97 results about "Drug resource" patented technology

The invention provides an amoxicillin / clavulanate (8:1) tablet and a preparation method thereof. The amoxicillin / clavulanate (8:1) tablet has the advantages of simple preparation process, good quality controllability and stability and low forming-production cost by adopting the mixed amoxicillin / clavulanate (8:1) intermediate materials having good quality controllability and stability as the main drug resource.

The invention discloses a method for planting fungi hexagona apiaria (CCTCC NO.M208121) sporocarp for a rare drug. The method comprises the following steps: the cultivation of a separated and purified hexagona apiaria seed, the cultivation of hypha in a fungus sack, the cultivation of the hexagona apiaria sporocarp and the harvest of the hexagona apiaria sporocarp. The planting of the hexagona apiaria sporocarp through a sack material needs about 2 to 3 months from the production of a strain, inoculation, fungus cultivation, fruiting cultivation to the harvest of the sporocarp; the method has short production period and rapid effect, realizes large-scale cultivation of the hexagona apiaria sporocarp, fundamentally solves the problem of insufficient wild resources, provides abundant drug resources for further research of the active components, the pharmacological action, a pharmaceutical mechanism and a toxicity test of the hexagona apiaria sporocarp, and lays a foundation for better developing and utilizing the hexagona apiaria.

A powdered drug for treating pressure sore through external application belongs to an external western medicine preparation, which mainly solves the problem of pressure sore treatment. Raw materials for preparing effective components of the powdered drug comprise the following weight parts: 1-10 parts of sulfamethoxazole compound, 1-10 parts of metronidazole, 5-50 parts of Vitamin C, 5-50 parts of vitamin B complex, 5-50 parts of nicotinic acid, 3-15 parts of egg shell inner membrane dried by excipients. When in use, a mackintosh, a plurality of sterilized dressings and a sterilized dressing bag are padded under the part with pressure sore; the sore surface is repeatedly washed from top to bottom with 0.9 percent physiological saline extracted with a disposable sterilized syringe until the wound is clean and then is washed from top to bottom for twice to three times with 0.1 percent chlorhexidine solution; when blisters are formed, a disposable sterilized syringe is used for drawing out the liquid in the blisters; when necrotic tissues are formed, the necrotic tissues are eliminated with sterile forceps and sterile shears, then repeated washing from top to bottom with 0.1 percent chlorhexidine solution is carried out until the sore surface is clean, and then the prepared powdered drug is evenly sprinkled on the sore surface by a sterilized cotton bud; the thickness of the powdered drug is about 1mm; finally the sore surface is covered with sterilized petroleum jelly gauze and bandaged with sterilized dressing; the drug is changed once a day to prevent local compression. When new granulation tissue outgrows, the sore surface is scattered with drug powder without dressing, and the drug powder self drops off after scab is formed until the sore is healed. The powdered drug has simple and convenient preparation method, abundant drug resources, low cost, convenient and simple clinical application and remarkable effect, which is deeply welcomed by broad patients.

The invention discloses a drug which cures psoriasis and is produced by the raw materials of swamp mahogany, radix paeoniae lactiflorae, tasselblower, daphne genkwa, breynia fruticosa, erigeren candensis, eurya chinensis, garter snake, radix-polygoni multiflori, ledeboruiella root, lightyellow sophora root and Chinese atractylodes herb medicine. The drug of the invention has the advantages that: the drug has no poisonous and side effect, no stimulating effect and hypersusceptibility reaction; the function is quick; the recrudescence does not easily occur; the curing charge is low, the drug resource is wide with cheap price; the effective rate of the drug of the invention curing psoriasis is 90 percent and the curing rate is 85 percent.

The invention discloses an antifungal pharmaceutical composition consisting of a periplaneta americana extract and an antifungal drug. The pharmaceutical composition has the antifungal effect obviously superior to that of single use of periplaneta americana and fluconazole, and has better application prospects. The antifungal pharmaceutical composition provides a new thought for development and utilization of medicinal resources of the periplaneta americana, provides a new candidate drug and therapeutic scheme for clinical treatment of vulva vaginal candidiasis, and is expected to relieve painof vast female patients. The antifungal pharmaceutical composition has great significance in reasonably and sustainably developing and utilizing the natural drug resource of periplaneta americana.

The invention provides a method of exploring a new indication of a drug. The method comprises the steps of searching, based on a drug name, drug-related molecules (genes or proteins) in a database; building an interaction network of the drug-related molecules (genes or proteins) or the drug-related molecules (genes or proteins) and first-order neighbors thereof; performing module identification on the interaction network, building a weighted or unweighted module interaction network, and performing key module identification so as to analyze functions, or directly performing function analysis of the drug-related molecules (genes or proteins) on the interaction network; and comparing a function analysis result with a known indication in a specification of the drug so as to obtain the new indication of the drug. The method uses a network pharmacology method and starts with characteristics of multiple targets and multiple paths of the drug go explore the new indication of the drug in multiple aspects such as drug-related molecules, modules and network. Compared with research of a brand-new drug, the method saves much manpower, financial and time costs, lowers the research risks, and uses existing drug resources more reasonably.

The invention discloses the application of starfishes to the preparation of a medicament for treating osteoporosis. The application of the starfishes is realized by steaming, drying, cooling and crushing Chinese medical starfish herbs, such as asterias rollestoni and asterias amurensis from asteriidae animals or Dow sun starfish from solasteridae animals, preparing and orally administrating. Proved by research, the starfishes have the functions of stimulating the growth of sclerotomal cells, promoting the pigmentation, enhancing the bone density, and the like and have remarkable effect of treating the osteoporosis. The medicament for treating osteoporosis, which is prepared by the technical scheme, has the advantages of good treatment, high effect taking, high curative effect without any side effect, and the like during clinical applications and has sufficient drug resources, simple preparation method and low cost.

The invention which belongs to the technical field of medicine relates to a new use of Esculentoside A in preparing drugs for controlling hepatic fibrosis or cirrhosis. Pharmacological experiments show that: Esculentoside A allows the generation of collagen in hepatic tissues to be substantially inhibited, the fibrosis degree to be reduced and the control effect on hepatic fibrosis and cirrhosis to be fine, so Esculentoside A can be used to prepare the drugs for controlling hepatic fibrosis or cirrhosis. The invention provides a new drug resource for controlling hepatic fibrosis or cirrhosis.

The invention discloses a method for preparing mixed amoxicillin / clavulanate materials and rapidly measuring the uniformity thereof. The purpose of uniformly mixing the amoxicillin / clavulanate materials can be achieved without forming amoxicillin / clavulanate and amoxicillin powder into granules respectively at first or adding diluting agents, such as microcrystalline cellulose and the like. The invention can provide the amoxicillin / clavulanate preparation with the main drug resource with high concentration ratio of amoxicillin / clavulanate and good quality controllability and mixing uniformity, and has the advantages of simple preparation process, good quality controllability and stability and low forming-production cost; meanwhile, the invention further provides a method for rapidly measuring the uniformity of the mixed amoxicillin / clavulanate materials, and the method, which is characterized in that the purpose of indirectly measuring the uniformity thereof can be achieved by directly measuring the water content of the mixed materials, has the advantages of high precision and repeatability.

The invention relates to a medicine for treating lumbar disc herniation, especially to a traditional Chinese medicine which is prepared from plant Chinese herbal medicines used as raw materials and is used for treating lumbar disc herniation. The traditional Chinese medicine is characterized in that Chinese herbal medicine ingredients comprise 13-19 g of Chinese angelica, 13-19 g of achyranthes root, 13-19 g of cornus officinalis, 5-15 g of poria cocos, 5-15 g of dipsacus asperoids, 5-15 g of eucommia, 13-19 g of white peony root, 6-13 g of cistanche, 3-9 g of green tangerine peel and 3-9 g of cortex acanthopanacis. Each ingredient of the traditional Chinese medicine is a natural Chinese herbal raw medicinal material. The traditional Chinese medicine has advantages of simple configuration, wide drug resource and low cost. With the efficacy of synergistic effects, the traditional Chinese medicine has effects of enriching the blood, nourishing yin, reinforcing essence and marrow, nourishing liver and kidney, managing disorder of blood system, invigorating the circulation of blood, stimulating the menstrual flow, dispersing blood stasis, strengthening the bones and muscles, dispelling wind to relieve exogenous syndrome, removing dampness to kill pain, diminishing swelling, settling pain and the like, and has a remarkable effect of treating lumbar disc herniation caused by qi-stagnancy and blood stasis, deficiency of qi and blood, liver-kidney deficiency, exogenous pathogenic factors, cold-damp arthralgia and the like.

The invention relates to a target protein for resisting cataract and the application thereof. The change rule of a crystallin beta B2 with special expression and special distribution along with the body aging process is discovered according to the phase change of the crystallin, and the crystallin is determined as the more appropriate target protein for resisting cataract. Also discovered is that dithiothreitol is the substance capable of effectively inhibiting denaturation by heat of crystallins such as beta B2. Accordingly, corresponding anti-cataract products can be prepared by selecting the target protein as the target point and using dithiothreitol and composition thereof as the raw materials. Cataract disease is an important pathogenic reason influencing the quality of life of Chinese people. The beta B2 is determined as the target protein with wide application, and provides the direction for the development of new drugs. The developed product is mainly used for prevention, and is used externally in combination. A novel drug resource is provided, and is the effective product for preventing, diagnosing and treating denaturation of crystallin or cataract and other related diseases, thereby generating remarkable social and economic benefits.