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Skin external-use composition for promoting wound healing

A composition for external use, a technology for wound healing, applied in the directions of skin diseases, drug combinations, medical preparations with inactive ingredients, etc. The effect of maintaining time, promoting wound healing, and high drug utilization

Inactive Publication Date: 2010-06-23
上海尚优生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

A major disadvantage of these dosage forms is that the active ingredients on the film layer in direct contact with the wound or sore, because the migration is hindered by the colloid, the amount reaching the wound is very small, and the utilization rate of the drug is very low, which affects the efficacy of the drug.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Simply mix recombinant human insulin-like growth factor (rhIGF-1) and recombinant human acidic fibroblast growth factor (rhaFGF) according to the contents listed in Table 1, and adjust the pH with a pH regulator to obtain it. The pharmaceutical composition in Example 1 was used for infection and suppuration after two-month non-healing abdominal surgery, and the wound healed within 5 days.

[0041] Table 1

[0042] Example 1

Embodiment 2

[0044] Simply mix recombinant human insulin-like growth factor (rhIGF-1) and recombinant human acidic fibroblast growth factor (rhaFGF) according to the contents listed in Table 2, and adjust the pH with a pH regulator to obtain it. The pharmaceutical composition in Example 2 was used for finger knife wounds, and the wounds healed within 2 days, 2 days faster than those without drugs.

[0045] Table 2

[0046] Example 2

Embodiment 3

[0048] Simply mix recombinant human insulin-like growth factor (rhIGF-1) and recombinant human acidic fibroblast growth factor (rhaFGF) according to the contents listed in Table 3, and adjust the pH with a pH regulator to obtain the product. The pharmaceutical composition in Example 3 is used for diabetic toe and leg ulcer.

[0049] table 3

[0050] Example 3

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PUM

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Abstract

The invention provides a skin external-use composition for promoting wound healing. The composition is aqueous solution containing recombinant human insulin-like growth factors and recombinant human acidic fibroblast growth factors, and the pH of the aqueous solution is 4 to 9. The skin external-use composition can effectively promote the healing of wounds or sores and accelerate healing. The skin external-use composition in a better embodiment of the invention can still have high biological activity after the composition is stored for a long time in the form of aqueous solution, thereby having high rate of medicament utilization.

Description

technical field [0001] The invention relates to a composition for external use on skin, in particular to a composition for external use on skin for promoting wound healing. Background technique [0002] Skin wounds and wound healing are a series of complex processes involving a variety of cell growth factors. This process can be roughly divided into hemostatic period, wound healing period and remodeling period. The cell growth factors that have been confirmed to participate in this process mainly include: epidermal growth factor (EGF), platelet-derived growth factor (PDGF), interleukin ( IL), transforming growth factor (TGF), insulin-like growth factor (IGF), fibroblast growth factor (FGF), vascular endothelial growth factor (VEGF), tumor necrosis factor (TNF), nerve growth factor (NGF), etc. [0003] General wound treatment and treatment are basically performed after hemostasis and enter the wound healing period. If the treatment is good at this stage, the wound will heal...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/30A61K47/04A61K47/02A61K47/16A61K47/20A61P17/02A61K38/18
Inventor 朱文洲
Owner 上海尚优生物科技有限公司