The invention discloses a corn foliar multi-effect anti-adversity agent and a preparation method thereof. The purpose of the invention is to solve the problems of corn output increase affection, soil hardening, bad mouthfeel, frequent pest disease and great increase of the dosage of pesticides, caused by years of continuous cultivation and single chemical components. The corn foliar multi-effect anti-adversity agent is provided in a pesticide and fertilizer combination mode. The corn foliar multi-effect anti-adversity agent has the advantages of low production cost, small chemical residual to corn, substantial enhancement of the cold, drought, wet, adversity and disease pest resistance of corn, effective killing of corn pests, prevention of the pest disease of corn, effective reduction of the application amount of pesticides, corn production cost reduction and corn product safety guaranteeing. The corn foliar multi-effect anti-adversity agent can effectively improve the corn output, solve crop element deficiency caused by unreasonable fertilization, alleviates fertilizer harms and pesticide harms caused by improper pesticide application, and also can effectively improve the soil structure, increase the soil fertility and restore soil.