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Application of quercetin in preparation of peripheral nerve injury treatment drugs

A technology for peripheral nerve injury and nerve injury, which can be applied in drug combinations, nervous system diseases, and pharmaceutical formulations, and can solve problems such as no relevant literature reports

Inactive Publication Date: 2014-08-20
CHINA PHARM UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] However, quercetin is effective in reversing or delaying the occurrence and development of peripheral nerve diseases, and there is still no relevant literature report

Method used

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  • Application of quercetin in preparation of peripheral nerve injury treatment drugs
  • Application of quercetin in preparation of peripheral nerve injury treatment drugs
  • Application of quercetin in preparation of peripheral nerve injury treatment drugs

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Example 1 Effect of quercetin on motor function of mice after sciatic nerve injury

[0016] 1. Experimental method

[0017] 1) Toe extension function test

[0018] To assess motor function recovery after nerve injury (sciatic nerve), we measured motor function in the toes. Use medical gauze to slowly wrap the body end of the mouse, and then lift the tail of the mouse to expose the hind feet until they can be clearly observed. In this condition, the toes are extended, and the toes are separated and reached the maximum distance of extension (extension reflex). The firing is controlled by the small muscles of the foot innervated, and is then scored using the reported method: 0, no extension; 1, partial extension; and 2, complete extension (see figure 1A). Full toe extension requires full extension, wide intertoe spacing, and duration (at least 2 seconds). Before testing the affected side of the mouse, it is necessary to observe that the toe of the healthy side is full...

Embodiment 2

[0032] Example 2 Effect of quercetin on sensory function of mice after sciatic nerve injury

[0033] 1. Experimental method

[0034] Mice (7 to 9 weeks old) were placed in wire mesh for 3 acclimation sessions one week before surgery (sciatic nerve pinch), followed by testing at corresponding time points after surgery. After 30 minutes of adaptive training, use the Austerlitz insect pin (model 000) (FST) to gently stimulate the plantar skin surface of the mouse, avoid moving the mouse's foot or puncturing the skin when stimulating. The outermost (sciatic nerve sensory area) of the mouse hindfoot plantar surface was divided into 5 areas (see figure 1 ). Acupuncture stimulation (2 times) was applied from the outermost toe (zone E) to the heel (zone A). The movement of the mouse's hind feet during the stimulation process will be regarded as an effective response, and this area will be recorded as 1 point, and then the next area will be tested. If there is no effective response...

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Abstract

The present invention belongs to the field of pharmacy, and relates to a new drug use of quercetin. According to the present invention, results of a series of the whole animal experiments show that the quercetin can enhance intrinsic regenerative capacity of the peripheral nerve and delay the degeneration process of the distal side stump so as to finally promote regeneration of the peripheral nerve, and make the recovery of movement and sensory functions be improved. In addition, experiment results prove that the quercetin can be used as the treatment drug for treating peripheral nerve injury and promoting function recovery of nerve after nerve injury.

Description

Technical field: [0001] The invention belongs to the field of research and development of nerve restoration drugs, and relates to the new drug application of quercetin, in particular to the application of quercetin in the preparation of drugs for recovering sensory function after nerve damage. Background technique: [0002] Peripheral nerve injury refers to the injury that occurs when the peripheral nerve trunk or its branches are subjected to external direct or indirect forces. Peripheral nerve injuries are very common clinically. Epidemiological investigations (Eser, F., L. Aktekin, et al. Etiological factors of traumatic peripheral nerve injuries. 2009. Neurology India57 (4): 434-437) show that in trauma patients Peripheral nerve injuries accounted for 10.4%, of which 77% were in the upper limbs and 23% were in the lower limbs. The most common nerve injuries in the upper and lower extremities were: the ulnar nerve in the upper extremities (27%) and the sciatic nerve in t...

Claims

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Application Information

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IPC IPC(8): A61K31/352A61P25/02
Inventor 廖红殷志琦陈明明张陆勇
Owner CHINA PHARM UNIV
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