60 results about "Transcatheter aortic" patented technology

Methods for determining likelihood of thrombosis based on patient-specific anatomic, valve, and flow parameters are disclosed herein. Such methods are used to select a transcatheter aortic valve that decreases likelihood of thrombosis after TAVR procedures. The methods correlate a number of fluid flow and geometric parameters such as stasis volume, neo-sinus volume, kinematic viscosity, dynamic viscosity, heart rate, the circulation, ejection time, velocity of the main jet, wall shear stress, total kinetic energy in the neo sinus volume, width of the neo-sinus, height or depth of the neo-sinus, the angle between the velocity direction and the stent of the transcatheter valve, the distance from the tip of the leaflet perpendicular to the leaflet edge and intersecting the sinotubular junction, and the cross-sectional area of the neo-sinus taken from a longitudinal or axial perspective. Such parameters are used to derive empirical or semi-empirical mathematical models to determine the likelihood of thrombosis.

Devices, systems and methods for filtering embolic particles that may be generated from a medical procedure including protection of the major branching vessels from the aorta, and catches and filters emboli that may be generated during the TAVR procedure. The filter devices disclosed herein form an improved seal against the vessel wall that is activated by flowing blood. Devices described herein also allow for the closing of the ends of the filter device after capture of emboli, providing further security against accidental loss of emboli post capture.

An integrated transcatheter valve replacement and Piezoelectric Micro-Machined Ultrasonic Transducer (pMUT) enabled ultrasonic imaging system, is disclosed. The system comprising a transcatheter valve replacement assembly having a longitudinal axis, a proximal end, and a distal end. The transcatheter valve replacement assembly comprises a self-expanding valve, a frame and leaflets. A micro-electromechanical (MEMS) based pMUT transducer having MEMS based pMUT array disposed within the distal end of the transcatheter valve replacement assembly. The MEMS based pMUT array comprises a substrate and a plurality of pMUT array elements arranged on the substrate. The integrated transcatheter valve replacement and pMUT enabled ultrasonic imaging system is used in left atrial appendage (LAA), atrial septal defect (ASD), transcatheter aortic valve replacement (TAVR), transcatheter mitral value replacement (TMVR), and transcatheter tricuspid valve replacement (TTVR) or other catheterized structural heart procedures.

A delivery system for delivering a prosthetic valve in a compressed condition over an inner shaft of a catheter. The delivery system includes a tip extending distally from the inner shaft. The tip has a proximal section and an opposite distal section extending to an end of the tip. The proximal section is configured to support an end of the prosthetic valve during loading and delivery of the prosthetic heart valve and includes a first portion, a second portion, and a third portion. The first portion is adjacent the distal section. The second portion is between the first portion and third portion. The third portion is adjacent a proximal end of the tip. An outer diameter of the first portion is greater than an outer diameter of the inner shaft, an outer diameter of the second portion, and an outer diameter of the third portion.

A catheter assembly for retaining a prosthetic valve as the prosthetic valve is guided to a point of delivery within a patient is provided with radioscopic markers. The markers are distributed within the catheter assembly such that an observer may discern a rotational orientation of the assembly from a radioscopic image of the assembly within the patient. Delivery of the prosthetic valve may include aligning the markers with the commissures of the prosthetic valve and radioscopic observation of the location or movement of the markers to rotationally align the prosthetic valve with a native valve within the patient, such as by aligning the commissures of the prosthetic valve with the commissures of the native valve.

The disclosure provides a subclinical valve leaflet thrombosis auxiliary identification method, system and signal acquisition device after transcatheter aortic valve replacement, belonging to the technical field of heart information acquisition and identification. The subclinical valve leaflet thrombosis auxiliary identification method is used for auxiliary diagnosis of subclinical valve leaflet thrombosis after transcatheter aortic valve replacement, comprising: collecting a heart sound signal, processing the heart sound signal, obtaining preset parameters of the heart sound signal, and the preset parameters at least including time, frequency and energy; determining a systolic period according to the heart sound signal; identifying the highest energy point in the characteristic interval of the systolic period; obtaining the characteristic frequency corresponding to the highest energy point, and judging whether the characteristic frequency is greater than the threshold frequency, if yes, marking the heart sound signal as an abnormal heart sound signal caused by subclinical valve leaflet thrombosis; if not, marking the heart sound signal as a normal heart sound signal. The method solves the problem that the subclinical valve leaflet thrombosis detection mainly uses multi-dimensional computed tomography, which leads to limited scope of application.

To provide a device, system, and method for filtering embolic particles that may occur during medical treatment. **Solution**: Devices, systems, and methods for filtering embolic particles that may occur during medical treatment include protecting major branch vessels from the aorta and capturing and filtering emboli that may occur during a TAVR procedure. The filter devices disclosed herein form an improved seal against the vessel wall that is actuated by blood flow. The devices described herein can also close both ends of the filter device after embolus capture, enhancing safety against the unexpected disappearance of captured emboli.

This invention discloses an auxiliary diagnostic system, method, program product, and device for transcatheter aortic valve repair (TAVR). By analyzing surgical images and physician questions, it automatically answers relevant diagnostic, treatment, and interpretation questions, and provides real-time surgical suggestions and optimization plans, thereby improving the safety and effectiveness of TAVR surgery. The auxiliary diagnostic system is based on a pre-trained visual question-answering model and includes an input module, a visual module, a language module, and an output module. The input module receives medical images and natural language questions as system input. The visual Transformer model processes the medical images and extracts visual features; the language Transformer model processes the questions and generates answers based on the visual features extracted by the visual module; the output module outputs the generated answers in text or speech form.

In various embodiments. provided herein are methods, devices and systems to optimize annular orientation of transcatheter valves and thereby facilitate transcatheter aortic valve replacement in the setting of challenging cardiovascular anatomy. These methods, devices and systems are used to treat patients with valvular diseases.

Devices and methods are configured to allow transcarotid or subclavian access via the common carotid artery to the native aortic valve, and implantation of a prosthetic aortic valve into the heart. The devices and methods also provide means for embolic protection during such an endovascular aortic valve implantation procedure.

An integrated transcatheter valve replacement and Piezoelectric Micro-Machined Ultrasonic Transducer (pMUT) enabled ultrasonic imaging system, is disclosed. The system comprising a transcatheter valve replacement assembly having a longitudinal axis, a proximal end, and a distal end. The transcatheter valve replacement assembly comprises a self-expanding valve, a frame and leaflets. A micro-electromechanical (MEMS) based pMUT transducer having MEMS based pMUT array disposed within the distal end of the transcatheter valve replacement assembly. The MEMS based pMUT array comprises a substrate and a plurality of pMUT array elements arranged on the substrate. The integrated transcatheter valve replacement and pMUT enabled ultrasonic imaging system is used in left atrial appendage (LAA), atrial septal defect (ASD), transcatheter aortic valve replacement (TAVR), transcatheter mitral value replacement (TMVR), and transcatheter tricuspid valve replacement (TTVR) or other catheterized structural heart procedures.

The application discloses a kind of left ventricular mass regression risk prediction method after transcatheter aortic valve replacement, belong to postoperative prediction technical field, its purpose is to solve the technical problem that there is no technology in prior art to effectively predict the risk of left ventricular reverse remodeling after mass regression after transcatheter aortic valve replacement.It includes the following steps: obtaining preoperative heart CT image to be predicted;According to the preoperative heart CT image to be predicted, the image-based parameters of epicardial fat are extracted;According to the extracted image-based parameters, calculate the image-based score;According to the image-based score, calculate the risk probability of left ventricular mass regression after transcatheter aortic valve replacement.Using innovative algorithm, the risk value of left ventricular mass regression can be calculated and predicted, and the risk of left ventricular reverse remodeling after mass regression after transcatheter aortic valve replacement can be effectively predicted.

The invention discloses a transcatheter aorta root covered stent system, and belongs to the field of covered stents.The transcatheter aorta root covered stent system comprises a catheter and a guide wire inserted into the catheter, a supporting mechanism is installed on the surface of the guide wire, a chimney mechanism is installed on the surface of the supporting mechanism, and a protection mechanism is installed in the chimney mechanism; through cooperative use of all the devices, the extrusion plate is pulled to extrude the elastic block, so that the elastic block deforms and is tightly attached to the hollow cylinder, the hollow cylinder is pushed out of the covered stent assembly, the hollow cylinder deforms and resets through the temperature in the body of a patient, and after it is guaranteed that the aorta true cavity is smooth, the hollow cylinder is reset. The covered stent assembly is pushed to be connected to the surface of the hollow cylinder in a sleeving mode and attached to the inner wall of the coronary artery opening, so that circulation of the aorta true cavity is smoother, and the situation that due to conflict between the unique anatomical structure of the aorta root and the mechanical effect of an interventional instrument, the aorta covered stent blocks the aorta root is avoided.

A split type precisely-anchorable transcatheter aortic valve system comprises a split transcatheter aortic valve anchoring stent (10) and a transcatheter artificial biological aortic valve (20), wherein the shape and structure of the transcatheter aortic valve anchoring stent (10) are matched with the real structure of the aortic valve after the patient's image data is subjected to three-dimensional reconstruction, the transcatheter aortic valve anchoring stent (10) is delivered to the aortic valve position of the patient to be released, deformed and combined with the aortic valve leaflet tissue and the subvalvular tissue of the patient; the transcatheter artificial biological aortic valve (20) is delivered into the transcatheter aortic valve anchoring stent (10) to be released, the valve stent is deformed to expand the valve to the functional state, the transcatheter aortic valve anchoring stent (10) is deformed again and combined with the expanded transcatheter artificial biological aortic valve (20), and meanwhile, the transcatheter aortic valve anchoring stent (10) is deformed and anchored again. A system designed based on three-dimensional reconstruction can realize accurate anchoring of transcatheter aortic valve personalization.

Devices and methods are configured to allow transcervical or subclavian access via the common carotid artery to the native aortic valve, and implantation of a prosthetic aortic valve into the heart. The devices and methods also provide means for embolic protection during such an endovascular aortic valve implantation procedure.

Noninvasive imaging plays an important role in determining the size of the transcatheter heart valve (THV) in preparation of a transcatheter aortic valve replacement (TAVR) procedure. The identification of the coronary cuspid landmarks or nadirs of each cusp plays a key role in determining the reference points for the two-dimensional (2D) images of the THV. Rather than using nadirs that are currently identified manually upon inspection of 2D computed tomography (CT) images, the methods and systems of the present disclosure utilizing structured 3D dataset of cusps to simultaneously determine the nadirs, which are especially beneficial, particularly when the sizes of cusps have significant difference (i.e., Type 1 aortic valve with two fused leaflets) or the aortic root has a bicuspid configuration rather than a tricuspid configuration.

A transcatheter aortic valve replacement apparatus having a bilateral locking function includes a self-expanding stent, a valve skirt, a valve leaflet, an elastic positioning member, and an outflow end release member; a through-hole is defined in the self-expanding stent, the self-expanding stent is provided with an inflow end and an outflow end, and the sidewall of the self-expanding stent is a grid structure; the valve skirt is connected to the sidewall of the through-hole; the valve leaflet is connected to the inner side of the valve skirt, and the sidewall of the self-expanding stent adjacent to the outflow end is defined by a plurality of outflow end grids; the elastic positioning member is provided with a U-shaped portion and connecting arms located at two ends of the U-shaped portion, and the connecting arms are connected to the self-expanding stent or to the outflow end release member, forming first connection points.

The utility model discloses an adjustable elbow of transcatheter aortic valve delivery system, which comprises an adjustable elbow body and a traction wire, the adjustable elbow body comprises an adjustable elbow outer tube, an adjustable elbow middle tube and an adjustable elbow inner tube from outside to inside, and a tubular traction wire channel is embedded between the adjustable elbow inner tube and the adjustable elbow middle tube. The traction wire channel extends in the axial direction of the adjustable elbow body, the traction wire penetrates through the traction wire channel, the far end of the traction wire is fixedly connected with the far end of the adjustable elbow body, and a first hollowed-out hole and a second hollowed-out hole which are symmetrically cut about the axis of the pipe body are formed in the pipe body at the far end of the middle pipe of the adjustable elbow. The first hollowed-out holes and the second hollowed-out holes are distributed at intervals in a staggered mode in the axial direction of the adjustable elbow middle pipe. Compared with the prior art, the middle pipe of the adjustable bent pipe adopts the pipe body with the cutting hollow hole, so that the bending direction accuracy of the adjustable bent pipe is realized, the adjustable bent pipe is not influenced by the path of the traction wire, and accurate bending adjustment is realized.

In some embodiments, a method of delivering a medical device includes providing a prosthetic heart valve including a collapsible and expandable stent having struts and a valve assembly coupled to the stent, the valve assembly having a plurality of leaflets and a cuff, providing a delivery device including a catheter extending between a proximal end and a distal end, an inflatable balloon disposed at the distal end of the catheter, and at least one sensor disposed proximal the inflatable balloon, inflating the inflatable balloon in a first stage, measuring a first pressure with the at least one sensor, and calculating a fluid resistance factor during the first stage.

Provided herein is a transcatheter aortic or pulmonary valve implant assembly that includes a bioresorbable docking station. The transcatheter valve implant assembly further includes a bioresorbable stent frame structure and a prosthetic valve that is connected with the docking station. This transcatheter valve implant assembly can be implanted adjacent to the aortic valve or pulmonary valve. In some embodiments, the transcatheter valve implant assembly includes a ventricular assist device that is releasably connectable with the bioresorbable docking station and the bioresorbable stent frame structure.

Calcific and noncalcific aortic tissue components can be quantified. Pre-intervention planning computed tomography angiography imaging data is received. A region of interest is defined between the lower coronary ostium and the virtual basal ring. Cross-sectional images of the region of interest are rendered and calcific and noncalcific tissue components are identified based on Hounsfield unit thresholds. The volumes of the identified calcific and noncalcific tissue components are calculated and used to determine a total tissue volume (e.g., fibrocalcific volume) for the valve, as well as component percentages of the total tissue volume for the calcific and noncalcific components. These volumes and / or component percentages can be leveraged to predict severe AS, identify prognosis of post-TAVI outcomes, or otherwise facilitate planning of medical intervention.

Systems and methods for evaluating a proposed valve-in-valve procedure for a patient in which a replacement transcatheter aortic valve will be deployed within a first bioprosthetic aortic valve. The methods include selecting predetermined benchmark measurements of a valve-in-valve combination. Images of anatomy of the patient are received. Anatomical measurements of the first bioprosthetic valve are obtained from the received images. The predetermined benchmark measurements and the anatomical measurements are reviewed. Based, at least in part, upon the review, risks of a valve-in-valve procedure for the patient are evaluated. The methods of the present disclosure can be used on baseline scans of a patient without a first bioprosthetic valve implanted; under these circumstances, dimensions of the first valve are determined by benchmark measurements. Where methods of the present disclosure are used on post-first implant scans, then the dimensions of the first valve are determined from the post-implant scans.

A computer implemented method of computing a personalized safe zone for transcatheter deployment of an aortic valve prosthesis device in a subject, comprising: identifying a location of an annulus plane of an aortic valve in at least one reference image, identifying a location of a cardiac conduction region between a perforating bundle and a branching point of the left branch bundle of a conduction system of the heart in the at least one reference image, and computing the personalized safe zone for transcatheter deployment of the aortic valve prosthesis device as a function of the location of the annulus plane and the location of the conduction region.

A method of performing a post-TAVR PCI procedure includes providing a catheter device including a housing, an outer tubular member coupled to the housing, an inner tubular member slidably received within an interior of the outer tubular member, and a slider coupled to the housing and the inner tubular member, wherein the inner tubular member is configured to slide relative to the outer tubular member. The outer tubular member is advanced into an interior of a TAVR valve disposed in an ascending aorta of a patient and a guidewire is extended from the outer tubular member to cause the guidewire to enter a coronary artery branching from the ascending aorta. The inner tubular member is extended from the outer tubular member into the coronary artery via a sliding of the slider relative to the housing, and the outer tubular member is optionally advanced further over the inner tubular member.

The invention provides a subclinical valve leaflet thrombus auxiliary identification method and system after transcatheter aortic valve replacement and a signal acquisition device, and belongs to the technical field of heart information acquisition and identification. The subclinical valve leaflet thrombus auxiliary identification method is used for auxiliary diagnosis of subclinical valve leaflet thrombus after transcatheter aortic valve replacement and comprises the steps that heart sound signals are collected and processed, preset parameters of the heart sound signals are obtained, and the preset parameters at least comprise time, frequency and energy; determining a systolic period according to the heart sound signal; identifying an energy highest point in the characteristic interval of the contraction period; acquiring a characteristic frequency corresponding to the highest point of the energy, judging whether the characteristic frequency is greater than a threshold frequency or not, and if so, marking the heart sound signal as an abnormal heart sound signal caused by the subclinical valve leaflet thrombus; and if not, marking the heart sound signal as a normal heart sound signal. According to the method, the problem that the applicable crowd range is limited due to the fact that multi-dimensional computed tomography is mainly adopted in subclinical leaflet thrombus detection is solved.

The invention discloses a transcatheter aortic valve conveying system, and relates to the technical field of interventional cardiology and medical instruments. The transcatheter aortic valve conveying system comprises a catheter base main limb, a catheter base side limb is fixed to one side of the catheter base main limb, a catheter body is fixed to one end of the catheter base main limb, and a center rod is fixed to one side of the catheter body; a limiting disc is fixed to the middle of the center rod, and two limiting ribs are fixed to one side of the center rod. According to the transcatheter aortic valve conveying system, the knob is manually rotated to rotate, the effect of convenient bending adjustment is achieved, the overall structure and surgical operation steps are simplified, the surgical time is shortened, a smooth inner wall is provided through the lining, the effect of stable use of the catheter is achieved, the structural stability in the conveying process is effectively guaranteed, and the service life of the catheter is prolonged. Due to the fact that the balloon has the core characteristic of being matched with valve conveying and releasing, the effect of safe use of the balloon component is achieved, and finally the functional effectiveness after the artificial valve is implanted is guaranteed.

The invention discloses a transcatheter aortic valve replacement auxiliary device, and relates to the technical field of TAVR treatment, and the transcatheter aortic valve replacement auxiliary device comprises a conveying and recycling unit which comprises a conveying pipe used for aortic valve replacement assistance; the protective umbrella unit is installed on the conveying pipe, used for intercepting thrombus / plaque and comprises a block body arranged on the surface of the conveying pipe in a sleeving mode, a rotating shaft is arranged on the block body in a rotating mode, and opening and closing pieces are installed on the rotating shaft and the conveying and recycling unit. The cerebral embolism risk is greatly reduced, operation safety is guaranteed, full coverage of three cerebral blood supply branches is achieved through the inverted-cone-shaped hollow filter screen, the aperture is accurately controlled within the balance interval of thrombus interception and blood circulation, thrombus / plaques can effectively enter the cerebral vessels of the brain, meanwhile, red blood cells and blood platelets are allowed to normally pass through, cerebral ischemia is avoided, and the blood circulation rate is increased. The hollow filter screen is made of a medical elastic material, the risk of blood vessel scratching is avoided in the unfolding / folding process, the protection effect and the biological safety are both considered, and a key guarantee is provided for high-risk patients.

Systems and methods for evaluating a proposed valve-in-valve procedure for a patient in which a replacement transcatheter aortic valve is to be deployed within a first bioprosthetic aortic valve. The method includes selecting a predetermined reference measurement of a lobe-in-lobe combination. An image of the patient's anatomy is received. An anatomical measurement of the first bioprosthetic valve is obtained from the received image. The predetermined reference measurement and the anatomical measurement are examined. Based at least in part on the examination, a risk of a valve-in-valve procedure is evaluated for the patient. The methods of the present disclosure may be used for baseline scanning of a patient without implanting a first bioprosthetic valve; in these cases, the size of the first valve is determined from a reference measurement. When the method of the present disclosure is used for a first post-implant scan, the size of the first valve is determined from the post-implant scan.

A method may include implanting a prosthetic heart valve into a heart valve of the patient. The method may include generating a series of baseline fluoroscopic images of the target site under contrast encompassing at least one complete heartbeat cycle of the patient. The series of baseline fluoroscopic images may be annotated to provide an anatomical landmark annotation and / or a target annotation representing a target location for deploying the prosthetic heart valve. The prosthetic heart valve may be advanced toward the target site while mounted to or in a delivery device in a collapsed condition. Real-time fluoroscopic images of the target site may be generated while the prosthetic heart valve is located within the target site. The real-time fluoroscopic images may be displayed so that the anatomical landmark annotation and / or the target annotation is overlaid on the displayed images, and the prosthetic heart valve may be implanted.