Novel shock wave therapy coupling agent with anti-inflammatory and pain relieving functions and preparation method of novel shock wave therapy coupling agent

An anti-inflammatory, analgesic, and couplant technology, applied in the field of shock wave therapy new couplant and its preparation, can solve problems such as low drug absorption rate, and achieve the effects of simple operation, appropriate mechanical strength and good stability

Pending Publication Date: 2020-05-08
邢更彦 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the skin barrier function of the stratum corneum (SC), there are strict requirements on pharmaceutical preparations, and the absorption rate of drugs is low.

Method used

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  • Novel shock wave therapy coupling agent with anti-inflammatory and pain relieving functions and preparation method of novel shock wave therapy coupling agent
  • Novel shock wave therapy coupling agent with anti-inflammatory and pain relieving functions and preparation method of novel shock wave therapy coupling agent
  • Novel shock wave therapy coupling agent with anti-inflammatory and pain relieving functions and preparation method of novel shock wave therapy coupling agent

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] First, configure a phosphate buffer solution (i.e. PBS solution) with pH=7.4, dissolve 37.932mg hyaluronic acid (HA) and 20.633mg N-N'cyclohexylcarbodiimide (EDC) in 90ml of PBS solution respectively, pass A magnetic stirrer was mixed and stirred at a speed of 100 rpm for 3 h to form A solution.

[0029] Then, 53.7 mg of D-α-glycerol monostearate (GMS) was dissolved in 10 ml of acetone, and stirred until completely dissolved to form B solution.

[0030] Then use a peristaltic pump to add solution A to solution B dropwise at a rate of 1 drop / second, and make the molar ratio of HA to GMS 1:1.5, stir and react at 35°C for 10 hours, and finally form a 100ml system solution, then Centrifuge at 12000rpm for 10min, take the precipitate and dialyze, intercept the substances with molecular weight of 8000-10000, purify and lyophilize to form HA-GMS powder, that is, hyaluronic acid powder modified by D-α-glycerol monostearate.

[0031] Then, 2.0 mg of HA-GMS powder and 2.0 mg of ...

Embodiment 2

[0033] First, configure a phosphate buffered saline solution (i.e. PBS solution) with pH=7.3, dissolve 56.898mg of hyaluronic acid (HA) and 30.949mg of N-N'cyclohexylcarbodiimide (EDC) in 90ml of PBS solution respectively, pass A magnetic stirrer was mixed and stirred at a speed of 100 rpm for 5 h to form A solution.

[0034] Then, 53.7 mg of D-α-glycerol monostearate (GMS) was dissolved in 10 ml of acetone, and stirred until completely dissolved to form B solution.

[0035] Then use a peristaltic pump to add solution A to solution B dropwise at a rate of 1 drop / second, and make the molar ratio of HA to GMS 1:1, stir and react at 32°C for 10 hours, and finally form a 100ml system solution, then Centrifuge at 12000rpm for 10min, take the precipitate and dialyze, intercept the substances with molecular weight of 8000-10000, purify and lyophilize to form HA-GMS powder, that is, hyaluronic acid powder modified by D-α-glycerol monostearate.

[0036] Next, 1.0 mg of HA-GMS powder a...

Embodiment 3

[0038]First, configure a phosphate buffered saline solution (i.e. PBS solution) with pH=7.4, dissolve 18.966mg of hyaluronic acid (HA) and 12.379mg of N-N'cyclohexylcarbodiimide (EDC) in 90ml of PBS solution respectively, pass A magnetic stirrer was mixed and stirred at a speed of 100 rpm for 2 h to form A solution.

[0039] Then, 21.48 mg of D-α-glycerol monostearate (GMS) was dissolved in 10 ml of acetone, and stirred until completely dissolved to form B solution.

[0040] Then use a peristaltic pump to add solution A to solution B dropwise at a rate of 1 drop / second, and make the molar ratio of HA to GMS 1:1.2, stir and react at 32°C for 10 hours, and finally form a 100ml system solution, then Centrifuge at 12000rpm for 10min, take the precipitate and dialyze, intercept the substances with molecular weight of 8000-10000, purify and lyophilize to form HA-GMS powder, that is, hyaluronic acid powder modified by D-α-glycerol monostearate.

[0041] Next, dissolve 0.75mg of HA-G...

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Abstract

The invention discloses a novel shock wave therapy coupling agent with anti-inflammatory and pain relieving functions. The coupling agent adopts a drug-loading hyaluronic acid nano microemulsion, anda loaded drug is a non-steroid anti-inflammatory drug. The invention further discloses a preparation method of the novel shock wave therapy coupling agent with anti-inflammatory and pain relieving functions. By use of good transdermal absorption and moisturizing and lubricating characteristics of hyaluronic acid, the modified drug-loading hyaluronic acid nano microemulsion is prepared, the drug-loading hyaluronic acid nano microemulsion can be applied to the in vitro shock wave coupling agent and can be matched with shock waves, so that the transdermal absorption effect of the anti-inflammatory drug coated by the drug-loading hyaluronic acid nano microemulsion can be improved under the action of shock wave energy, the anti-inflammatory effect of shock wave therapy and transdermal drug delivery therapy can be enhanced significantly, the operation is simple, and the clinical therapeutic effect is significantly.

Description

technical field [0001] The invention relates to the field of medical couplants, in particular to a novel couplant for shock wave therapy with anti-inflammatory and analgesic effects and a preparation method thereof. Background technique [0002] Extracorporeal shock wave (ESW) is a sound wave that can transmit energy, and has more characteristics than ultrasound, and acts on human tissue through its mechanical effect, cavitation effect and thermal effect. For example, during treatment, the shock wave transmits the sound wave energy to the target cells in the human body through the treatment probe and coupling agent, and then through the positioning and movement of the treatment probe, it can act on a wide range of human pain areas. The treatment area is wide, the operation is simple, and the risk is small. , no side effects, can play a good therapeutic effect on myofascial pain syndrome, intervertebral disc disease, sciatica, spinal abnormalities, neck and shoulder pain, etc...

Claims

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Application Information

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IPC IPC(8): A61K41/00A61K9/107A61K47/36A61K47/14A61K31/196A61K31/192A61P29/00
CPCA61K41/0047A61K9/1075A61K9/0014A61K9/0009A61K47/36A61K47/14A61K31/196A61K31/192A61P29/00
Inventor 邢更彦梁伟邢更妹
Owner 邢更彦
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