The invention relates to a control method of potato field weed. The method comprises the following steps: S1, before potato planting: S11, deep ploughing to turn up the soil and S12, applying fertilizer; S2, during potato planting: S21, carrying out sealing treatment on the soil; S22, mulching with a film, and S3, after potato planting: S31, carrying out stem and leave treatment after seedling emergence; S32, carrying out cultivation and earthing up; S33, artificial weeding, and S34, carrying out cultivation and earthing up, and S4, carrying crop rotation. The control method of potato field weed has the advantages of high weed control rate, high potato quality, non-pollution and high safety.