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A bionic artificial skin with waterproof and breathable function and preparation method thereof

A technology of artificial skin and epidermis, applied in the field of bionic artificial skin and its preparation, can solve the problems of slow degradation of silk fibroin, insignificant scaffolding effect, and affecting skin healing effect, etc., achieve good flexibility and mechanical strength, and promote regeneration Effect

Active Publication Date: 2017-10-13
BEIJING PAISHENG BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the dermis of this skin is easy to dissolve without cross-linking operation, the scaffolding effect is not obvious, the thickness is only less than 0.17mm, and the silk fibroin used in the epidermis to increase the mechanical strength degrades slowly, and even the epidermis needs to be peeled off when using it. Affects skin healing
[0005] In order to overcome the shortcomings of the existing artificial skin, the invention provides a bionic artificial skin with waterproof and breathable functions and a preparation method thereof, which has a three-layer structure of a protective layer, an epidermis layer and a dermis layer. Eliminates the defects and deficiencies of the existing skin

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Embodiment 1: The bionic artificial skin is composed of a protective layer, an epidermis and a dermis. The protective layer is a non-degradable silica gel film with micropores, the epidermis is composed of a degradable and absorbable collagen film with a microporous structure, and the dermis is a collagen sponge structure.

[0032] The preparation method of bionic artificial skin is as follows:

[0033] Step 1: Using 0.1% acetic acid aqueous solution as a solvent, take a certain amount of collagen, configure a collagen solution with a concentration of 1 wt%, put it into a dialysis bag and dialyze for 9 days to form solution I;

[0034] Step 2: Using 0.1% acetic acid aqueous solution as a solvent, take a certain amount of collagen, and prepare a 0.5wt% collagen solution;

[0035]Step 3: Inject solution 2 into a mold with a depth of 5mm, freeze-dry at -80°C to form a sponge, and then use an ethanol solution with a concentration of 0.05% formaldehyde for cross-linking. Af...

Embodiment 2

[0037] Embodiment 2: The bionic artificial skin is composed of a protective layer, an epidermis and a dermis. The protective layer is a non-degradable polyurethane film with micropores, the epidermis is composed of a degradable and absorbable collagen film with a microporous structure, and the dermis is a sponge composed of a blend of collagen and hyaluronic acid.

[0038] The preparation method of bionic artificial skin is as follows:

[0039] Step 1: Using 1.1% acetic acid aqueous solution as a solvent, take a certain amount of collagen, configure a collagen solution with a concentration of 1.3wt%, put it into a dialysis bag and dialyze for 7 days to form solution I;

[0040] Step 2: Take 0.5% acetic acid aqueous solution as solvent, take a certain amount of collagen and sodium hyaluronate, and configure a mixed solution with a concentration of 0.7wt% collagen and sodium hyaluronate, wherein the weight ratio of collagen and sodium hyaluronate 2:1;

[0041] Step 3: inject s...

Embodiment 3

[0043] Embodiment 3: The bionic artificial skin is composed of a protective layer, an epidermis and a dermis. The protective layer is a non-degradable silica gel film, the epidermis is composed of degradable and absorbable collagen and chitosan blend film with microporous structure, and the dermis is a sponge of collagen and sodium hyaluronate blend material.

[0044] The preparation method of bionic artificial skin is as follows:

[0045] Step 1: Take 0.5% propionic acid aqueous solution as a solvent, take a certain amount of collagen and chitosan, configure a concentration of 0.3wt% collagen solution, wherein the weight ratio of collagen and chitosan is 3:1, load Dialyze in the dialysis bag for 4 days to form solution I;

[0046] Step 2: Take 1% propionic acid aqueous solution as solvent, take a certain amount of collagen and sodium hyaluronate, and configure a mixed solution of 0.5wt% collagen and sodium hyaluronate, wherein the weight of collagen and sodium hyaluronate T...

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Abstract

The invention relates to a bionic artificial skin, comprising a protective layer, an epidermis and a dermis, characterized in that the protective layer is composed of a non-degradable or slowly degradable polymer film containing micropores, and the epidermis is composed of a microporous structure Composed of biodegradable and absorbable biopolymers, the dermis is composed of biodegradable and absorbable biopolymer sponges. The protective layer has a waterproof and moisture-permeable function. The material of the epidermis is the same as that of the human epidermis, and has a microporous structure, which can make the artificial skin have oxygen and moisture permeability similar to that of human skin, and endow the artificial skin with a breathing function. The composition of the epidermis and dermis Capable of degrading, because the ingredients are close to autologous skin, the degradation products help to promote the regeneration of epidermal cells and fibroblasts. The invention also provides a preparation method of the bionic artificial skin.

Description

technical field [0001] The invention belongs to the field of tissue engineering biomedical materials and medical devices, and relates to a bionic artificial skin with waterproof and breathable functions and a preparation method thereof. Background technique [0002] The current artificial dermis substitute materials include heterogeneous acellular dermal matrix, cell-free extracellular matrix dermal substitute, and dermal substitute containing allogeneic cells. Each has its own advantages and disadvantages in clinical application. Xenogeneic acellular dermal matrix is ​​the earliest permanent dermal substitute developed from heterogeneous sources. The main disadvantages are the lack of viable fibroblasts, collagen may cause immune reactions, and there is a risk of spreading viruses. Dermal substitute materials with allogeneic cells have disadvantages such as difficulty in preservation and high application costs, and extracellular matrix dermal substitutes without cells are t...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/60A61L27/50A61L27/58A61L27/56A61L27/40A61F2/10
Inventor 张自强其他发明人请求不公开姓名
Owner BEIJING PAISHENG BIOTECH CO LTD
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