Skin-care, defect-repairing, anti-aging and winkle-removing cosmetic preparation

A technology of cosmetics and compound preparations, which is applied in the direction of skin care preparations, cosmetic preparations, cosmetics, etc., and can solve problems such as affecting and limiting the function of active ingredients

Inactive Publication Date: 2010-11-17
孙杰
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0012] Due to the presence of epidermal barriers in healthy skin, water, oil, electrolytes, and protein macromolecules cannot freely enter and exit the stratum corneum of the epidermis, so that rhPDGF and other conditioning and repairing ingredients can only enter a very small part of the dermis through channels such as hair follicles and sweat glands. Limit the action of these active ingredients

Method used

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  • Skin-care, defect-repairing, anti-aging and winkle-removing cosmetic preparation

Examples

Experimental program
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Effect test

preparation example Construction

[0018] Preparation of freeze-dried powder preparation: the active ingredient, functional ingredient and auxiliary ingredient are prepared into an aqueous solution with low-temperature purified water, and placed in an ice bath for later use. The above aqueous solution was divided into clean vials, the rubber stopper was half-stoppered, and placed in a lyophilizer. Turn on the vacuum freeze-drying agent to lower the temperature of the preparation to -60°C, and the cooling time is delayed for 3-6 hours. Start the vacuum pump to draw the vacuum in the working room to 0.3MPa. Gradually heat up and sublimate, and the sublimation time is 12-24 hours. After the sublimation of the water in the preparation is completed, the working room is filled with nitrogen, the plug is pressed, and the cap is crimped for packaging.

[0019] Manufacture of special lysozyme: Dissolve auxiliary components in PBS solution with pH 5.0-7.4, add glycerol, mix evenly, dispense into vials according to dosa...

Embodiment 1

[0021] Anti-aging essence: Measure rhPDGF 0.01g~0.1g, TGF 0.001g~0.1g, HA 1g~10g, mannitol 10~100g, dextran 10~100g, water-soluble collagen 5~50g, add purified water To 1000g, subpackaged, freeze-dried, filled with nitrogen, corked, crimped and sealed. Leucine borate 0g~10g, valine borate 0g~10g, alanine borate 0g~10g, N-acetylcysteine ​​0g~10g, propylene glycol 0g~5g, Zorn 0g~5g, pH5.0~ 7.5 Add PBS to 1000g, subpackage, crimp the cap, and sterilize with steam at 105°C for 20 minutes.

[0022] The cell growth factor compound preparation described in Example 1 is suitable for pressure introduction, scrubbing and exfoliation introduction, microwave radio frequency introduction, ultrasound introduction, electrophoresis introduction and combination thereof.

Embodiment 2

[0024] Anti-wrinkle essence: measure rhPDGF 0.01g~0.1g, TGF 0.001g~0.1g, HA 5g~20g, mannitol 10~100g, add purified water to 1000g, subpackage, freeze-dry, fill with nitrogen, and press the plug , crimp cap package. Add 10-100g of dextran, 5-50g of water-soluble collagen, and PBS of pH 5.0-7.5 to 1000g, subpackage, crimp and seal, and sterilize with steam at 105°C for 20 minutes.

[0025] The cell growth factor compound preparation described in Example 2 is suitable for microneedle introduction, scrubbing and exfoliation introduction, injection introduction, intradermal injection introduction, laser introduction and combination thereof.

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Abstract

The invention discloses a skin-care, defect-repairing, anti-aging and winkle-removing cosmetic preparation. A recombinant human platelet-derived growth factor (rhPDGF) which contains bioactive constituents and has a dermis repairing function, other growth factors such as a transforming growth factor (TGF-beta), an acidic fibroblast growth factor (aFGF), a basic fibroblast growth factor (bFGF) and an epidermal growth factor (EGF), and a hyaluronic acid (HA) compound preparation are introduced into the dermis by a daily skin care or cosmetic introducing method to stimulate the growth and the mitosis of fibroblasts in the dermis, the synthesis and the secretion of collagen and the HA and the growth and repair of collagenous fiber and elastic fiber so as to repair skin tissue defects such as skin depression, deep wrinkle, fracture of dermis fibrous tissue and the like caused by aging or skin damage. Therefore, skin beautifying and anti-aging effects are achieved.

Description

technical field [0001] The invention discloses a new beauty application of recombinant human platelet-derived growth factor rhPDGF and recombinant human transforming growth factor rhTGF-β. The technical field involved in the patent is the application of genetic engineering and biopharmaceutical technology in the fields of skin beauty and anti-aging. Background technique [0002] The skin is the largest organ of the human body, with a total weight of 5% to 15% of the body weight and a total area of ​​1.5 to 2 square meters. The skin has the function of maintaining the stability of the internal environment of the human body, preventing the loss of water, electrolytes and other nutrients in the body, and acting as a barrier to prevent the invasion of harmful substances from the outside. It plays an important protective function physiologically. Important signs and signs have important cosmetic functions. Skin damage happens from time to time, and skin aging is inevitable. [...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/64A61K8/81A61K8/73A61K8/65A61Q19/08A61Q19/00
Inventor 孙杰
Owner 孙杰
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