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Preparation method of Ag/TiO2 whisker-medical polyurethane composite material

A composite material and polyurethane technology, which is applied in the preparation field of Ag/TiO2 whisker-medical polyurethane composite material, can solve the problem of inability to ensure reliable adhesion of nano-silver particles, and achieves improved biocompatibility, reduced biotoxicity, and equipment requirements. low effect

Inactive Publication Date: 2012-05-02
SOUTHEAST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the existing preparation methods cannot ensure the reliable attachment of silver nanoparticles to the surface of TiO2 whiskers

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0028] In the present embodiment, Ag / TiO The preparation method of whisker-medical polyurethane composite material comprises the following steps:

[0029] a. Prepare a silver salt solution with a concentration of 0.01~1M, add an appropriate amount of positive hole trapping agent, and remove oxygen in the reaction system by double-row tube method or nitrogen bubbling method. Wherein the silver salt can be a soluble silver salt, such as silver nitrate; the hole trapping agent includes isopropanol, ethanol, and formic acid, etc.;

[0030] b. According to the mass ratio of silver and titanium oxide whiskers is 1:1~1:50, add titanium oxide whiskers into the silver salt solution, stir and adsorb for 0.5~8h;

[0031] c. Under stirring and anaerobic conditions, silver ions were reduced by ultraviolet light to prepare silver particles on the surface of titanium oxide. The light intensity is 5w~2kw, and the reaction time is 10min~8h;

[0032] d. After the reaction is over, wash and fi...

Embodiment 1

[0038] Weigh 1.7 g of silver nitrate to prepare a silver nitrate solution with a concentration of 0.1 M, add 5 ml of ethanol as a positive hole trapping agent, and continuously bubble for 1 h by nitrogen bubbling method to remove oxygen in the reaction system. Add 2g of TiO2 whiskers in anatase configuration, and stir under the action of magnetic force, so that 2g of TiO2 whiskers can fully absorb silver ions, and the reaction time is 4h.

[0039] Then, the reaction conditions were controlled under stirring and anaerobic state, and 8w black light was used to reduce silver ions, and the reaction time was 4h. After the reaction, the sample was rinsed by suction filtration with a large amount of water, dried in vacuum until the weight was constant, and stored for use.

[0040]Under the condition of 18-25°C, take 20g of medical aliphatic polyurethane and 200g of tetrahydrofuran to prepare a medical aliphatic polyurethane polymer solution. After the medical aliphatic polyurethane...

Embodiment 2

[0043] Weigh 0.85 g of silver nitrate to prepare a silver nitrate solution with a concentration of 0.05 M, add 3 ml of isopropanol as a positive hole trapping agent, and use nitrogen bubbling method for continuous bubbling for 1 h to remove oxygen in the reaction system. Add 2 g of TiO2 whiskers in anatase configuration, and magnetically stir and adsorb for 4 h.

[0044] Then, under stirring and anaerobic state, a 500w high pressure lamp was used to irradiate the reaction system, so that the silver ions were reduced to elemental silver under the light conditions, and the reaction time was 2h. After the reaction, the sample was rinsed by suction filtration with a large amount of water, dried in vacuum until the weight was constant, and stored for use.

[0045] Under the condition of 18-25°C, weigh 20g of medical aliphatic polyurethane and 200g of N,N-dimethylformamide, and use N,N-dimethylformamide as an organic solvent to prepare a medical aliphatic polyurethane polymer soluti...

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Abstract

The invention provides a preparation method of a Ag / TiO2 whisker-medical polyurethane composite material. The preparation method is characterized by comprising the following steps of: a, preparing 0.01-1M silver-salt solution, adding a positive-hole trapping agent and removing oxygen in a reaction system; b, adding TiO2 whiskers into the reaction system according to the mass ratio of silver to TiO2 of (1:1)-(1:50) in the silver-salt solution, stirring and adsorbing for 0.5-8h; c, under the stirring and anaerobic conditions, adopting a photochemical reduction method to reduce silver ions so asto prepare silver particles on the surfaces of the TiO2 whiskers; d, after the reaction is finished, filtering, obtaining the TiO2 whiskers carrying the silver particles, drying the TiO2 whiskers under the vacuum condition till the weight is constant, and storing for spare use; e, under room temperature, preparing polyurethane solution according to the proportion of the medical polyurethane to anorganic solvent of (1:3)-(1:30); and f, adding the Ag / TiO2 whiskers obtained in the step d into the medical polyurethane solution obtained in the step e, fully stirring to lead the Ag / TiO2 whiskers to be distributed uniformly in the medical polyurethane solution, then adopting a solvent volatilization method to prepare a polyurethane film with uniformly-dispersed Ag / TiO2 whiskers, drying the polyurethane film under the vacuum condition till the weight is constant, and storing for spare use. The Ag particles are prepared by the photo-reduction method, and the Ag particles carried by the Ag / TiO2 whiskers are not easy to fall, so that the possible biotoxicity possible to exist in the nano silver particles can be reduced furthest.

Description

technical field [0001] The invention relates to a method for preparing an antibacterial composite material, in particular to a method for preparing an Ag / TiO2 whisker-medical polyurethane composite material used in the field of medical materials and medical devices. Background technique [0002] Polymers are an important branch of biomaterials, which are widely used in the manufacture of clinical interventional materials due to their excellent mechanical properties and biocompatibility. However, bacterial adhesion and infection are the main problems of interventional medical materials, so it is particularly important to design and prepare polymers with antibacterial properties. [0003] Due to its unique antibacterial characteristics and antibacterial mechanism, nano silver has been widely used as an antibacterial material in the field of biomedicine. Like other nano-materials, after nano-silver enters the living body, the chemical properties and biological activities produ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J5/18C08L75/04C08L75/06C08L75/08C08K7/08C08K3/08
Inventor 周雪锋顾宁张天柱江筱莉
Owner SOUTHEAST UNIV
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