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Application of BefA protein in preparing medicament for treating type I diabetes or complications thereof

A technology for diabetes and complications, applied in the field of medicine, can solve the problems of unclear reports on the protein of type I diabetes, and achieve the effect of alleviating symptoms of hyperglycemia and weight loss

Pending Publication Date: 2020-11-24
华润博雅生物制药集团股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] However, the above-mentioned are all vaccines, and the protein reports for the treatment of type 1 diabetes in the prior art are not clear

Method used

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  • Application of BefA protein in preparing medicament for treating type I diabetes or complications thereof
  • Application of BefA protein in preparing medicament for treating type I diabetes or complications thereof
  • Application of BefA protein in preparing medicament for treating type I diabetes or complications thereof

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Embodiment Construction

[0049] The present application will be further introduced below in conjunction with the embodiments.

[0050] In order to more clearly describe the embodiments of the present invention or the technical solutions in the prior art, in the following description, different "an embodiment" or "an embodiment" do not necessarily refer to the same embodiment. Different embodiments can be replaced or combined, and those skilled in the art can obtain other implementations based on these embodiments without any creative efforts.

[0051] A kind of application of BefA albumen in preparation treatment type 1 diabetes or type 1 diabetes complication medicine, comprises the steps:

[0052] First, construct a T1DM animal model:

[0053] Eight-week-old male C57BL / 6 mice were divided into normal control group, T1DM model group, low-concentration BefA protein treatment group of 10 groups, high-concentration BefA protein treatment group of 50 groups, 15 mice in each group;

[0054] After one we...

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PUM

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Abstract

The invention belongs to the technical field of medicines, and particularly relates to an application of BefA protein in preparing a medicament for treating type I diabetes or complications of type Idiabetes. The medicament has an oral dosage form. The oral dosage form is a tablet, powder, suspension, emulsion, capsule, granule, pill, syrup or lemonade. According to the application, oral administration of BefA protein to T1DM mice can alleviate the symptoms of hyperglycemia and weight loss; oral administration of BefA protein can significantly reduce expression of TLR-4 / NF-kappaB, which is consistent with the diabetic inflammatory signal pathway, in the pancreas of T1DM mice; and BefA protein exerts a concentration-dependent inhibition of pancreatic islet cell necrosis and promotes the differentiation and proliferation of pancreatic beta cells.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to the application of a BefA protein in the preparation of drugs for treating type I diabetes or complications of type I diabetes. Background technique [0002] The description of the background technology of the present invention belongs to the relevant technology related to the present invention, and is only used to illustrate and facilitate the understanding of the content of the present invention. prior art on the filing date. [0003] Diabetes mellitus (DM) is a metabolic disease characterized by continuous rise in blood sugar, which can be clinically divided into Type 1 diabetes mellitus (T1DM) and Type 2 diabetes mellitus ( Type 2 diabetes mellitus, T2DM). Multiple organ damage such as diabetic foot, eye disease, kidney disease and cardiomyopathy may occur in the late stage of diabetes. The treatment of diabetes varies according to its type, whether it is accompanied by c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/17A61K9/00A61P3/10A61P1/18
CPCA61K38/1709A61K9/0053A61P3/10A61P1/18
Inventor 陈廷涛梁小明
Owner 华润博雅生物制药集团股份有限公司
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