The invention discloses a traditional Chinese medicine for treating liver depression and spleen deficiency. The traditional Chinese medicine is mainly prepared from, by weight, radix bupleuri, radix angelica sinensis, radix paeoniae alba, poria cocos, rhizoma atractylodis macrocephalae, radix codonopsis, milkvetch roots, fresh ginger, herba menthae, fructus aurantii immaturus, honey-fried licorice roots, rhizoma chuanxiong, dried tangerine peel, rhizoma acori tatarinowii, rhizoma cyperi, fructus amomi, semen ziziphi spinosae, cortex albiziae, dry radix ginseng and barbary wolfberry fruits. The traditional Chinese medicine materials are used in a matched mode, the traditional Chinese medicine has the advantages of being significant in curative effect and capable of treating both symptoms and root causes, and the relapse is less likely to occur after healing. In addition, the traditional Chinese medicine is prepared from pure traditional Chinese medicine, and therefore the traditional Chinese medicine has the advantages of being small in toxic and side effects, low in treatment cost and the like.