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Preparation based on autologous tissue and application thereof

An autologous and preparation technology, used in tissue regeneration, medical preparations containing active ingredients, prostheses, etc., can solve problems such as unnatural hand feeling, liquefaction infection, hardening, etc., achieve good filling effect, promote blood vessel regeneration, source rich effects

Inactive Publication Date: 2018-12-25
白晋
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Since the early 1880s, breast augmentation has experienced liquid paraffin injection breast augmentation, silicone oil, silicone prosthetic breast implants, etc., but due to its related complications, including contracture, deformation, hardening, leakage, and unnatural hand feeling, etc. Confused seekers and doctors
However, the success or failure of autologous fat injection for breast augmentation is related to the survival rate of fat cells. There are problems such as absorption after fat tissue injection, so multiple operations are often required, and there are complications such as liquefaction infection.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] The preparation method of the autologous tissue-based injection of this embodiment comprises:

[0030] Step 1. Preparation of autologous collagen

[0031] The blood is collected from the human body through blood collection. After the first centrifugation, the blood enters the whole blood separator and undergoes a second centrifugation in the whole blood separator. The whole blood is centrifuged into three layers, from top to bottom are the plasma layer and the buffy coat layer. and erythrocyte layer, the plasma layer, buffy coat layer and erythrocyte layer liquid are respectively introduced into different storage units through catheters and stored separately, and an appropriate amount of plasma layer and buffy coat layer liquid is taken out from the storage unit and mixed at a ratio of 1:1, and passed through the chromatography unit Carry out preliminary purification and further purification by diafiltration unit to obtain the desired autologous collagen;

[0032] Step...

Embodiment 2

[0038] A kind of injection based on autologous tissue, its preparation method comprises:

[0039] Step 1. Preparation of autologous collagen

[0040] The blood is collected from the human body through blood collection. After the first centrifugation, the blood enters the whole blood separator and undergoes a second centrifugation in the whole blood separator. The whole blood is centrifuged into three layers, which are plasma layer and buffy coat layer from top to bottom. and the red blood cell layer, the plasma layer, the buffy coat layer and the red blood cell layer are respectively introduced into different storage units through catheters for separate storage, and an appropriate amount of plasma layer and buffy coat liquid is taken out from the storage unit and mixed at a ratio of 1:1, and passed through the chromatography unit Carry out preliminary purification and further purification by diafiltration unit to obtain the desired autologous collagen;

[0041] Step 2. Prepar...

Embodiment 3

[0047] A kind of injection based on autologous tissue, its preparation method comprises:

[0048] Step 1. Preparation of autologous collagen

[0049] The blood is collected from the human body through blood collection. After the first centrifugation, the blood enters the whole blood separator and undergoes a second centrifugation in the whole blood separator. The whole blood is centrifuged into three layers, from top to bottom are the plasma layer and the buffy coat layer. and erythrocyte layer, the plasma layer, buffy coat layer and erythrocyte layer liquid are respectively introduced into different storage units through catheters and stored separately, and an appropriate amount of plasma layer and buffy coat layer liquid is taken out from the storage unit and mixed at a ratio of 1:1, and passed through the chromatography unit Carry out preliminary purification and further purification by diafiltration unit to obtain the desired autologous collagen;

[0050] Step 2. Preparat...

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PUM

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Abstract

The invention discloses a preparation based on autologous tissue. The preparation includes autologous collagen and autologous adipose-derived stem cells. The invention also discloses application of the preparation based on autologous tissue. Breast implants mediated by autologous collagen and autologous adipose-derived stem cells are used in the embodiment of the invention; the autologous adipose-derived stem cells can significantly increase the survival rate of transplanted adipose cells; tissue differentiated from the autologous adipose-derived stem cells combines with the autologous collagen; a cell growth factor that promotes cell growth is further utilized so that absorption, infection and necrosis of transplanted adipose can be effectively inhibited, vascular regeneration of the transplanted adipose tissue can be promoted, the transplanted adipose has high survival rate, and breast forming effect is good. The effective ingredients of the autologous tissue are utilized in the embodiment to carry out tissue filling; the extract is from the autologous tissue of a patient, foreign object response cannot occur, and safety and reliability are good; the preparation has the advantages of good acquisition convenience, rich resources, good filling effect, small wound and the like.

Description

technical field [0001] The invention relates to the technical field of biological preparations, in particular to a preparation based on autologous tissue and its application. Background technique [0002] Breast augmentation, also known as breast augmentation or breast augmentation, is a surgery that enlarges the volume of the breast, makes it plump and well-proportioned, improves the body shape of women, and restores the unique curves of women by implanting medical materials or transplanting their own tissues. Since the early 1880s, breast augmentation has experienced liquid paraffin injection breast augmentation, silicone oil, silicone prosthetic breast implants, etc., but due to its related complications, including contracture, deformation, hardening, leakage, and unnatural hand feeling, etc. Confused seekers and doctors. Therefore, finding a safe, effective, non-toxic and durable tissue substitute has become the key to the development of breast augmentation. [0003] A...

Claims

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Application Information

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IPC IPC(8): A61K38/39A61P15/14A61L27/24A61L27/38A61L27/22A61L27/50A61L27/54A61K35/28A61K38/18A61K38/30
CPCA61K38/1808A61K38/1825A61K38/30A61K38/39A61L27/227A61L27/24A61L27/3834A61L27/3895A61L27/50A61L27/54A61P15/14A61K9/0019A61K35/28A61L2430/40A61L2430/34A61L2400/06A61L2300/414A61L2430/04A61K2300/00C08L89/00
Inventor 白晋
Owner 白晋
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