Preparation method of 3D printing elastic polymer stent for articular cartilage repair and product and application of 3D printing elastic polymer stent

An elastic polymer, 3D printing technology, applied in 3D printing, joint implants, joint implants, etc., can solve the problems of defect area recovery and poor regeneration, achieve good biocompatibility, preparation method Simple, Growth-Promoting Effects

Pending Publication Date: 2021-12-07
SHANGHAI NAT ENG RES CENT FORNANOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the current repair scaffolds often ignore the difference between the shape, thickness and mechanical strength of the implant and the natural cartilage, resulting in poor recovery and regeneration of the defect area.

Method used

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  • Preparation method of 3D printing elastic polymer stent for articular cartilage repair and product and application of 3D printing elastic polymer stent

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] A 3D printed elastic polymer scaffold for articular cartilage repair, using 3D printing at room temperature to prepare PCLA / PLGT blend polymer loaded with modified nano-hydroxyapatite and silk fibroin, to obtain elastic and degradable joint repair Implants, prepared as follows:

[0024] (1) Preparation of PLLA-modified PLLA-n-HA by step-by-step reaction: prepare ethanol aqueous solution (90% ethanol) containing 2% (w / v) γ-aminopropyltriethoxysilane (KH550), and add 10% (w / v) n-HA, ultrasonically dispersed, adjusted the pH to 9~10 with NaOH solution, reacted at 70 °C for 8 h, and dried in vacuum at 60 °C to obtain the product KH550-n-HA;

[0025] Dissolve 3 g of KH550-n-HA and 3 g of lactide (LLA) in 30 mL of DMF, and add 0.01 g of stannous octoate as a catalyst, reflux at 120 °C for 24 h, and the obtained product is treated with dichloro After washing with methane three times, vacuum drying at 40°C for 8 h after centrifugation, the product PLLA-HA was obtained;

[002...

Embodiment 2

[0029] A 3D printed elastic polymer scaffold for articular cartilage repair, the others are the same as in the embodiment, except that step (2) is prepared according to the following steps:

[0030] (1) Stepwise reaction to prepare PLLA-modified PLLA-HA, the method is the same as in Example 1;

[0031] (2) Mix 8mL dichloromethane with 2mL DBP, add 3.5g PCLA, 0.5g PLGT, 0.95g PLLA-HA, 0.05g silk fibroin in sequence, fully dissolve and disperse under closed mechanical stirring;

[0032] (3) According to the model design, use a 3D printer in the layer-by-layer accumulation mode to perform 3D printing at room temperature. After printing, the product is placed in a 40°C oven to evaporate the solvent to obtain an elastic polymer scaffold.

Embodiment 3

[0034] A 3D printed elastic polymer scaffold for articular cartilage repair, the others are the same as in the embodiment, except that step (2) is prepared according to the following steps:

[0035] (1) Stepwise reaction to prepare PLLA-modified PLLA-HA, the method is the same as in Example 1;

[0036] (2) Mix 5mL dichloromethane with 5mL DBP, add 1g PCLA, 0.6g PLGT, 0.38g PLLA-HA, 0.02g silk fibroin in sequence, fully dissolve and disperse under airtight mechanical stirring;

[0037] (3) Use a 3D printer in the layer-by-layer accumulation mode to perform 3D printing at room temperature. After printing, the product is placed in a 40°C oven to evaporate the solvent to obtain an elastic polymer scaffold.

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Abstract

The invention relates to a preparation method of a 3D printing elastic polymer stent for articular cartilage repair. The preparation method is characterized in that a PCLA/PLGT blend polymer loaded with modified nano-hydroxyapatite and silk fibroin is prepared by normal-temperature 3D printing, and an elastic degradable joint repair implant is prepared. The material has proper elasticity and mechanical strength, and the modified n-HA and silk fibroin are added, so that the material has good biocompatibility, and the growth of cartilage fiber cells and osteoblasts can be promoted. The 3D printing technology enables the stent to be matched with a wound part in shape and thickness, and the preparation method is simple and suitable for personalized treatment.

Description

technical field [0001] The invention relates to a method in the technical field of biomedical materials, in particular to a method for preparing a 3D printed elastic polymer scaffold for articular cartilage repair and its products and applications, a method for preparing a 3D printed elastic polymer scaffold, The PCLA / PLGT blend polymer loaded with modified nano-hydroxyapatite and silk fibroin was prepared by 3D printing at room temperature, and an elastic and degradable implant for joint repair was prepared. Background technique [0002] Articular cartilage tissue damage caused by various reasons such as diseases and traffic accidents is a common clinical symptom in orthopedics. Since articular cartilage has no blood vessels and nerves, its self-repair ability is very limited, and fillers need to be implanted to promote cartilage regeneration and repair. Tissue engineering provides a new idea for clinically solving the problem of articular cartilage repair, and artificial ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B29C64/106A61F2/30B33Y10/00B33Y70/10
CPCB29C64/106A61F2/30756B33Y10/00B33Y70/10A61F2002/30766A61F2002/30985B29L2031/753
Inventor 崔大祥杨迪诚朱君徐艳
Owner SHANGHAI NAT ENG RES CENT FORNANOTECH
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