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3 results about "Cucurbitacin" patented technology
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Cucurbitacin is any of a class of biochemical compounds that some plants — notably members of the family Cucurbitaceae, which includes the common pumpkins and gourds — produce and which function as a defence against herbivores. Cucurbitacins are chemically classified as triterpenes, formally derived from cucurbitane, a triterpene hydrocarbon—specifically, from the unsaturated variant cucurbita-5-ene, or 19-(10→9β)-abeo-10α-lanost-5-ene. They often occur as glycosides. They and their derivatives have been found in many plant families (including Brassicaceae, Cucurbitaceae, Scrophulariaceae, Begoniaceae, Elaeocarpaceae, Datiscaceae, Desfontainiaceae, Polemoniaceae, Primulaceae, Rubiaceae, Sterculiaceae, Rosaceae, and Thymelaeaceae), in some mushrooms (including Russula and Hebeloma) and even in some marine mollusks.
Application of cucumber CsNPF1 gene in regulating parthenocarpy and fruit bitterness
The application provides application of a cucumber CsNPF1 gene in regulation of parthenocarpy and fruit bitterness, research finds that the content of auxin in the fruit of a CsNPF1 gene knockout mutant cucumber is significantly lower than that of a wild type, and it is further proved that CsNPF1 promotes the synthesis of auxin in ovules and the formation of parthenocarpic fruits by directly combining with the CsYUC4 promoter sequence and activating the expression thereof; meanwhile, the content of cucurbitacin CuC in the fruit of the mutant cucumber is significantly higher than that of the corresponding wild type, and the expression of a key gene Bitterfruit (Bt) for controlling the CuC content of the cucumber fruit is significantly up-regulated, indicating that CsNPF1 reduces the bitterness of the fruit and improves the quality of the fruit by directly combining with the Bt promoter sequence and inhibiting the expression thereof. The application is conducive to developing a new cucumber variety with high yield and low bitterness of fruit, provides a new direction and important theoretical basis and practical guidance for cucumber molecular breeding, and has a good agricultural application prospect.
Owner:CHINA AGRI UNIV
L-amino acid ligase mutants and their use for the synthesis of l-valyl-citrulline dipeptides
This invention discloses an L-amino acid ligase mutant and its application in the synthesis of L-val-cucurbitacin. Compared with existing chemical synthesis methods for L-val-cucurbitacin, the L-val-cucurbitacin synthesis method using the L-amino acid ligase mutant of this invention has convenient raw material sources, simple operation, is green and environmentally friendly, and is easy to implement industrially.
Owner:SHANGHAI STA PHARMA R&D CO LTD
Use of cucurbitacin as a marker in the preparation of a product for the differential diagnosis or diagnosis of adrenocortical carcinoma
The present application relates to the use of cucurbitacin as a marker in the preparation of products for identifying or diagnosing adrenocortical carcinoma. The present application finds that cucurbitacin is closely related to the occurrence of adrenocortical carcinoma, and therefore first proposes to use cucurbitacin as a marker in the preparation of related products for identifying, diagnosing, and screening adrenocortical carcinoma. By using this compound as a marker for predicting the occurrence of adrenocortical carcinoma, the early onset of adrenocortical carcinoma can be accurately and sensitively predicted and identified, thereby reducing the technical difficulty of diagnosing adrenocortical carcinoma, and further providing a brand-new objective index for the identification, diagnosis, screening, or drug efficacy evaluation of adrenocortical carcinoma.
Owner:PEKING UNION MEDICAL COLLEGE HOSPITAL