Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Spinal cord fusion agent, preparation method and use thereof

A fusion agent and spinal cord technology, which is applied in the field of spinal cord fusion products and its preparation, can solve problems such as inability to completely cure functional defects of patients, achieve the effects of inhibiting neuronal necrosis and local inflammation, reducing morbidity, and promoting nerve regeneration

Inactive Publication Date: 2018-01-19
HARBIN MEDICAL UNIVERSITY
View PDF1 Cites 10 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, although clinical therapy can improve the quality of life of patients to a certain extent, none of them can completely cure the functional defects of SCI patients.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Spinal cord fusion agent, preparation method and use thereof
  • Spinal cord fusion agent, preparation method and use thereof
  • Spinal cord fusion agent, preparation method and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] The preparation of embodiment 1 spinal cord fusion agent

[0027] 1. Materials and sources

[0028] The polyethylene glycol used in this example is a sterile liquid stock solution, purchased from sigma company; bone marrow mesenchymal stem cells are extracted from autologous bone marrow; Schwann cells are extracted from autologous sural nerve; GDNF is synthesized by the applicant of the present invention; Phenolic acid was purchased from Tianjin Tasly as an injection; nano-graphene microtubes were purchased from Mitsui Corporation of Japan as a powder.

[0029] 2. Method

[0030] (1) Weigh 0.1 g of bone marrow mesenchymal stem cells, 0.01 g of glial cell-derived neurotrophic factor (GDNF), 1 g of nano-graphene, 0.01 g of Schwann cells, 1 g of salvianolic acid, and polyethylene glycol 600 97.88g;

[0031] (2) Stir the weighed raw materials (sterile) evenly before use.

Embodiment 2

[0032] The preparation of embodiment 2 spinal cord fusion agent

[0033] 1. Materials and sources

[0034] With embodiment 1.

[0035] 2. Method

[0036] (1) Weigh 0.5 g of bone marrow mesenchymal stem cells, 0.01 g of glial cell-derived neurotrophic factor (GDNF), 0.05 g of nano-graphene, 0.1 g of Schwann cells, 3 g of salvianolic acid, polyethylene glycol 400 91.39g;

[0037] (2) Stir the weighed raw materials (sterile) evenly before use.

Embodiment 3

[0038] The preparation of embodiment 3 spinal cord fusion agent

[0039] 1. Materials and sources

[0040] With embodiment 1.

[0041] 2. Method

[0042] (1) Weigh 0.01 g of bone marrow mesenchymal stem cells, 0.05 g of glial cell-derived neurotrophic factor (GDNF), 1 g of nano-graphene, 1 g of Schwann cells, 1 g of salvianolic acid, and polyethylene glycol 800 96.94 g;

[0043] (2) Stir the weighed raw materials (sterile) evenly before use.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a spinal cord fusion agent and a preparation method and use thereof. The spinal cord fusion agent disclosed by the invention is prepared from polyethylene glycol, bone mesenchymal stem cells, Schwann cells, glial cell lined derived neurotrophic factor (GDNF), salvianolic acid and nano graphene. Studies show that the use of the spinal cord fusion agent of the invention enables rapid reconnection of divided white matter fiber tracts and gray matter staple fibers to reconstitute spinal integrity and electrical conduction and is capable of recovering motion and sensory functions below the lesion level in a short period of time, thereby effectively reducing the incidence of paraplegia and complications thereof, and no relevant products exist at home and abroad. The spinal cord fusion agent disclosed by the invention can have a wide application prospect clinically.

Description

technical field [0001] The invention relates to an intraoperative spinal cord fusion product and its preparation method and application, in particular to a product containing polyethylene glycol, bone marrow mesenchymal stem cells, glial cell-derived neurotrophic factor (GDNF), salvianolic acid, Spinal cord fusion product of nano-graphene, preparation method and application thereof. The invention belongs to the technical field of medical instruments. Background technique [0002] With the continuous advancement of science and technology, modern surgical techniques and methods are also advancing with each passing day, but spinal cord injury is still a major problem for neurosurgeons and orthopedic surgeons. Tens of thousands of people around the world suffer from spinal cord injuries every year, severe cases lead to paraplegia or even death, and the quality of life of patients is extremely low. [0003] Traditional medicine believes that the central nervous system cannot be...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K38/18A61K47/10A61K47/04A61P25/00A61K35/30A61K35/28A61K31/77A61K31/336
Inventor 任晓平刘泽汉任帅
Owner HARBIN MEDICAL UNIVERSITY
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com