45 results about "Transcatheter aortic" patented technology

Methods for determining likelihood of thrombosis based on patient-specific anatomic, valve, and flow parameters are disclosed herein. Such methods are used to select a transcatheter aortic valve that decreases likelihood of thrombosis after TAVR procedures. The methods correlate a number of fluid flow and geometric parameters such as stasis volume, neo-sinus volume, kinematic viscosity, dynamic viscosity, heart rate, the circulation, ejection time, velocity of the main jet, wall shear stress, total kinetic energy in the neo sinus volume, width of the neo-sinus, height or depth of the neo-sinus, the angle between the velocity direction and the stent of the transcatheter valve, the distance from the tip of the leaflet perpendicular to the leaflet edge and intersecting the sinotubular junction, and the cross-sectional area of the neo-sinus taken from a longitudinal or axial perspective. Such parameters are used to derive empirical or semi-empirical mathematical models to determine the likelihood of thrombosis.

Devices, systems and methods for filtering embolic particles that may be generated from a medical procedure including protection of the major branching vessels from the aorta, and catches and filters emboli that may be generated during the TAVR procedure. The filter devices disclosed herein form an improved seal against the vessel wall that is activated by flowing blood. Devices described herein also allow for the closing of the ends of the filter device after capture of emboli, providing further security against accidental loss of emboli post capture.

A delivery system for delivering a prosthetic valve in a compressed condition over an inner shaft of a catheter. The delivery system includes a tip extending distally from the inner shaft. The tip has a proximal section and an opposite distal section extending to an end of the tip. The proximal section is configured to support an end of the prosthetic valve during loading and delivery of the prosthetic heart valve and includes a first portion, a second portion, and a third portion. The first portion is adjacent the distal section. The second portion is between the first portion and third portion. The third portion is adjacent a proximal end of the tip. An outer diameter of the first portion is greater than an outer diameter of the inner shaft, an outer diameter of the second portion, and an outer diameter of the third portion.

A catheter assembly for retaining a prosthetic valve as the prosthetic valve is guided to a point of delivery within a patient is provided with radioscopic markers. The markers are distributed within the catheter assembly such that an observer may discern a rotational orientation of the assembly from a radioscopic image of the assembly within the patient. Delivery of the prosthetic valve may include aligning the markers with the commissures of the prosthetic valve and radioscopic observation of the location or movement of the markers to rotationally align the prosthetic valve with a native valve within the patient, such as by aligning the commissures of the prosthetic valve with the commissures of the native valve.

The disclosure provides a subclinical valve leaflet thrombosis auxiliary identification method, system and signal acquisition device after transcatheter aortic valve replacement, belonging to the technical field of heart information acquisition and identification. The subclinical valve leaflet thrombosis auxiliary identification method is used for auxiliary diagnosis of subclinical valve leaflet thrombosis after transcatheter aortic valve replacement, comprising: collecting a heart sound signal, processing the heart sound signal, obtaining preset parameters of the heart sound signal, and the preset parameters at least including time, frequency and energy; determining a systolic period according to the heart sound signal; identifying the highest energy point in the characteristic interval of the systolic period; obtaining the characteristic frequency corresponding to the highest energy point, and judging whether the characteristic frequency is greater than the threshold frequency, if yes, marking the heart sound signal as an abnormal heart sound signal caused by subclinical valve leaflet thrombosis; if not, marking the heart sound signal as a normal heart sound signal. The method solves the problem that the subclinical valve leaflet thrombosis detection mainly uses multi-dimensional computed tomography, which leads to limited scope of application.

To provide a device, system, and method for filtering embolic particles that may occur during medical treatment. **Solution**: Devices, systems, and methods for filtering embolic particles that may occur during medical treatment include protecting major branch vessels from the aorta and capturing and filtering emboli that may occur during a TAVR procedure. The filter devices disclosed herein form an improved seal against the vessel wall that is actuated by blood flow. The devices described herein can also close both ends of the filter device after embolus capture, enhancing safety against the unexpected disappearance of captured emboli.

This invention discloses an auxiliary diagnostic system, method, program product, and device for transcatheter aortic valve repair (TAVR). By analyzing surgical images and physician questions, it automatically answers relevant diagnostic, treatment, and interpretation questions, and provides real-time surgical suggestions and optimization plans, thereby improving the safety and effectiveness of TAVR surgery. The auxiliary diagnostic system is based on a pre-trained visual question-answering model and includes an input module, a visual module, a language module, and an output module. The input module receives medical images and natural language questions as system input. The visual Transformer model processes the medical images and extracts visual features; the language Transformer model processes the questions and generates answers based on the visual features extracted by the visual module; the output module outputs the generated answers in text or speech form.

The application discloses a kind of left ventricular mass regression risk prediction method after transcatheter aortic valve replacement, belong to postoperative prediction technical field, its purpose is to solve the technical problem that there is no technology in prior art to effectively predict the risk of left ventricular reverse remodeling after mass regression after transcatheter aortic valve replacement.It includes the following steps: obtaining preoperative heart CT image to be predicted;According to the preoperative heart CT image to be predicted, the image-based parameters of epicardial fat are extracted;According to the extracted image-based parameters, calculate the image-based score;According to the image-based score, calculate the risk probability of left ventricular mass regression after transcatheter aortic valve replacement.Using innovative algorithm, the risk value of left ventricular mass regression can be calculated and predicted, and the risk of left ventricular reverse remodeling after mass regression after transcatheter aortic valve replacement can be effectively predicted.

The invention discloses a transcatheter aorta root covered stent system, and belongs to the field of covered stents.The transcatheter aorta root covered stent system comprises a catheter and a guide wire inserted into the catheter, a supporting mechanism is installed on the surface of the guide wire, a chimney mechanism is installed on the surface of the supporting mechanism, and a protection mechanism is installed in the chimney mechanism; through cooperative use of all the devices, the extrusion plate is pulled to extrude the elastic block, so that the elastic block deforms and is tightly attached to the hollow cylinder, the hollow cylinder is pushed out of the covered stent assembly, the hollow cylinder deforms and resets through the temperature in the body of a patient, and after it is guaranteed that the aorta true cavity is smooth, the hollow cylinder is reset. The covered stent assembly is pushed to be connected to the surface of the hollow cylinder in a sleeving mode and attached to the inner wall of the coronary artery opening, so that circulation of the aorta true cavity is smoother, and the situation that due to conflict between the unique anatomical structure of the aorta root and the mechanical effect of an interventional instrument, the aorta covered stent blocks the aorta root is avoided.

Devices and methods are configured to allow transcervical or subclavian access via the common carotid artery to the native aortic valve, and implantation of a prosthetic aortic valve into the heart. The devices and methods also provide means for embolic protection during such an endovascular aortic valve implantation procedure.

Noninvasive imaging plays an important role in determining the size of the transcatheter heart valve (THV) in preparation of a transcatheter aortic valve replacement (TAVR) procedure. The identification of the coronary cuspid landmarks or nadirs of each cusp plays a key role in determining the reference points for the two-dimensional (2D) images of the THV. Rather than using nadirs that are currently identified manually upon inspection of 2D computed tomography (CT) images, the methods and systems of the present disclosure utilizing structured 3D dataset of cusps to simultaneously determine the nadirs, which are especially beneficial, particularly when the sizes of cusps have significant difference (i.e., Type 1 aortic valve with two fused leaflets) or the aortic root has a bicuspid configuration rather than a tricuspid configuration.

A transcatheter aortic valve replacement apparatus having a bilateral locking function includes a self-expanding stent, a valve skirt, a valve leaflet, an elastic positioning member, and an outflow end release member; a through-hole is defined in the self-expanding stent, the self-expanding stent is provided with an inflow end and an outflow end, and the sidewall of the self-expanding stent is a grid structure; the valve skirt is connected to the sidewall of the through-hole; the valve leaflet is connected to the inner side of the valve skirt, and the sidewall of the self-expanding stent adjacent to the outflow end is defined by a plurality of outflow end grids; the elastic positioning member is provided with a U-shaped portion and connecting arms located at two ends of the U-shaped portion, and the connecting arms are connected to the self-expanding stent or to the outflow end release member, forming first connection points.

In some embodiments, a method of delivering a medical device includes providing a prosthetic heart valve including a collapsible and expandable stent having struts and a valve assembly coupled to the stent, the valve assembly having a plurality of leaflets and a cuff, providing a delivery device including a catheter extending between a proximal end and a distal end, an inflatable balloon disposed at the distal end of the catheter, and at least one sensor disposed proximal the inflatable balloon, inflating the inflatable balloon in a first stage, measuring a first pressure with the at least one sensor, and calculating a fluid resistance factor during the first stage.

Provided herein is a transcatheter aortic or pulmonary valve implant assembly that includes a bioresorbable docking station. The transcatheter valve implant assembly further includes a bioresorbable stent frame structure and a prosthetic valve that is connected with the docking station. This transcatheter valve implant assembly can be implanted adjacent to the aortic valve or pulmonary valve. In some embodiments, the transcatheter valve implant assembly includes a ventricular assist device that is releasably connectable with the bioresorbable docking station and the bioresorbable stent frame structure.

Calcific and noncalcific aortic tissue components can be quantified. Pre-intervention planning computed tomography angiography imaging data is received. A region of interest is defined between the lower coronary ostium and the virtual basal ring. Cross-sectional images of the region of interest are rendered and calcific and noncalcific tissue components are identified based on Hounsfield unit thresholds. The volumes of the identified calcific and noncalcific tissue components are calculated and used to determine a total tissue volume (e.g., fibrocalcific volume) for the valve, as well as component percentages of the total tissue volume for the calcific and noncalcific components. These volumes and / or component percentages can be leveraged to predict severe AS, identify prognosis of post-TAVI outcomes, or otherwise facilitate planning of medical intervention.

Systems and methods for evaluating a proposed valve-in-valve procedure for a patient in which a replacement transcatheter aortic valve will be deployed within a first bioprosthetic aortic valve. The methods include selecting predetermined benchmark measurements of a valve-in-valve combination. Images of anatomy of the patient are received. Anatomical measurements of the first bioprosthetic valve are obtained from the received images. The predetermined benchmark measurements and the anatomical measurements are reviewed. Based, at least in part, upon the review, risks of a valve-in-valve procedure for the patient are evaluated. The methods of the present disclosure can be used on baseline scans of a patient without a first bioprosthetic valve implanted; under these circumstances, dimensions of the first valve are determined by benchmark measurements. Where methods of the present disclosure are used on post-first implant scans, then the dimensions of the first valve are determined from the post-implant scans.

A computer implemented method of computing a personalized safe zone for transcatheter deployment of an aortic valve prosthesis device in a subject, comprising: identifying a location of an annulus plane of an aortic valve in at least one reference image, identifying a location of a cardiac conduction region between a perforating bundle and a branching point of the left branch bundle of a conduction system of the heart in the at least one reference image, and computing the personalized safe zone for transcatheter deployment of the aortic valve prosthesis device as a function of the location of the annulus plane and the location of the conduction region.

A method of performing a post-TAVR PCI procedure includes providing a catheter device including a housing, an outer tubular member coupled to the housing, an inner tubular member slidably received within an interior of the outer tubular member, and a slider coupled to the housing and the inner tubular member, wherein the inner tubular member is configured to slide relative to the outer tubular member. The outer tubular member is advanced into an interior of a TAVR valve disposed in an ascending aorta of a patient and a guidewire is extended from the outer tubular member to cause the guidewire to enter a coronary artery branching from the ascending aorta. The inner tubular member is extended from the outer tubular member into the coronary artery via a sliding of the slider relative to the housing, and the outer tubular member is optionally advanced further over the inner tubular member.

The invention discloses a transcatheter aortic valve conveying system, and relates to the technical field of interventional cardiology and medical instruments. The transcatheter aortic valve conveying system comprises a catheter base main limb, a catheter base side limb is fixed to one side of the catheter base main limb, a catheter body is fixed to one end of the catheter base main limb, and a center rod is fixed to one side of the catheter body; a limiting disc is fixed to the middle of the center rod, and two limiting ribs are fixed to one side of the center rod. According to the transcatheter aortic valve conveying system, the knob is manually rotated to rotate, the effect of convenient bending adjustment is achieved, the overall structure and surgical operation steps are simplified, the surgical time is shortened, a smooth inner wall is provided through the lining, the effect of stable use of the catheter is achieved, the structural stability in the conveying process is effectively guaranteed, and the service life of the catheter is prolonged. Due to the fact that the balloon has the core characteristic of being matched with valve conveying and releasing, the effect of safe use of the balloon component is achieved, and finally the functional effectiveness after the artificial valve is implanted is guaranteed.

The invention discloses a transcatheter aortic valve replacement auxiliary device, and relates to the technical field of TAVR treatment, and the transcatheter aortic valve replacement auxiliary device comprises a conveying and recycling unit which comprises a conveying pipe used for aortic valve replacement assistance; the protective umbrella unit is installed on the conveying pipe, used for intercepting thrombus / plaque and comprises a block body arranged on the surface of the conveying pipe in a sleeving mode, a rotating shaft is arranged on the block body in a rotating mode, and opening and closing pieces are installed on the rotating shaft and the conveying and recycling unit. The cerebral embolism risk is greatly reduced, operation safety is guaranteed, full coverage of three cerebral blood supply branches is achieved through the inverted-cone-shaped hollow filter screen, the aperture is accurately controlled within the balance interval of thrombus interception and blood circulation, thrombus / plaques can effectively enter the cerebral vessels of the brain, meanwhile, red blood cells and blood platelets are allowed to normally pass through, cerebral ischemia is avoided, and the blood circulation rate is increased. The hollow filter screen is made of a medical elastic material, the risk of blood vessel scratching is avoided in the unfolding / folding process, the protection effect and the biological safety are both considered, and a key guarantee is provided for high-risk patients.

A method may include implanting a prosthetic heart valve into a heart valve of the patient. The method may include generating a series of baseline fluoroscopic images of the target site under contrast encompassing at least one complete heartbeat cycle of the patient. The series of baseline fluoroscopic images may be annotated to provide an anatomical landmark annotation and / or a target annotation representing a target location for deploying the prosthetic heart valve. The prosthetic heart valve may be advanced toward the target site while mounted to or in a delivery device in a collapsed condition. Real-time fluoroscopic images of the target site may be generated while the prosthetic heart valve is located within the target site. The real-time fluoroscopic images may be displayed so that the anatomical landmark annotation and / or the target annotation is overlaid on the displayed images, and the prosthetic heart valve may be implanted.

The invention discloses a balloon structure of a transcatheter aortic valve delivery system, and relates to the technical field of interventional cardiology and medical instruments. The balloon structure of the transcatheter aortic valve conveying system comprises a catheter seat, and one end of the catheter seat is fixedly sleeved with an outer tube connecting piece and an inner tube connecting piece. According to the balloon structure of the transcatheter aortic valve delivery system, the tip connecting piece adopts the stepped design of accumulation of a plurality of circular rings or valve circular rings formed by injection molding of nylon materials, so that the effects of reducing the size of the connecting piece and reserving a larger gap are achieved, and the balloon filling effect is facilitated; the tip connecting piece makes contact with the inner wall of the blood vessel in the process of penetrating into the blood vessel of the human body, the flexible contact effect of the tip connecting piece and the inner wall of the blood vessel is achieved, the purpose of improving the use safety of the balloon structure is achieved, the flexible positioning effect is achieved after the tip connecting piece penetrates into the target position, and the effect of improving the implantation stability of the balloon structure is achieved.

A delivery device for delivering a prosthetic heart valve may include a balloon catheter shaft having a distal end, an inner shaft extending through the balloon catheter in a proximal to distal direction, an atraumatic distal tip positioned at the distal end of the inner shaft, and a balloon positioned between the distal end of the balloon catheter shaft and the atraumatic distal tip. In an uninflated state of the balloon, the balloon may include a proximal bulge, a distal bulge, and an intermediate section having a diameter less than a diameter of the proximal bulge and less than a diameter of the distal bulge. The distal protrusion may extend a first length in a proximal-to-distal direction, and the proximal protrusion may extend a second length in the proximal-to-distal direction, the first length being different than the second length.

A system for implanting two or more implants into a heart of a patient may include a multi-device steerable guide catheter ("MDSGC"), a transcatheter edge-to-edge repair ("TEER") implant delivery device, and an additional implant delivery device for implanting an additional medical device. The additional medical device may be a collapsible and expandable prosthetic transcatheter aortic valve repair ("TAVR") device or a collapsible and expandable left atrial appendage ("LAA") occluder device. The MDSGC may have a first handle and may be steerable, the TEER delivery device may have a second handle, and the additional delivery device may have an additional handle. The system may include a fixation device to capture native heart valve leaflets therebetween as part of a TEER procedure. The TEER delivery device and the additional delivery device may each have a catheter sized and shaped to pass through an interior of a catheter of the MDSGC.

The invention relates to the technical application field of transcatheter artificial heart valves, and discloses a transcatheter aortic valve integrated skirt which comprises a valve support, an inner skirt edge is arranged on the inner side of the valve support, an outer skirt edge is arranged on the outer side of the valve support, and the inner skirt edge and the outer skirt edge are manufactured through an integrated forming process. A plurality of protruding supporting bosses are arranged on the side, away from the outer skirt edge, of the inner skirt edge, a plurality of leakage-proof assemblies are arranged on the side, away from the inner skirt edge, of the outer skirt edge, and a plurality of fixing assemblies are arranged on the inner side and the outer side of the valve support. The integrated inner skirt edge and outer skirt edge are free of suture lines, the hidden danger of perivalvular leakage caused by suture gaps is fundamentally eliminated, skirt edge dislocation caused by manual operation errors is avoided, meanwhile, bulb-shaped hollowed-out grooves formed by the adjacent leakage-proof bosses form pocket-shaped spaces, trace blood breaking through attachment gaps can be actively intercepted, and the leakage-proof effect is achieved. And the use safety of the artificial valve is improved.

The invention discloses a transcatheter aortic valve conveying system bending adjusting mechanism, and relates to the technical field of interventional cardiology and medical instruments. The bending adjusting mechanism of the transcatheter aortic valve conveying system comprises a catheter base and a catheter body, and the catheter body is fixed to one end of the catheter base; the guide pipe further comprises a bending adjusting driving assembly, the guide pipe body penetrates through the bending adjusting driving assembly, a first sliding block or a second sliding block, a winding boss, a steel core and a pull wire are arranged in the bending adjusting driving assembly, the winding boss is fixed to one side of the first sliding block or one side of the second sliding block, and a through hole is formed in one side of the first sliding block or one side of the second sliding block. According to the bending adjusting mechanism of the transcatheter aortic valve conveying system, the first rotary knob or the second rotary knob is manually rotated to rotate, power transmission is achieved only by reserving cooperation of a single set of threads, a transmission link is simplified, the number of parts is reduced, the operation reliability of the mechanism is improved, meanwhile, the production and assembly difficulty and cost are remarkably reduced, and the production efficiency is improved. And compared with a traditional structure, the structure is more practical and economical.

This invention provides an intelligent image measurement and navigation method and system for transcatheter aortic valve replacement (TAVR), relating to the field of medical auxiliary diagnosis. Utilizing a dual-temporal collaborative repair strategy, it can use the texture information of clear temporal phases to complete the anatomical details of blurred temporal phases, obtaining complete anatomical boundaries even under imperfect cross-sections. This significantly reduces the time and frequency of physical probe adjustments during surgery, lowering the reliance on the operational skills of anesthesiologists or sonographers. Through cascaded positioning with anatomical region locking, and using a probability field strength prior forced algorithm to focus on high-probability anatomical structures, it shields background noise that is easily interfered with by the human eye, ensuring the objectivity and consistency of measurement results. This allows less experienced surgeons to achieve measurement accuracy consistent with senior experts, providing standardized data support for valve model selection. It can intelligently filter out motion interference, ensuring the safety of intraoperative navigation, and its sub-pixel accuracy meets the requirements of refined TAVR surgery.

Provided herein is an apparatus, method, and system for Transcatheter Aortic Valve Replacement extraction. The apparatus may include: an outer housing; an inner shaft configured to move in a first direction relative to the outer housing and in a second direction relative to the outer housing opposite the first direction; a plurality of hooks, each of the plurality of hooks having a first end connected to the inner shaft and a second end, where each of the plurality of hooks defines a deployed position where the second end is distal from the outer housing and a retracted position where the second end is proximal the outer housing; and a debris catcher proximate a distal end of the outer housing, the debris catcher defining a deployed position opened to receive debris and a stowed position closed to trap debris.

Methods and devices are provided for protecting cerebrovascular circulation from embolic fragments released during indexed surgery. The embolic protection filter is delivered in a reduced profile configuration via the access catheter and positioned on the aorta across the three major vascular openings leading to the cerebral circulation. Thereafter, the indexing surgical catheter is advanced through the same access catheter to perform indexing surgery. The indexing procedure may be transcatheter aortic valve replacement.