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Pharmaceutical composition of injection ceftizoxime sodium and compound amino acid injection

A technology of ceftizoxime sodium and compound amino acids, which can be used in drug combinations, antibacterial drugs, pharmaceutical formulations, etc., and can solve problems such as slow intravenous injection

Inactive Publication Date: 2013-05-22
海南路易丹尼生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] In addition, the prior art only mentions that ceftizoxime sodium for injection can be dissolved in water for injection, sodium chloride injection, 5% glucose injection in the instructions for use. Slow intravenous injection, can also be added to 10% glucose injection, electrolyte injection or amino acid injection by intravenous infusion for 30 minutes to 2 hours
However, in clinical use, it is necessary to purchase joint applications separately, and there is no combination package of ceftizoxime sodium for injection and compound amino acid injection on the market or in medical institutions.

Method used

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  • Pharmaceutical composition of injection ceftizoxime sodium and compound amino acid injection
  • Pharmaceutical composition of injection ceftizoxime sodium and compound amino acid injection
  • Pharmaceutical composition of injection ceftizoxime sodium and compound amino acid injection

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033]

[0034] Preparation Process:

[0035] (1) Ceftizoxime sodium sterile powder 500g (in C 13 h 13 N 5 o 5 S 2 (calculated) into the subpackaging room (the ambient temperature of the subpackaging post is 18°C-26°C, and the relative humidity is below 65%), debug the subpackaging machine, adjust the number of steps to adjust the loading volume, so that the loading volume reaches the specified range, and then distribute Put it in a low borosilicate glass control injection bottle, press the stopper completely, and crimp the cap.

[0036] (2) Ceftizoxime sodium sterile powder 1000g (in C 13 h 13 N 5 o 5 S 2 (calculated) into the subpackaging room (the ambient temperature of the subpackaging post is 18°C-26°C, and the relative humidity is below 65%), debug the subpackaging machine, adjust the number of steps to adjust the loading volume, so that the loading volume reaches the specified range, and then distribute Put it in a low borosilicate glass control injection ...

Embodiment 2

[0039] Arginine Hydrochloride 289g Alanine 188g

[0040] Histidine Hydrochloride 246g Proline 100g

[0041] Leucine 379g Tyrosine 11g

[0042] Isoleucine 170g Serine 67g

[0043] Lysine HCl 333g Cysteine ​​HCl 44g

[0044] Phenylalanine 283g Aspartic Acid 115g

[0045] Threonine 197g Glutamic Acid 197g

[0046] Valine 136g Sodium Bisulfite 50g

[0047] Methionine 106g Xylitol 5000g

[0048] Tryptophan 039g Add water for injection to 100L

[0049] Glycine 324g

[0050] Preparation Process:

[0051] (1) Take 60L of water for injection and boil it, add 5000g of xylitol to dissolve it, then add 150g of activated carbon and boil for 20 minutes, filter back to decolorize for 20 minutes, then filter into dilute irrigation.

[0052] (2) After filtering the xylitol liquid into the dilution tank, nitrogen gas is introduced immediately, and at the same time, another 40 L of water for injection that has been pretreated with 150 g of activated carbon for 20 minutes of boiling and a...

Embodiment 3

[0058] Combination 2: Ceftizoxime Sodium for Injection 0.5g and Compound Amino Acid Injection 250ml.

[0059] Combination 3: Ceftizoxime Sodium for Injection 1.0g and Compound Amino Acid Injection 250ml.

[0060] Combination 4: Ceftizoxime Sodium for Injection 1.0g and Compound Amino Acid Injection 500ml.

[0061] Combination 5: Ceftizoxime Sodium for Injection 2.0g and Compound Amino Acid Injection 250ml.

[0062] Combination 6: Ceftizoxime Sodium for Injection 2.0g and Compound Amino Acid Injection 500ml.

[0063] Combination 7: 1.0 g of ceftizoxime sodium for injection and 100 ml of compound amino acid injection.

[0064] Combination 8: Ceftizoxime Sodium for Injection 3.0g and Compound Amino Acid Injection 250ml.

[0065] Combination 9: Ceftizoxime Sodium for Injection 3.0g and Compound Amino Acid Injection 500ml.

[0066] Combination 10: Ceftizoxime Sodium for Injection 4.0g and Compound Amino Acid Injection 500ml.

[0067] Example 4 Stability test

[0068] In ord...

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PUM

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Abstract

The invention relates to a pharmaceutical composition of injection ceftizoxime sodium and compound amino acid injection and in particular relates to combined application package. The pharmaceutical composition includes injection ceftizoxime sodium and compound amino acid injection. During a using process, the injeciton ceftizoxime sodium is dropped to the compound amino acid injection for intravenous infusion of 30 minutes to 2 hours. For the compatibility mixing of the injection ceftizoxime sodium and the compound amino acid injection, the combined application package disclosed by the invention is used for simplifying the steps and improving the safety. Moreover, the stability of the ceftizoxime sodium is greatly facilitated, and the clinical application quality and the bioavailability of the medicine are improved.

Description

technical field [0001] The invention relates to a pharmaceutical composition of ceftizoxime sodium for injection and compound amino acid injection, in particular to a combination of ceftizoxime sodium for injection, sterilized injection prepared from 18 kinds of crystalline amino acids and xylitol The application packaging belongs to the technical field of medicine. Background technique [0002] Ceftizoxime sodium is a third-generation cephalosporin with broad-spectrum antibacterial activity and is stable to broad-spectrum β-lactamase produced by most Gram-positive and Gram-negative bacteria. Ceftizoxime sodium has a good antibacterial effect on Haemophilus influenzae and Neisseria gonorrhoeae. [0003] The mechanism of action of ceftizoxime sodium for injection is to achieve bactericidal effect by inhibiting the biosynthesis of bacterial cell wall mucopeptides. It is suitable for lower respiratory tract infection, urinary tract infection, abdominal infection, pelvic infect...

Claims

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Application Information

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IPC IPC(8): A61K31/546A61K31/401A61K31/405A61P31/04A61K31/4172A61K31/198A61P3/02
Inventor 祝云琴
Owner 海南路易丹尼生物科技有限公司
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