Compound amoxicillin breast injectant prescription and preparation method thereof

A breast injection and amoxicillin technology, applied in the compound amoxicillin breast injection formulation and the field of preparation thereof, can solve the problems of uneven mixing of main drugs, delayed curative effect, precipitation of insoluble crystals, etc., and achieve preventive and therapeutic effects Good, enhanced antibacterial efficacy, strong tissue affinity

Active Publication Date: 2015-03-18
RINGPU TIANJIN BIOLOGICAL PHARMA
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  • Abstract
  • Description
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AI Technical Summary

Problems solved by technology

[0007] In the existing patented technology, the lactating breast injection is a traditional Chinese medicine, which acts slowly and has a slow curative effect. The preparation is prone to tannic acid precipitation, and some prescriptions contain water. After a long period of storage, stratification will occur. Disadvantages such as shaking first
This type of dosage form does not mix the main ingredients evenly, which can easily lead to excessive local drug dosage, or the content of the drug decreases due to demulsification, and there are many problems such as the precipitation of insoluble crystals after the temperature is lowered.
[0008] The dosage form of "a dry dairy cow udder perfusion agent for preventing and treating dairy cow mastitis and its preparation method (CN1286463C; publication date: September 14, 2005)" is a

Method used

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  • Compound amoxicillin breast injectant prescription and preparation method thereof
  • Compound amoxicillin breast injectant prescription and preparation method thereof
  • Compound amoxicillin breast injectant prescription and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 6

[0039] Embodiment 6: curative effect test

[0040] 1 material

[0041] Blank control group: normal saline

[0042] Drug control group: suspension of amoxicillin, colistin sulfate and prednisolone, self-made according to patent 101953784A, main drug content: amoxicillin 20%, colistin sulfate 2%, prednisolone 0.04% .

Embodiment 2

[0043] Example 2 Sample group: (Example 2) Lactating udder injection of amoxicillin, potassium clavulanate and prednisolone.

[0044] 2 methods

[0045] Dairy cows in the lactation period in the dairy farms in the northeastern part of North China were selected and diagnosed with clinical mastitis and recessive mastitis by clinical diagnosis and CMT examination. Among them, there were 188 clinical disease animals and 482 recessive disease animals.

[0046] 2.1 Diagnostic criteria for clinical mastitis:

[0047] Udder fever, pain, swelling, abnormal milk, flakes, clots, or water samples in the milk, high body temperature, depression, loss of appetite and other systemic symptoms.

[0048] 2.2 Diagnostic criteria for occult mastitis: The detection of occult mastitis is operated and judged according to the CMT method (California Mastitis Test). The judgment criteria are shown in Table 1.

[0049] Table 1 CMT Response Judgment Criteria

[0050]

[0051]2.3 Grouping and Process...

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Abstract

The invention relates to a compound amoxicillin breast injectant prescription and a preparation method thereof. The compound amoxicillin breast injectant prescription comprises a suspending aid, an antioxidant and a solid dispersion carrier which are prepared through a special process to obtain white to off-white oily suspension. The compound amoxicillin breast injectant prescription disclosed by the invention has the advantages of simple preparation process, stable content, easy injection and the like. The composition disclosed by the invention is compounded from amoxicillin, clavulanate potassium and prednisolone; compared with other amoxicillin patent preparations, the composition has drug-tolerant bacteria for penicillins, and also has a high inhibition effect on the chromosome exzymes generated by klebsiella peneumoniae, bacillus proteus vulgaris and bacteroides fragilis; prednisolone has anti-inflammatory and antiallergic functions, and has a synergistic effect on bacterial infection and allergic inflammation.

Description

technical field [0001] The invention belongs to the field of veterinary drug preparations, in particular to a compound amoxicillin breast injection formulation and a preparation method thereof. Background technique [0002] Cow mastitis is one of the diseases that cause the most serious losses in the dairy industry worldwide. In the United States alone, the annual loss caused by cow mastitis reaches 200 million U.S. dollars, which seriously restricts the development of the dairy industry. Between 30% and 70% of cows in the United States have at least one udder infected. The incidence of mastitis in dairy cows in my country is higher. According to the survey results of Yuan Yonglong and others, the average incidence rate of clinical mastitis is 33.41%, the average positive rate of recessive mastitis is 73.91%, and the prevalence rate of milk chamber is 44.74%. Therefore, mastitis causes huge losses such as increased treatment costs, decreased milk production, and premature c...

Claims

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Application Information

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IPC IPC(8): A61K31/573A61P15/14A61P29/00A61P31/04A61K31/43A61K31/424
Inventor 李梁聂丽娜孙俊
Owner RINGPU TIANJIN BIOLOGICAL PHARMA
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