Degradable porous glass rack having bioactivity and preparation method
A bioactive glass, glass technology, applied in glass manufacturing equipment, glass molding, manufacturing tools and other directions, can solve the problems of poor applicability of stent materials, affecting the use effect, easy to break, etc., to achieve good biological interface and chemical properties, The effect of good biological activity, good degradability
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[0040] Example 1:
[0041] The raw materials used are as described above.
[0042] Will analyze pure SiO 2 , Na 2 CO 3 , CaCO 3 , P 2 O 5 The raw materials are uniformly mixed in proportion, melted into a homogeneous melt at 1420°C, then cooled, crushed, and sieved to obtain bioactive glass powder with a particle size of 40-300um. The composition of the glass powder is CaO 24.5%, SiO 2 45%, Na 2 O 24.5%, P 2 O 5 6%.
[0043] The bioactive glass powder with a particle size of 150-200 microns and polyethylene glycol powder with 200-300 microns are mixed at a mass percentage of 60:40, and a polyvinyl alcohol solution with a concentration of 6% is added as a binder. After being uniformly adjusted, it is dry-pressed and molded under a pressure of 14 MPa, and demolded to obtain a green porous material. The green body is plasticized at 400° C. and then sintered at 850° C. for 2 hours to obtain the porous material of the present invention with a compressive strength of about 1.25 MPa and ...
Example Embodiment
[0045] Example 2:
[0046] Will analyze pure SiO 2 , CaCO 3 , Ca 3 (PO 4 ) 2 , MgCO 3 , CaF 2 The raw materials are uniformly mixed in proportion, melted into a homogeneous melt at 1450°C, then cooled, crushed, and sieved to obtain bioactive glass powder with a particle size of 40-300um. The composition of the glass powder is CaO 40.5%, SiO 2 39.2%, MgO 4.5%, P 2 O 5 15.5%, CaF 2 0.3%.
[0047] The obtained powder is taken and mixed according to the mass percentage of the bioactive glass powder and the 300-600 micron polyvinyl alcohol powder at a mass percentage of 50:50 to obtain a solid mixture. Prepare an aqueous solution containing 20% acrylamide, 2% N, N'-methylene bisacrylamide and 8% polyacrylamide, and combine 10 grams of the above solid mixture with the above aqueous solution at a volume percentage of 50:50 Mix evenly, add a few drops of 3% by mass ammonium persulfate and 3% by mass N, N, N', N'-tetramethylethylenediamine, and stir evenly to obtain a slurry with better ...
Example Embodiment
[0048] Example 3:
[0049] The raw materials used and the preparation method of the bioactive glass powder are the same as in Example 2.
[0050] According to the mass ratio of 40:60, mix the bioactive glass powder with a particle size of 150-200 microns and the PEG powder with 200-300 microns, add a polyvinyl alcohol solution with a concentration of 6% as a binder, and adjust it evenly. Dry press molding under 14MPa pressure and demold to obtain a green body of porous material. The green body is plasticized at 400° C., and then sintered at 800° C. The compressive strength of the porous material of the present invention is about 1.5 MPa and the porosity is about 65%. After immersing in simulated body fluid for 3 days, the degradation rate was 38% (mass percentage of dissolved Si). The performance evaluation of the porous material is as in Example 1. It can be used as a cell scaffold for bone tissue culture in vitro.
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