PVA fiber/polyamino acid/hydroxyapatite bone support material and its preparation

A technology of hydroxyapatite and amino acid, applied in medical science, prosthesis, tissue regeneration, etc., can solve problems such as failure to meet the requirements of hard tissue repair and reconstruction, loose repair materials, bone tissue wear, etc., and achieve good biological activity and biosafety, high elastic modulus, high elastic modulus effect

Active Publication Date: 2022-05-27
中鼎凯瑞科技成都有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the far difference in mechanical strength, hardness, stiffness and elastic modulus of bone tissue in the past, ceramic materials and metal materials often cause stress shielding, causing problems such as loosening of repair materials, wear and necrosis of bone tissue, and separation.
[0004] Therefore, single-component ceramics, metals, or polymer materials cannot meet the clinical requirements for hard tissue repair and reconstruction.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] A preparation of a support type bone repair implant, comprising the following steps:

[0045] (1) Weigh 1000g of hydroxyapatite, 30g of isopropyl trioleic acid acyloxy titanate (titanate coupling agent HY~105), and put hydroxyapatite into a 5L reaction flask with stirring , the titanate coupling agent HY~105 was put into the atomizer, sprayed while stirring, the atomization was completed in 30 minutes, and the stirring was continued for one hour, and then the hydroxyapatite was poured out and vacuum-dried at 80 °C for 6 hours, get C4;

[0046] (2) Weigh 1000g of high-strength PVA fiber (diameter 15μm, length 6mm), 50g isopropyl trioleic acid acyloxy titanate (titanate coupling agent HY~105), PVA fiber into 5L with stirring Put the titanate coupling agent HY~105 into the atomizer, spray while stirring, the atomization is completed in 30 minutes, continue stirring for one hour, then take out the high-strength PVA fiber, and vacuumize it with 80 °C Dry for 6 hours to obt...

Embodiment 2

[0053] A preparation of a support type bone repair implant, comprising the following steps:

[0054] (1) Weigh 1000g of hydroxyapatite, 45g of isopropyl tris(dioctylphosphoryloxy) titanate, titanate coupling agent HY~102, and hydroxyapatite into 5L with stirring In the reaction flask, the titanate coupling agent HY~102 was put into the atomizer, and sprayed while stirring. The atomization was completed in 45 minutes, and the stirring was continued for one hour. Vacuum drying for 6 hours to obtain C4;

[0055] (2) Weigh 1000g high-strength PVA fiber (diameter 15μm, length 6mm), 50g isopropyl tris(dioctylphosphoryloxy) titanate, titanate coupling agent HY~102, PVA fiber into 5L In the reaction bottle with stirring, put the titanate coupling agent HY~102 into the atomizer, spray while stirring, the atomization is completed in 45 minutes, continue stirring for one hour, then take out the high-strength PVA fiber and mix it with 80 ℃ and vacuum drying for 6 hours to obtain C3;

...

Embodiment 3

[0062] A preparation of a support type bone repair implant, comprising the following steps:

[0063] (1) Weigh 1000g of hydroxyapatite, 35g of tetraisopropylbis(dioctylphosphite acyloxy) titanate coupling agent HY~401, and hydroxyapatite into a 5L reaction flask with stirring In the middle, the titanate coupling agent HY~401 was put into the atomizer, sprayed while stirring, the atomization was completed in 25 minutes, and the stirring was continued for one hour, and then the hydroxyapatite was poured out and vacuum-dried at 80 °C. 6 hours to get C4;

[0064] (2) Weigh 1000g high-strength PVA fiber (diameter 15μm, length 9mm), 45g tetraisopropyl bis(dioctylphosphite acyloxy) titanate coupling agent HY~401, PVA fiber into 5L belt In the stirred reaction flask, put the titanate coupling agent HY~401 into the atomizer, spray while stirring, the atomization is completed in 25 minutes, continue stirring for one hour, and then take out the high-strength PVA fiber and pump it with 8...

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Abstract

The invention relates to a medical composite material, in particular to a PVA fiber polyamino acid hydroxyapatite composite bone support material and a preparation method thereof. The invention provides a composite bone repair material. The bone repair material is composed of polyamino acid polymer, polyvinyl alcohol fiber, calcium phosphate salt and coupling agent, and the mass ratio of each raw material is: calcium phosphate salt 20% to 50%, poly Vinyl alcohol fiber 15-30%, polyamino acid polymer 20-55%, coupling agent 1-5%. The PVA fiber polyamino acid calcium phosphate composite material obtained in the present invention has high strength, high toughness and high elastic modulus, and can be made into a supporting bone repair implant by rapid injection molding or hot pressing molding, and the obtained supporting bone repair implant The bending strength of the material is 120-160MPa, the bending modulus is 5-15GPa, the compressive strength is 120-180MPa, and its biomechanical properties are close to those of human bone tissue.

Description

technical field [0001] The invention relates to a medical composite material which can be used for the repair and reconstruction of load-bearing bone, in particular to a high-strength PVA fiber polyamino acid hydroxyapatite composite bone supporting material and a preparation method thereof. Background technique [0002] Bone is the support system of the human body, the core system that bears the weight, movement and activities of the human body. The main body damage of load-bearing bones caused by various factors needs to be repaired and replaced in time to maintain its normal supporting function. The formation cycle is generally 26 to 28 weeks, and then complete bone tissue is formed through multiple reconstructions to complete its functional repair. Therefore, it is difficult for a slightly larger damaged module (diameter greater than 3 cm and length greater than 5 cm) to form a complete new bone module to replace the implanted bone material during the bone formation cyc...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/12A61L27/16A61L27/18A61L27/50
CPCA61L27/16A61L27/18A61L27/12A61L27/50A61L2430/02A61L2430/38C08L29/04C08L77/00
Inventor 严永刚邓光进吴亚男任浩浩
Owner 中鼎凯瑞科技成都有限公司
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