37 results about "Rehmanniae Radix" patented technology

This invention relates to an anti-swine pseudorabies virus (PRV) preparation and the application of Rehmannia glutinosa polysaccharide in its preparation, belonging to the field of biopharmaceutical technology. This invention provides an anti-swine pseudorabies virus (PRV) preparation comprising Rehmannia glutinosa polysaccharide. It also provides the application of Rehmannia glutinosa polysaccharide in the preparation of an anti-PRV preparation for the prevention and / or treatment of swine pseudorabies. This invention utilizes Rehmannia glutinosa polysaccharide to prevent infection by the PRV variant XJ5 by reducing intracellular oxidative stress levels; it also resists viral infection by affecting viral adsorption. Furthermore, when the concentration of Rehmannia glutinosa polysaccharide is between 50 and 400 μg / mL, it can also affect viral entry and replication, and has no cytotoxicity to PK-15 cells.

The invention relates to the technical field of traditional Chinese medicine, in particular to a medicine for improving sperm quality and application thereof.The medicine is reasonably combined according to etiology and pathogenesis of male infertility with abnormal sperm quality, prepared rehmannia root and poria cocos serve as monarch medicine, cistanche, astragalus membranaceus and ginseng serve as ministerial medicine, maca serves as adjuvant medicine, kidney tonifying is assisted, and the effect of improving the sperm quality is achieved. The traditional Chinese medicine composition has the effects of tonifying kidney, replenishing essence, promoting diuresis, dissolving turbidity and treating spleen and kidney through compatibility and synergism of all the medicines, improves abnormal sperm quality, improves sperm quality, effectively treats male infertility and can take both symptoms and root causes into consideration.

The present application provides a DNA barcode specific identification method of radix rehmanniae decoction pieces, and relates to the technical field of true and false identification of traditional Chinese medicine decoction pieces. The specific identification method comprises the following steps: extracting sample DNA to be detected; screening universal and specific DNA barcode genes; amplifying universal and specific DNA barcode gene fragments; amplifying the amplification product; and obtaining amplified DNA barcode sequences after sequence correction and splicing, and performing online BLAST comparison with NCBI database, so as to determine the base origin of the sample to be detected. The method provided by the present application can overcome the problem that the DNA barcode of the conventional ITS2 sequence of the decoction piece after processing is not easy to amplify, and the PCR amplification product of the present application has high quality, the molecular identification result is accurate, and the rapid identification of radix rehmanniae and radix rehmanniae preparata decoction pieces can be efficiently and high-quality solved, and the urgent need for true and false identification of radix rehmanniae decoction pieces during acceptance is solved.

The invention discloses a novel traditional Chinese medicine honeyed pill for treating alopecia, and relates to the technical field of traditional Chinese medicine preparations. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: radix rehmanniae praeparata, angelica sinensis, raw radix paeoniae alba, semen cuscutae fried with wine, radix saposhnikoviae, gastrodia elata, ligusticum wallichii, radix ophiopogonis, asparagus cochinchinensis, radix bupleuri, radix puerariae, cassia twig, radix curcumae, caulis spatholobi and other traditional Chinese medicines which are subjected to superfine grinding and then are matched according to a specific proportion. The preparation process comprises the steps of crushing; refining honey; and mixing and waking up the medicine. The traditional Chinese medicine composition has the following effects: the composition takes effect at multiple targets: up-regulating hair follicle survival promoting factors and down-regulating inflammatory mediators; the process has the advantages that the stability of pills is improved by controlling the viscosity of refined honey; the clinical application has the advantages that the cure rate of severe alopecia totalis is improved compared with the traditional prescription The recurrence rate is low after the medicine is stopped for one year. The formula is mainly used for treating alopecia, alopecia areata, sticktight and alopecia totalis.

The application discloses a composition for treating lumbar intervertebral disc herniation and repairing annulus fibrosus, relates to the technical field of traditional Chinese medicine compositions, and comprises the following raw materials: radix rehmanniae preparata, plastrum testudinis, fructus psoraleae, eucommia ulmoides oliver, walnut kernel, bee pollen, ligustilide, saikosaponin A, salvianolic acid B, ferulic acid, calycosin, stibene glycoside, prunol, loganin, hydroxysafflor yellow A and ligustilide. Experiments show that the composition can strengthen the repair of annulus fibrosus, has anti-inflammatory and analgesic effects, protects collagen, inhibits degeneration, can effectively treat lumbar intervertebral disc herniation and realize the structural repair of damaged annulus fibrosus, and provides a new technical scheme for the clinical treatment of lumbar intervertebral disc herniation.

The present application relates to the technical field of traditional Chinese medicine, in particular to a traditional Chinese medicine composition for reducing adverse reactions after radiotherapy and chemotherapy of tumor patients and a preparation method thereof, comprising the following components in parts by weight: Radix Bupleuri 6-9 parts, Radix Paeoniae Alba 6-9 parts, Rhizoma Atractylodis Macrocephalae 6-9 parts, Poria 6-9 parts, Angelica sinensis 6-9 parts, Zingiber officinale 3 parts, Radix Rehmanniae Recens 3-6 parts, Gardenia 3-6 parts, Radix Paeoniae Rubra 3-6 parts, Radix Paeoniae Alba 12-20 parts, Rhizoma Chuanxiong 6 parts, and Radix Glycyrrhizae 3-6 parts; the traditional Chinese medicine composition can improve the spirit and movement state of mice, and the weight and food intake of mice are obviously increased, the number of dead mice is significantly reduced, and the tumor volume and weight of mice are significantly reduced; the spleen and thymus indexes, the number of white blood cells, red blood cells and platelets in peripheral blood, and the hemoglobin content are all significantly increased; the number of bone marrow cells and the CD4 + T / CD8 + T cell ratio in peripheral blood are all significantly increased; when applied to clinical patients, the traditional Chinese medicine composition can reduce adverse reactions after radiotherapy and chemotherapy of tumor patients, and has a broad application prospect.

The application discloses application of a rehmannia glutinosa extract in preparation of drugs for treating kidney injury caused by cisplatin. The application of the rehmannia glutinosa extract in preparation of drugs for preventing and / or treating kidney injury caused by cisplatin; a preparation method of the rehmannia glutinosa extract, comprising the following steps: S1, adding water to the rehmannia glutinosa to perform extraction, to obtain a rehmannia glutinosa water extract; S2, adding ethyl acetate to the rehmannia glutinosa water extract to perform extraction, separating ethyl acetate phase and water phase, to obtain the rehmannia glutinosa extract. The application constructs an animal model by inducing mouse kidney injury by cisplatin, and it is found that the rehmannia glutinosa extract obtained by further separating the rehmannia glutinosa water extract by using solvents such as ethyl acetate and ethanol can improve acute kidney injury caused by cisplatin, and the effect is better than that of the rehmannia glutinosa water extract.

The invention relates to the technical field of requirements, and particularly discloses radix puerariae four-material soap for improving blood deficiency and wind dryness type skin diseases and a preparation method thereof.The radix puerariae four-material soap is prepared from, by weight, 12-18 parts of radix puerariae, 9-15 parts of wine-processed radix angelicae sinensis, 6-12 parts of wine-processed rhizoma chuanxiong, 12-18 parts of radix rehmanniae praeparata and 9-15 parts of bran-processed radix paeoniae alba. And 0.5-10 parts of a synergistic carrier material containing at least one of a hempleaf negundo chastetree leaf and fructus viticis co-extract, microencapsulated volatile oil or a nano-liposome coated active component. According to the invention, a synergistic carrier material is introduced and is combined with a classical blood-nourishing dryness-moistening radix puerariae four-material basic formula, and a modern preparation technology is used for processing, so that the stability and bioavailability of active ingredients in the product are improved, and particularly, good protection and targeted delivery effects are achieved on volatile and degradable effective ingredients; meanwhile, due to the application of a modern extraction and forming process, the effects of the traditional Chinese medicines can be integrated into a stable and uniform soaping agent matrix more efficiently and controllably.

The invention discloses a traditional Chinese medicine composition for treating perimenopausal dry eyes and a preparation method and application thereof, and relates to the technical field of traditional Chinese medicine formulas. The traditional Chinese medicine composition for treating the perimenopausal dry eye comprises herba epimedii, prepared rehmannia root, rhizoma anemarrhenae, cortex phellodendri, radix paeoniae alba, angelica sinensis, radix bupleuri, poria cocos and honey-fried licorice root. The traditional Chinese medicine composition for treating perimenopausal dry eye, namely the kidney-warming dry eye formula, has the functions of warming kidney, nourishing yin, soothing liver and strengthening spleen, can effectively improve perimenopausal symptoms such as dry eye, photophobia, asthenopia, foreign body sensation, burning sensation, soreness and weakness of waist and knees, dysphoria, irritability, hot sweating, insomnia, amnesia and the like of patients with perimenopausal dry eye, improves the estrogen level, and has the efficacy of treating perimenopausal dry eye. The ocular surface inflammatory response is inhibited, and the tear film stability is improved.

The invention provides a traditional Chinese medicine composition for preventing hair loss and promoting hair growth and application thereof, and relates to the technical field of hair loss prevention and promoting hair growth, the traditional Chinese medicine composition is composed of Chinese doughnut, cockscomb, albizia flower, Chinese honey locust, schizonepeta, lithospermum, polygonum multiflorum, prepared rehmannia root, notopterygium root, radix angelicae pubescentis, ruddle and periostracum cicada; in-vitro experiments show that the traditional Chinese medicine composition can promote proliferation of human dermal papilla cells HDPC, relieve the damage degree of HDPC and induce cycle transformation of hair follicles, so that the effect of promoting hair growth is achieved; animal experiments show that the traditional Chinese medicine composition can significantly increase the number of hair follicles and the thickness of skin and dermis fat of mice, reduce the levels of mouse serum IL-2, TNF-alpha and TGF-beta1 and reduce the levels of testosterone, dihydrotestosterone and estradiol in mouse skin tissue, so that hair follicle fibrosis is inhibited, the growth period of hair follicles is accelerated, the growth period is prolonged, the hair loss phenomenon is improved, and the hair loss rate is increased. The hair growth is promoted.

Use of Huolingshengji Keli granules in the preparation of a pharmaceutical composition for treating amyotrophic lateral sclerosis (ALS). The traditional Chinese medicine composition comprises: 60-130 parts by weight of Epimedii folium, 60-150 parts by weight of raw Rehmanniae radix, 60-100 parts by weight of alcohol-processed Cornus officinalis, 90-150 parts by weight of Astragali radix, 40-110 parts by weight of Atractylodis macrocephalae rhizoma stir-fried with bran, and 30-90 parts by weight of Poria. The amyotrophic lateral sclerosis is non-familial amyotrophic lateral sclerosis.

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for replenishing qi, enriching blood, tonifying spleen and nourishing kidney as well as a preparation method and application thereof. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 2 to 12 parts of radix angelicae sinensis, 5 to 20 parts of radix codonopsis, 5 to 20 parts of radix astragali seu hedysari, 2 to 12 parts of rhizoma atractylodis macrocephalae, 2 to 15 parts of poria cocos, 3 to 13 parts of colla corii asini, 3 to 13 parts of tortoise-shell glue, 2 to 12 parts of herba cistanche, 5 to 15 parts of radix rehmanniae praeparata, 3 to 15 parts of rhizoma polygonati, 3 to 13 parts of herba epimedii, 2 to 12 parts of fructus crataegi, 5 to 15 parts of arillus longan, 2 to 12 parts of fructus ligustri lucidi, 2 to 6 parts of fructus schisandrae chinensis and 1 to 5 parts of cortex cinnamomi. The traditional Chinese medicine composition has the main effects of replenishing qi, enriching blood, tonifying spleen and nourishing kidney, is used for rehabilitation after cancer surgery or chemotherapy and used for resisting cancer relapse, is particularly used for patients with spleen and kidney deficiency type cachexia after cancer surgery or chemotherapy, and improves the problems of emaciation, insomnia, inappetence, mental fatigue and tiredness and the like of the patients with the patients with the spleen and kidney deficiency type cachexia after cancer surgery or chemotherapy.

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a compound cypress-astragalus pill and application thereof. The compound cypress and radix astragali pill is prepared from the following components in parts by mass: 10 to 25 parts of cortex phellodendri, 40 to 80 parts of radix hedysari, 20 to 40 parts of radix rehmanniae and 10 to 30 parts of folium crataegi. The compound cypress-stilbene pill takes radix hedysari as a monarch drug to tonify qi, promote urination, nourish yin and promote salivation, the radix rehmanniae is matched to clear heat, cool blood, nourish yin and promote salivation, the golden cypress is used to clear heat, dry dampness, purge fire and remove steam, so that the heat-clearing and yin-nourishing effects are more prominent, the hawthorn leaves for regulating qi, activating blood, dispersing blood stasis, dredging collaterals, dissolving turbidity and reducing lipid are used, and the medicines are used in compatibility to achieve the effects of clearing heat, resolving dampness, removing blood stasis and reducing phlegm. The traditional Chinese medicine composition can effectively relieve symptoms of patients with glucolipid metabolism syndromes, and the purpose of treating both symptoms and root causes is achieved.

The invention provides a python oil composition for preventing and treating chap as well as a preparation method and application thereof, and relates to the field of compositions for preventing and treating chap. The boa oil composition comprises the following raw materials in parts by weight: 5-10 parts of boa oil, 3-8 parts of egg oil, 2-4 parts of butyrospermum parkii butter, 0.5-1.5 parts of salicylic acid, 8-12 parts of angelica sinensis, 5-10 parts of radix paeoniae alba, 3-8 parts of prepared rehmannia root, 2-4 parts of rhizoma polygonati, 5-10 parts of radix stemonae, 5-15 parts of folium artemisiae argyi, 2-4 parts of lucid ganoderma, 8-12 parts of rhizoma bletillae, 5-10 parts of tortoise shell, 4-6 parts of beewax and 12-18 parts of dragon's blood. The python oil composition is applied to treatment of chapped skin, the total effective rate and the cure rate are high, safety is good, and the python oil composition can be well applied to prevention and treatment of chapped skin.

The invention relates to the technical field of pharmacy, in particular to application of prepared rehmannia root to preparation of medicine for improving chronic kidney diseases, and effective components of the medicine comprise an active component I and an active component II extracted from the prepared rehmannia root. The PubChem CID number of the active ingredient I is 5280450, the active ingredient I can be specifically combined with JUN protein, and the PDB database number of the JUN protein is 1JUN; the PubChem CID number of the active ingredient II is 24721256, the active ingredient II can be specifically combined with STAT3 protein, and the PDB database number of the STAT3 protein is 6NJS. According to the application disclosed by the invention, the PubChem CID 5280450 and the PubChem CID 24721256 are determined to be core active components of the prepared rehmannia root for intervening the CKD for the first time, and the PubChem CID 5280450 and the PubChem CID 24721256 are proved to respectively and specifically act on two key signal nodes, namely JUN protein and STAT3 protein, so that a clear modern pharmacological material basis and action mechanism explanation are provided for treating the CKD by the prepared rehmannia root.

Disclosed are a compound traditional Chinese medicine composition for treating diabetic nephropathy, a method for preparing same, and use thereof. The compound traditional Chinese medicine composition is prepared from Astragali Radix, Atractylodis Macrocephalae Rhizoma, Corni Fructus, Cinnamomi Cortex, Psoraleae Fructus, Rehmanniae Radix, Eucommiae Cortex, Achyranthis Bidentatae Radix, and Schisandrae Chinensis Fructus. Marsdenia tenacissima Caulis may also be added to the substance of the compound traditional Chinese medicine composition.

This invention relates to the field of special medical foods, and particularly to a special medical food formula for colorectal cancer patients, its preparation method, and its application. The raw materials, in parts by weight, include: 20-30 parts Codonopsis pilosula, 20-30 parts Rehmannia glutinosa (processed), 20-30 parts Astragalus membranaceus, 10-20 parts Coix lacryma-jobi (raw), 10-20 parts Atractylodes macrocephala, 10-20 parts Poria cocos, 10-20 parts Angelica sinensis, 10-20 parts Paeonia lactiflora, 10-20 parts Prunus persica, 3-6 jujubes, 3-15 parts Glycyrrhiza uralensis, 6-15 parts phycocyanin, and 6-15 parts citric acid. This formula can have anti-tumor effects, reduce the toxic side effects of chemotherapy, enhance the reticuloendothelial cell system, promote the enhancement of specific and non-specific immune functions in the body, thereby reducing tumor volume and inhibiting tumor proliferation and metastasis. The drug is encapsulated in Dunaliella salina exosomes and targeted modified to ensure accurate delivery to the lesion site, increasing bioavailability and reducing the drawbacks of a small therapeutic window and high toxicity.

The invention relates to the technical field of pharmaceutical preparations, and provides a pharmaceutical composition for preventing and / or treating leucopenia caused by chemotherapy and a preparation method of the pharmaceutical composition. The pharmaceutical composition is prepared from the following raw materials: red ginseng, prepared rehmannia root, morinda officinalis, pericarpium citri reticulatae, semen cuscutae, rhizoma atractylodis macrocephalae, Chinese yam, astragalus membranaceus, poria cocos, radix achyranthis bidentatae, cistanche, cinnamon, angelica sinensis, fructus lycii, cornu cervi pantotrichum, fennel, radix paeoniae alba and liquorice. The pharmaceutical composition provided by the invention realizes prevention and / or treatment of leucopenia caused by chemotherapy, specifically, the pharmaceutical composition is combined with the chemotherapeutic drug 5-fluorouracil for use, and is applied before, during or after chemotherapeutic drug administration, and the leucocyte level of a subject is increased by promoting lymphocyte and / or monocyte proliferation.

The invention belongs to the technical field of traditional Chinese medicine preparations, and particularly relates to a traditional Chinese medicine decoction for inhibiting invasion and metastasis of cervical cancer and a preparation method thereof.The traditional Chinese medicine decoction is prepared from, by weight, 20-30 parts of radix rehmanniae praeparata, 15-30 parts of radix astragali, 10-20 parts of rhizoma curcumae longae, 10-15 parts of deer-horn glue, 3-6 parts of ginger charcoal, 3-6 parts of licorice roots, 6-10 parts of mixed medicine residues and 40-80 parts of volatile oil inclusion liquid. Volatile oil of cortex cinnamomi, semen brassicae and herba ephedrae is prepared into an inclusion compound through cyclodextrin, the stability and bioavailability of a liquid preparation are improved, turmeric and astragalus membranaceus are introduced on the basis of a classic prescription Yanghe decoction to form multi-target cooperation, cellulase and pectinase are adopted for enzymolysis auxiliary extraction, the dissolution rate of effective components is increased, and the bioavailability of the liquid preparation is improved. The prepared traditional Chinese medicine decoction can effectively inhibit proliferation, migration and invasion of cervical cancer cells under the hypoxic condition, and the action mechanism of the traditional Chinese medicine decoction is closely related to down-regulation of an HIF-1alpha / CXCL6 signal axis.

The invention relates to the technical field of functional healthy foods, in particular to an anti-aging functional healthy food. The functional healthy food provided by the invention comprises grape seeds, codonopsis pilosula or ginseng, astragalus membranaceus, folium cortex eucommiae or eucommia ulmoides, prepared rehmannia root, medlar, sea-buckthorn and mulberry. The raw materials are mainly selected from health-care food raw materials, medicinal and edible food materials and part of common nutritional food materials which are all natural plant raw materials. The applicant finally determines the raw materials and proper component proportion and processing technology of the food through research on the characteristics of the raw materials, screening and blending of various food raw materials and verification of in-vivo experiments, so that the antioxidant level of a human body can be effectively improved, the cognitive ability is improved, and the food quality is improved. The traditional Chinese medicine composition has the multiple effects of improving the skin collagen content and improving liver lesions (fatty liver) and kidney lesions (kidney fibrosis, kidney tissue inflammatory cell infiltration, renal tubular necrosis and abnormal renal tubular structure) of a body, and the anti-aging purpose is achieved through the multiple effects.

The present application relates to the application of Radix Rehmanniae Preparata polysaccharide in postmenopausal osteoporosis, and relates to the application of active ingredients of traditional Chinese medicine in the treatment of bone metabolism diseases. The Radix Rehmanniae Preparata polysaccharide can improve the postmenopausal osteoporosis by up-regulating the expression of estrogen receptors and promoting the synthesis of estrogen.

The invention relates to a composition with a sleep quality improving function and a preparation method thereof, and belongs to the technical field of cosmetics and external preparations. The composition comprises gamma-aminobutyric acid, isosorbide dimethyl ether, a plant extract compound (pink passion fruit, spina date seed, polygala tenuifolia and prepared rehmannia root), aromatic essential oil (lavender oil, sandalwood oil and agilawood extract), menthol, ammonium polyacryloyldimethyl taurine and a moisturizing and preservative system. Isosorbide dimethyl ether and gamma-aminobutyric acid are premixed to form a permeation precursor solution, so that the problem of difficulty in transdermal penetration of gamma-aminobutyric acid is solved; through a specific preparation technology, gradient sleep-aiding release based on essential oil volatility difference and gel wrapping is constructed, and the staged sleep-aiding effects of instant cooling, dysphoria blocking, relaxation inducing, synergistic interaction and all-night slow-release deep sleep maintaining are achieved. The composition disclosed by the invention is high in transdermal absorption rate, controllable in fragrance release time sequence and lasting in sleep aiding effect, and has a good application prospect.

The invention provides a preparation method and application of a traditional Chinese medicine composition for growing and nourishing hair, and belongs to the technical field of traditional Chinese medicines. In the formula, prepared rehmannia root and prepared fleeceflower root are used as monarch drugs, wine-processed glossy privet fruit, dodder and refined sealwort are used as ministerial drugs, ligusticum wallichii, peach kernel, safflower and white peony root are used as adjuvant drugs, and notopterygium root and pawpaw are used as conductant drugs. According to the traditional Chinese medicine composition for growing and nourishing hair, through mutual cooperation of pure natural traditional Chinese medicine raw materials, hair output of existing hair follicles can be promoted, the unit number of functional hair follicles can be increased in the modes of improving the microenvironment of the hair follicles, activating dormant hair follicles and the like, and the purposes of growing hair and nourishing hair are achieved; and the risk of relapse of alopecia is effectively reduced.

The invention relates to a yang warming and governor meridian dredging pill which is prepared by the following steps: 1) weighing raw materials: (1) centipede and gecko; (2) cynomorium songaricum, flastem milkvetch seed (fried), gordon euryale seed (steamed), dragon bone (calcined), oyster (calcined) and lotus seed; (3) amur corktree bark and rhizoma atractylodis (fried); (4) mantis egg-case, prepared rehmannia root, morinda officinalis, cistanche, spina date seed (fried), cornu cervi degelatinatum, poria cocos, bighead atractylodes rhizome (fried), salted eucommia ulmoides, pulp of dogwood fruit, herba epimedii, Chinese yam, raw liquorice, white paeony root (fried) and angelica sinensis; (5) schisandra chinensis, semen plantaginis, semen cuscutae, fructus lycii and (2) grinding (1) into fine powder, putting into pills, decocting (2), (4) and (5), concentrating, and refining with (1) to obtain pills as large as phoenix tree seeds. The traditional Chinese medicine has the advantages that the raw materials are reasonable, the preparation is convenient, and the traditional Chinese medicine can treat soreness, cold and pain of waist, dyspepsia and lumbago caused by liver and kidney deficiency, kidney deficiency and essence deficiency; sciatic nerve numbness and pain; and the traditional Chinese medicine composition has the advantages of good popularization prospect and economic value, and can be used for treating symptoms such as joint soreness, cold pain, fatigue, impotence, sterility, spermatorrhea, premature ejaculation and residual urination.

The present application relates to a composition with improved sleep quality function and its preparation method, belonging to the technical field of cosmetics and external preparation. The composition comprises: gamma-aminobutyric acid, isosorbide dimethyl ether, plant extract compound (pink passion fruit, jujube kernel, polygala, rehmannia), aromatic essential oil (lavender oil, dalbergia odorifera oil, linaloe extract), menthol, polyacryl dimethyl ammonium taurate and moisturizing and preservative system. By using isosorbide dimethyl ether and gamma-aminobutyric acid to form a penetration precursor solution, the problem of transdermal difficulty of gamma-aminobutyric acid is solved; and through a specific preparation process, a gradient sleep-aiding release based on the volatility difference of essential oil and gel wrapping is constructed, realizing the phased sleep-aiding effect of instant cooling to block irritability, induction of relaxation synergistic effect, and whole night slow release to maintain deep sleep. The composition has high transdermal absorption rate, controllable aroma release timing, long-lasting sleep-aiding effect, and good application prospect.

The invention provides a composition for preventing and treating ovarian senescence and a preparation method and application thereof, and belongs to the technical field of ovarian senescence prevention and treatment. The composition for preventing and treating ovarian aging provided by the invention is prepared from radix rehmanniae praeparata, fructus lycii, poria cocos, astragalus membranaceus and perilla frutescens. According to the method, multidisciplinary technologies such as data mining, network pharmacology, weighted gene co-expression network analysis (WGCNA) combined machine learning and molecular docking verification are integrated; the multi-component-multi-target-multi-channel action mechanism of the medicinal and edible composition consisting of prepared rehmannia root, wolfberry fruit, poria cocos, astragalus membranaceus and purple perilla for preventing and treating ovarian aging is systematically illuminated. According to the medicinal and edible composition disclosed by the invention, the release of SASP (senescence-related secretory phenotype) senescence-related factors is slowed down by regulating and controlling a PI3K-Akt / SIRT1-TP53 signal axis, so that the senescence of ovarian cells is delayed, the effect of resisting ovarian senescence is exerted, and a theoretical basis is provided for the research of a modern pharmacological mechanism.

The invention provides a Shandong colla corii asini pulp composition without causing internal heat and a preparation process thereof. The composition comprises colla corii asini, fructus lycii, radix rehmanniae praeparata, radix astragali and fructus ziziphi jujubae. The invention also provides a preparation method and application of the composition. According to the composition, traditional Chinese medicinal materials and donkey-hide gelatin are matched, so that the blood replenishing and nourishing effects of the donkey-hide gelatin are enhanced, discomfort caused by poor taste when part of people eat the donkey-hide gelatin is solved, the dryness of the donkey-hide gelatin is relieved, the risk of excessive internal heat after eating is reduced, and meanwhile, the Shandong donkey-hide gelatin pulp prepared by adopting the preparation method is fine and smooth in taste, delicious in taste and free of toxic and side effects. The product is suitable for people with various constitutions.

The application discloses a natural medicine compound for treating Alzheimer's disease and application thereof, and the compound comprises the following components: 3-6 parts of Gastrodia elata, 3-6 parts of Polygala, 3-6 parts of Radix Notoginseng, 3-6 parts of Uncaria, 9-15 parts of Radix Rehmanniae Preparata, 9-15 parts of Radix Anemarrhenae, 6-10 parts of Fructus Schisandrae, 6-9 parts of Fried Semen Ziziphi Preparatum, 2-5 parts of Chuanxiong Rhizoma, 3-6 parts of Radix Paeoniae Alba, 9-15 parts of Radix et Rhizoma Bambusae, 1-5 parts of Carthamus, 6-10 parts of Atractylodes, 6-9 parts of Poria, 9-15 parts of Ophiophagus, 3-9 parts of Angelica, 9-15 parts of Radix et Rhizoma Ginseng, 2-5 parts of Salvia, and 2-5 parts of Radix Glycyrrhizae. The application further discloses a pharmacological action mechanism of the Tianqi granules for treating AD and application of the Tianqi granules in preventing and / or treating Alzheimer's disease. The application is a natural medicine, contains multiple active components, has scientific dosage, no side effect, and provides a new effective natural medicine compound for treating AD, and plays a significant role in benefiting a large number of patients and benefiting human health.

This invention discloses a composition for enhancing the disease resistance of frogs and its applications. The composition mainly consists of the core active peptide Peptide-3, astragalus polysaccharide, ginseng polysaccharide, prepared rehmannia root, and rosmarinic acid. Targeting "tiltosis and cataracts" in frogs caused by Elizabethanella miltiorrhiza, this invention works based on a synergistic mechanism of "targeted sterilization—immune warning—neural repair": Peptide-3 destroys the cell membrane of drug-resistant bacteria through a physical perforation mechanism to reduce pathogen load; plant polysaccharides induce non-specific immune warning in the body; prepared rehmannia root and rosmarinic acid synergistically scavenge free radicals, enhance SOD activity, and inhibit the expression of the pro-inflammatory factor TNF-α, precisely repairing damage to the central nervous system and eye tissues. Experiments show that the composition of this invention can increase the survival rate of diseased frogs to 92.4%, significantly reduce the incidence of tilted head and cataracts, and achieve a technological leap from single sterilization to comprehensive protection of the body.

The application discloses a traditional Chinese medicine composition for treating lumbar pain caused by diseases of the motor system and application thereof, and relates to the technical field of traditional Chinese medicines.The traditional Chinese medicine composition comprises yam, dogwood, prepared rehmannia, cassia twig, radix angelicae pubescentis, raw eucommia, rhizoma anemarrhenae, drynaria, frankincense, myrrh, chuanxiong, angelica sinensis, cyperus rotundus, achyranthes bidentata, amomum villosum, tangerine peel, gentiana, polygala, and licorice.The traditional Chinese medicine composition has the effects of tonifying liver and kidney, strengthening bones and muscles, promoting blood circulation to remove meridian obstruction, and relieving swelling and pain, and can be used for treating lumbar pain caused by various diseases of the motor system, such as lumbar hyperosteogeny, intervertebral disc herniation, lumbar vertebra hypertrophy, spinal stenosis, lumbar fracture, spinal canal tumor, acute and chronic trauma or strain of the lumbar region, lumbar muscle strain, and ankylosing spondylitis, and has outstanding curative effects on acute and chronic lumbar pain.