The invention relates to an inhibitor for preventing the formation of natural gas hydrate of high-sulfur acid gas fields, which comprises the following components in percentage by weight: 5 to 30 percent of biopolymer, which has the weight average molecular weight of between 3,000 and 10,000, of vinyl pyrrolidone and vinyl caprolactam or terpolymer, which has the weight average molecular weight of between 65,000 and 100,000,of the vinyl pyrrolidone, the vinyl caprolactam and N, N-(dimethylamino)ethyl methacrylate, 5 to 30 percent of amido group-containing and lipid group-containing polyesteramide or amidation product which is formed by polymerizing maleic anhydride, a derivative thereof and alkyl alcohol amine and has the number average molecular weight of between 1,000 and 15,000, 10 to 15 percent of surfactant and defoaming agent, and 50 to 70 percent of mixture of methanol or ethanol and glycol. The inhibitor has better inhibition effect on acid natural gas hydrate which has the H2S content between 0 and 8 percent, the CO2 content between 0 and 5 percent, and no hydrocarbon components above C2.