Degradable bioprosthetic valve system which is implanted in high elasticity external stent through conduit, preparation thereof and application thereof

Abstract

The invention relates to a degradable bioprosthetic valve system which is implanted in high elasticity external stent through conduit, preparation thereof and application thereof. The degradable bioprosthetic valve system comprises a round tube external stent, and a valve is cut and seamed in the external stent. The preparation comprises winding and braiding degradable polylactic acid fiber to form a round tube netted external stent, and fixing the round tube netted external stent on a mould; thermohardening; and cutting a bioprosthetic valve and seaming the bioprosthetic valve in the external stent. The application is that the external stent clings to the blood vessel wall after the bioprosthetic valve is implanted through a conduit, the external stent gradually degrades after being covered and wrapped with intima, the periphery of the valve gradually clings to the blood vessel wall, and the bioprosthetic valve firmly clings to the blood vessel wall after all the external stent degrades. The degradable bioprosthetic valve system can be implanted and is degradable, the bioprosthetic valve can be totally adhered to the blood vessel wall, so the degradable bioprosthetic valve system has good prospect on clinical application.

Description

technical field [0001] The invention belongs to the field of bio-valve system implantation, in particular to a degradable bio-valve system implanted with a highly elastic outer stent through a catheter, as well as its preparation and application. Background technique [0002] In 2000, Bonhoeffer et al performed the first successful human pulmonary valve replacement using a valve stent, and the clinical effect was satisfactory. Since then, transcatheter valve replacement has entered a new era. For advanced age and multiple other diseases, the risk of surgical valve replacement is high, and minimally invasive transcatheter treatment is more attractive. In 2002, after the successful transcatheter implantation of the first aortic valve stent led by Cribier, the clinical application of transcatheter aortic valve stent implantation technology has grown exponentially. In just 12 years, the number of operations worldwide has exceeded 8 Thousands of cases. [0003] However, various...

AI Technical Summary

Problems solved by technology

In addition, the long-term retention of metal stents in blood vessels will affect the "steady state" of the blood vessels themselves, and the diastolic function of the blood vessels themselves will be affected, causing potential risks.

Finally, in the right heart and venous system with slow blood flow and low pressure on the surface of metal foreign bodies, the probability of thrombus formation increases significantly, which may lead to the occurrence of thromboembolic diseases

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