Beta- lactamase suppressing antibacterial compound drugs

A lactamase and drug technology, applied in the direction of antibacterial drugs, pharmaceutical formulations, medical preparations containing active ingredients, etc., can solve the problems of decreased curative effect of ceftizoxime and cefodizime, and improve phagocytic activity and bactericidal rate Effect

Inactive Publication Date: 2005-01-19
张哲峰
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The present invention aims at the problem that the curative effect of ceftizoxime and cefodizime is reduced due to drug-resistant bacteria producing β-lactamase, and provides an antibacterial combination drug for inhi

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] Embodiment 1: Under aseptic and clean conditions, 10 kilograms of ceftizoxime sodium (calculated as ceftizoxime) and 1 kilogram of clavulanic acid potassium (calculated as active acid) were mixed, and the powder injection preparation process was operated to prepare this product. Invented 10,000 powder injections.

Embodiment 2

[0044] Embodiment 2: Under aseptic and clean conditions, 10 kilograms of ceftizoxime sodium (calculated as ceftizoxime) and 20 kilograms of clavulanic acid potassium (calculated as active acid) were mixed, and the powder injection preparation process was operated to prepare this product. Invented 10,000 powder injections.

Embodiment 3

[0045] Embodiment 3: under aseptic and clean conditions, 10 kilograms of ceftizoxime sodium (calculated as ceftizoxime) and 2 kilograms of potassium clavulanate (calculated as active acid) were mixed, and the preparation process was performed according to the freeze-dried powder injection. Prepare 10000 powder injections of the present invention.

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PUM

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Abstract

The invention discloses a beta- lactamase suppressing antibacterial compound drugs, which comprises ceftizoxime, or cefodizime and beta-lactam enzyme inhibitor by the active acid weight ratio of 1-10:10-1, which are in the forms of alkali metal salts or free acid and assisting solvents, the beta-lactam enzyme inhibitor can be Tazobactam, or clavulanic acid, or tapazole or their derivatives.

Description

technical field [0001] The present invention relates to a kind of antibiotic compound drug that inhibits the β-lactamase produced by bacteria, specifically a kind of β-lactamase inhibitor and the third generation cephalosporin antibiotic—Ceftizoxime (Ceftizoxime) or cefodizime ( Cefodizime) is a compound preparation composed of compatibility. Background technique [0002] Cephalosporin antibiotics have been widely used clinically, and have achieved therapeutic effects that are difficult to achieve with traditional antibiotics. However, due to the long-term and extensive clinical use of antibiotics, and even the abuse of antibiotics, bacteria have become increasingly resistant to antibiotics. For example, penicillin in β-lactams was particularly effective when used 200,000 units each time in clinical practice in the 1950s, but now it is difficult to achieve results when 800,000 units are used each time. Cephalosporins, which belong to the same β-lactam c...

Claims

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Application Information

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IPC IPC(8): A61K31/546A61P31/04
Inventor 张哲峰
Owner 张哲峰
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