41results about How to "Overcome the defect of poor stability" patented technology

The invention provides an esomeprazole magnesium contained enteric-coated tablet and a preparation method thereof. The enteric coated tablet is composed of an inner tablet core layer which uses esomeprazole as an active ingredient, an intermediate insulation layer and an enteric coating protection layer. According to the esomeprazole magnesium contained enteric-coated tablet, the conditions that basic remedies are instable and prone to be oxidized and decomposed are overcome, the prepared enteric-coated tablet is even in coating, compact in coating layer, stable and reliable in quality and capable of meeting large-scale production requirements of enterprises at the present stage and has good market development prospects, the releasing rate can reach over 90%, the bioavailability is obviously improved, and safe and effective drug using is guaranteed.

The invention relates to an amphoteric ion composite microsphere as well as a preparation method and application thereof. The amphoteric ion composite microsphere comprises the following components in parts by weight: 10-50 parts of a monomer, 0.05-1 part of a cross-linking agent, 0.2-10 parts of alkali, 0-40 parts of a filler, 0.05-1 part of an initiating agent and 40-70 part of deionized water. As a profile modification/water shutoff agent with high salinity resistance and high temperature stratum condition resistance for oil field profile modification, the amphoteric ion composite microsphere provided by the invention overcomes the defect of poor stability of an existing profile modification/water shutoff agent under a stratum environment with high temperature and high salinity and can be used for profile modification and water shutoff in an oil field with high temperature and high salinity, and the recovery ratio is improved.

The invention relates to a cyclodextrin inclusion drug composition for ocular inflammation resistance, which consists of vitamin C or a derivative thereof as an active ingredient, glucocorticoid, cyclodextrin and one or more pharmaceutically acceptable pharmaceutical excipients capable of acting on eyes, wherein the glucocorticoid and/or the derivative of the vitamin C are included by the cyclodextrin.

The invention relates to an ionic liquid modified graphene oxide/polymer composite film, a preparation method and applications thereof, wherein the composite film is prepared from the following raw materials by weight: 100 parts of a macromolecule polymer film material, and 0.1-2 parts of ionic liquid modified graphene oxide powder, and an ionic liquid is linked to the interlayer and the surface of silanized graphene oxide through bonding to prepare the ionic liquid modified graphene oxide powder. According to the preparation, graphene oxide is firstly prepared, an ionic liquid is linked to the interlayer and the surface of the graphene oxide, a film casting liquid is formed with a macromolecule polymer film material in an organic solvent, and finally film scraping molding is performed toobtain the composite film. Compared to the film in the prior art, the film of the present invention has the following characteristic that the ionic liquid modified graphene oxide is used in the modification of the pervaporation film, such that the disadvantage that the direct application of the ionic liquid in the modification of the pervaporation film can cause the easy loss of the ionic liquid so as to cause the poor stability of the film can be overcome.

The invention relates to an intelligent configuration method for technological parameters in a polyester fiber production process. The method is characterized in that the performance indexes of the expected polyester fibers are inputted into a trained improved SA-PSO-ELM algorithm model, and the trained improved SA-PSO-ELM algorithm model outputs the technological parameters in the production process of the expected polyester fibers; the improved SA-PSO-ELM algorithm model is characterized in that a weight value and a threshold value between an ELM network input layer and a hidden layer are used as the particles of a PSO algorithm; a mean square error function is used as a fitness function of a PSO algorithm, the PSO algorithm is adopted to optimize the ELM algorithm, meanwhile the difference value of the maximum fitness and the minimum fitness of the initial group particles of the PSO algorithm is used as the initial temperature in the improved SA algorithm, and the improved SA algorithm is adopted to optimize the PSO algorithm; and during training, the performance indexes of historical polyester fibers and the production process technological parameters are used as input items and output items of the improved SA-PSO-ELM algorithm model. According to the present invention, the production process technological parameters can be directly obtained according to the expected fiberperformance index, the process is simple, the consumed time is short, the configuration result stability is good, and the precision is high.

The invention discloses an anti-aging high-flame-retardant ethylene propylene diene monomer rubber pipe comprising the raw materials: ethylene propylene diene monomer, polyvinyl chloride, chlorinated polyethylene, zinc oxide, stearic acid, bromo-octyl-phenolic curing resin, dicumyl peroxide, modified nano-silicon dioxide, attapulgite, expandable graphite, polyacrylonitrile fiber, cerous phosphate, pentaerythritol, ammonium polyphosphate, an anti-aging agent MC, an anti-aging agent MB, zinc nitrilotiracetate, calcium nitrilotiracetate, an accelerant, diethylene glycol dibenzoate, tricresyl phosphate, and a silane coupling agent. The anti-aging high-flame-retardant ethylene propylene diene monomer rubber pipe disclosed by the invention has the advantages of high strength, excellent anti-aging and flame-retardant property and long service life.

The invention relates to the fields of medicine and dosage forms of medicine, in particular to an oral liquid preparation of rupatadine fumarate and a preparation method of the oral liquid preparation, and discloses an oral liquid preparation of rupatadine fumarate. The oral liquid preparation per 100 mL contains 0.128 g of rupatadine fumarate, 1-20 g of a solubilizer, 1-30 g of a sweetening agent, 0-0.2 g of a flavoring agent, 0-0.01 g of a coloring agent, 0-0.20 g of a preservative and a pH regulator for adjusting the pH value to 4.6-5.6. The oral liquid preparation of rupatadine fumarate has good stability in the study of accelerated stability.

The invention discloses an under-forest water and fertilizer integrated block intelligent control planting method. The method comprises the following steps: S1, a low-hill ecological public welfare forest with the tree age of 20 years or older is selected; S2, a plurality of soil slopes are leveled in an under-forest open field in a layered mode, each soil slope is a block, and at least two kinds of commercial crops are planted in each block in a crossed mode; S3, a microbial organic liquid fertilizer is sprayed to the planted economic crops respectively by adopting a water and fertilizer integrated block intelligent control technology; and the microbial organic liquid fertilizer is prepared from the following raw materials: under-forest residues, soybean meal, egg shells, traditional Chinese medicine residues, tobacco residues, bagasse, a compound microbial agent, biogas slurry, selenomethionine and vitamin C magnesium phosphate. The space under the public welfare forest is fully utilized, various commercial crops are planted at the same time, block management is carried out, the unit yield per mu and quality are improved, and economic benefits are increased.

The invention discloses a facial cleanser and a preparation method thereof. The facial cleanser comprises the following components in percentage by mass: 10 to 20% of sodium cocoyl apple amino acid, 6to 12% of sodium stearyl dimethyl glycine, 2 to 10% of hydrogenated tallowoyl glutamic acid, 1 to 6% of protein hydrolysate ester, 3 to 9% of cyclodextrin laurate complex enzyme, 0.5 to 2% of sodiumtocopheryl phosphate, 1 to 4% of PEG-1182 methyl ester sericin protein, 1 to 5% of xylitylglucoside, 0.1 to 0.5% of preservative and the balance of water. The facial cleanser disclosed by the invention has an obvious exfoliating effect, is very low in damage to skin, nearly has no irritation, meanwhile, has excellent effects of control oil and removing blackheads and comedones, and is prominent inskin cleansing effect, very rich in foam and easy to wash; after the facial cleanser is washed, a fake smooth feeling cannot be generated; the facial cleanser has a good moisturizing property; a dryand tense case cannot be generated; and a subject feeling of use is good.

The invention discloses a method for organically and efficiently cultivating caulis spatholobi in a pine forest. The method comprises the following steps that S1, a low-hill ecological public benefit pine forest is selected; S2, caulis spatholobi is planted in the open field under the forest, the caulis spatholobi crawls and grows along the ground, when the caulis spatholobi grows to the length larger than 0.8 m, soil blocks are adopted for compaction, and the caulis spatholobi at the compacted position roots and grows; when caulis spatholobi newly grows to the length larger than 0.8 m, the soil blocks are adopted for compaction again, the growth direction of caulis spatholobi is adjusted, and the spacing distance between the adjacent soil blocks ranges from 0.8 m to 1.2 m; in a similar fashion, when the rattans grow to the roots of pine trees, the rattans are guided to grow along the trunks of the pine trees in a winding mode; and S3, a microbial organic fertilizer is applied to caulis spatholobi in the step S2 by adopting a water and fertilizer integrated block accurate control technology for cultivation. According to the method, caulis spatholobi is cultivated by fully utilizing the under-forest space, the under-forest economic crops are cultivated under the low-hill ecological public benefit pine forest, the caulis spatholobi medicinal material with high yield and good quality can be obtained, and the economic benefit is remarkable.

The invention belongs to the technical field of aerogel preparation, and particularly relates to a chitosan-tungsten disulfide aerogel composite material as well as a preparation method and application thereof. The chitosan-tungsten disulfide aerogel composite material is prepared from the following raw materials: chitosan, an acid solution, sodium hydroxide and tungsten disulfide. Wherein the acid solution is one of glacial acetic acid, hydrochloric acid, formic acid or malic acid; the mass concentration of the acid solution is 5-10%, the solid-to-liquid ratio of the chitosan to the acid solution is (1-2): 100, and the unit is g/ml. The chitosan-tungsten disulfide aerogel composite material disclosed by the invention has a three-dimensional pore structure, low density, high specific surface area, high porosity and good adsorption capacity, and particularly has a good adsorption effect on lead ions. The chitosan-tungsten disulfide aerogel composite material prepared by the method disclosed by the invention is stable in performance, has a directional porous structure and good adsorption performance, and is suitable for industrial popularization and application.