Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Anticancer Chinese medicine compound nanometer emulsion and its preparation method

A compound emulsion and anti-cancer drug technology, which is applied in the field of medicine, can solve problems such as adverse reactions, achieve the effects of improving curative effect, avoiding instability problems, and good light-blocking effect

Inactive Publication Date: 2007-07-18
TAIJI MEDICINE INST CHONGQING
View PDF9 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the preparation avoids the side effects caused by the cosolvent polyoxyethylene castor oil contained in the clinical paclitaxel injection, it brings the adverse reactions caused by other cosolvents such as Tween 80, etc.
[0006] After inquiring about patents and literature, there is no report on combining paclitaxel, docetaxel, cucurbitacin, or hydroxycamptothecin with one or more of javanica javanica oil to make compound preparations, including the preparation of intravenous emulsions

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Prepare raw materials, auxiliary materials and other components according to the following component quantities

[0015] Docetaxel 1g

[0016] Brucea javanica oil 100g

[0017] Soy Lecithin for Injection 20g

[0018] Poloxamer 12g

[0019] Glycerin 200g

[0020] Add water for injection to 1000ml

[0021] Preparation of water phase: add an appropriate amount of water for injection into a high-speed mashing tissue mixer, add soybean lecithin for injection, emulsion aid for injection, and isotonic agent, stir for 7-12 minutes, heat the solution and keep it at 45-75°C to obtain a solution ①, for the water phase.

[0022] Preparation of the oil phase: heat and maintain the Brucea javanica oil at 45-75°C, add solid docetaxel into the Brucea javanica oil, stir until the paclitaxel dissolves, and obtain solution ②, which is the oil phase.

[0023] Slowly add the oil phase solution ② into the stirring water phase solution ①, keep the solution temperature at 45-75°C for 5-8...

Embodiment 2

[0025] Prepare raw materials, excipients and other components according to the component quantity

[0026] Docetaxel 1g

[0027] Brucea javanica oil 150g

[0028] Soy Lecithin for Injection 20g

[0029] Poloxamer 15g

[0030] Glycerin 225g

[0031] Add water for injection to 1000ml

[0032] The preparation steps are the same as in Example 1.

Embodiment 3

[0034] Prepare raw materials, excipients and other components according to the component quantity

[0035] Paclitaxel 1g

[0036] Brucea javanica oil 200g

[0037] Soy Lecithin for Injection 35g

[0038] Poloxamer 17.5g

[0039] Glycerin 225g

[0040] Add water for injection to 1000ml

[0041] Preparation of the oil phase: add paclitaxel-containing 25ml of isopropanol solution into an equal volume of Brucea javanica oil, vortex to mix, and remove the alcohol by rotary evaporation at 45-75°C to obtain solution ②, which is the oil phase.

[0042] All the other preparation steps are the same as in Example 1.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

An anticancer Chinese medicine in the form of nano-class emulsion for treating cancers is proportionally prepared from taxol or polyene taxol or amarin or hydroxy camptothecine, brucea fruit oil, soybean phosphatide or lecithin for injection, poloxamer, glycerine for injection and the water for injection. Its preparing process is also disclosed.

Description

technical field [0001] The invention belongs to the field of medicine, and relates to an emulsion for intravenous injection, in particular to an anticancer traditional Chinese medicine compound nanoemulsion prepared by combining a natural medicine solid extract and a natural medicine liquid extract, and also relates to a preparation method of the emulsion. Background technique [0002] Cancer is one of the diseases with the highest incidence rate in the world, and there is still no cure for it. It is of great practical significance to develop new dosage forms of anticancer drugs with low toxicity and side effects and good curative effect. [0003] Paclitaxel, a broad-spectrum anticancer drug isolated from the bark of Yew brevifolia, has been used as a first-line drug for ovarian cancer and breast cancer, and is also used for the treatment of prostate cancer, upper gastrointestinal cancer, small cell and non-small cell Lung cancer, head cancer and neck cancer etc. The anti-...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K45/00A61K9/107A61K47/44A61K31/337A61K31/475A61K31/575A61P35/00
Inventor 张景勍秦少容刘佳邱晓莉李张宇
Owner TAIJI MEDICINE INST CHONGQING
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com