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A kind of chitosan and polypropylene carbonate composite medical dressing and preparation method

A technology of polypropylene carbonate and chitosan, which is applied in medical science, bandages, coatings, etc., can solve the problems of poor absorption performance, poor anti-immune rejection performance, poor antibacterial performance, etc., and achieve improved air permeability and price Inexpensive and emission reduction effect

Active Publication Date: 2021-10-22
JILIN UNIV +1
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  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] In order to solve the problems of poor tissue exudate absorption performance, poor anti-immune rejection performance, and poor antibacterial performance in polypropylene carbonate-based medical dressings, the present invention proposes a composite dressing made of chitosan and polypropylene carbonate. Bionic medical dressing and preparation method thereof

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  • A kind of chitosan and polypropylene carbonate composite medical dressing and preparation method

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Embodiment Construction

[0033] The present invention will be further elaborated below through specific embodiments in conjunction with the accompanying drawings.

[0034] Such as figure 1 Shown, the preparation method of the chitosan of the present embodiment and the composite bionic medical dressing of polypropylene carbonate may further comprise the steps:

[0035] 1) Prepare sodium chloride pore-forming agent, grind 40 g of solid sodium chloride and sieve the sample with standard sub-sampling sieves of different sizes. Sodium chloride pore-forming agents of 100 μm, 200 μm, 300 μm, 400 μm, 500 μm, and 600 μm were selected, and solid sodium chloride with a pore size of 300 μm was selected as the pore-forming agent for the next experiment;

[0036] 2) Preparation of a polypropylene carbonate suspension containing a pore-forming agent: 2 g of polypropylene carbonate pellets are dissolved in 50.76 ml of acetone solution to obtain a mass fraction of polypropylene carbonate of 5 wt %, and 0.86 g The 30...

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Abstract

The invention discloses a chitosan-polypropylene carbonate composite medical dressing and a preparation method. The present invention uses polypropylene carbonate as the base film of the dressing, which helps to reduce the discharge of medical solid waste and the application of petrochemical products; the air permeability of the polypropylene carbonate film is improved by making holes through the pore-forming agent; Dopamine is used as a bionic bioadhesive to connect hydrophilic and degradable biomaterial chitosan to hydrophobic polypropylene carbonate, and modify it by polydopamine and chitosan to improve its physical properties as a dressing, Biological properties; and using spermidine as a cross-linking agent, on the one hand, chitosan can be better fixed on the surface of PPC through secondary cross-linking, and on the other hand, the bioactive small molecule spermidine is introduced to improve the rejection of the wound Inflammatory response helps to shorten wound repair time and reduce scar formation.

Description

technical field [0001] The invention relates to the field of medical materials, in particular to a bionic medical dressing compounded with chitosan and polypropylene carbonate and a preparation method thereof. Background technique [0002] In modern society, thousands of people suffer from various traumas every year due to surgery, burns, scalds or other reasons, and dressings play an important role in the wound healing process. Traditional dressings, such as gauze dressings, are far from meeting the requirements of wound repair dressings in the medical field due to their shortcomings such as poor hemostatic effect, easy infection, and easy adhesion. Compared with traditional dressings, the emergence of new medical dressings has brought hope to people, such as natural biological dressings with good biocompatibility such as chitosan and alginate, and synthetic dressings with good mechanical properties such as polyethylene and polyurethane. . However, most dressings still ha...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L15/28A61L15/26A61L15/20A61L15/42A61L15/44A61L15/46C08J9/36
CPCA61L15/20A61L15/26A61L15/28A61L15/42A61L15/44A61L15/46A61L2300/404A61L2300/412C08J9/365C08J2369/00C08J2405/08C08J2479/04C08L5/08C08L79/02C08L69/00
Inventor 刘镇宁王丽梁嵩于家傲冯超仲英惠秦政吴倩倩卢国龙
Owner JILIN UNIV
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