Anti-allergic composition for relieving as well as application thereof

Abstract

The invention relates to an anti-allergic composition for relieving as well as an application thereof. The anti-allergic composition for relieving comprises the following components: a first anti-allergic composition, a second anti-allergic composition, an anti-allergic peptide composition, Crambe abyssinica seed oil, bisabolol, and a Cardiospermum halicacabum extract product; the active componentof the first anti-allergic composition comprises 4-tert-butylcyclohexanol and 2-(3-(4-hydroxyphenyl)propanamido)benzoic acid; the active components of the second anti-allergic composition comprise anextract product of Stephania tetrandra, potassium lactate, phenoxyethanol, and dipotassium glycyrrhizinate; the active components of the anti-allergic composition comprise palmitoyl tripeptide-8 andacetyl tetrapeptide-15. The anti-allergic composition for relieving is evaluated by a macrophage nitric oxide inflammation releasing model, inhibition rate of nitric oxide releasing reaches 46.07%, and inhibition rate of histamine reaches 61.59%.

Description

technical field [0001] The invention relates to the technical field of skin care products, in particular to an anti-allergy soothing composition and its application. Background technique [0002] Allergic disease (also known as allergic disease) is not just a common disease, but has become a worldwide epidemic. In fact, an epidemiological survey of 1.2 billion people in 30 countries revealed that 250 million people (22%) suffer from allergic diseases. This is the survey data released by the World Allergy Organization (WAO), so July 8th is designated as World Allergic Disease Day every year. [0003] Mainly focus on food allergy, insect allergy, plant allergy, cosmetic allergy, photoallergy caused by ultraviolet rays, which cause skin itching, redness, fever, tingling, and tissue damage. [0004] The etiology of allergic diseases has not yet been definitively concluded, but the main reason for the accelerated increase in the incidence of the disease is the gradual deteriora...

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Problems solved by technology

[0008] Second-generation antihistamines: commonly used are cetirizine, loratadine, mizolastine, ebastine, etc., with few adverse reactions, but almost no obvious anticholinergic and sedative effects

However, it has recently been found that astemizole (Astemizole) and terfenadine (Mitel) may cause rare, severe cardiotoxicity, which can cause fatal arrhythmia; when combined with conazole and erythromycin, the above-mentioned Adverse reactions

[0009] Third-generation antihistamines: such as desloratadine, fexofenadine, etc., have milder adverse reactions, and will not cause cardiotoxicity when used with erythromycin and ketoconazole, but there may also be potential unknown risks

[0010] There are also plant-based anti-allergic components on the market, but there are relatively few effective additives, mainly concentrated in chamomile, licorice, purslane, rhodiola, and more concentrated on skin repair and maintenance. The added amount and the most There are few studies on the optimal combination

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