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33results about How to "Appropriate mechanical strength" patented technology

Method for preparing chitosan/hyaluronic acid/gelatin crosslinked composite porous stent

The invention relates to the technical field of novel materials, and in particular relates to a method for preparing a chitosan / hyaluronic acid / gelatin crosslinked composite porous stent. The method uses chitosan, hyaluronic acid, gelatin and other natural biological materials as raw materials and dialdehyde starch as a crosslinking agent, and combines a lyophilisation method and a particulate leaching method to prepare the chitosan / hyaluronic acid / gelatin crosslinked composite porous stent, which is excellent in mechanical performance and made of a pure natural biological material. The chitosan / hyaluronic acid / gelatin crosslinked composite porous stent prepared by the method has the characteristics of high porosity, high pore strength, large pore diameter and the like, the pore diameter is 100-300 mu m, and the porosity is more than 90 percent. The stent is of an opening pore structure with small pores in large pores, and is suitable for cell implanting on the surface of the composite stent. Compared with a chitosan stent, the crosslinked composite porous stent has a better mechanical performance, proliferation and differentiation of cells on the surface of the composite stent can be more favored, and the compatibility of the composite stent to biological cells is excellent.
Owner:江苏创基新材料有限公司

Injection moldable bone repair composite material and preparation method thereof

InactiveCN101716380ARelieve painAppropriate selection rangeProsthesisIn situ polymerizationBiocompatibility Testing
The invention relates to an injection moldable bone repair composite material and a preparation method and a using method thereof. The composite material is a powder material consisting of a copolymer of multiple amino acids and a sulfate component of calcium, the sulfate component of the calcium accounts for 60-95% of total weight of the component material, and the balance is the copolymer of the multiple amino acids. The sulfate component of the calcium comprises alpha-hemihydrated calcium sulfate which accounts for 15%-60% of the total weight of the composite material and the balance of other sulfates of the calcium. The copolymer of the multiple amino acids is formed by polymerizing epsilon-aminocaproic acid and at least two types of other amino acids, and the molar ratio of each amino acid in the other amino acids is not less than 1% of the total weight of the amino acids. When in preparation, an intermediate parent body is obtained by in-situ polymerization and composition of other sulfates of the calcium and the amino acid monomers under inert gas protection and heating, and the composite material is prepared by smashing and then being composed with the alpha-hemihydrated calcium sulfate. The composite material powder is mixed with curing liquid, and then the composite material can be used by injection. The composite material can be fast molded after the injection and has the strength which is equivalent to that of cancellous bone, good biocompatibility and adjustable degradation speed, thereby being applicable to fixation and repair of clinical orthopedic complicated and irregular traumas.
Owner:SICHUAN UNIV

Degradable bioprosthetic valve system which is implanted in high elasticity external stent through conduit, preparation thereof and application thereof

ActiveCN104983484AGood biocompatibilityGood material-tissue interfaceHeart valvesCoatingsFiberBioprosthetic valve
The invention relates to a degradable bioprosthetic valve system which is implanted in high elasticity external stent through conduit, preparation thereof and application thereof. The degradable bioprosthetic valve system comprises a round tube external stent, and a valve is cut and seamed in the external stent. The preparation comprises winding and braiding degradable polylactic acid fiber to form a round tube netted external stent, and fixing the round tube netted external stent on a mould; thermohardening; and cutting a bioprosthetic valve and seaming the bioprosthetic valve in the external stent. The application is that the external stent clings to the blood vessel wall after the bioprosthetic valve is implanted through a conduit, the external stent gradually degrades after being covered and wrapped with intima, the periphery of the valve gradually clings to the blood vessel wall, and the bioprosthetic valve firmly clings to the blood vessel wall after all the external stent degrades. The degradable bioprosthetic valve system can be implanted and is degradable, the bioprosthetic valve can be totally adhered to the blood vessel wall, so the degradable bioprosthetic valve system has good prospect on clinical application.
Owner:SHANGHAI HANYU MEDICAL TECH CO LTD

Preparation method of crosslinked chitosan/hyaluronic acid compound porous scaffold

The invention relates to the technical field of new materials and relates to a preparation method of a crosslinked chitosan/hyaluronic acid compound porous scaffold. According to the preparation method, natural biological materials such as chitosan and hyaluronic acid are used as raw materials and an organic silane coupling agent KH-560 is used as a crosslinking agent, and the crosslinked chitosan/hyaluronic acid compound porous scaffold which is made of purely natural biological materials and is excellent in mechanical property is prepared adopting a freeze-drying method. The crosslinked chitosan/hyaluronic acid compound porous scaffold prepared by adopting the preparation method has the characteristics of high porosity, high pores strength, large pores diameter and the like, is of an open type pore structure that small pores are contained in large pores, and is suitable for planting cells on the surface of the scaffold, wherein the pore diameter is 100-300 mu m and porosity is more than 90%. Compared with a chitosan scaffold, the crosslinked chitosan/hyaluronic acid compound porous scaffold has the advantages that the mechanical property is better; proliferation and differentiation effect of the cells on the surface of the porous scaffold is better due to the addition of the organic silane coupling agent, and affinity to biological cells is better.
Owner:TONGJI UNIV

A kind of preparation method of cross-linked chitosan/hyaluronic acid composite porous scaffold

The invention relates to the technical field of new materials and relates to a preparation method of a crosslinked chitosan / hyaluronic acid compound porous scaffold. According to the preparation method, natural biological materials such as chitosan and hyaluronic acid are used as raw materials and an organic silane coupling agent KH-560 is used as a crosslinking agent, and the crosslinked chitosan / hyaluronic acid compound porous scaffold which is made of purely natural biological materials and is excellent in mechanical property is prepared adopting a freeze-drying method. The crosslinked chitosan / hyaluronic acid compound porous scaffold prepared by adopting the preparation method has the characteristics of high porosity, high pores strength, large pores diameter and the like, is of an open type pore structure that small pores are contained in large pores, and is suitable for planting cells on the surface of the scaffold, wherein the pore diameter is 100-300 mu m and porosity is more than 90%. Compared with a chitosan scaffold, the crosslinked chitosan / hyaluronic acid compound porous scaffold has the advantages that the mechanical property is better; proliferation and differentiation effect of the cells on the surface of the porous scaffold is better due to the addition of the organic silane coupling agent, and affinity to biological cells is better.
Owner:TONGJI UNIV

High-capacity rechargeable nickel-metal hydride battery and manufacturing method thereof

The invention discloses a high-capacity rechargeable nickel-metal hydride battery and a manufacturing method thereof, and belongs to the field of batteries. The high-capacity rechargeable nickel-metalhydride battery comprises the following materials of a battery positive plate, a battery negative plate, a positive tab, a negative tab, an electrolyte, an isolating membrane, a steel shell, a cap and a sealing ring. The battery positive plate is a nickel hydroxide positive plate, and the battery negative plate is a hydrogen storage alloy negative plate. The manufacturing method of the nickel-metal hydride battery in the scheme is simple in step and convenient to operate, the overcharge and overdischarge resistance of the battery can be more effectively improved in the overcharge and overdischarge reaction process, the use safety performance of the battery is greatly improved due to the excellent overcharge and overdischarge resistance, and the problems that a nickel-metal hydride batterymanufacturing process in an existing nickel-metal hydride battery manufacturing technology is very troublesome, so that the nickel-metal hydride battery production efficiency is lower and the safetyperformance is lower, is solved.
Owner:山东华太新能源电池有限公司

A preparation method of chitosan/hyaluronic acid/gelatin cross-linked composite porous scaffold

The invention relates to the technical field of novel materials, and in particular relates to a method for preparing a chitosan / hyaluronic acid / gelatin crosslinked composite porous stent. The method uses chitosan, hyaluronic acid, gelatin and other natural biological materials as raw materials and dialdehyde starch as a crosslinking agent, and combines a lyophilisation method and a particulate leaching method to prepare the chitosan / hyaluronic acid / gelatin crosslinked composite porous stent, which is excellent in mechanical performance and made of a pure natural biological material. The chitosan / hyaluronic acid / gelatin crosslinked composite porous stent prepared by the method has the characteristics of high porosity, high pore strength, large pore diameter and the like, the pore diameter is 100-300 mu m, and the porosity is more than 90 percent. The stent is of an opening pore structure with small pores in large pores, and is suitable for cell implanting on the surface of the composite stent. Compared with a chitosan stent, the crosslinked composite porous stent has a better mechanical performance, proliferation and differentiation of cells on the surface of the composite stent can be more favored, and the compatibility of the composite stent to biological cells is excellent.
Owner:江苏创基新材料有限公司
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