The invention relates to selenium-enriched health care thick wine containing cordyceps sinensis and mulberries. Fresh ripe selenium-enriched mulberries are picked, repeatedly washed, ground into a thick liquid and filtered, a soybean extract is added, the mixture is filtered and subjected to enzymolysis and juice filtration, and mulberry juice is obtained; glucose, a yeast extract and other nutrients are added to the mulberry juice, the mixture is sterilized, cordyceps sinensis is inoculated and cultured, and a cordyceps sinensis mycelium fermentation broth is obtained; after the fermentation broth is concentrated or not concentrated, white granulated sugar is added, the sugar degree is adjusted, a lactobacillus seed solution and high-activity dry yeast are added, after anaerobic fermentation is performed, filtration and clarification are performed, konjak oligosaccharides are added for blending, the mixture is filtered for sterilization, and the selenium-enriched health care thick wine containing the cordyceps sinensis and the mulberries is obtained. The formula is reasonable, and the thick wine has transparent color and luster, tastes sticky, refreshing and nutritious, has heavy ester fragrance and can reduce the blood glucose, relieve fatigue, improve the immunity of a human body, clear heat, remove internal heat, replenish blood, nourish yin, help produce saliva and slake thirst and adjust intestinal flora. Through measurement, the content of cordyceps sinensis polysaccharides is 0.76 g / 100 mL or higher, the content of cordycepin is 0.09 / 100 mL or higher, and the viscosity is higher than 200 mPa*s.