Materials and methods for treating neuropathies and related disorders including those involving a keystone nerve

Abstract

Methods, apparatus, compositions and kits for inhibiting a disorder in a human patient, including non-cerebral neurovascular disorder or muscular headache pain, or loss of motor or sensory function, sympathetic tone or range or fluidity of motion that affect a nerve pathway at more than one locus associated with the disorder to inhibit the disorder. Alternatively or in addition, neuropathy associated with a disorder is treatable by palpating to determine a Keystone nerve essential to the neuropathy, applying pressure to determine a point of maximum discomfort or trigger of increased symptoms to identify a Levin Sign as a locus of initial intervention, and intervening to treat the neuropathy at the location of the Levin Sign by administering a pharmaceutically active agent, internal implanted or external neuro stimulation affecting the nerve pathway to inhibit the neuropathy.

Description

[0001]This application is a continuation of U.S. patent application Ser. No. 15 / 998,669, filed Aug. 15, 2018, which claims the benefit of U.S. Provisional Patent Application No. 62 / 545,536, filed Aug. 15, 2017, and is a continuation-in-part of U.S. patent application Ser. No. 14 / 777,145, filed Sep. 15, 2015, which is the U.S. national stage application of PCT / US2014 / 031025 filed Mar. 18, 2014, which claims priority from Provisional Application No. 61 / 793,123, filed Mar. 15, 2013 and Provisional Application No. 61 / 813,432 filed Apr. 18, 2013, the disclosures of each of which are hereby incorporated herein by reference in their entireties.BACKGROUND OF THE INVENTION[0002]This invention relates to compositions, devices, kits and methods for treating neuropathies and related disorders, including those involving a “Keystone nerve” (as defined hereinafter), including inhibiting pain associated with them, or for improving functionality, such as functionality resulting from the loss of moto...

AI Technical Summary

Benefits of technology

[0037]To treat pain, disease or suboptimal function involving any neurologic, intracranial, extracranial, nerve structure, spinal cord, cerebellar, pontine, Brainstem, basal ganglia, cranial nerve, or related structure, or peripheral nerve and particularly to treat of headache, cluster headache, migraine, facial pain, posttraumatic headache, Cervicogenic headache, occipital neuralgia, tinnitus, hearing or visual issues, postoperative or post surgical head, neck or facial pain, Post herpetic neuralgia or to enhance recovery from reconstructive, or other surgeries from trauma, Oncologic, or deformative pathologies or states, to improve cognitive function, treat PTSD, treat psychiatric disorders, vascular dementia, Alzheimer's disease symptoms or cognitive decline, control dangerous individuals or to keep them within or away from certain locations, improve sleep hygiene, improve wakefulness, decrease unwanted sequelae of sleep deprivation and in the treatment of dysesthesias or dental or oral pain including but not limited to burning mouth syndrome.

Problems solved by technology

Neuropathies may result from metabolic, toxic, traumatic, postsurgical, oncologic, or degenerative spinal or other insults.

Neuropathies compromise sensory, motor, autonomic and other functions and often result in severely compromised function and pain and dyssesthesias.

They are very difficult to treat and patients often require ongoing high dose opioid and other medications and have poor responses to these and other therapies.

However, many cases involve only a minor, seemingly inconsequential injury, such as a sprain.

However, no single drug or combination of drugs has produced consistent long-lasting improvement in symptoms.

These have not been optimally effective for many patients.

Systemic administration of a local anesthetic is not a practical method for delivery of the local anesthetic to provide lasting relief of pain or other symptoms and indications associated with traumatic neuropathies and related disorders in a human patient, due to known adverse reactions, occasionally including acute emergencies, associated therewith.

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