Product
Patsnap Eureka
For R&D, Patsnap Eureka makes reading and utilizing patents & technical documents easy.
Patsnap Eureka AIR
Designed for self-driven R&D workflows. Generate viable solutions, solve complex R&D challenges, empower your innovation with AI.
Patsnap Eureka Materials
Designed for material experts only. Revolutionize your material R&D, from search, analyze, to developing new materials.
Feature
TechResearch
Generate reliable direction feasibility study reports for your R&D in just a few steps.
TechSeek
Discover and master advanced knowledge NOW. Basics, ideas, possibilities, all at once.
TechMind
As an expert in R&D Theories, TechMind can generates customized viable solutions instantly.
TechRisk
Analyze your overall solution with one click, know your potential R&D risks in advance.
TechMonitor
Get weekly tech updates, stay abreast of the latest tech innovations and key insights.
Patents
Literature
Hiro is an intelligent assistant for R&D personnel, combined with Patent DNA, to facilitate innovative research.
65 results about "Acidic Fibroblast Growth Factor" patented technology
Efficacy Topic
Property
Owner
Technical Advancement
Application Domain
Technology Topic
Technology Field Word
Patent Country/Region
Patent Type
Patent Status
Application Year
Inventor
Muscle-derived cells (MDCs) for treating muscle- or bone-related injury or dysfunction
The present invention provides muscle-derived cells, preferably myoblasts and muscle-derived stem cells, genetically engineered to contain and express one or more heterologous genes or functional segments of such genes, for delivery of the encoded gene products at or near sites of musculoskeletal, bone, ligament, meniscus, cartilage or genitourinary disease, injury, defect, or dysfunction. Ex vivo myoblast mediated gene delivery of human inducible nitric oxide synthase, and the resulting production of nitric oxide at and around the site of injury, are particularly provided by the invention as a treatment for lower genitourinary tract dysfunctions. Ex vivo gene transfer for the musculoskeletal system includes genes encoding acidic fibroblast growth factor, basic fibroblast growth factor, epidermal growth factor, insulin-like growth factor, platelet derived growth factor, transforming growth factor-β, transforming growth factor-α, nerve growth factor and interleukin-1 receptor antagonist protein (IRAP), bone morphogenetic protein (BMPs), cartilage derived morphogenetic protein (CDMPs), vascular endothelial growth factor (VEGF), and sonic hedgehog proteins.
Owner:UNIVERSITY OF PITTSBURGH
Engineered human acidic fibroblast growth factors and associated methods
InactiveUS7790682B1Improve protein stabilityGreat mitogenic potencySugar derivativesPeptide/protein ingredientsWild typeAcidic Fibroblast Growth Factor
An engineered, purified polypeptide of acidic fibroblast growth factor (FGF-1) is described, the amino acid sequence of which consists essentially of SEQ ID NO: 1. The engineered polypeptide provides 70 times the mitogenic activity of wild type acidic fibroblast growth factor. Other engineered FGFs are also described, having altered properties, including reduced heparin binding affinity and increased mitogenicity as demonstrated with a model mammalian cell line derived from mice, NIH 3T3 fibroblasts.
Owner:FLORIDA STATE UNIV RES FOUND INC
Muscle-derived cells (MDCs) for treating muscle- or bone-related injury or dysfunction
The present invention provides muscle-derived cells, preferably myoblasts and muscle-derived stem cells, genetically engineered to contain and express one or more heterologous genes or functional segments of such genes, for delivery of the encoded gene products at or near sites of musculoskeletal, bone, ligament, meniscus, cartilage or genitourinary disease, injury, defect, or dysfunction. Ex vivo myoblast mediated gene delivery of human inducible nitric oxide synthase, and the resulting production of nitric oxide at and around the site of injury, are particularly provided by the invention as a treatment for lower genitourinary tract dysfunctions. Ex vivo gene transfer for the musculoskeletal system includes genes encoding acidic fibroblast growth factor, basic fibroblast growth factor, epidermal growth factor, insulin-like growth factor, platelet derived growth factor, transforming growth factor-β, transforming growth factor-α, nerve growth factor and interleukin-1 receptor antagonist protein (IRAP), bone morphogenetic protein (BMPs), cartilage derived morphogenetic protein (CDMPs), vascular endothelial growth factor (VEGF), and sonic hedgehog proteins.
Owner:UNIVERSITY OF PITTSBURGH
Skin-care, defect-repairing, anti-aging and winkle-removing cosmetic preparation
InactiveCN101884602AAchieve anti-aging effectCosmetic preparationsToilet preparationsWrinkle skinAcidic Fibroblast Growth Factor
The invention discloses a skin-care, defect-repairing, anti-aging and winkle-removing cosmetic preparation. A recombinant human platelet-derived growth factor (rhPDGF) which contains bioactive constituents and has a dermis repairing function, other growth factors such as a transforming growth factor (TGF-beta), an acidic fibroblast growth factor (aFGF), a basic fibroblast growth factor (bFGF) and an epidermal growth factor (EGF), and a hyaluronic acid (HA) compound preparation are introduced into the dermis by a daily skin care or cosmetic introducing method to stimulate the growth and the mitosis of fibroblasts in the dermis, the synthesis and the secretion of collagen and the HA and the growth and repair of collagenous fiber and elastic fiber so as to repair skin tissue defects such as skin depression, deep wrinkle, fracture of dermis fibrous tissue and the like caused by aging or skin damage. Therefore, skin beautifying and anti-aging effects are achieved.
Owner:孙杰
Recombination human acidic mechanocyte growth factor temperature sensitive type gel preparation and preparation method thereof
ActiveCN101143212AGuaranteed stabilityImprove uniformityPeptide/protein ingredientsPharmaceutical delivery mechanismGel preparationGel based
The invention provides a temperature-sensitive gel of recombinant human acid fibroblast growth factor (rh-aFGF) and the preparation method of the gel. The temperature-sensitive gel of recombinant human acid fibroblast growth factor of the invention contains the recombinant human acid fibroblast growth factor and a gel matrix, which are the active components, wherein the gel matrix contains poloxamer based on the weight of 10 to 50 percent of the gel matrix. The rh-aFGF solution is added under the liquor state, so the uniformity of the preparation is better, and at the same time the operation under 4 DEG C can keep the stability of the rh-aFGF better.
Owner:BIOPHARM RES & DEV CENT JINAN
Modified human acidic fibroblast growth factor gene and recombinant vector and applications thereof
ActiveCN104513821ABiologically activeProliferative functionFermentationVector-based foreign material introductionNucleotideFactor ii
A modified human acidic fibroblast growth factor gene is disclosed. The nucleotide sequence of the gene is shown as the number 25 locus to the number 450 locus of SEQ ID NO.1. The sequence is designed according to codon preferences of bombyx mori, and can be normally expressed and translated in the bombyx mori. A recombinant vector containing the modified human acidic fibroblast growth factor gene is also disclosed. The recombinant vector comprises an enhanser hr3 and a secreting type sericin 1 promoter Ser1, specifically expresses a modified human acidic fibroblast growth factor in a middle silk gland cell of the bombyx mori, and secretes a recombinant protein to a sericin layer of silk. The obtained silk has bioactivity, has a function of promoting cell proliferation when the silk is directly used, and is a good medical material.
Owner:SOUTHWEST UNIVERSITY
Gene for modifying human acidic fibroblast growth factor applied to silkworm silk gland expression, and expression system and application of gene
ActiveCN103911383APeptide preparation methodsFibroblast growth factorBiologyDrug biological activity
The invention discloses a gene for modifying a human acidic fibroblast growth factor applied to silkworm silk gland expression, and an expression system and application of the gene. The gene for modifying the human acidic fibroblast growth factor is represented by the 7-450 site of SEQ ID NO.1; the amino acid coded by the gene is represented by SEQ ID NO.2; the gene for modifying the human acidic fibroblast growth factor, a gene promoter of secretory type sericin 1 and a gene terminator of the secretory type sericin 1 form an expression box, and the expression box is expressed by using an enhancer hr3 in an enhanced manner; simultaneously, the expression system is constructed by accessing a piggyBac transposable arm and a fluorescent selected and marked gene. The expression system is capable of expressing and recombining the human acidic fibroblast growth factor in silkworm silk gland at high efficiency; furthermore, the expression system has biological activity and can be used for producing and recombining the human acidic fibroblast growth factor in a large scale, therefore, the expression system has good market prospects.
Owner:SOUTHWEST UNIVERSITY
Application of lettuce used as host to expressing growth factors
The invention relates to the field of biotechnologies, in particular to application of lettuce used as a host to expressing growth factors. The human acidic fibroblast growth factors (FGF-1) and the basic fibroblast growth factors (FGF-2) are expressed by the aid of recombinant vectors and agrobacterium tumefaciens mediated vacuum infiltration methods. Expression systems can be collected after the fact that plant exogenous proteins are infected in agrobacterium tumefaciens for 4 d is confirmed. Successful expression of recombinant FGF-1 and FGF-2 is confirmed by the aid of SDS-PAGE (sodium dodecyl sulfate-polyacrylamide gel electrophoresis) methods and western blotting methods (Western methods). The biological activity of the FGF-1 and the FGF-2 which are produced by the lettuce is provided by cell proliferation experiments. The application has the advantage that methods for producing large quantities of the active recombinant human FGF-1 and FGF-2 are low in cost and are convenient.
Owner:SAGACITY FAITHFUL CONVERGENCE HEALTH TECH LTD
Method of producing biologically active human acidic fibroblast growth factor and its use in promoting angiogenesis
Owner:CARDIOVASCULAR BIOTHERAPEUTICS
Skin external-use composition for promoting wound healing
InactiveCN101745101AHeal fastImprove permeabilityPeptide/protein ingredientsInorganic non-active ingredientsInsulin-like growth factorPharmaceutical drug
The invention provides a skin external-use composition for promoting wound healing. The composition is aqueous solution containing recombinant human insulin-like growth factors and recombinant human acidic fibroblast growth factors, and the pH of the aqueous solution is 4 to 9. The skin external-use composition can effectively promote the healing of wounds or sores and accelerate healing. The skin external-use composition in a better embodiment of the invention can still have high biological activity after the composition is stored for a long time in the form of aqueous solution, thereby having high rate of medicament utilization.
Owner:上海尚优生物科技有限公司
Confluent protein capable of self-cracking into polypeptide with antibiosis and reparation function
The invention discloses an antibiotic peptide, blood coagulation apoenzyme slicing sequence and fusion protein sequence of phoroblast growth factor, wherein the antibiotic peptide can be bacteria resistant peptide, antimycotic peptide, or genetic engineering hybrid peptide for bacteria and fungus resistant simultaneously, while the phoroblast growth factor can be acidic phoroblast growth factor (aFGF) or basic fibroblast growth factor (bFGF), the nucleic acid sequence for coding the fusion protein can be inserted into appropriate expression carrier and expressed in Pichia pastoris yeast.
Owner:BIOPHARM RES & DEV CENT JINAN
Human stem cell factor skin repairing solution and preparation method thereof
ActiveCN104622709ARestore qualityImprove health indexCosmetic preparationsPeptide/protein ingredientsVascular endotheliumSkin repair
The invention discloses a human stem cell factor skin repairing solution and a preparation method thereof. The solution is prepared from the following components by content: 50-75ug / l of epidermal growth factor, 15-20ug / l of acidic fibroblast growth factor, 15-20ug / l of basic fibroblast growth factor and 4-6ug / l of vascular endothelial growth factor. A series of cell factors against quick proliferation of germinal cells, and the effects of quickly repairing damaged skin and repairing skin quality can be achieved according to reasonable environment which accords with human cell growth and accelerating growth.
Owner:姜振宇
Recombination food-grade lactic acid bacterium capable of being used for preventing or treating human ulcerative colitis as well as preparation method and application of recombination food-grade lactic acid bacterium
The invention relates to a recombination food-grade lactic acid bacterium for secreting and expressing a fusion protein containing a human acidic fibroblast growth factor, a preparation method of the recombination food-grade lactic acid bacterium, and in particular relates to a method for carrying out fusion expression by using a Usp45 protein signal peptide, a secretion-promoting protein peptide and the human acidic fibroblast growth factor. According to the invention, genes for coding the fusion proteins are cloned to a lactic acid bacterium constitutive expression vector pMG36m, then transformed into lactococcus lactis NZ9000, and subjected to recombinant screening by using melibiose as a carbon source. The recombination lactic acid engineering bacterium can continuously secret the fusion protein containing the human acidic fibroblast growth factor in a fermentation expression process. The invention relates to an application of the recombination food-grade lactic acid bacterium in the preparation of cosmetics and medicines or foods for preventing and treating human ulcerative colitis.
Owner:JINAN UNIVERSITY +1
Method for in vitro preparation of hepatocyte induced by umbilical cord blood hematopoietic stem cell
This invention discloses a method for producing liver cells by inducing haemopoietic stem cells in vitro, comprising: inoculating the haemopoietic stem cells or CD34+ cells into the culture media containing embryonic bovine serum, human stem cell factor, human interleukins 3(IL-3), interleukins 6(IL-6), human liver cell growth factor, human epidermal growth factor(EGF), human acdic fibroblast growth factor, human basic fibroblast growth factor(bFGF), human leukemia inhibitory factor(LIF) and oncostatin M(OSM), and inducing the producing of liver cells in vitro. By applying the method of this invention to induce liver cells from the haemopoietic stem cells, it can acquire a high proportion of liver cells in the culture with good effects.
Owner:EAST CHINA UNIV OF SCI & TECH
Non-blood serum low density culture medium for animal cell and use thereof
ActiveCN101333513ASolving technical bottlenecks in the field of biopharmaceuticalsSerum-free cloning achievedAnimal cellsLipid formationBiotechnology
The invention discloses a culturing medium for cultivating animal cells without serum and with low density and an application thereof. The culturing medium for cultivating animal cells without serum and with low density is characterized in that synthetic culturing medium is adopted as the raw material, and insulin powder, transferrin powder, L-glutamine powder, sodium selenite powder, ethanolamine solution, lipid solution, epidermal growth factor powder, a recombinant human acidic fibroblast growth factor, vitamin solution, plant hydrolysate solution, putrescine, ferrous sulfate, hydrocortisone and an insulin-like factor are added into the synthetic culturing medium. The culturing medium can be suitable for the growth and metabolism and product expression of the cells of the mammals in the condition of low density without the serum. Combined with the method that D- polylysine powder is coated on a culture plate with 96 holes, the use of the culturing medium for cultivating animal cells without serum and with low density can clone the animal cells without the serum, thereby realizing the continuity of cultivating the animal cells without the serum, improving the stability of product expression, assuring the quality and safety of the product, and enhancing the controllability of the production process. Thus, the culturing medium for cultivating animal cells without serum and with low density has wide application range.
Owner:陈志南 +1
Biopreparate for healing wounded surface and curing intractable ulcer
InactiveCN1485091APeptide/protein ingredientsDermatological disorderClinical efficacyCurative effect
The invention relates to an aerosol preparation produced by restructured human acidic desmocyte growth factor for treating wound surface assimilation and refractoriness ulcer. The preparation by the invention has good stableness and substantial clinical curative effect. íí
Owner:武汉格瑞生物工程有限公司
Plant oil-body expression vector and process of expressing human acid fibroblast growth factor with plant oil-body
The present invention is gene recombination process, in which human acidic fibroblast growth factors (haFGF) and oil-body protein gene are fused and synthesized to constitute one plant oil-body expressing vector and establish oil-body protein genetically transforming and expressing system. Root nodule agrobacterium is used to transform Arabidopsis thalianuum, safflower, soybean, black bean and rape to obtain transgenic plant. The molecular biology detection on transgenic safflower and rape proves the integration and expression of exogenous gene, and the activity detection proves the bioactivity corresponding to the standard haFGF activity of obtained recombinant protein. The present invention also provides the method of expressing aFGF in plant seed, and the method may be used in producing aFGF at low cost and developing new medicine.
Owner:JILIN AGRICULTURAL UNIV
Preparation method of recombinant human acidic fibroblast growth factor (haFGF) protein
ActiveCN103882047AEasy to prepareImprove product qualityFermentationVector-based foreign material introductionEscherichia coliGenetic engineering
The invention relates to a preparation method of a recombinant protein in the field of gene engineering and in particular relates to a preparation method of a recombinant human acidic fibroblast growth factor (haFGF) protein. The preparation method comprises the following steps: (1) designing primers according to the full-length sequence of the haFGF to obtain an original gene segment through cloning, and replacing a codon which exists in the original gene segment and is unfavourable to be expressed by escherichia coli, thus obtaining an optimized haFGF gene, wherein the nucleotide sequence of the optimized haFGF gene is shown in SEQ ID NO.1; cloning to obtain an original gene segment of a molecular chaperone PDI (protein disulfide isomerase), and replacing a codon which exists in the original gene segment and is unfavourable to be expressed by escherichia coli, thus obtaining an optimized PDI gene, wherein the nucleotide sequence of the optimized PDI gene is shown in SEQ ID NO.2; (2) linking and cloning the optimized haFGF gene, the optimized PDI gene, tag sequences and a protease cutting site sequence into a vector to obtain an efficient expression vector through construction; or firstly constructing standby vectors of part of the sequences, and then linking the remaining sequences on part of the sequences.
Owner:杨霞
Simple and convenient chemical industrial technology for acidic fibroblast growth factor (aFGF)
InactiveCN102344930AMicroorganism based processesPeptide preparation methodsProkaryotic expressionBio engineering
The invention relates to a simple and convenient chemical industrial technology for prokaryotic expression and purification of humanized acidic fibroblast growth factor (aFGF), and aims to construct engineering bacteria of recombinant haFGF (Human Acidic Fibroblast Growth Factor) gene by using a recombinant DNA (Deoxyribonucleic Acid) technology, realize expression of a large amount of humanized FGF-1 in prokaryotic cells and obtain a target gene with higher purity through simple purification steps. haFGF is produced by using the biological engineering method, so that the technology has the advantages of easiness in forming scale production capacity, high yield and low cost.
Owner:ABZYME BIOTECH
Use of acidic fibroblast growth factor in preparing cosmetics
InactiveCN101548935APromote repairTo promote metabolismCosmetic preparationsToilet preparationsWrinkle skinAbnormal skin
The present invention discloses a user of acidic fibroblast growth factor in preparing cosmetics, and simultaneously provides a production process. The invention uses biotechnology for beautifying. The acidic fibroblast growth factor is used for external beautifying. The physiologic status of skin is improved at root and the restoring and metabolism of epidermic tissue are promoted through complementing the biological active factors which promote the metabolism and proliferation of epidermic cell. The skin can be smoothed and young. The color spot is faded and the wrinkle is pacified. The damage of sunshine to the skin is reduced. The skin smoothing and beautifying effect is obvious. Furthermore the acidic fibroblast growth factor is safe and reliable without side effect.
Owner:冯来坤
Method for instantaneously expressing acidic fibroblast growth factor in plant
InactiveCN101307322AHigh expressionReduce manufacturing costFermentationVector-based foreign material introductionProtein targetPlant virus
The invention discloses a method for realizing instant expression of acidic fibroblast growth factors in plant, relating to an improvement in the process for making acidic fibroblast growth factor and further belonging to the plant genetic engineering technical field. The method is as follows: firstly, the construction of the plant virus expression vector of anthropogenic acidic fibroblast growth factors is carried out; a coded anthropogenic acidic fibroblast growth factor DNA sequence 468bp is connected with a reconstructive plant virus expression vector, and then is transformed to agrobacterium GV3101 so as to be used in the instant expression in plant; a plant material of proper seedling age is selected to carry out agrobacterium infection, that is, slight scars are respectively scraped at both sides of a main vein on the back side of a leaf by a syringe needle; then, bacterial liquid is injected into the leaf from the scars by a syringe with the needle removed so as to ensure that plant virus carrying target gene hafgf can be quickly diffused, expressed and aggregated in a plant body; when the aggregation reaches to a peak value, plants are collected to carry out the extraction of target protein.
Owner:东北师范大学遗传与细胞研究所
Preparation method of FGF1 (fibroblast growth factor 1) full-length protein by utilizing escherichia coli
InactiveCN102978212AImprove solubilityHigh purityFibroblast growth factorFermentationSolubilityEscherichia coli
The invention relates to recombinant human acidic fibroblast growth factor (FGF1), in particular relates to a preparation method of FGF1 full-length protein by utilizing escherichia coli, which comprises the following steps of amplifying by utilizing a PCR (polymerase chain reaction) method to obtain a human FGF1 full-length gene PCR product; and digesting the PCR product by using incision enzyme. According to the preparation method, the full-length gene of the human acidic fibroblast growth factor is cloned to a pMAL-p5X expression carrier; the recombinant plasmid expresses the FGF1 full-length protein containing MBP (myelin basic protein) fusion label at high efficiency in the escherichia coli, wherein the protein in soluble expression; and the protein with MBP infusion label is purified by utilizing an MBP affinity column, and a complete FGF1 protein without the fusion label is prepared by utilizing TEV (tobacco etch virus) enzyme binding site and using TEV digested and purified infusion protein. The FGF1 full-length protein has high solubility and higher purity.
Owner:赵谦
Method of producing biologically active human acidic fibroblast growth factor and its use in promoting angiogenesis
The present invention relates to the treatment of coronary heart disease by revascularization therapy, and more particularly to the intramyocardial injection of a pharmaceutical composition comprising a recombinant fibroblast growth factor-1 protein or a fragment of a recombinant fibroblast growth factor-1 protein, optionally, with a physiologic glue for inducing local neoangiogenesis in ischemic myocardium. Methods of producing the recombinant fibroblast growth factor 1 protein and fragments are also disclosed.
Owner:VENTURIS THERAPEUTICS INC
Fibroblast culture system
InactiveCN105400734APromote growthGuaranteed purityVertebrate cellsArtificial cell constructsZoologyAcidic Fibroblast Growth Factor
The invention discloses a fibroblast culture system, which comprises: a DMEM basic medium, 10%-20% fetal calf serum, and 50-500ng / ml aFGF (Acidic fibroblast growth factor). According to the invention, a new culture system is established, i.e. the aFGF is added into a common culture system to inhibit the fibroblast growth, also proliferation of stem cells is not affected, and the cell purity is ultimately ensured.
Owner:GUANGZHOU SALIAI STEMCELL SCI & TECH CO LTD
Novel fusion protein production and uses
The invention provides a production method and use of a novel fusion protein, in particular a human acidic fibroblast growth factor variant fusion protein and its preparing process, wherein the fusion protein is the fusion of human acidic fibroblast growth factor variant with thioredoxin, the fusion protein can be used for the treatment of wound healing.
Owner:天津博发生物技术有限公司
Spray for treating burns, scalds and chronic ulcer and its prepn
InactiveCN1739775AImprove immunityAnti-inflammatoryAerosol deliveryDermatological disorderBiological half-lifePreservative
The spray for treating burns, scalds and chronic ulcer has PEG-aFGF decorated chemically with polyethylene glycol as acid fibroblast growth factor as main medicinal component. The spray contains mainly PEG-aFGF decorated chemically with polyethylene glycol as acid fibroblast growth factor 1-100 microgram, hot zedoary oil 1-100 mg, protecting agent 0.001-0.05 mg, preservative 0.001-0.01 mg, stabilizer 0.0001-0.001 mg and corrective 0.01-0.2 mg in each milliliter, and the rest is physiological saline or water for injection. The spray has high stability, long biological half time, high safety and other features.
Owner:WENZHOU MEDICAL UNIV
Non-blood serum low density culture medium for animal cell and use thereof
ActiveCN101333513BSolving technical bottlenecks in the field of biopharmaceuticalsSerum-free cloning achievedAnimal cellsLipid formationBiotechnology
Owner:陈志南 +1
Artificial polypeptide capable of inducing bone mesenchymal stem cells to differentiate into hepatic cells and biological product of such artificial polypeptide
ActiveCN107056895AArtificial cell constructsDepsipeptidesAcidic Fibroblast Growth FactorBiologic Products
The invention discloses an artificial polypeptide capable of inducing bone mesenchymal stem cells to differentiate into hepatic cells and a biological product of such artificial polypeptide. The artificial polypeptide is a polypeptide containing an amino acid sequence shown in formula (IV): LGENQPDAK(Xa)PCFQEDPMA(Xb)GTDCTLMEIWN, (IV), wherein each of Xa and Xb is selected from M, Y, L, V, W or E. Professionals in the field know that a strong ability to induce the bone mesenchymal stem cells to differentiate into the hepatic cells is achieved in case of combination of acidic fibroblast growth factor, hepatocyte growth factor and oncostatin M, and after induced culture for 14 days, alpha fetal protein mRNA and albumin mRNA in the cells are in remarkably positive expression. It is proven that the artificial polypeptide with the same effect is capable of inducing the bone mesenchymal stem cells to differentiate into the hepatic cells, and accordingly the artificial polypeptide can be prepared into the biological product for inducing the bone mesenchymal stem cells to differentiate into the hepatic cells.
Owner:诺赛联合(北京)生物医学科技有限公司
Recombination human acidic mechanocyte growth factor temperature sensitive type gel preparation and preparation method thereof
ActiveCN101143212BGuaranteed stabilityImprove uniformityPeptide/protein ingredientsPharmaceutical delivery mechanismGel preparationGel based
Owner:GUANGZHOU BIOPHARMACEUTICAL R&D CENT OF JINAN UNIV CO LTD
Human acid fibroblast growth factor resistant single-chain antibody gene
InactiveCN1800394AImprove permeabilityWeak immunogenicityImmunoglobulins against animals/humansGenetic engineeringAntigenSingle-Chain Antibodies
The invention relates to a single-chain antibody gene, recombinant vector and expressing product of anti-human acid desmocyte growth factor in the field of gene project technology. It provides a single-chain Fv which has real value. ScFv is a signal chain which is formed by two variable areas of a light chain and a heavy chain. It folds the two variable areas whose non-covalent bond forms the section with antigen conjugated function.
Owner:NORTHEAST NORMAL UNIVERSITY
Who we serve
- R&D Engineer
- R&D Manager
- IP Professional
Why Patsnap Eureka
- Industry Leading Data Capabilities
- Powerful AI technology
- Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.
© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com