59 results about "Ceftizoxime Sodium" patented technology

The invention provides a method for preparing high purity ceftizoxime or a ceftizoxime salt, a method for preparing a powder-injection of ceftizoxime or the ceftizoxime salt, and high purity ceftizoxime or ceftizoxime salt and corresponding powder-injections prepared according the methods.

The invention relates to a ceftizoxime sodium drug injection powder and a preparation method thereof, as well as a synthetic method of bulk drug ceftizoxime sodium. The ceftizoxime sodium drug injection powder consists of 100% ceftizoxime sodium, wherein the ceftizoxime sodium is pretreated, and the pretreatment is aseptic refining and/or grinding. The ceftizoxime sodium drug has the advantages of high purity, almost no impurity, better and more stable quality, better clarity and the like; and the synthetic method of bulk drug ceftizoxime sodium has lower bulk cost, less synthesis technology difficulty, mild reaction condition, stable and reliable yield and quality, and high purity and yield of products.

The invention relates to a preparation method of ceftizoxime sodium. The method comprises the following steps: based on 7-acetamido-3-hydroxy-3-cephalosporin-4-formic acid-diphenyl methyl ester (II) sas a starting material, carrying out reduction, sulfoacid esterification, de-exterification sulfonation and 4-site and 7-site protective groups removal so as to obtain an important intermediate, namely, 7-amino-3-free-3-cephalosporin-4-formic acid (VI, 7-ANCA); reacting 7-amino-3-free-3-cephalosporin-4-formic acid (VI, 7-ANCA) with an active ester so as to obtain ceftizoxime acid (VIII); and generating the product, namely, ceftizoxime sodium (I), from the ceftizoxime acid (VIII) in the presence of a salt forming agent. The method for preparing ceftizoxime sodium is simple in operation, low in cost and suitable for industrial production, and the total yield can reach 52.9%. The product is white or light yellow, and rectification is not needed, thereby ensuring the quality and yield of the product.

The invention provides a cefuroxime sodium compound and a new preparation method thereof. The method comprises the following steps: performing acid-base reaction, absorbing with activated carbon, and separating and purifying with a chromatographic column. By adopting the method, the purity and content of cefuroxime sodium can be greatly increased, the product quality of the preparation can be increased, the toxic or side effects can be reduced and the safety of the preparations of the medicines for curing respiratory tract infection and urinary tract infection can be ensured; and compared with the prior art, the method has the advantages of simple and practical technology, mild reaction conditions, low cost, high yield and high product purity and is suitable for industrial production.

The invention relates to a ceftizoxime sodium crystalline hydrate and a preparation method and application thereof. The ceftizoxime sodium crystalline hydrate has high storage stability, and is suitable for preparing medicaments for treating or preventing diseases such as infection of respiratory systems, liver and biliary systems, five sense organs and urinary tracts of human bodes or animals, infection of abdominal cavity, infection of pelvic cavity, ichorrhemia, infection of skin tissues, and infection of bones and joint caused by gram positive or negative bacteria, meningitis caused by streptococcus pneumonia or haemophilus influenza, and simple gonorrhea.

The invention relates to a ceftizoxime sosium compound of a new way. Ceftizoxime sosium is prepared by firstly reacting a cefotaxime acid with a methanoic acid to generate 2-(2-formyl aminothiazole-4-radical)-2-methoxyl imine acetic acid, then adding 7-amino-3-nor-3-cephem-4-carboxylic acid, taking triphenylphosphine oxide and triphosgene as catalysts, stirring and reacting, and regulating an acid-base pH value.

The invention relates to a pharmaceutical composition of injection ceftizoxime sodium and compound amino acid injection and in particular relates to combined application package. The pharmaceutical composition includes injection ceftizoxime sodium and compound amino acid injection. During a using process, the injeciton ceftizoxime sodium is dropped to the compound amino acid injection for intravenous infusion of 30 minutes to 2 hours. For the compatibility mixing of the injection ceftizoxime sodium and the compound amino acid injection, the combined application package disclosed by the invention is used for simplifying the steps and improving the safety. Moreover, the stability of the ceftizoxime sodium is greatly facilitated, and the clinical application quality and the bioavailability of the medicine are improved.

The invention discloses a Convenia synthetic method and a Convenia sodium salt synthetic method. A ceftizoxime sodium midbody is taken as the raw material and is subjected to bromination, electrophilic addition, nucleophilic substitution, deprotection, amidation and the like to obtain Convenia and Convenia sodium salt. According to the Convenia synthetic method, synthetic routes and steps are simplified through technology improvement and reaction condition improvement, and cost is saved. The Convenia synthetic method and the Convenia sodium salt synthetic method are easy to operate, mild in reaction condition, low in requirement for production equipment, and capable of creating sound conditions for industrialization. It shows through analysis and detection that a prepared product is high in quality and can meet the requirements of industrial and agricultural production.

The invention discloses a ceftizoxime sodium compound crystal form. By adopting X-ray powder diffraction determination, the crystal form has the following main characteristic peaks expressed by the diffraction angles of 2 theta +/- 0.2 DEG in a spectrogram: 4.7 DEG, 6.3 DEG, 6.7 DEG, 8.8 DEG, 9.4 DEG, 9.7 DEG, 12.1 DEG, 12.5 DEG, 13.7 DEG, 14.1 DEG, 14.6 DEG, 16.4 DEG, 17.0 DEG, 17.7 DEG, 18.0 DEG, 18.5 DEG, 18.9 DEG, 19.8 DEG, 20.1 DEG, and 21.2 DEG. The invention also discloses a preparation method and a pharmaceutical preparation of the crystal form. Through in-depth study of ceftizoxime sodium, the new ceftizoxime sodium crystal form is obtained after recrystallization, the compound crystal form is obviously of a small granular shape, has uniform particle size distribution and good fluidity, and has the hygroscopicity decreased; and during the production process, no smashing is required, no static electricity is generated, and the stability of the product installed capacity is improved.

The invention relates to ceftizoxime sodium liposome injection and a preparation method therof. The ceftizoxime sodium liposome freezing-drying preparation comprises ceftizoxime sodium, buffer salt system, liposome matrix, freezing-drying excipient and antioxidant. By selecting particular buffer salt system and the liposome matrix, the ceftizoxime sodium liposome injection has good formation and parcel rate as well as good stability.

The invention provides ceftizoxime sodium for injection and a preparation method thereof as well as a synthetic method for ceftizoxime sodium serving as a crude drug. The ceftizoxime sodium for injection has the advantages of moderate grain size range, high purity, low impurity content, high and stable quality, good clarity and the like, so that the sub-packaging efficiency during production is high, the difference of the packaging amount is small, the dissolution speed of drugs in the clinical application is high and the dissolubility is good. The preparation method of the ceftizoxime sodium for injection is simple in process, low in energy consumption, low requirement on equipment and low in cost, is suitable for large-scale industrial production and application and has wide application prospect. The synthetic method for ceftizoxime sodium serving as crude drug is simple in process, low in energy consumption, low requirement on the equipment and low in cost, and is suitable for large-scale industrial production and application.

The invention relates to a preparation method of high purity Ceftizoxime. The method comprises the following steps of: (1) conducting adsorption on Ceftizoxime with a strong-acid ion exchange resin, then carrying out elution, collecting the elution solution, and performing pressure reduced concentration so as to obtain Ceftizoxime acid; (2) performing neutralization with an alkali sodium salt aqueous solution, and implementing filtration to remove insoluble matters to obtain a Ceftizoxime aqueous solution; and (3) adding a proper amount of ethanol into the aqueous solution, controlling the temperature and carrying out recrystallization, thus obtaining high purity Ceftizoxime.

The invention relates to a ceftizoxime sodium preparation and refining method through utilizing ceftizoxime acid. The method comprises the following steps: producing product-ceftizoxime sodium through utilizing the ceftizoxime acid by the action of a salt forming agent; achieving the purposes of refining and purifying through recrystallization; and finally obtaining high purityceftizoxime sodium. According to the invention, the product quality of API is improved, the toxic side effect is reduced, and safety is ensured during preparation of anti-bacterial medicines. Compared with the prior art, the method has the advantages of high product purity, simplicity and convenience in operation, low cost, high yield, reduced toxic side effect, and suitability for industrialized production.

The invention discloses a ceftizoxime sodium novel crystal form capable of reducing anaphylactic reactions, a preparation method and a pharmaceutic preparation of the ceftizoxime sodium novel crystal form. Ceftizoxime sodium is measured through an X-ray powder diffraction method, and feature diffraction peaks are displayed at the 6.8-degree position, the 11.5-degree position, the 14.6-degree position, the 15.8-degree position, the 19.4-degree position, the 20.2-degree position, the 21.8-degree position, the 24.0-degree position, the 27.4-degree position and the 30.5-degree position of an X ray powder diffraction pattern expressed by a 2 theta +/-0.2-degree diffraction angle. The content of ceftizoxime sodium compound impurities is obviously reduced compared with the prior art, and the ceftizoxime sodium novel crystal form has the advantages of being good in stability and fluidity, not prone to absorb moisture, high in dissolution speed, good in clinical effect, low in occurrence rate of adverse reactions and very suitable for clinical application.

The invention discloses a refining method of ceftizoxime sodium. The refining method comprises the following steps: dissolving cefazoxime acid into water, adding concentrated hydrochloric acid to control the pH value after dissolution and clarification, adding sodium bicarbonate, adding an organic solvent, uniformly carrying out stirring, adding activated carbon for decoloration, carrying out filtering, controlling the temperature to be 15-20 DEG C, rapidly carrying out stirring at frequency of 30-40 HZ, adding acetone, carrying out cooling to 0-5 DEG C, controlling the stirring frequency to be 20 HZ, carrying out crystal growing for 1-2 hours, and carrying out drying to obtain a cefazoxime sodium fine product. According to the refining method disclosed by the invention, the purity of theobtained cefazoxime sodium can reach 99.9% or above, the content of total impurities and the content of a maximum single impurity are respectively controlled to be within 0.2% and 0.05%, the quality of the product is remarkably improved, the refining process is simple and convenient to operate, and the method is suitable for industrial production.

The invention discloses a 1/2 water ceftizoxime sodium compound and a preparation method of the 1/2 water ceftizoxime sodium compound, each molar of ceftizoxime sodium contains 1/2 molar of water, theceftizoxime sodium compound is white crystalline powder, and the ceftizoxime sodium compound has a characteristic diffraction peak when the angle 2theta of the corresponding main X-ray characteristicdiffraction peak is 11.43 plus or minus 0.2 degrees, 13.24 plus or minus 0.2 degrees, 16.54 plus or minus 0.2 degrees, 17.85 plus or minus 0.2 degrees, 19.46 plus or minus 0.2 degrees, 20.66 plus orminus 0.2 degrees, 22.33 plus or minus 0.2 degrees, 23.30 plus or minus 0.2 degrees, 23.65 plus or minus 0.2 degrees, 24.60 plus or minus 0.2 degrees. The 1/2 water ceftizoxime sodium compound prepared through the method is excellent stability and meets the requirement of the raw material of a preparation.

The invention discloses a preparation method and a detection method for ceftizoxime sodium. Various factors which influence the quality and yield of the product in the process of producing the ceftizoxime sodium are subjected to experimental analysis and research, and optimal process conditions for producing the ceftizoxime sodium are obtained; and a method which meets the requirement of a national medicine inspection sample and is used for measuring ceftizoxime sodium high polymer is established.

The invention discloses a ceftizoxime sodium ultrafine powder preparation which comprises 99.0-99.9 weight percent of ceftizoxime sodium and 0.10-1.00 weight percent of sodium carbonate, wherein the granularity of the ceftizoxime sodium ultrafine powder preparation is 1.0-3.0mu m. The invention also discloses a method for preparing the ceftizoxime sodium ultrafine powder preparation. The prepared ceftizoxime sodium ultrafine powder preparation is high in purity, the granularity of powder particles can be controlled to be in a range from 1.0 to 3.0mu m by adjusting the preparation conditions, the powder is in micron-scale, uniform in size distribution and high in re-dissolubility, and active ingredients in the medicine are absorbed, so that the curative effect of the medicine is enhanced. The preparation method is mild in reaction conditions, simple in steps and process and easy to regulate, and volume production of the ceftizoxime sodium ultrafine powder preparation can be conveniently realized.

The invention discloses a ceftizoxime sodium liposome composition for injection and a preparation method thereof. The ceftizoxime sodium liposome composition comprises ceftizoxime sodium, phospholipid, cholesterol and citrate buffer solution, wherein the mass ratio of the phospholipid to cholesterol is (1.5-2):1. The ceftizoxime sodium liposome composition provided by the invention has the advantages of good stability, high encapsulation efficiency, low leakage rate, and is suitable for industrial production.