68 results about "Rehmanniae Radix" patented technology

The invention provides a herbal composition for preventing hair loss and promoting hair growth as well as a preparation method and application thereof, the herbal composition for preventing hair loss and promoting hair growth comprises a herbal extract, and the herbal extract is obtained by extracting a herbal mixture, the herbal mixture comprises ginseng, ganoderma atrum, radix polygoni multiflori preparata, prepared rehmannia root, ligusticum wallichii, angelica sinensis, gallnut, cacumen biotae, small yellow ginger, salvia miltiorrhiza, eclipta prostrata, glossy privet fruit, camellia seed, moutan bark, soapberry, gleditsia sinensis, folium artemisiae argyi, folium mori, senecio scandens, honeysuckle, fructus psoraleae, emblic leafflower fruit, radix sophorae flavescentis, fructus cnidii, euphorbia thymifolia, Chinese knotweed herb, duckweed, aloe juice, elm bark, agilawood, cortex dictamni and mint leaf. According to the herbal composition for preventing alopecia and growing hair, various components in the herbal extract are compounded to achieve a synergistic effect, scalp is deeply cleaned and nourished, scalp blood circulation is promoted, hair follicles are activated, hair roots are strengthened, and the herbal composition has the effects of preventing alopecia and growing hair, protecting and blackening hair, controlling oil and supplementing water, removing dandruff and relieving itching.

This invention relates to an anti-swine pseudorabies virus (PRV) preparation and the application of Rehmannia glutinosa polysaccharide in its preparation, belonging to the field of biopharmaceutical technology. This invention provides an anti-swine pseudorabies virus (PRV) preparation comprising Rehmannia glutinosa polysaccharide. It also provides the application of Rehmannia glutinosa polysaccharide in the preparation of an anti-PRV preparation for the prevention and / or treatment of swine pseudorabies. This invention utilizes Rehmannia glutinosa polysaccharide to prevent infection by the PRV variant XJ5 by reducing intracellular oxidative stress levels; it also resists viral infection by affecting viral adsorption. Furthermore, when the concentration of Rehmannia glutinosa polysaccharide is between 50 and 400 μg / mL, it can also affect viral entry and replication, and has no cytotoxicity to PK-15 cells.

The invention provides a traditional Chinese medicine composition and application thereof in preparation of products for preventing or improving gingival atrophy. The traditional Chinese medicine composition comprises rhizoma anemarrhenae, cortex phellodendri, cortex moutan, radix rehmanniae recen and radix ophiopogonis. The problem of limitation of a treatment scheme for improving gingival atrophy in the prior art can be solved, and the method is suitable for the field of gingival atrophy treatment.

The invention provides a broad-spectrum combined medicine for treating colorectal cancer. The broad-spectrum combined medicine is prepared from the following components in parts by weight: 100 parts of purified water, 38 to 90 parts of tripterygium wilfordii alkaloid, 38 to 90 parts of tripterygium hypoglaucum alkaloid, 28 to 85 parts of chamaejasmine, 28 to 85 parts of gelsmium elegans alkaloid and 28 to 85 parts of xanthoxylin. The medicine is prepared from the following raw materials in parts by weight: 16 to 80 parts of ganoderan, 16 to 80 parts of pinellia ternate sitosterol, 16 to 80 parts of radix rehmanniae praeparata, 16 to 80 parts of astragaloside, 16 to 80 parts of oldenlandia diffusa alkaloid, 16 to 80 parts of sculellaria barbata alkaloid, 16 to 80 parts of tanshinone, 16 to 80 parts of carthamin, 16 to 80 parts of honeysuckle chlorogenic acid and 16 to 80 parts of pericarpium citri reticulatae flavone. By integrating anti-tumor components with multiple action mechanisms, tripterygium wilfordii alkaloid, tripterygium hypoglaucum alkaloid and the like, tumor cell proliferation can be directly inhibited, and apoptosis can be induced; tanshinone, emodin and the like can inhibit tumor angiogenesis; ganoderma lucidum polysaccharides, astragaloside and the like can activate the immune system of the body, enhance the activity of T cells and NK cells, and form double strikes of direct killing and immune surveillance.

The invention relates to the technical field of traditional Chinese medicine, in particular to a medicine for improving sperm quality and application thereof.The medicine is reasonably combined according to etiology and pathogenesis of male infertility with abnormal sperm quality, prepared rehmannia root and poria cocos serve as monarch medicine, cistanche, astragalus membranaceus and ginseng serve as ministerial medicine, maca serves as adjuvant medicine, kidney tonifying is assisted, and the effect of improving the sperm quality is achieved. The traditional Chinese medicine composition has the effects of tonifying kidney, replenishing essence, promoting diuresis, dissolving turbidity and treating spleen and kidney through compatibility and synergism of all the medicines, improves abnormal sperm quality, improves sperm quality, effectively treats male infertility and can take both symptoms and root causes into consideration.

The present application provides a DNA barcode specific identification method of radix rehmanniae decoction pieces, and relates to the technical field of true and false identification of traditional Chinese medicine decoction pieces. The specific identification method comprises the following steps: extracting sample DNA to be detected; screening universal and specific DNA barcode genes; amplifying universal and specific DNA barcode gene fragments; amplifying the amplification product; and obtaining amplified DNA barcode sequences after sequence correction and splicing, and performing online BLAST comparison with NCBI database, so as to determine the base origin of the sample to be detected. The method provided by the present application can overcome the problem that the DNA barcode of the conventional ITS2 sequence of the decoction piece after processing is not easy to amplify, and the PCR amplification product of the present application has high quality, the molecular identification result is accurate, and the rapid identification of radix rehmanniae and radix rehmanniae preparata decoction pieces can be efficiently and high-quality solved, and the urgent need for true and false identification of radix rehmanniae decoction pieces during acceptance is solved.

The invention discloses a novel traditional Chinese medicine honeyed pill for treating alopecia, and relates to the technical field of traditional Chinese medicine preparations. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: radix rehmanniae praeparata, angelica sinensis, raw radix paeoniae alba, semen cuscutae fried with wine, radix saposhnikoviae, gastrodia elata, ligusticum wallichii, radix ophiopogonis, asparagus cochinchinensis, radix bupleuri, radix puerariae, cassia twig, radix curcumae, caulis spatholobi and other traditional Chinese medicines which are subjected to superfine grinding and then are matched according to a specific proportion. The preparation process comprises the steps of crushing; refining honey; and mixing and waking up the medicine. The traditional Chinese medicine composition has the following effects: the composition takes effect at multiple targets: up-regulating hair follicle survival promoting factors and down-regulating inflammatory mediators; the process has the advantages that the stability of pills is improved by controlling the viscosity of refined honey; the clinical application has the advantages that the cure rate of severe alopecia totalis is improved compared with the traditional prescription The recurrence rate is low after the medicine is stopped for one year. The formula is mainly used for treating alopecia, alopecia areata, sticktight and alopecia totalis.

The application discloses a composition for treating lumbar intervertebral disc herniation and repairing annulus fibrosus, relates to the technical field of traditional Chinese medicine compositions, and comprises the following raw materials: radix rehmanniae preparata, plastrum testudinis, fructus psoraleae, eucommia ulmoides oliver, walnut kernel, bee pollen, ligustilide, saikosaponin A, salvianolic acid B, ferulic acid, calycosin, stibene glycoside, prunol, loganin, hydroxysafflor yellow A and ligustilide. Experiments show that the composition can strengthen the repair of annulus fibrosus, has anti-inflammatory and analgesic effects, protects collagen, inhibits degeneration, can effectively treat lumbar intervertebral disc herniation and realize the structural repair of damaged annulus fibrosus, and provides a new technical scheme for the clinical treatment of lumbar intervertebral disc herniation.

The present application relates to the technical field of traditional Chinese medicine, in particular to a traditional Chinese medicine composition for reducing adverse reactions after radiotherapy and chemotherapy of tumor patients and a preparation method thereof, comprising the following components in parts by weight: Radix Bupleuri 6-9 parts, Radix Paeoniae Alba 6-9 parts, Rhizoma Atractylodis Macrocephalae 6-9 parts, Poria 6-9 parts, Angelica sinensis 6-9 parts, Zingiber officinale 3 parts, Radix Rehmanniae Recens 3-6 parts, Gardenia 3-6 parts, Radix Paeoniae Rubra 3-6 parts, Radix Paeoniae Alba 12-20 parts, Rhizoma Chuanxiong 6 parts, and Radix Glycyrrhizae 3-6 parts; the traditional Chinese medicine composition can improve the spirit and movement state of mice, and the weight and food intake of mice are obviously increased, the number of dead mice is significantly reduced, and the tumor volume and weight of mice are significantly reduced; the spleen and thymus indexes, the number of white blood cells, red blood cells and platelets in peripheral blood, and the hemoglobin content are all significantly increased; the number of bone marrow cells and the CD4 + T / CD8 + T cell ratio in peripheral blood are all significantly increased; when applied to clinical patients, the traditional Chinese medicine composition can reduce adverse reactions after radiotherapy and chemotherapy of tumor patients, and has a broad application prospect.

The invention discloses a traditional Chinese medicine capsule for treating diabetes and a preparation method thereof, and belongs to the technical field of medicine preparation. The capsule is composed of main materials and auxiliary materials. The main materials are composed of 23-27 g of radix astragali, 23-27 g of radix puerariae, 18-22 g of rhizoma polygonati, 18-22 g of Chinese yam, 13-17 g of radix scrophulariae, 13-17 g of radix rehmanniae praeparata, 13-17 g of radix salviae miltiorrhizae, 8-12 g of rhizoma coptidis, 8-12 g of silkworm excrement, 8-12 g of rhizoma polygoni cuspidati, 7-9 g of liquorice and 5-7 g of fructus momordicae. The auxiliary material consists of lactose, microcrystalline cellulose and superfine silica powder in a mass ratio of 10: 10: 1, and the total weight of the auxiliary material is 210g. Double-section countercurrent extraction and low-temperature belt type drying are adopted, the retention rate of effective components is increased, the content of berberine and the content of salvianolic acid B are increased by 18% and 22% respectively, in addition, particle size grading compatibility is adopted, quick release and gastrointestinal tolerance are both considered, artificial sweeteners or chemical hypoglycemic drugs are not additionally added to the finished product, and the finished product conforms to human body metabolic motility.

The application discloses application of a rehmannia glutinosa extract in preparation of drugs for treating kidney injury caused by cisplatin. The application of the rehmannia glutinosa extract in preparation of drugs for preventing and / or treating kidney injury caused by cisplatin; a preparation method of the rehmannia glutinosa extract, comprising the following steps: S1, adding water to the rehmannia glutinosa to perform extraction, to obtain a rehmannia glutinosa water extract; S2, adding ethyl acetate to the rehmannia glutinosa water extract to perform extraction, separating ethyl acetate phase and water phase, to obtain the rehmannia glutinosa extract. The application constructs an animal model by inducing mouse kidney injury by cisplatin, and it is found that the rehmannia glutinosa extract obtained by further separating the rehmannia glutinosa water extract by using solvents such as ethyl acetate and ethanol can improve acute kidney injury caused by cisplatin, and the effect is better than that of the rehmannia glutinosa water extract.

The invention discloses a composition for regulating female endocrine and a preparation method thereof. Belongs to the technical field of biological medicine. The invention aims to solve the defects of female endocrine dyscrasia in the prior art, including unstable curative effect, slow effect, inconvenience in taking and the like, through the synergistic effect of specific components and an optimized preparation process. According to the composition, a prepared rehmannia root extract, a coptis chinensis extract, a white peony root extract, a scutellaria baicalensis extract, donkey-hide gelatin and poria cocos are taken as main active ingredients, oryzanol, vitamin B6 and 7-methylisonorethindrone are taken as auxiliary ingredients, and comprehensive regulation on female endocrine systems with climacteric and menopausal syndromes is realized through a scientific proportion and a unique preparation process. The components in the traditional Chinese medicine composition have a synergistic effect and comprehensively and accurately regulate endocrine, the core traditional Chinese medicine extracts are complementary, the endocrine dyscrasia mechanism is improved in a targeted manner, and the curative effect stability is guaranteed through scientific proportioning; the extraction process is optimized, and the utilization rate and activity of effective components are improved; the product form and the taking mode are optimized, the user compliance is improved, the multi-scene requirement is met, and the industrial pain point is solved.

The invention relates to the technical field of requirements, and particularly discloses radix puerariae four-material soap for improving blood deficiency and wind dryness type skin diseases and a preparation method thereof.The radix puerariae four-material soap is prepared from, by weight, 12-18 parts of radix puerariae, 9-15 parts of wine-processed radix angelicae sinensis, 6-12 parts of wine-processed rhizoma chuanxiong, 12-18 parts of radix rehmanniae praeparata and 9-15 parts of bran-processed radix paeoniae alba. And 0.5-10 parts of a synergistic carrier material containing at least one of a hempleaf negundo chastetree leaf and fructus viticis co-extract, microencapsulated volatile oil or a nano-liposome coated active component. According to the invention, a synergistic carrier material is introduced and is combined with a classical blood-nourishing dryness-moistening radix puerariae four-material basic formula, and a modern preparation technology is used for processing, so that the stability and bioavailability of active ingredients in the product are improved, and particularly, good protection and targeted delivery effects are achieved on volatile and degradable effective ingredients; meanwhile, due to the application of a modern extraction and forming process, the effects of the traditional Chinese medicines can be integrated into a stable and uniform soaping agent matrix more efficiently and controllably.

The invention discloses a novel method for extracting and concentrating efficient components of a kidney-tonifying Juanbi pill, which comprises the following steps: pretreating medicinal materials: taking prescription medicinal materials of the kidney-tonifying Juanbi pill; the traditional Chinese medicine composition is prepared from rhizoma drynariae, prepared rehmannia root, Chinese angelica, paniculate swallowwort root, ground beetle, stiff silkworm (stir-fried with bran), centipede, scorpio, honeycomb (stir-fried with clear water), lumbricus (processed with wine), zaocys dhumnade (processed with wine), corydalis tuber, pyrola, epimedium, berba aristolochiae mollissimae, geranium wilfordii, caulis spatholobi, scandent hop, radix rehmanniae recen and polygonum cuspidatum. Through targeted medicinal material pretreatment and ultrasonic-assisted extraction, the problems of slow dissolution of plant medicinal effective components and difficult extraction of animal medicinal cuticle of the kidney-tonifying Juanbi pill are effectively solved, and the extraction rate of the medicinal effective components stably reaches 60% or above. Effective components of medicinal materials such as polygonum cuspidatum, caulis spatholobi, berba aristolochiae mollissimae, geranium wilfordii and rehmannia in the prescription can be fully dissolved out, and waste of raw materials is avoided.

The invention provides a traditional Chinese medicine composition for diabetes and application, and relates to the technical field of traditional Chinese medicine pharmacy, the traditional Chinese medicine composition is composed of twelve traditional Chinese medicines of prepared rehmannia root, pulp of dogwood fruit, Chinese yam, rhizoma alismatis, poria cocos, cortex moutan, wolfberry fruit, semen cuscutae, rhizoma polygonati, radix polygonati officinalis, radices trichosanthis and mantis egg-case. Animal experiments show that the traditional Chinese medicine composition disclosed by the invention can be used for remarkably improving the weight loss trend of diabetic mice and improving the glucose metabolism disorder state by reducing fasting blood-glucose and 2h glucose tolerance; in addition, the traditional Chinese medicine composition can increase TP and GLB contents in serum of mice, reduce ALT and AST activity, effectively repair anabolism functions of livers of diabetic mice and inhibit inflammation and necrosis of hepatocytes, and a safe and efficient treatment scheme is provided for diabetes.

The invention discloses a traditional Chinese medicine composition for treating perimenopausal dry eyes and a preparation method and application thereof, and relates to the technical field of traditional Chinese medicine formulas. The traditional Chinese medicine composition for treating the perimenopausal dry eye comprises herba epimedii, prepared rehmannia root, rhizoma anemarrhenae, cortex phellodendri, radix paeoniae alba, angelica sinensis, radix bupleuri, poria cocos and honey-fried licorice root. The traditional Chinese medicine composition for treating perimenopausal dry eye, namely the kidney-warming dry eye formula, has the functions of warming kidney, nourishing yin, soothing liver and strengthening spleen, can effectively improve perimenopausal symptoms such as dry eye, photophobia, asthenopia, foreign body sensation, burning sensation, soreness and weakness of waist and knees, dysphoria, irritability, hot sweating, insomnia, amnesia and the like of patients with perimenopausal dry eye, improves the estrogen level, and has the efficacy of treating perimenopausal dry eye. The ocular surface inflammatory response is inhibited, and the tear film stability is improved.

The invention provides a traditional Chinese medicine composition for preventing hair loss and promoting hair growth and application thereof, and relates to the technical field of hair loss prevention and promoting hair growth, the traditional Chinese medicine composition is composed of Chinese doughnut, cockscomb, albizia flower, Chinese honey locust, schizonepeta, lithospermum, polygonum multiflorum, prepared rehmannia root, notopterygium root, radix angelicae pubescentis, ruddle and periostracum cicada; in-vitro experiments show that the traditional Chinese medicine composition can promote proliferation of human dermal papilla cells HDPC, relieve the damage degree of HDPC and induce cycle transformation of hair follicles, so that the effect of promoting hair growth is achieved; animal experiments show that the traditional Chinese medicine composition can significantly increase the number of hair follicles and the thickness of skin and dermis fat of mice, reduce the levels of mouse serum IL-2, TNF-alpha and TGF-beta1 and reduce the levels of testosterone, dihydrotestosterone and estradiol in mouse skin tissue, so that hair follicle fibrosis is inhibited, the growth period of hair follicles is accelerated, the growth period is prolonged, the hair loss phenomenon is improved, and the hair loss rate is increased. The hair growth is promoted.

Use of Huolingshengji Keli granules in the preparation of a pharmaceutical composition for treating amyotrophic lateral sclerosis (ALS). The traditional Chinese medicine composition comprises: 60-130 parts by weight of Epimedii folium, 60-150 parts by weight of raw Rehmanniae radix, 60-100 parts by weight of alcohol-processed Cornus officinalis, 90-150 parts by weight of Astragali radix, 40-110 parts by weight of Atractylodis macrocephalae rhizoma stir-fried with bran, and 30-90 parts by weight of Poria. The amyotrophic lateral sclerosis is non-familial amyotrophic lateral sclerosis.

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for replenishing qi, enriching blood, tonifying spleen and nourishing kidney as well as a preparation method and application thereof. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 2 to 12 parts of radix angelicae sinensis, 5 to 20 parts of radix codonopsis, 5 to 20 parts of radix astragali seu hedysari, 2 to 12 parts of rhizoma atractylodis macrocephalae, 2 to 15 parts of poria cocos, 3 to 13 parts of colla corii asini, 3 to 13 parts of tortoise-shell glue, 2 to 12 parts of herba cistanche, 5 to 15 parts of radix rehmanniae praeparata, 3 to 15 parts of rhizoma polygonati, 3 to 13 parts of herba epimedii, 2 to 12 parts of fructus crataegi, 5 to 15 parts of arillus longan, 2 to 12 parts of fructus ligustri lucidi, 2 to 6 parts of fructus schisandrae chinensis and 1 to 5 parts of cortex cinnamomi. The traditional Chinese medicine composition has the main effects of replenishing qi, enriching blood, tonifying spleen and nourishing kidney, is used for rehabilitation after cancer surgery or chemotherapy and used for resisting cancer relapse, is particularly used for patients with spleen and kidney deficiency type cachexia after cancer surgery or chemotherapy, and improves the problems of emaciation, insomnia, inappetence, mental fatigue and tiredness and the like of the patients with the patients with the spleen and kidney deficiency type cachexia after cancer surgery or chemotherapy.

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a compound cypress-astragalus pill and application thereof. The compound cypress and radix astragali pill is prepared from the following components in parts by mass: 10 to 25 parts of cortex phellodendri, 40 to 80 parts of radix hedysari, 20 to 40 parts of radix rehmanniae and 10 to 30 parts of folium crataegi. The compound cypress-stilbene pill takes radix hedysari as a monarch drug to tonify qi, promote urination, nourish yin and promote salivation, the radix rehmanniae is matched to clear heat, cool blood, nourish yin and promote salivation, the golden cypress is used to clear heat, dry dampness, purge fire and remove steam, so that the heat-clearing and yin-nourishing effects are more prominent, the hawthorn leaves for regulating qi, activating blood, dispersing blood stasis, dredging collaterals, dissolving turbidity and reducing lipid are used, and the medicines are used in compatibility to achieve the effects of clearing heat, resolving dampness, removing blood stasis and reducing phlegm. The traditional Chinese medicine composition can effectively relieve symptoms of patients with glucolipid metabolism syndromes, and the purpose of treating both symptoms and root causes is achieved.

The invention provides a python oil composition for preventing and treating chap as well as a preparation method and application thereof, and relates to the field of compositions for preventing and treating chap. The boa oil composition comprises the following raw materials in parts by weight: 5-10 parts of boa oil, 3-8 parts of egg oil, 2-4 parts of butyrospermum parkii butter, 0.5-1.5 parts of salicylic acid, 8-12 parts of angelica sinensis, 5-10 parts of radix paeoniae alba, 3-8 parts of prepared rehmannia root, 2-4 parts of rhizoma polygonati, 5-10 parts of radix stemonae, 5-15 parts of folium artemisiae argyi, 2-4 parts of lucid ganoderma, 8-12 parts of rhizoma bletillae, 5-10 parts of tortoise shell, 4-6 parts of beewax and 12-18 parts of dragon's blood. The python oil composition is applied to treatment of chapped skin, the total effective rate and the cure rate are high, safety is good, and the python oil composition can be well applied to prevention and treatment of chapped skin.

The invention relates to the technical field of pharmacy, in particular to application of prepared rehmannia root to preparation of medicine for improving chronic kidney diseases, and effective components of the medicine comprise an active component I and an active component II extracted from the prepared rehmannia root. The PubChem CID number of the active ingredient I is 5280450, the active ingredient I can be specifically combined with JUN protein, and the PDB database number of the JUN protein is 1JUN; the PubChem CID number of the active ingredient II is 24721256, the active ingredient II can be specifically combined with STAT3 protein, and the PDB database number of the STAT3 protein is 6NJS. According to the application disclosed by the invention, the PubChem CID 5280450 and the PubChem CID 24721256 are determined to be core active components of the prepared rehmannia root for intervening the CKD for the first time, and the PubChem CID 5280450 and the PubChem CID 24721256 are proved to respectively and specifically act on two key signal nodes, namely JUN protein and STAT3 protein, so that a clear modern pharmacological material basis and action mechanism explanation are provided for treating the CKD by the prepared rehmannia root.

Disclosed are a compound traditional Chinese medicine composition for treating diabetic nephropathy, a method for preparing same, and use thereof. The compound traditional Chinese medicine composition is prepared from Astragali Radix, Atractylodis Macrocephalae Rhizoma, Corni Fructus, Cinnamomi Cortex, Psoraleae Fructus, Rehmanniae Radix, Eucommiae Cortex, Achyranthis Bidentatae Radix, and Schisandrae Chinensis Fructus. Marsdenia tenacissima Caulis may also be added to the substance of the compound traditional Chinese medicine composition.

The invention relates to the technical field of traditional Chinese medicines, in particular to application of a prepared rehmannia root extract in preparation of a medicine for treating ovarian injury. The inventor finds a single traditional Chinese medicine for treating ovarian injury based on a traditional Chinese medicine compound core medicinal material data mining model. The prepared rehmannia root is taken as a representative core medicinal material screened and output by a model, efficacy verification is carried out in a cyclophosphamide induced ovarian injury mouse model, and the result shows that the prepared rehmannia root can improve E2 and AMH levels, reduce FSH and LH levels, improve orbital cycle disorder and reduce oxidative stress level, so that the prepared rehmannia root can improve the ovarian reserve function of a mouse, and can be used for treating ovarian injury. And a certain improvement effect is achieved on ovarian injury. The invention provides a quantifiable traditional Chinese medicine compound medicinal material screening thought, realizes a closed loop of a method from data mining to efficacy verification, and provides a theoretical basis and an experimental basis for developing novel traditional Chinese medicines for treating ovarian injury.

This invention relates to the field of special medical foods, and particularly to a special medical food formula for colorectal cancer patients, its preparation method, and its application. The raw materials, in parts by weight, include: 20-30 parts Codonopsis pilosula, 20-30 parts Rehmannia glutinosa (processed), 20-30 parts Astragalus membranaceus, 10-20 parts Coix lacryma-jobi (raw), 10-20 parts Atractylodes macrocephala, 10-20 parts Poria cocos, 10-20 parts Angelica sinensis, 10-20 parts Paeonia lactiflora, 10-20 parts Prunus persica, 3-6 jujubes, 3-15 parts Glycyrrhiza uralensis, 6-15 parts phycocyanin, and 6-15 parts citric acid. This formula can have anti-tumor effects, reduce the toxic side effects of chemotherapy, enhance the reticuloendothelial cell system, promote the enhancement of specific and non-specific immune functions in the body, thereby reducing tumor volume and inhibiting tumor proliferation and metastasis. The drug is encapsulated in Dunaliella salina exosomes and targeted modified to ensure accurate delivery to the lesion site, increasing bioavailability and reducing the drawbacks of a small therapeutic window and high toxicity.

The invention relates to the technical field of pharmaceutical preparations, and provides a pharmaceutical composition for preventing and / or treating leucopenia caused by chemotherapy and a preparation method of the pharmaceutical composition. The pharmaceutical composition is prepared from the following raw materials: red ginseng, prepared rehmannia root, morinda officinalis, pericarpium citri reticulatae, semen cuscutae, rhizoma atractylodis macrocephalae, Chinese yam, astragalus membranaceus, poria cocos, radix achyranthis bidentatae, cistanche, cinnamon, angelica sinensis, fructus lycii, cornu cervi pantotrichum, fennel, radix paeoniae alba and liquorice. The pharmaceutical composition provided by the invention realizes prevention and / or treatment of leucopenia caused by chemotherapy, specifically, the pharmaceutical composition is combined with the chemotherapeutic drug 5-fluorouracil for use, and is applied before, during or after chemotherapeutic drug administration, and the leucocyte level of a subject is increased by promoting lymphocyte and / or monocyte proliferation.

The invention belongs to the technical field of traditional Chinese medicine preparations, and particularly relates to a traditional Chinese medicine decoction for inhibiting invasion and metastasis of cervical cancer and a preparation method thereof.The traditional Chinese medicine decoction is prepared from, by weight, 20-30 parts of radix rehmanniae praeparata, 15-30 parts of radix astragali, 10-20 parts of rhizoma curcumae longae, 10-15 parts of deer-horn glue, 3-6 parts of ginger charcoal, 3-6 parts of licorice roots, 6-10 parts of mixed medicine residues and 40-80 parts of volatile oil inclusion liquid. Volatile oil of cortex cinnamomi, semen brassicae and herba ephedrae is prepared into an inclusion compound through cyclodextrin, the stability and bioavailability of a liquid preparation are improved, turmeric and astragalus membranaceus are introduced on the basis of a classic prescription Yanghe decoction to form multi-target cooperation, cellulase and pectinase are adopted for enzymolysis auxiliary extraction, the dissolution rate of effective components is increased, and the bioavailability of the liquid preparation is improved. The prepared traditional Chinese medicine decoction can effectively inhibit proliferation, migration and invasion of cervical cancer cells under the hypoxic condition, and the action mechanism of the traditional Chinese medicine decoction is closely related to down-regulation of an HIF-1alpha / CXCL6 signal axis.

A method for establishing fingerprint of traditional Chinese medicine compound or its preparation with improving cognition is disclosed. By weight, the traditional Chinese medicine compound is made from following raw materials: 1-20 parts of Gastrodiae Rhizoma, 1-15 parts of Polygala tenuifolia, 1-30 parts of Acorus tatarinowii, 0.1-10 parts of Cistanche deserticola Ma, 0.1-10 parts of Rehmanniae Radix Praeparata, and 0.01-1 parts of curcumin. A chromatogram of a test sample solution is established by high performance liquid chromatography. Chromatographic conditions are as follows: a chromatographic column is octadecyl silane bonded silica gel chromatographic column. A column temperature is 25˜35 ° C. A flow rate is 0.9˜ 1.1 ml / min. Detection wavelengths are 210˜230 nm and 310˜330 nm respectively. A mobile phase A is acetonitrile and a mobile phase B is water. And gradient elution is carried out.

The invention relates to the technical field of functional healthy foods, in particular to an anti-aging functional healthy food. The functional healthy food provided by the invention comprises grape seeds, codonopsis pilosula or ginseng, astragalus membranaceus, folium cortex eucommiae or eucommia ulmoides, prepared rehmannia root, medlar, sea-buckthorn and mulberry. The raw materials are mainly selected from health-care food raw materials, medicinal and edible food materials and part of common nutritional food materials which are all natural plant raw materials. The applicant finally determines the raw materials and proper component proportion and processing technology of the food through research on the characteristics of the raw materials, screening and blending of various food raw materials and verification of in-vivo experiments, so that the antioxidant level of a human body can be effectively improved, the cognitive ability is improved, and the food quality is improved. The traditional Chinese medicine composition has the multiple effects of improving the skin collagen content and improving liver lesions (fatty liver) and kidney lesions (kidney fibrosis, kidney tissue inflammatory cell infiltration, renal tubular necrosis and abnormal renal tubular structure) of a body, and the anti-aging purpose is achieved through the multiple effects.

The invention provides a traditional Chinese medicine composition, a traditional Chinese medicine preparation, a preparation method of the traditional Chinese medicine preparation and application of the traditional Chinese medicine preparation in preparation of medicine for preventing and / or treating Alzheimer's disease, and particularly belongs to the technical field of traditional Chinese medicine. The invention provides a traditional Chinese medicine composition for preventing and / or treating Alzheimer's disease, which comprises the following components in parts by weight: 25-35 parts of rhizoma polygonati, 25-35 parts of radix polygonati officinalis, 7-10 parts of semen cassiae and 2-4 parts of ligusticum wallichii, and further comprises any one or more of the following components in parts by weight: 15-25 parts of radix rehmanniae praeparata, 9-10 parts of processed polygala tenuifolia, 8-12 parts of ginseng, 12-18 parts of fossil fragments, 12-18 parts of rhizoma acori graminei and 12-18 parts of vinegar tortoise shells. The brain nourishing soup, the core effective components thereof and the traditional Chinese medicine composition can prevent and / or treat Alzheimer's disease.