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Research method for effect of extracts of modified five-ingredient toxin-dispersing beverage to carrageenan-induced inflammation in mice

A technology of Wuwei disinfection drink and carrageenan, which is applied in the medical field

Inactive Publication Date: 2012-12-26
SUZHOU HEALTH COLLEGE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] However, there is no domestic literature report about the effect of this prescription on non-bacterial inflammation

Method used

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  • Research method for effect of extracts of modified five-ingredient toxin-dispersing beverage to carrageenan-induced inflammation in mice

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Experimental program
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Effect test

Embodiment 1

[0020] The research method of the Wuwei Xiaoxiaoyin flavored extract of the present invention on mouse carrageenan inflammation, the specific research experimental steps are as follows:

[0021] Step 1) Prepare materials

[0022] Materials: honeysuckle, Viola chinensis, dandelion, dandelion, wild chrysanthemum, kudzu root, and salvia miltiorrhiza are all commercially available medicinal materials, which have been identified and confirmed by Chen Xuan, a practicing Chinese pharmacist of Suzhou Leiyunshang Pharmaceutical Co., Ltd.

[0023] Clean grade KM mice (Shanghai Slack Experimental Animal Co., Ltd.), animal license number: SCXK (Shanghai) 2007-0005, half male and half female, weighing 20-25g;

[0024] Flavored extract of Wuwei antiseptic drink (self-made in laboratory);

[0025] Carrageenan (Sigma company, batch number: 09JK1394);

[0026] Aspirin effervescent tablets (Bayer, Germany, specification and batch number: H32026201);

[0027] Mouse tumor necrosis factor-α ...

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Abstract

The invention discloses a research method for effect of the extract of modified five-ingredient toxin-dispersing beverage to carrageenan-induced inflammation in mice. According to the method, the five-ingredient toxin-dispersing beverage is as a base, and is modified by adding two Chinese medicinal herbs of root of kudzu vine and red sage root. The method comprises: by using water extraction and alcohol precipitation, extracting and separating a crude extract of the modified five-ingredient toxin-dispersing beverage; by using the classic model of carrageenan-induced paw edema in mice, observing the anti-inflammatory effect of the extract; and determining the influence of the extract to tumor necrosis factor-alpha and interleukin-6 in serum of mice. By using the research method for the effect of the extract of modified five-ingredient toxin-dispersing beverage to carrageenan-induced inflammation in mice of the invention, the conclusion that the effect of the extract of modified five-ingredient toxin-dispersing beverage has inhibiting effect for the tumor necrosis factor-alpha and the interleukin-6 levels, which means that the anti-inflammatory effect of the extract is achieved by inhibiting the secretion of inflammatory cytokines and provides experimental basis for the application of the extract in nonbacterial inflammatory disease.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a method for studying carrageenan inflammation in mice by the flavored extract of Wuwei Xiaoxiaoyin. [0002] Background technique [0003] Wuwei Xiaoxiaoyin, which was first recorded in "The Golden Book of Medicine·Surgical Heart Method", is a famous prescription for treating sores and swelling. It is composed of honeysuckle, viola chinensis, purple-backed geranium, dandelion, and wild chrysanthemum. It has the functions of clearing away heat and detoxification, dissipating heat and treating sores. A large number of clinical studies have confirmed that this prescription has broad-spectrum antibacterial, antiviral and immune function-enhancing effects. Modified and subtracted prescriptions based on this prescription have been widely used in dermatology, surgery, gynecology and other diseases caused by fire, poison and damp heat. The treatment of various infectious diseases has definite...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/86A61K49/00A61P29/00
Inventor 向敏
Owner SUZHOU HEALTH COLLEGE
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