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Medicament for treating overactive bladder caused by bladder outlet obstruction

A technology for overactive bladder and tract obstruction, applied in the field of medicine, can solve the problems of undeveloped drug treatment research and achieve good results

Inactive Publication Date: 2012-10-24
张家华
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition to surgery, studies of drug therapy based on the above point of view have not been carried out

Method used

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  • Medicament for treating overactive bladder caused by bladder outlet obstruction
  • Medicament for treating overactive bladder caused by bladder outlet obstruction
  • Medicament for treating overactive bladder caused by bladder outlet obstruction

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Example 1 Application of M3 receptor blockers in overactive bladder caused by female bladder outflow tract obstruction

[0019] The patient took tolterodine tartrate (tolterodine L-tartrate) 4 mg alone, once a day, and the symptoms of frequent urination and urgency were somewhat relieved, but the dysuria increased and the urinary stream became thinner. In addition to tolterodine tartrate, solifenacin succinate is also an M3 receptor blocker with the same effect.

[0020] The inventor believes that the above-mentioned treatment only relaxes the detrusor muscle of the bladder, but does not deal with the cause of the disease, so the curative effect is limited. The histopathological examination results of surgical resection of the above patient showed: hyperplasia caused by chronic inflammatory tissue of the urethra. Analysis of the cause of female urethral obstruction may be chronic inflammatory hyperplasia of the urethra caused by chronic urethritis, vaginitis, and pelvic...

Embodiment 2

[0023] Example 2 Application of α1-A receptor blockers in overactive bladder caused by female bladder outflow tract obstruction

[0024] Tamsulosin hydrochloride is a specific blocker of α1 receptor subtypes, and the α1 receptors in the bladder outflow tract are mainly α1A receptors. The body has a highly selective blocking effect, which relaxes the smooth muscle, reduces the urethral pressure and reduces the closed area of ​​the urethra. In addition to tamsulosin hydrochloride, tamsulosin hydrochloride is also an α1 receptor blocker, which can highly selectively block the α1 receptors on the smooth muscle of the urethra, bladder neck and prostate. Relax the smooth muscle, reduce the pressure of the urethra and reduce the closed area of ​​the urethra.

[0025] In 40 cases similar to Example 1, tamsulosin hydrochloride 0.2 mg was taken alone, dysuria was relieved, frequency and urgency were only slightly alleviated, and no good therapeutic effect was achieved. The inventors b...

Embodiment 3

[0027] Example 3 Application of M3 receptor blockers and α1-A receptor blockers combined with overactive bladder caused by female bladder outflow tract obstruction

[0028] Another 40 female patients were taken tamsulosin hydrochloride (trade name: Harold) 0.2 mg and tolterodine L-tartrate (trade name: Cheniting) 4 mg, once a day, and after 1 week, the patient's Symptoms such as urgency, frequent urination, thinner urine stream, dribbling, and dysuria were relieved, and the bladder capacity of the patient was expanded, and the urine output increased each time. After 6 weeks, the symptoms basically disappeared.

[0029]

[0030] The present invention is further set forth below in conjunction with embodiment. It should be understood that these examples are only used to illustrate the present invention, not to limit the scope of the present invention. In the following examples, the methods for which specific conditions are not indicated and the reagents for which formulas ar...

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Abstract

The invention relates to the field of medicaments, in particular relates to a medicament for treating overactive bladder caused by bladder outlet obstruction, and specifically relates to application of an M3 receptor inhibitor and an alpha1-A receptor inhibitor in preparation of a medicament for treating overactive bladder caused by bladder outlet obstruction. The medicament for treating the bladder outlet obstruction consists of the following components in parts by weight: 15 to 20 parts of M3 receptor inhibitor, and 0.5 to 2 parts of alpha1-A receptor inhibitor. By investigating the indexes of bladder sensory function, bladder detrusor pressure, highest urine flow rate, vesical neck pressure, functional urethral length, urethral closing area and the like, the M3 receptor inhibitor and the alpha1-A receptor inhibitor applied to treatment of the overactive bladder caused by the bladder outlet obstruction have a good effect.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a medicine for treating excessive bladder activity caused by bladder outflow tract obstruction. Background technique [0002] Sphincter refers to a circular muscle distributed in the walls of certain lumens in humans and animals. When the sphincter contracts, it can close the lumen and open the lumen when it relaxes. It is usually in a contracted state. Generally subject to autonomic innervation or hormone regulation. The traditional theory holds that: the internal and external urethral sphincters are the most important in urinary control, and when both are damaged, urinary incontinence will inevitably occur. However, there is no such anatomical structure as the "internal urethral sphincter" in anatomy, and many phenomena in clinical work cannot be satisfactorily explained by the internal and external urethral sphincters. It has been confirmed by hundreds of patients with posterior uret...

Claims

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Application Information

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IPC IPC(8): A61K45/06A61K31/137A61K31/18A61P13/10
Inventor 张家华
Owner 张家华
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