORDA THERAPEUTICS INC
Stent with autonomic function
To provide a stent which holds various performances such as deliverability, prevention of restenosis, flexible shape conformability, and so on and is therefore adaptable not only to a bile duct but also to a blood vessel system such as a tortuous coronary artery substantially without causing restenosis.A stent with an autonomic function is made of a Ti—Ni based shape memory alloy and has a maximum expanding force at a center portion in its lengthwise direction.
Owner:TOHOKU UNIV +2
Pen shaped analytical apparatus of heart rate variability
InactiveUS20100191135A1High precisionSimplify analytical processingDiagnostic recording/measuringSensorsAutonomic functionEcg signal
The present invention provides a pen shaped analytical apparatus of heart rate variability having a view to simplifying the analytical process and carrying out automation. The pen shaped analytical apparatus of heart rate variability mainly includes an electrocardiogram signal converter; a micro-controller unit; a feature extraction unit; a decision making unit; a display unit and a switching unit. It is noted that the pen shaped analytical apparatus of heart rate variability further comprises: a plurality of electrodes and a battery. In practice, the pen shaped analytical apparatus of heart rate variability put forth in the present invention is quite time-saving and easy to use, as it prints out a person heart rate variability analytical result and autonomic function data in just five minutes after a plurality of electrodes are pressed simultaneously.
Owner:NATIONAL YANG MING UNIVERSITY
Measurement for autonomic function
The present invention is an article of manufacture and method for using same, comprising at least two self adhesive sensors having a paired offset potential of consistently below about + / −1.0 mV; and a data gathering device connected to the sensors capable of measuring the voltage difference between the sensors. The sensors preferably are AgCl coated Silver.
Owner:BIOGRAPHS
Method and apparatus for the measurement of autonomic function for the diagnosis and validation of patient treatments and outcomes
A pain measurement and diagnostic system (PMD) for bioanalytical analysis of pain matrix activity and the autonomic nervous system to diagnose and validate patient treatments, health status and outcomes. The PMD is implemented using medical devices for measuring and reporting objective measurements of pain through patient monitoring and analyzing related biological, psychological, social, environmental, and demographic factors that may contribute to and effect physiological outcomes for patients and through the integrated and iterative analysis improve diagnosis of pain, the evaluation of related disease states, health status, and treatment options.
Owner:DULLEN DEBORAH
Pressure feedback automatic turning bed
A pressure feedback type automatic turning bed, including a bed body, a transmission mechanism and an automatic pressure sensing control system: the bed body is composed of a bottom bed board, a middle bed board, an upper movable bed board, a bedside baffle, a bed foot baffle, a left The side baffle and the right side baffle are composed. The transmission mechanism is composed of a hydraulic transmission system and a four-bar linkage mechanism. An oil tank is arranged on the bottom bed. Composed of coder and automatic control circuit, used to control the work of the hydraulic transmission system. The invention realizes multi-dimensional, multi-angle, adjustable folding and flipping of the system, realizes the collection of parameters such as the patient's position and weight, realizes parameter identification, and independently sets motion parameters.
Owner:SHANGHAI JIAO TONG UNIV
System and method for autonomous function closed loop control
PendingCN114390934ASpinal electrodesEvaluation of blood vesselsAutonomic functionPhysical medicine and rehabilitation
A neuromodulation system (10, 110), in particular a neurostimulation system (10, 110), for treating a patient, in particular for enhancing at least one autonomous function, such as blood circulation and / or respiration, where the system comprises:-at least one signal input module (12, 112) configured to receive at least one or more signals indicative of blood circulation, the invention relates to a neuromodulation system (10, 110) comprising a signal input module (12, 112), in particular indicative of a pulse and / or blood pressure, at least one control module (14, 114), where the control module (14, 114) is connected to the signal input module (12, 112), where the control module (14, 114) is configured to adjust a neurostimulation provided by the neuromodulation system (10, 110) based on a signal received by the signal input module (12, 112).
Owner:ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL) +2
Stent with autonomic function
To provide a stent which holds various performances such as deliverability, prevention of restenosis, flexible shape conformability, and so on and is therefore adaptable not only to a bile duct but also to a blood vessel system such as a tortuous coronary artery substantially without causing restenosis. A stent with an autonomic function is made of a Ti—Ni based shape memory alloy and has a maximum expanding force at a center portion in its lengthwise direction.
Owner:TOHOKU UNIV +2
Sensor monitoring interactive control automatic autonomic function detector
ActiveCN103445767BOptimize dataThe analysis result is accurateDiagnostic recording/measuringSensorsData acquisitionDisplay device
The invention discloses a sensing monitoring interaction control fully automatic autonomic nerve function detection instrument and a detection method. The detection instrument comprises a computer, a display, an electrocardiogram monitoring device, a blood pressure monitoring device, an air passage pressure monitoring device, a holding force monitoring device and a breath monitoring device, wherein the display, the electrocardiogram monitoring device, the blood pressure monitoring device, the air passage pressure monitoring device, the holding force monitoring device and the breath monitoring device are respectively connected to the computer. The detection method has the advantages that through specifying the test action of testees, the optimum data collection is realized, and the accuracy and the precision of the later-stage autonomic nerve function evaluation results are ensured. The display, the air pressure monitoring device, the holding force monitoring device and the breath monitoring device are respectively adopted for realizing the real-time detection and display on each test action of the testees, the computer can prompt the test action which does not conform to the standard in time, and the computer is enabled to obtain the optimum data in the monitoring process through the electrocardiogram monitoring device and the blood pressure monitoring device so that the accurate and precise autonomic nerve function evaluation results with high comparability and high repeatability can be obtained.
Owner:邝建
Method and system of auditory evoked heart rate variability analysis
InactiveUS8452385B2High precisionSimplify analytical processingElectrocardiographyCatheterFrequency spectrumSOUND STIMULATION
The present invention provides a method and system of auditory evoked heart rate variability analysis having advantage of simply analytical process and portability. The disclosed method mainly includes the following steps of: stimulating the auditory system of a person by a sound through a sound transmission device, capturing an electrocardiogram signal of the person, performing analog-to-digital conversion of the electrocardiogram signal, selecting the peaks of the electrocardiogram signal and transforming the qualified peaks to a consecutive peak signal, and performing spectrum analysis to the peak signal in frequency domain, and obtaining the difference of the spectral parameters before and after the evoked sounds. Moreover, the sound further is selected from the group consisting of noise, short tone burst, click, and any other sound with the intensity of 30 dB to 100 dB. By comparing the heart rate variability analysis before or after sound stimulation in order to get the differences, the disclosed method and system of auditory evoked heart rate variability analysis can evaluate a changing index of stimulated autonomic functions.
Owner:NATIONAL YANG MING UNIVERSITY
Diabetes and Hypertension Screening by Assessment of Arterial Stiffness and Autonomic Function
InactiveUS20190029532A1Reliable and convenient and cost-effectiveHealth-index calculationDiagnostics using spectroscopyDiabetes mellitusAutonomic function
Owner:MEDICI TECH LLC
System and method for controlling autonomous functions
Owner:ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL) +1
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