146results about How to "Inhibit biosynthesis" patented technology

Pharmaceutical compositions are disclosed suitable for parenteral administration having anti-inflammatory, analgesic, and anti-pyretic properties, which consist of a therapeutically effective amount of d,l or l-lysine salt of R,S or S-ibuprofen as active ingredient dissolved in sterile water to form a solution in the absence of an inert atmosphere and either substantially free or absolutely free of any excipient, organic solvent, buffer, acid, base, salt other than the active ingredient and capable of storage in the absence of an inert atmosphere. Also disclosed are methods employing the new compositions in the treatment of pain and inflammation, in reducing fever and in treating patent ductus arterious or intraventricular hemorrhage in prematurely born neonates.

The present invention relates to solenopsin alkaloid derivatives which are trans-2,6-disubstituted piperidines according to the structure:wherein R1 and R2 are selected from a C1 to C20 saturated or unsaturated linear, cyclic or branch-chained substituted or unsubstituted hydrocarbon group or a substituted or unsubstituted aromatic group, or an ester group. In certain preferred embodiments, where R1 or R2 contains an unsaturated group, such as an alkenyl group, the double bond in the alkenyl group preferably is found in the hydrocarbon chain between the carbon atom bonded to the piperidine ring and the adjacent carbon atom (alpha and beta carbons).

The invention relates to an anti-allergic composition for relieving as well as an application thereof. The anti-allergic composition for relieving comprises the following components: a first anti-allergic composition, a second anti-allergic composition, an anti-allergic peptide composition, Crambe abyssinica seed oil, bisabolol, and a Cardiospermum halicacabum extract product; the active componentof the first anti-allergic composition comprises 4-tert-butylcyclohexanol and 2-(3-(4-hydroxyphenyl)propanamido)benzoic acid; the active components of the second anti-allergic composition comprise anextract product of Stephania tetrandra, potassium lactate, phenoxyethanol, and dipotassium glycyrrhizinate; the active components of the anti-allergic composition comprise palmitoyl tripeptide-8 andacetyl tetrapeptide-15. The anti-allergic composition for relieving is evaluated by a macrophage nitric oxide inflammation releasing model, inhibition rate of nitric oxide releasing reaches 46.07%, and inhibition rate of histamine reaches 61.59%.

The present invention discloses a coronary artery medicine coating scaffold for inhibiting endometrial hyperplasia and preventing restenosis in the scaffold. It includes dilating scaffold base body and inner coating layer coated on the dilating scaffold base body, the above-mentioned inner coating layer is formed from medicine carrier and ligustrazine, their mass ratio is 3:1-1:3, the above-mentioned inner coating layer is one of methyl acrylate, methyl methacrylate copolymer, polylactic acid, polyglycollic acid, polymonoracemic lactic acid, polylactide-diglycolide polymer, phosphorylcholine, ethyl polyurethane inorganic micropore aluminium oxide and cellulose or their composite.

A microsphere carrying fluoroplex is prepared through dissolving polylactic acid to dichloromethane, dispersing SiO2 in it to become suspension, filling it in the aqueous solution of gelatin while stirring to become oil-in-water O/W emulsion, stirring for volatilizing dichloromethane, solidifying microspheres, centrifugal collecting, washing with secondary distilled water, vacuum drying to obtain SiO2-PLA microspheres, immersing them in the solution of fluoroplex in hydrochloric acid, centrifugal collecting, washing with secondary distilled water and freeze drying. Its advantages are durable acting, slow releasing and targeting function.

The invention belongs to the field of animal feeds, and particularly discloses a feed additive capable of improving yolk color and egg quality. The feed additive capable of improving the yolk color and the egg quality is prepared from the following active components in parts by weight: 50-150 parts of thallus laminariae powder, 0.002-0.006 part of lactoflavin, 50-150 parts of chili meal, 0.0005-0.005 part of xanthophyll, 50-150 parts of southernwood powder, 50-150 parts of dried marine algae powder and 50-150 parts of orange peel powder. The feed additive capable of improving the yolk color and the egg quality is reasonable in formula, and simple to prepare, can notably increase the egg laying rate of egg layers, and can prolong the peak period of egg laying. After laying hens eat the feed additive, the yolk color can be obviously improved, the egg weight is increased, a cholesterol content in yolk is reduced, the immunity of the laying hens is improved, the color of eggshells is deepened, the egg destruction rate is reduced, and the material egg ratio is reduced; after the laying hens eat the feed additive, the situation that toxin is remained in the bodies and eggs is avoided, the commodity value of the eggs is increased, and the market competitiveness is improved; besides, the feed additive improves the economic benefits for breeding households.

The invention discloses production of apple flavonoids by using a tissue culture method. The invention provides a method for preparing the flavonoids by using the tissue culture method, wherein the method comprises the following steps: 1) carrying out induction culture of an R6R6 genotype plant explant in a callus induction culture medium, to obtain a callus; 2) carrying out successive transfer culture of the callus in a successive transfer culture medium, to obtain a successive transfer callus; 3) carrying out enhancement culture of the successive transfer callus in an enhancement culture medium, to obtain an enhanced callus; and 4) extracting the flavonoids in the enhanced callus, to obtain the objective product. Experiments prove that the callus cultured by the method has the flavonoids content more than 30 times that of fruit pulp flavonoids of 'Jinshuai' and other apple varieties, and industrialized production of the apple flavonoids can be realized by using the tissue culture method.

The invention provides a composite leaf fertilizer. The composite leaf fertilizer comprises 20%-50% of seaweed extract. The seaweed extract is obtained in the mode that fresh seaweed serves as raw materials and is subjected to enzymolysis through alginate lyase. The composite leaf fertilizer further comprises urea, soluble phosphate, soluble magnesium salt, borax and soluble molybdenum salt. The invention further provides a preparing method and application of the composite leaf fertilizer. According to the composite leaf fertilizer and the preparing method and application, the seaweed extract is organically combined with nitrogen, phosphorus, potassium, magnesium, sulfur, boron and molybdenum to form the composite leaf fertilizer, plant absorption can be facilitated, and plant nutritional deficiency symptoms are avoided.

Provided are a pharmaceutical composition and a method for reducing, preventing, or delaying the development of a biological condition associated with administration of an opioid drug, in particular, tolerance to and/or physical dependence on an opioid drug. The pharmaceutical composition includes an opioid drug, a ceramide biosynthesis inhibitor and a pharmaceutically acceptable carrier. The method of treatment involves administration of an opioid drug and a ceramide biosynthesis inhibitor. Also provided are a method of screening for an agent that reduces, prevents or delays the development of tolerance to and/or physical dependence on an opioid drug as well as compositions comprising a dsRNA for inhibiting ceramide biosynthesis in a cell and a vector for expressing a shRNA for inhibiting ceramide biosynthesis in a cell.

The invention discloses a cut flower fresh-keeping agent which is composed of 1 to 3 wt% of sugar, 0.1 to 0.3 mmol.L of 8-hydroxyquinoline salt and 30-120 mu mol.L of resveratrol and/or sodium nitroprusside. The invention provides a scientific basis for the application of sodium nitroprusside on the cut flower fresh-keeping; the cut flower fresh-keeping agent prepared by pure natural plant extractive resveratrol delays the ageing process of cut flowers, prolongs vase life, and effectively avoids toxic action of Ag and other injurants on the environment; and the resveratrol has wide source, and is economic and practical, natural and environmental-friendly, and safe and stable, thus having wide application prospect in the future gardening post harvest industry when being used to prepare cut flower fresh-keeping agent.

The invention relates to a bactericidal composition with a synergistic effect, and in particular relates to a bactericidal composition containing bellkute and difenoconazole. The weight ratio of the bellkute to the difenoconazole is 1:100 to 100:1; and the bellkute and the difenoconazole together account for 5%-90% of the bactericidal composition by weight. The bactericidal composition provided by the invention is applied to prevention and treatment of leaf spot disease, banded sclerotial blight, full rot, rust disease, anthracnose, early blight, powdery mildew, gray mold, leaf blight, purpura, loose kernel smut, scab, black spot, alternaria leaf spot, stem wilt, soft rot of fruits, and diseases of fruits in a storage period. The invention also relates to application of the bactericidal composition containing the active ingredients of the bellkute and the difenoconazole to protection of plant propagation materials and plant organs grown later. The composition provided by the invention is wide in antimicrobial spectrum, has both prevention and treatment effects, has good prevention and treatment effects to the plant diseases, and further is capable of retarding or avoiding the resistance to drugs of pathogenic bacteria.

The invention discloses a cassiabarktree twig extract-containing whitening cosmetic preparation method, which comprises: 1, adopting ethanol to extract cassiabarktree twig, Chinese thorowax root, common macrocarpium fruit and rose to obtain an extract; 2, carrying out heating mixing melting on C18 alcohol, inositol hexaphosphate, glycerol and stearic acid, and adding tert-butylhydroquinone to dissolve to obtain an oil phase; 3, adding borax, glyceryl monostearate and refined water to the Chinese herbal extract, and mixing to obtain a water phase; and 4, adding the oil phase to the water phase, carrying out emulsification, and adding flavor to obtain the cosmetic with effects of whitening and spot removing. The cassiabarktree twig extract-containing whitening cosmetic has effects of skin metabolism improvement, skin blood circulation promotion, skin nutrition increase, effective free radical removal, pigmentation elimination, skin wrinkle and color spot fading, and delicate, smooth, white and flexible skin achievement.

The invention belongs to the technical field of compound pesticides and particularly relates to antifungal composition comprising fenpyrazamine and difenoconazole. The fenpyrazamine and the difenoconazole are taken as the effective ingredients and account for 1%-80% by weight of the composition, and the weight ratio of the fenpyrazamine to the difenoconazole is 50:1-1:10. The composition can be prepared in one of the forms including an emulsifiable concentrate, wettable powder, a suspension, granules, a microemulsion, an emulsion in water and water dispersible granules. The antifungal composition is used for controlling crop diseases and has the characteristics of broad antifungal spectrum, high efficiency, low toxicity, low residues, obvious synergistic effect, reduction of use cost and the like.

The invention discloses a herbicide composition containing fomesafen and pyroxasulfone. The herbicide composition mainly adopts the fomesafen and the pyroxasulfone as effective components; the mass ratio of the fomesafen to the pyroxasulfone is 1:50 to 50:1; then the fomesafen, the pyroxasulfone and a pesticide allowable additive and/or accessory ingredient are prepared into the composition with adosage form being a suspension agent, an emulsifiable concentrate, a microemulsion, a dispersible oil suspension agent, wettable powder or a water dispersible granule. According to the herbicide composition, the fomesafen and the pyroxasulfoneare are synergized to play a pesticide effect through completely different function mechanisms, so that gramineae and broadleaf weeds can be effectively controlled, the generation of the drug resistance of the weeds is greatly retarded, the herbicidal activity of the herbicide is improved, and the safety to crops is high. The herbicide composition has abetter application prospect.

The invention discloses a feed additive capable of replacing antibiotics and a preparation method of the feed additive. The feed additive comprises components in parts by weight as follows: 40-60 parts of 1% allicin, 6-10 parts of cinnamyl aldehyde powder, 3-5 parts of 50% vitamin E acetate, 2.0-2.4 parts of D-calcium pantothenate, 5.60-5.68 parts of zinc oxide powder, 4-6 parts of see-enriched yeast and 25.14-25.18 parts of a carrier, namely, calcium carbonate powder. The feed additive can meet requirements of domestic animals such as chickens for nutrition and increase the growth speed and improve the anti-disease capacity.

The invention discloses a mixed herbicide containing flazasulfuron and dithiopyr. The herbicide takes flazasulfuron and dithiopyr as the main effective components, and flazasulfuron and dithiopyr are in a mass ratio of 0.1-80:0.1-80. The mixed herbicide provided by the invention has significant application effect in lawn weeding, especially in control and elimination of various Gramineae, cyperaceae and broadleaf weed in lawn. Relative to a single agent, under the premise of improving the efficacy, the herbicide provided by the invention delays the weed resistance and has wide weeding spectrum, long duration and safety to lawn.

The invention provides methods of preparing 8-hydroxyl-2,2,14,14-tetramethyl pentadecanedioic acid and methods of making a pharmaceutical material comprising a purified amount of 8-hydroxyl-2,2,14,14-tetramethyl pentadecanedioic acid. Also provided are compositions and pharmaceutical materials including a purified amount of 8-hydroxyl-2,2,14,14-tetramethyl pentadecanedioic acid as well as methodsof treating various diseases and conditions using the compositions and pharmaceutical materials.

The invention discloses a mixed herbicide containing clodinafop-propargyl and procarbazone sodium. According to the herbicide, the clodinafop-propargyl and the procarbazone sodium are taken as main effective components, and the mass ratio of the clodinafop-propargyl to the procarbazone sodium is 1:(4-18). The mixed herbicide disclosed by the invention has a significant effect in application of weeding in a wheat paddock, particularly an application thereof in preventing and removing various graminaceous and broadleaved weeds in the wheat paddock. Compared with a single dosage, by adopting the herbicide disclosed by the invention, the weed resistance is delayed under the premise that the pesticide effect is improved, and the mixed herbicide is wide in weed control spectrum, long in lasting period, and has safety on wheat and after-reap crops.

The invention discloses coating liquid containing atoxigenic aspergillus flavus and a coating method and application thereof, and belongs to the technical field of food safety and processing. The coating liquid containing the atoxigenic aspergillus flavus, which is disclosed by the invention, is prepared by adding spores of the atoxigenic aspergillus flavus into coating agent solution; an additiveamount of the spores of the atoxigenic aspergillus flavus is 10<7> to 10<9> pieces per litre. 0.1 to 0.5% of bioflavonoid is added into the coating liquid to take a synergistic effect with the sporesof the atoxigenic aspergillus flavus. The coating liquid disclosed by the invention can effectively prevent pollution of aflatoxin to peanuts, wherein the spores of the atoxigenic aspergillus flavusand the bioflavonoid take the synergistic effect so as to improve the effect of preventing aflatoxin pollution.

The invention discloses a silkworm pupa protein source tetrapeptide SGQR. The amino acid sequence of the silkworm pupa protein source tetrapeptide SGQR is Ser-Gly-Gln-Arg. The invention also disclosesapplication of the silkworm pupa protein source tetrapeptide SGQR in preparation of lipid-lowering drugs. The SGQR can significantly reduce the HMGCR gene and protein amount, and therefore it is proved that the SGQR can reduce the synthesis amount of cholesterol.

The invention relates to recombinant oxygen inhibition oriented transdermal drug delivery skin stubborn disease removing emulsion. External emulsion for treating skin diseases is prepared by adopting ketoconazole, clobetasol, a cream base, pseudolarice tincture, benzoic acid, salicylic acid, absolute ethanol and a gel substrate as raw materials and carrying out proper weight proportioning, all components in the external emulsion which is finally prepared and obtained realize a synergistic effect, and an oriented drug penetration force is formed; oxygen in air is blocked through glue sealing on the surface of disease skin, and germs die due to lack of oxygen supply; meanwhile, inward action of pharmaceutical effect is realized, and powerful sterilization is realized, so that inside and outside coordination can be realized, and all kinds of skin stubborn diseases can be rapidly and efficiently treated. The external emulsion disclosed by the invention has very good effect and curative effect in treating all kinds of tinea corporis, tinea of feet and hands, skin itch, tinea cruris and the like, and has specific curative effect on difficult disease, miscellaneous internal disease and stubborn disease of the skin diseases caused by multiple germ cross infection and unknown pathogeny.

A sporting type healthcare slimming beverage and a preparing method thereof are provided. The beverage comprises, by weight, 1-3 parts of betaine, 3-7 parts of oligosaccharide and 1000 parts of water. The beverage according to an embodiment contains the betaine and the oligosaccharide. The oligosaccharide is a natural active compound, has sweetness that is 0.3-0.6 time of sweetness of cane sugar, maintains pure sweet properties of the cane sugar and is more refreshing in sweet taste than the cane sugar. The oligosaccharide can't be directly digested or absorbed by human bodies, and only can be absorbed and utilized by intestinal tract bacteria, and therefore the oligosaccharide does not cause obesity and is a good sweetener. At present the oligosaccharide is relatively ideal sugar used for sporting beverages. Under a situation that osmotic pressure is limited, the oligosaccharide can provide more heat, is fast in stomach passing, is lower in hypoglycaemia reaction after absorption than glucose, and has good effects for maintaining blood sugar levels and supplementing hepatic glycogen.

The invention discloses a mixed herbicide containing flazasulfuron and bensulfuron methyl. The herbicide takes flazasulfuron and bensulfuron methyl as the main effective components, and flazasulfuron and bensulfuron methyl are in a mass ratio of 1-80:1-80. The mixed herbicide provided by the invention has significant application effect in lawn weeding, especially in control and elimination of various Gramineae, cyperaceae and broadleaf weed in lawn. Relative to a single agent, under the premise of improving the efficacy, the herbicide provided by the invention delays weed resistance and has wide weeding spectrum, long duration and safety to lawn.

The invention provides a storage method of Huangguo mandarin oranges. The storage method comprises the following steps of before picking of the Huangguo mandarin oranges, spraying a calcium chloride solution onto crowns, and spraying palmityl alcohol or thiophanate sodium percarbonate liquid, so that the condition that fruits infect with moulds can be avoided, and the storage resistance of the fruits can be improved; a fresh keeping agent is made, and can perform fresh keeping treatment on the Huangguo mandarin oranges, so that the fresh keeping capacity of the Huangguo mandarin oranges can bestrengthened; in the storage process, an artificial controlled atmosphere storage method is adopted for storing the Huangguo mandarin oranges, low-oxygen high-carbon dioxide can also restrain biologysynthesis of ethylene, the physiological action of the ethylene can be weakened, the development action of physiological diseases can be restrained, and the rotting loss in the storage process is reduced, so that prolonging the storage life of fresh fruits and vegetables is facilitated, and low-oxygen high-carbon dioxide concentration effect is notable under low temperature. Because the proportion of the oxygen and carbon dioxide can be strictly controlled, and through tight cooperation with storage temperature, the Huangguo mandarin oranges are good in storage effect and long in quality guarantee period. The storage method is simple to operate, and worth of promotion.