Materials and methods for treating neuropathies and related disorders including those involving a keystone nerve

a neuropathic and related disorder technology, applied in the field of neuropathies and related disorders, can solve the problems of severe impairment of function and pain and dysesthesia, poor response, difficult treatment, etc., and achieve the effect of improving the composition of the invention

Pending Publication Date: 2022-05-19
BHL PATENT HLDG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0037]To treat pain, disease or suboptimal function involving any neurologic, intracranial, extracranial, nerve structure, spinal cord, cerebellar, pontine, Brainstem, basal ganglia, cranial nerve, or related structure, or peripheral nerve and particularly to treat of headache, cluster headache, migraine, facial pain, posttraumatic headache, Cervicogenic headache, occipital neuralgia, tinnitus, hearing or visual issues, postoperative or post surgical head, neck or facial pain, Post herpetic neuralgia or to enhance recovery from reconstructive, or other surgeries from trauma, Oncologic, or deformative pathologies or states, to improve cognitive function, treat PTSD, treat psychiatric disorders, vascular dementia, Alzheimer's disease symptoms or cognitive decline, control dangerous individuals or to keep them within or away from certain locations, improve sleep hygiene, improve wakefulness, decrease unwanted sequelae of sleep deprivation and in the treatment of dysesthesias or dental or oral pain including but not limited to burning mouth syndrome.

Problems solved by technology

Neuropathies may result from metabolic, toxic, traumatic, postsurgical, oncologic, or degenerative spinal or other insults.
Neuropathies compromise sensory, motor, autonomic and other functions and often result in severely compromised function and pain and dyssesthesias.
They are very difficult to treat and patients often require ongoing high dose opioid and other medications and have poor responses to these and other therapies.
However, many cases involve only a minor, seemingly inconsequential injury, such as a sprain.
However, no single drug or combination of drugs has produced consistent long-lasting improvement in symptoms.
These have not been optimally effective for many patients.
Systemic administration of a local anesthetic is not a practical method for delivery of the local anesthetic to provide lasting relief of pain or other symptoms and indications associated with traumatic neuropathies and related disorders in a human patient, due to known adverse reactions, occasionally including acute emergencies, associated therewith.

Method used

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  • Materials and methods for treating neuropathies and related disorders including those involving a keystone nerve
  • Materials and methods for treating neuropathies and related disorders including those involving a keystone nerve
  • Materials and methods for treating neuropathies and related disorders including those involving a keystone nerve

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0228]A female patient with pain and decreased range of motion for many months following repair of a torn rotator cuff, was treated using a fan like injection of lidocaine 1% (3 ml) merely in the vicinity of the suprascapular nerve, hitting small fibers in the area. The patient showed remarkable improvement in pain and range of motion.

[0229]This block differs from classic suprascapular block in that the area around the nerve was targeted and treated, rather than the nerve itself. This procedure was easier to perform than trying to block the suprascapular nerve directly, which would have been much more difficult to target or specific, direct treatment. In terms of neurostimulation, or blocking with energy sources such as light, laser, infrasound or electricity, it means that transcutaneous methods can work well by targeting the area around a major nerve, or merely within its general area of innervation, and not necessarily the nerve itself. It also shows that a regional sympathetic b...

example 2

[0230]A female patient with severe leg and foot pain for several years due to prior surgical trauma resulting from an initial bunionectomy and other follow-up surgeries was treated by a saphenous nerve injection of ropivacaine 0.25% (5 ml) after exquisite tenderness was noted on palpation of the saphenous nerve greater than 14 cm proximal to the level of her foot trauma. However, much of her symptomatology was in the distribution of other nerves. Indeed, she had motor dysfunction of the toes and her saphenous nerve is a purely sensory nerve. Within 10 minutes, the patient reported almost complete relief of pain and had normalized sensation and strength in the distribution of other peripheral nerves, including the peroneal nerves. She could walk like she had not in many years. Surprisingly, we see that block of one nerve with purely sensory function decreased symptoms across the distribution of other nerves.

example 3

[0231]A female patient with CRPS and severe pain, including pins and needles sensation in her right hand for over 20 years, presented with these symptoms and major discoloration in her right arm due to compartment syndrome many years ago and could barely open and close her fist. After a single treatment with bupivacaine 0.25% (3 ml) in the fanlike distribution of the radial nerve, she felt dramatically better and could open and close her hand and make and maintain a fist. Neurotrophic findings of decreased temperature, edema, allodynia, discoloration and severe restriction of range of motion decreased dramatically. This shows that CRPS of a limb can be treated by a compartment-type of peripheral block not previously done for single peripheral nerves.

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Abstract

Methods, apparatus, compositions and kits for inhibiting a disorder in a human patient, including non-cerebral neurovascular disorder or muscular headache pain, or loss of motor or sensory function, sympathetic tone or range or fluidity of motion that affect a nerve pathway at more than one locus associated with the disorder to inhibit the disorder. Alternatively or in addition, neuropathy associated with a disorder is treatable by palpating to determine a Keystone nerve essential to the neuropathy, applying pressure to determine a point of maximum discomfort or trigger of increased symptoms to identify a Levin Sign as a locus of initial intervention, and intervening to treat the neuropathy at the location of the Levin Sign by administering a pharmaceutically active agent, internal implanted or external neuro stimulation affecting the nerve pathway to inhibit the neuropathy.

Description

[0001]This application is a continuation of U.S. patent application Ser. No. 15 / 998,669, filed Aug. 15, 2018, which claims the benefit of U.S. Provisional Patent Application No. 62 / 545,536, filed Aug. 15, 2017, and is a continuation-in-part of U.S. patent application Ser. No. 14 / 777,145, filed Sep. 15, 2015, which is the U.S. national stage application of PCT / US2014 / 031025 filed Mar. 18, 2014, which claims priority from Provisional Application No. 61 / 793,123, filed Mar. 15, 2013 and Provisional Application No. 61 / 813,432 filed Apr. 18, 2013, the disclosures of each of which are hereby incorporated herein by reference in their entireties.BACKGROUND OF THE INVENTION[0002]This invention relates to compositions, devices, kits and methods for treating neuropathies and related disorders, including those involving a “Keystone nerve” (as defined hereinafter), including inhibiting pain associated with them, or for improving functionality, such as functionality resulting from the loss of moto...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61N1/36A61N1/04A61N1/378A61K31/445A61P29/00A61P25/06A61P25/02A61K31/167A61M19/00
CPCA61N1/36071A61N1/36021A61N1/0484A61N1/3787A61K31/445A61M11/007A61P25/06A61P25/02A61K31/167A61M19/00A61N1/36139A61P29/00A61M15/08A61M2202/048A61M2210/0618A61M2202/0007
Inventor LEVIN, BRUCE H
Owner BHL PATENT HLDG
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