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Spray for treating burns, scalds and chronic ulcer and its prepn

A technology for chronic ulcers and sprays, which is used in aerosol delivery, medical preparations containing active ingredients, and pharmaceutical formulations, which can solve the problems of easy immunogenicity, poor stability, and accelerated burn wound healing.

Inactive Publication Date: 2006-03-01
WENZHOU MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, animal experiments have confirmed that aFGF has a significant effect on some body damage repair and disease treatment, such as: aFGF can accelerate the healing of burn wounds; it can reduce acute ischemia-reperfusion damage to liver, kidney, heart and other internal organs ; Participate in the repair of spinal cord injury; can delay and prevent further damage of cochlear hair cells in the process of sound damage; can promote the establishment of collateral circulation, but like other protein drugs, acidic fibroblast growth factor aFGF also has poor stability, Short half-life in vivo and easy to produce immunogenicity and other problems, the above defects have been effectively improved by the method of chemical modification of polyethylene glycol

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] (1) Take 1 mg of acidic fibroblast growth factor polyethylene glycol chemically modified product (PEG-aFGF), 50 mg of albumin, 5 mg of ethylparaben, 0.1 mg of EDTA-2Na, add 10 mL of water for injection or normal saline, and finally It is best to dissolve in normal saline, filter and sterilize after the dissolution is complete; (2) Dissolve 1g of zedoary oil and 100mg of cinnamon syrup in 990mL of water for injection or normal saline, preferably in water for injection, and filter to sterilize; (3) Dissolve The above-mentioned PEG-aFGF solution was thoroughly mixed with the warm zedoary oil solution, sterilized by filtration, and set aside.

Embodiment 2

[0019] (1) Take acidic fibroblast growth factor polyethylene glycol chemically modified product (PEG-aFGF) 100mg, mannitol 1mg, sodium benzoate 10mg, EDTA-2Na 0.5mg, use 10mL water for injection or normal saline, preferably physiological Dissolve in saline, filter and sterilize after complete dissolution; (2) dissolve 20 mg of zedoary oil and 10 mg of xylitol in 990 mL of water for injection or normal saline, preferably in water for injection, and filter to sterilize; (3) the above PEG - The aFGF solution and the warm zedoary oil solution were thoroughly mixed, sterilized by filtration, and set aside.

Embodiment 3

[0021] (1) Take 50 mg of acidic fibroblast growth factor polyethylene glycol chemically modified product (PEG-aFGF), 30 mg of chitin polysaccharide, 1 mg of sorbitol, 1 mg of EDTA-2Na, and use 10 mL of water for injection or normal saline, preferably physiological Dissolve in saline, filter and sterilize after complete dissolution; (2) dissolve 100mg of zedoary oil and 200mg of apple essence in 990mL water for injection or normal saline, preferably in water for injection, and sterilize by filtration; (3) mix the above PEG- The aFGF solution and the warm zedoary oil solution were thoroughly mixed, sterilized by filtration, and set aside.

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Abstract

The spray for treating burns, scalds and chronic ulcer has PEG-aFGF decorated chemically with polyethylene glycol as acid fibroblast growth factor as main medicinal component. The spray contains mainly PEG-aFGF decorated chemically with polyethylene glycol as acid fibroblast growth factor 1-100 microgram, hot zedoary oil 1-100 mg, protecting agent 0.001-0.05 mg, preservative 0.001-0.01 mg, stabilizer 0.0001-0.001 mg and corrective 0.01-0.2 mg in each milliliter, and the rest is physiological saline or water for injection. The spray has high stability, long biological half time, high safety and other features.

Description

technical field [0001] The invention relates to a liquid or freeze-dried powder spray with additional solvent mainly used for treating burns, fresh wounds, chronic ulcers, cervical erosion and other diseases, specifically chemically modified with acidic fibroblast growth factor polyethylene glycol The product PEG-aFGF is a liquid or freeze-dried spray with additional solvent as the main pharmaceutical ingredient. Background technique [0002] Acidic fibroblast growth factor (aFGF) is the second member of the FGFs family to be isolated and purified. Thomas isolated and purified a mixture of two sizes of polypeptides (140Aa and 134Aa) from bovine brain in 1984. It is A broad-spectrum mitogen, which has 55% amino acid sequence identity with cationic polypeptide bFGF isolated from bovine pituitary gland. aFGF is mainly distributed in organs or tissues such as brain, pituitary gland, nerve tissue, retina, adrenal gland, heart and bone, and the content of other tissues is very sm...

Claims

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Application Information

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IPC IPC(8): A61K36/9066A61K9/12A61P17/02
Inventor 黄志锋郑青李校堃吴晓萍许华
Owner WENZHOU MEDICAL UNIV
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