The invention discloses a ceftizoxime sodium compound crystal form. By adopting X-ray powder diffraction determination, the crystal form has the following main characteristic peaks expressed by the diffraction angles of 2 theta +/- 0.2 DEG in a spectrogram: 4.7 DEG, 6.3 DEG, 6.7 DEG, 8.8 DEG, 9.4 DEG, 9.7 DEG, 12.1 DEG, 12.5 DEG, 13.7 DEG, 14.1 DEG, 14.6 DEG, 16.4 DEG, 17.0 DEG, 17.7 DEG, 18.0 DEG, 18.5 DEG, 18.9 DEG, 19.8 DEG, 20.1 DEG, and 21.2 DEG. The invention also discloses a preparation method and a pharmaceutical preparation of the crystal form. Through in-depth study of ceftizoxime sodium, the new ceftizoxime sodium crystal form is obtained after recrystallization, the compound crystal form is obviously of a small granular shape, has uniform particle size distribution and good fluidity, and has the hygroscopicity decreased; and during the production process, no smashing is required, no static electricity is generated, and the stability of the product installed capacity is improved.