The invention relates to a cultivating method of healthcare cassia seed contained coprinus comatus. The cultivating medium is prepared by components: by weight, 50-60 parts of cornstalk, 30-40 parts of cottonseed hull, 5-10 parts of rice bran, 10-15 parts of potato powder, 1-2 parts of land plaster, 1-2 parts bagasse, 0.2-0.3 part of calcium carbonate, 2-3 parts of quick lime, 1-2 parts of sealwort powder, 1-3 parts of immature bitter orange powder, 1-2 parts of radix angelicae powder, 1-2 parts of cassia seed powder, 1-3 parts of caragana microphylia flower, 1-3 parts of momordica grosenori leaves, 2-3 parts of sepiolite powder, and 8-10 parts of bone soup. The cultivating method includes mixing the components according to proportion, adding water to mix, bagging, sterilizing, inoculating, growing fungus in a growing room, replenishing nutrient solution and fruiting to obtain coprinus comatus. The coprinus comatus cultivated is rich in nutrients, high in content of microelements, vitamins and calcium, has healthcare function of the cassia seeds, and is high in anti-infection ability and yield during fruiting of the coprinus comatus.