Soft capsule of decoction of four ingredients possessing effect of enriching blood and regulating menstruation and preparation method

A technology of soft capsules and decoctions, which is applied in the field of medicine, can solve the problems that there are no reports on the formulation of Siwu Decoction soft capsules, the pharmacological effects of chuanxiong volatile oil have decreased or even disappeared, and the content of active substances is low. Novelty, dosage reduction effect

Inactive Publication Date: 2005-03-30
陈志成
View PDF0 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But the mixture has the following disadvantages: (1) poor stability, which affects the quality of medicines: one of the main effective parts of Angelica and Rhizoma Chuanxiong volatile oil is extremely unstable in aqueous solution
Ligustilide has the highest content (30-80%) in the volatile oil of Angelica and Chuanxiong, and the most active ingredient, ligustilide, is easily decomposed by isomerization reaction at room temperature, especially in aqueous solution, ligustilide The pharmacological effects of the decomposed volatile oil of Rhizoma Chuanxiong significantly decreased or even disappeared [Shi Lifu, et al. Chinese Journal of Pharmacology and Toxicology, 1995; 9(2): 157], thereby affecting the quality of the drug; (2) long-term storage is easy to produce precipitation; ( 3) It is inconvenient to carry and transport; (4) The volatile oil of angelica and chuanxiong has a special odor and is irritating to the gastrointestinal tract, which is difficult for patients to accept
Therefore, it is unreasonable to make Siwu Decoction into a mixture dosage form
And Siwu Decoction Granules is 10g at a time, and the dosage is large; the content of active substances is low, and the content of auxiliary materials is more than 80%; it needs to be taken with water, which is inconvenient to take
At present, there is no report on the development of Siwutangfang soft capsule formulations

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Example 1 Preparation of Siwu Decoction Extract, Angelica Sinensis and Ligusticum Chuanxiong Volatile Oil

[0023] Raw material formula: Angelica 500g, Chuanxiong 500g, Baishao 500g, Rehmannia glutinosa 500g.

[0024] Preparation method: (1) take angelica and chuanxiong, add 15 times the amount of water to distill and extract the volatile oil for 8 hours, and collect the volatile oil to obtain the volatile oil of angelica and chuanxiong; Above-mentioned dregs, Radix Paeoniae Alba, Rehmannia glutinosa and the percolation method (Chinese Pharmacopoeia 2000 edition, appendix 10) under the item of Radix Paeoniae Alba, Radix Rehmanniae Radix Radix Extracte, make 50% ethanol solution with the aqueous solution after the above-mentioned distillation as solvent, soak after 24 hours Carry out percolation, collect percolation liquid, recover ethanol under reduced pressure, concentrate to a relative density of 1.23, and spray dry to obtain Siwutangfang extract.

Embodiment 2

[0025] Example 2 Preparation of Siwu Decoction Extract, Angelica Sinensis and Ligusticum Chuanxiong Volatile Oil

[0026] Raw material formula: Angelica 400g, Chuanxiong 400g, Baishao 500g, Rehmannia glutinosa 700g.

[0027] Preparation method: (1) take angelica and chuanxiong, add 13 times the amount of water to distill and extract the volatile oil for 6 hours, and collect the volatile oil to obtain the volatile oil of angelica and chuanxiong; the distilled aqueous solution is collected in another device, and the medicinal residue is for use; Above-mentioned medicinal dregs, and the percolation method (Chinese Pharmacopoeia 2000 edition, appendix 10) under Radix Paeoniae Alba Radix, Rehmannia Radix Radix Radix Extract and Extract item, the aqueous solution after the above-mentioned distillation is made into 60% ethanol solution as solvent, after soaking for 28 hours Carry out percolation, collect the percolation liquid, recover ethanol under reduced pressure, concentrate to a...

Embodiment 3

[0028] Example 3 Preparation of Siwu Decoction Extract, Angelica Sinensis and Ligusticum Chuanxiong Volatile Oil

[0029] Raw material formula: Angelica 500g, Chuanxiong 500g, Baishao 500g, Rehmannia glutinosa 500g.

[0030] Preparation method: (1) take angelica and chuanxiong, extract volatile oils with supercritical carbon dioxide extraction method to obtain volatile oils of angelica and chuanxiong, combine the dregs of angelica and chuanxiong after extracting volatile oils with rehmannia glutinosa and white peony root, and use 55% ethanol For solvent reflux extraction twice, each time 10 times the amount of solvent, 2 hours, combined extracts, recovered ethanol under reduced pressure, concentrated to a relative density of 1.36 (55 ~ 60 ° C), dried under reduced pressure, crushed into fine powder, that is, Get the extract of Siwu Tang Fang.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

A Chinese medicine in the form of softgel for nourishing blood, promoting blood circulation and treating menoxenia is composed of the core prepared from rehmannia root, white peony root, Chinese angelica root and Chuan-xiong rhizome and the softgel wall prepared from gelatin, plasticizer, water, light shielding agent and nipagin. Its preparing process is also disclosed.

Description

Technical field [0001] The invention belongs to the technical field of medicine, and relates to a new preparation of Chinese patent medicine, more specifically, to a Siwutangfang soft capsule made of four Chinese herbal extracts of rehmannia glutinosa, white peony root, angelica, and chuanxiong rhizoma as raw materials and its preparation method. Background technique [0002] Siwu Decoction comes from the "Taiping Huimin Heji Bureau Prescription" in the Song Dynasty, and is composed of four traditional Chinese medicines: rehmannia glutinosa, white peony root, angelica, and chuanxiong. It has the functions of nourishing blood, promoting blood circulation, and regulating menstruation. It is used for all symptoms such as stagnation of nutrient blood deficiency, women's irregular menstruation, pain in the navel and abdomen, metrorrhagia, hard lumps of blood, pale tongue with white fur, etc. Siwu Decoction is a common prescription for nourishing blood and a basic prescription fo...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/48A61P3/14A61P7/06A61P13/12A61P15/00A61P25/04
Inventor 陈志成
Owner 陈志成
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap