The invention provides a red wine facial mask having anti-aging and whitening effects and a preparation method thereof, and relates to the technical field of skin care products. The facial mask contains an A component, a B component, a C component, a D component and purified water; the A component is composed of the following components in percentages by weight: 1-10% of glycerin, 0.05-0.5% of oligomerization sodium hyaluronate, 0.05-0.5% of small-molecular sodium hyaluronate, 0.05-0.5% of middle-molecular sodium hyaluronate, 0.05-0.5% of macromolecular sodium hyaluronate, and 0.05-0.5% of hydroxyethyl cellulose; the component B is composed of the following components in percentages by weight: 0.3-3% of carnitine, 0.3-3% of nicotinamide, and 0.05-1% of a nucleotide compound; the C component is composed of the following components in percentages by weight: 1-10% of propylene glycol, 1-10% of 1,2-hexanediol, 0.3-3% of glycereth-26, 0.1-1% of p-hydroxyacetophenone, and 0.1-1% of tea treeessential oil; and the D component is composed of the following components in percentages by weight: 5-20% of red wine, 0.5-5% of dendrobii officinalis caulis extract, 0.5-5% of harba dendrolii nobilis extract, 0.5-5% of chamomile extract, and 0.5-10% of plant extract. The facial mask can obviously enhance cell activity to achieve the anti-aging effect, effectively remove free radicals in cells, enhance the skin blood oxygen content and cell activity, and make skin moist, shiny and full of elasticity.