39results about How to "Increase savings" patented technology

The invention provides a nano-drug hydrogel composite system for bladder perfusion and application thereof, and provides a new concept for bladder perfusion drugs, i.e., hydrogel is used as a drug loading platform, and a concentration gradient is formed through permeation of urea; therefore, the nano-particles modified with the'motor 'in the hydrogel generate directional movement due to different pushing forces on the two sides. And the disorderly moving nano-particles are limited by external conditions, so that the aim of orderly and directionally moving the nano-particles is fulfilled. In the aspect of treatment, the effective concentration of the perfusion medicine is improved, deep penetration is carried out on the bladder tissue, a feasible scheme is provided for medicine delivery of deep tumor tissue, technical support and a new thought are provided for bladder perfusion treatment, and good application prospects are achieved.

The invention belongs to the technical field of medicines, and discloses a lonidamine-entrapped tumor cell membrane bionic metal organic framework nanoparticle as well as preparation and application thereof. The preparation method comprises the following steps: firstly, preparing lonidamine-entrapped metal organic framework nanoparticles by adopting a one-pot method, then coating tumor cell membranes on the surfaces of the nanoparticles through repeated membrane extrusion or ultrasonic treatment, and finally preparing the lonidamine-entrapped tumor cell membrane bionic nano-drug. The preparation process is simple, the cost is low, the stability is good, and the repeatability is high. The bionic nano-drug disclosed by the invention is helpful for solving the problems of poor solubility, low bioavailability and the like of an anti-cancer drug lonidamine. And meanwhile, the tumor cell membrane camouflage technology can promote the nano-drug to realize relatively high tumor tissue accumulation by utilizing the dual effects of EPR passive targeting effect and homologous active targeting, so that the anti-tumor effect is improved, and the toxic and side effects of lonidamine are reduced.

The rotary double-color mold comprises a plate A, a plate B and a bottom plate, a fixed mold core and a movable mold core which are matched in a mold closing mode are arranged in the plate A and the plate B respectively, square iron is arranged between the plate B and the bottom plate, and two different fixed mold cavities are formed in the fixed mold core; the movable mold core is composed of a positioning mold core arranged on the plate B and two independent inserts vertically fixed to the square iron, the positioning mold core is provided with two first movable mold cavities vertically corresponding to the fixed mold cavities, and the top ends of the two independent inserts are each provided with a second movable mold cavity; the plate B is provided with a driving mechanism which is only used for driving the positioning mold core to rotate by 180 degrees; according to the double-color mold, only other parts of the movable mold core need to be rotated by 180 degrees, the fixed mold cavity and the movable mold cavity discharge glue for injection molding at the same time, high-quality products can be obtained through synchronous and rapid 360-degree coating injection molding of soft glue and hard glue, the injection molding products do not need to be lifted and turned over, the design difficulty of the double-color mold is greatly reduced, the cost is reduced, and the production efficiency is improved.

The invention discloses a ternary carrier-free nanoparticle as well as a preparation method and application thereof. The ternary carrier-free nanoparticles comprise nanoparticles which are formed by the chlorine e6, the lonidamine and the RG108 through an intermolecular interaction force. The nanoparticles can improve effective absorption and accumulation of drugs in tumors, can induce tumor specific pyroptosis and immunogenic effect under laser irradiation, and can promote maturation of antigen presenting cells and recruitment and activation of cytotoxic T lymphocytes, thereby starting adaptive anti-tumor immunity.

The invention provides a fluorescence-labeled bionic uricase-loaded hollow Prussian blue nanoparticle and a preparation method and application thereof.The fluorescence-labeled bionic uricase-loaded hollow Prussian blue nanoparticle has a fluorescence label, takes hollow Prussian blue as an inner core and takes a neutrophil-like cell membrane as a shell, and the hollow Prussian blue core and the neutrophil-like cell membrane are combined to form the fluorescence-labeled bionic uricase-loaded hollow Prussian blue nanoparticle. Uricase is loaded in the hollow Prussian blue; the preset emission wavelength of the near-infrared laser equipment is 808nm, the laser power density is 1W / cm < 2 >, and the action time is 5min; when the fluorescent mark shows that the nanoparticles reach the preset action part, the near-infrared laser equipment is started. The fluorescently-labeled bionic uricase-loaded hollow Prussian blue nanoparticles have the effects of clearing urate crystals and reducing the active oxygen level, and meanwhile, Prussian blue has good photo-thermal conversion efficiency and can be combined with photo-thermal therapy to remarkably relieve acute gout and reduce the degree of swelling of the sole of a mouse.

The invention relates to the technical field of biological medicines, and discloses hyaluronic acid modified metal coordination albumin nanoparticles as well as a preparation method and application thereof. The hyaluronic acid modified metal coordination albumin nanoparticle comprises a core and a hyaluronic acid shell layer, wherein the core is formed by self-assembly of an albumin-drug compound, poly-L-aspartic acid and ferric ions through coordination, and the hyaluronic acid shell layer is connected to the surface of the core through coordination or adsorption. According to the hyaluronic acid modified metal coordination albumin nanoparticles as well as the preparation method and the application thereof, the preparation method is simple, convenient and rapid, does not need complex covalent modification, is mild in condition and is easy for large-scale production, and the prepared nanoparticles are uniform in particle size, good in stability and high in stability. In addition, due to the fact that the hyaluronic acid is modified on the surface, the active targeting capacity on CD44 receptor high-expression tumor cells is achieved, the enrichment and treatment effects of the medicine on the tumor site are remarkably improved, and the application prospect in preparation of the anti-tumor medicine is wide.

The invention relates to the technical field of assembling devices, and discloses an automatic trichogramma ball buckling and assembling device which comprises an equipment box, a first feeding machine and a second feeding machine, the first feeding machine and the second feeding machine are used for feeding two semicircles of a trichogramma ball respectively, the automatic trichogramma ball buckling and assembling device further comprises an equipment table, the equipment table is fixedly installed on the top of the equipment box, and the first feeding machine and the second feeding machine are used for feeding the two semicircles of the trichogramma ball respectively. A base is fixedly mounted in the middle of the top of the equipment table. By arranging the buckling auxiliary mechanism, when a buckled bee ball passes through the lower portion of the material blocking support, the unbuckled bee ball can be extruded and buckled by means of an inclined face on one side of an extrusion block, products which are seriously staggered in buckling and pressing and cannot be corrected through the extrusion block can be extruded and separated by the extrusion block, and then the product is prevented from being damaged. And then the products are separated from the finished product area through the discharging mechanism, so that the phenomenon that the products which are not tightly buckled are scattered and leaked when being transferred is effectively avoided, and the effectiveness of buckling and assembling of the equipment is improved.

The utility model provides a video image intelligent identification terminal. The video image intelligent identification terminal comprises a first column body and a second column body, a solar panel is fixedly installed on the side face of the second column body, one side of the first column body is fixedly sleeved with a first supporting plate, and the other side of the first column body is fixedly sleeved with a second supporting plate. The top of the first supporting plate is fixedly connected with a first box body. The video image intelligent identification terminal provided by the utility model is provided with the solar panel, when video monitoring processing is carried out, the solar panel is started, so that the solar panel converts solar energy into electric energy and transmits the electric energy into the storage battery for storage, and at the moment, the storage battery continuously supplies power to the processing host; therefore, the effect that the processing host keeps the continuous standby work is achieved, the problem that much electric energy needs to be consumed during long-time video monitoring processing is avoided, and the effect of saving the electric energy during video monitoring processing is improved.

The utility model provides a continuous stirring pulp blending device for sweet potato starch. The continuous stirring pulp blending device for sweet potato starch comprises a box body, the top of the box body is fixedly connected with a first supporting column, the top of the first supporting column is fixedly connected with a second supporting column, and the top of the first supporting column is fixedly connected with a stirring box. According to the continuous stirring pulp blending device for the sweet potato starch, provided by the utility model, the delivery pump is arranged, and when starch is stirred and blended, the delivery pump is started, so that the delivery pump can absorb water flow in the box body through the floating block and the absorption pipe, and then the water flow is discharged into the stirring box through the water delivery pipe; the water flow can wash sweet potato residues in the stirring box, so that the continuous recycling effect of the water flow is achieved, the problem that a large amount of water flow needs to be consumed when sweet potato starch is blended is avoided, and the water flow saving effect is improved.

The utility model provides an atomizing hair straightening comb. The atomizing hair straightening comb comprises a hair straightening comb body, a control circuit board arranged in the hair straightening comb body, a smoke cartridge assembly used for atomizing essential oil, an air pump unit used for pumping mist and smoke and comb teeth located at one end of the hair straightening comb body. The smoke cartridge assembly comprises a ceramic heating core used for heating and atomizing essential oil and further comprises a smoke storage bin fixedly arranged on the inner side of the comb teeth and a heat insulation piece located between the smoke storage bin and the comb teeth. The air pump unit is communicated with the smoke cartridge assembly through an air inlet hose and communicated with the smoke storage bin through the mist outlet hose, and mist and smoke are pumped into the smoke storage bin from the smoke cartridge assembly. The PTC heating piece and the NTC temperature control sensor are arranged on the inner side of the comb tooth part, and in practical application, the smoke storage bin and the heat insulation piece can be well utilized, so that the fog accumulation and fog outlet effects are improved.

This utility model provides a shampoo and hair care ingredient release device, belonging to the technical field of release devices. It includes a storage bottle body and a storage bottle cap. A pump-feeding bottle body is mounted on the storage bottle body, and a piston is installed inside the pump-feeding bottle body. A one-way valve is located at the bottom of the pump-feeding bottle body. A pump head is located above the storage bottle cap, and a pump body is located inside the storage bottle cap. An adjustment knob is located on the top of the pump head, and a flow-limiting head is located below the adjustment knob. A stirring component for stirring is located at the bottom of the storage bottle body. The user can drive the piston inside the pump-feeding bottle body to move, replenishing the hair care ingredients in the pump-feeding bottle body into the shampoo in the storage bottle body through the pump nozzle and the one-way valve. This improves the flexibility of adding hair care ingredients, and the pump head can buffer the pumped shampoo to prevent it from being pumped too far, thus improving the dispensing stability of the device.

This invention discloses a lactobridged protein-derived calcium chelating peptide and its applications, belonging to the field of bioactive small molecule peptide technology. The calcium chelating peptide provided by this invention is safe and non-toxic, exhibiting better physicochemical activity compared to traditional calcium supplements. Its calcium chelating capacity reaches over 419.36 μg / mg, and it can promote calcium transport in the Caco-2 cell monolayer, thereby improving calcium absorption and bioavailability in the human body, making it suitable for use as a calcium supplement. This invention can develop a new protein source for calcium supplements and makes a significant contribution to the high-value utilization of dairy products.

The utility model provides a multistage mixing device for alkyd paint. The alkyd paint multi-stage mixing device comprises a supporting table, the top of the supporting table is fixedly connected with a first box body, an air cylinder is fixedly installed at the top of the first box body, and the bottom of the air cylinder is fixedly connected with a first pushing frame. According to the alkyd paint multi-stage mixing device provided by the utility model, by arranging the air cylinders, when paint is mixed and needs to be discharged, the air cylinders are started, so that the two air cylinders can drive the first pushing frame and the second pushing frame to move up and down; at the moment, the first pushing frame and the second pushing frame which move up and down can scrape the inner wall of the first box body, so that paint adhered to the inner wall of the first box body can be pushed to the bottom of an inner cavity of the first box body by the first pushing frame and the second pushing frame, and the paint discharging effect is improved; and the problem that the paint is adhered to the inner wall of the first box body and is difficult to discharge, so that the paint is wasted is solved, and the saving effect during paint mixing is improved.

The utility model discloses a dyeing vat with dye function is saved, including vertical dip dye vat jar body, the lower side fixed mounting of vertical dip dye vat jar body front end surface has the liquid pump valve, one side of liquid pump valve upper end surface is connected with the return pipe, and the inside upper side of return pipe is equipped with the liquid outlet. Through the utility model uses vertical dip dye vat jar body to be able to circulate up and down flow dye when dip dyeing coloring, and the dye in the process of flowing, through stepping motor, transmission shaft, grinding disc, grinding ring and fine grinding groove can carry out grinding operation to it simultaneously, through above technical scheme, guarantee the dye fluidity, prevent dye from happening settlement phenomenon simultaneously, can regrind the flocculation precipitate generated by calcium ion in water source and dye or auxiliary agent, this structure can improve the utilization of dye, to reduce the endless loss of dye, improve vertical dip dye vat jar body whole dye saving rate.

The invention discloses a hybrid cell membrane disguised hexagonal boron nitride nano-particle as well as a preparation method and application thereof, relates to the technical field of medicines, and aims to solve the problems of poor targeting property and biocompatibility of a boron carrying agent, insufficient in-vivo stability and tumor accumulation capacity of nano-particles and the like in BNCT tumor treatment in the prior art. The composite material comprises hexagonal boron nitride nanoparticles and a hybrid cell membrane coating the peripheries of the hexagonal boron nitride nanoparticles, and the hybrid cell membrane is formed by fusing a macrophage cell membrane and a tumor cell membrane. The targeting property and biocompatibility of the boron carrying agent and the in-vivo stability and tumor accumulation capacity of nanoparticles can be effectively enhanced, and the BNCT treatment effect of glioma is improved.

The utility model discloses watering equipment, and relates to the technical field of road roller equipment. The device comprises a mounting plate, a supporting plate is fixedly connected to the top of one side of the mounting plate, a watering assembly is fixedly connected to the side, close to the mounting plate, of the top of the supporting plate, a cleaning plate is fixedly connected to the bottom of the side, away from the mounting plate, of the supporting plate, and a reserved groove is formed in the inner side of the side, away from the mounting plate, of the supporting plate; the reserved groove is located between the cleaning plate and the water spraying assembly, and the cleaning assembly is installed on the inner side of the reserved groove. Through the arrangement of the water sprinkling assembly, clean water is directly sprayed to the surface of the mill wheel, so that the effect of cleaning the surface of the mill wheel can be improved, and meanwhile, water flow can be controlled, so that the mill wheel can be prevented from being cleaned by the water flow all the time, and the effect of saving water resources is improved.

The invention provides a power switch circuit, a chip, a terminal and a control method of the power switch circuit, and belongs to the technical field of circuit design. The power switch circuit comprises a first buffer and a plurality of voltage drop layers. The plurality of voltage drop layers are sequentially connected in series, and the head ends of the plurality of voltage drop layers are electrically connected with the output end of the first buffer and a power supply respectively; the tail ends of the plurality of voltage drop layers are electrically connected with a mature design IP (Internet Protocol) of a circuit module with an independent function in a controlled chip; the first buffer is used for receiving a standby signal and transmitting the standby signal to the plurality of voltage drop layers; and the plurality of voltage drop layers are used for reducing the voltage transmitted to the IP by the power supply in response to the standby signal. The power consumption saving effect can be improved.

The utility model relates to the technical field of weighing devices, and provides a powdery material quantitative weighing device which comprises a base arranged on the ground in parallel, the base is of an L-shaped structure, and the base can be fixed to charging barrels at different positions in the height direction of the base through a lifting mechanism arranged on the vertical section of the base. The first motor drives the bidirectional screw rod to rotate and drives the two sliding blocks to slide and get close to each other in the groove, so that the two arc-shaped positioning blocks are driven to get close to each other to be in contact and fixed with the weighing cylinder, and therefore the effect that the weighing cylinder is centered and positioned is achieved, and the weighing cylinder and the charging barrel can be aligned conveniently; the situation that powder cannot accurately fall into the weighing cylinder due to the fact that the weighing cylinder is not placed in the middle is prevented, and the stability and the effect of powder weighing are effectively improved.

The present invention belongs to the field of biology and medicine and the field of pharmaceutical preparation technology, and specifically relates to the preparation and application of a gold nanoparticle and its liposome. The present invention prepares an asymmetrically modified gold nanoparticle (HAM) of arginine and maleimide groups, and an active targeted liposome HAM‑αLip encapsulating gold nanoparticles. On the one hand, the large-diameter targeted modified liposomes ensure that they will not be cleared by the reticuloendothelial system in the blood circulation system, ensuring the accumulation of HAM‑αLip in the tumor site; on the other hand, the modified gold nanoparticles are released when they reach the tumor site, achieving deep penetration of the tumor and improving the anti-tumor treatment effect.

The invention discloses a preparation method of IR780 and gambogic acid prodrug-loaded lipidosome, which comprises the following steps: dissolving mPEG-TK-NH2 in dimethylformamide, adding gambogic acid, benzoyl peroxide and triethylamine, stirring for reaction, concentrating and recrystallizing to obtain mPEG-TK-GA, adding mPEG-TK-GA, soybean phosphatidylcholine, cholesterol and IR780 into an organic solvent, and carrying out rotary evaporation to remove the organic solvent, thereby obtaining the IR780 and gambogic acid prodrug-loaded lipidosome. The SIRP-alpha gene engineering exosome preparation method comprises the following steps: preparing a lipid membrane, adding a phosphate buffer solution, heating, carrying out ultrasonic treatment, granulating to obtain a liposome solution, mixing an SIRP-alpha gene engineering exosome and IG Lipo, and carrying out membrane fusion by adopting a freeze-thaw method to obtain the SIRP-alpha gene engineering exosome preparation. Compared with the prior art, the liposome prepared by the method has a responsive drug release effect, can relieve toxic and side effects while improving the treatment effect, is also loaded with IR780, and can reduce the dosage and improve the treatment effect in combination with photothermal therapy.

The invention provides a polypeptide lysosome targeting chimera for degrading CTGF (cytotoxic growth factor) protein, and the structural formula of the polypeptide lysosome targeting chimera is as shown in the specification, namely # imgabs0 #. The invention also provides a lysosome targeted chimera self-assembled micelle for degrading the CTGF protein, and the structure of the lysosome targeted chimera self-assembled micelle is as follows: # imgabs 1 #. The invention also provides a preparation method of the lysosome targeted chimera self-assembled micelle for degrading the CTGF protein and application of the lysosome targeted chimera self-assembled micelle in preparation of medicines for treating tumors. The CTGF in the triple negative breast cancer tumor tissue can be efficiently degraded, tumor growth, lung metastasis and bone metastasis are inhibited, and then the anti-tumor effect is achieved.

The utility model discloses a photovoltaic pest killing device for agricultural planting, which comprises a bottom plate, the top of the bottom plate is provided with a pest prevention assembly, and the top of the pest prevention assembly is provided with a solar assembly; the fixing frame is arranged at the top of the bottom plate, the weak current radiation net cover is arranged on one side of the fixing frame, the frame is arranged at the top of the bottom plate, the blocking plate is arranged in the frame, and the blocking plate is located on one side of the weak current radiation net cover. By arranging the solar assembly, a power source can be provided for the pest removal assembly through solar energy in the process, solar energy storage and electric power conversion can be achieved, the pest removal assembly can get rid of connection of a long power line in the using process, energy consumption is reduced, and the pest removal efficiency is improved. And a power supply can be provided for the pest removal assembly at night, so that the energy conservation is improved, and the energy efficiency of the pest removal assembly is ensured.

The utility model relates to the technical field of photovoltaic power generation and energy storage, and discloses a photovoltaic comprehensive energy storage device which comprises a substrate, a first motor, an angle adjusting mechanism, a mounting plate, a photovoltaic power generation assembly, a light sensor, an inverter and an energy storage box. An output shaft of the first motor is fixedly connected with the connecting sleeve, a single chip microcomputer is installed at the bottom of the base plate, an angle adjusting mechanism is arranged at the top of the base plate, a mounting plate is arranged on the angle adjusting mechanism, a photovoltaic power generation assembly is installed at the top of the mounting plate, and light sensors are arranged at the four corners of the mounting plate respectively. The photovoltaic power generation assembly is electrically connected with the energy storage box through the inverter, a plurality of installation grooves are formed in the energy storage box, each installation groove is provided with a storage battery support, and a storage battery is installed on the inner side of each storage battery support.

An electric vehicle collaborative power grid power supply recovery strategy considering multi-time-domain EV-EPSV comprises the steps that a multi-time-sequence electric vehicle EV equivalent power supply model is established according to a travel rule of an electric vehicle user in a typical travel scene; a load importance index system is constructed, a load power loss model is established in combination with the load capacity and the power failure duration, and quantitative calculation of economic and social losses of different types of loads in the multi-time-sequence power failure process is achieved; and constructing a collaborative optimized power supply model of the electric vehicle EV and the emergency power supply vehicle EPSV, and realizing static power distribution of the electric vehicle and dynamic path and power optimization scheduling of the emergency power supply vehicle. According to the strategy, a multi-time-sequence EV equivalent power supply model is established, a load power loss evaluation system is constructed, and a collaborative optimization scheduling method of the electric vehicle and the emergency power supply vehicle is provided, so that efficient distribution of limited power supply resources and improvement of power supply recovery efficiency are realized. The scheduling flexibility of electric vehicle resources and the power supply toughness of a power grid can be effectively improved in a sudden power failure situation.

The utility model discloses a multi-layer goods shelf with a telescopic storage space, and particularly relates to the technical field of goods shelves, the multi-layer goods shelf comprises a goods shelf, the front end of the goods shelf is movably connected with a door plate, the front end of the door plate is fixedly connected with a first pull rod, and the inner wall of the goods shelf is fixedly connected with a push-pull device. Telescopic devices are symmetrically arranged on the two sides of the goods shelf body, third pull rods are fixedly connected to the left ends of the telescopic devices, a moisture-proof device is fixedly connected to the lower end of the goods shelf body, and supporting legs are fixedly connected to the lower end of the moisture-proof device. The storage space can be freely separated, the application range of the equipment is effectively widened, meanwhile, the push-pull arrangement facilitates taking of objects on the goods shelf, the storage space of the goods shelf can be widened, the objects can be stored or high goods can be placed, the interior of the goods shelf can be ventilated, and meanwhile the goods can be prevented from being corroded by moisture deposition; and a certain protection effect is achieved.

The utility model relates to the technical field of paint production, and discloses a paint transportation lifting platform for paint production, which comprises a table top, the top of the table top is fixedly connected with a protection box, the top of the protection box is slidably connected with a sliding plate, the top of the sliding plate is rotatably connected with an electric push rod, and the output end of the electric push rod is rotatably connected with a placing box. The bottom of the placing box is arranged at the top of the sliding plate, an inclined plate is fixedly connected to the outer wall of the placing box, a connecting piece is fixedly connected to the outer wall of the placing box, the outer wall of the connecting piece is slidably connected to the interior of the protection box, and a gear is rotatably connected to the interior of the protection box. According to the utility model, through the structures such as the inner toothed belt and the gears, the manpower and the cost in the coating production process are reduced, the dependence of carrying operation on personnel is reduced, the problem that the coating on the top of the platform needs to be carried and unloaded by an additional device is solved, and the economy and the convenience of the device are improved.

The utility model relates to the technical field of pneumatic discharging doors of concrete batching machines, in particular to a pneumatic discharging door of a concrete batching machine, which comprises a bin body, a dismounting structure is arranged outside the bin body, the dismounting structure comprises a discharging door base, the discharging door base is welded on the outer wall of the bin body, and the discharging door base is connected with the bin body. The material door base and the connecting plate are connected through a mounting bolt, and a hanging plate is assembled outside the mounting bolt and can be assembled conveniently and rapidly. According to the pneumatic discharge door of the concrete batching plant, the problems of disassembly, maintenance and replacement of accessories of the discharge door can be solved, meanwhile, the service life of products is prolonged, the repeated utilization rate of materials is increased, and the practicability and the economization of the device are improved.

A multi-time-sequence EV equivalent power supply model modeling method considering a vehicle travel rule comprises the following steps: according to dynamic evolution characteristics of the travel rule of an electric vehicle user, combining travel sample data, dividing into a summer scene and a winter scene according to seasons, and dividing into a workday scene and a holiday scene according to a time sequence to complete data fitting; then, a vehicle travel state transition matrix is established through a semi-Markov chain SMC, and a Monte Carlo method MCM is utilized to perform random simulation on vehicle behaviors to obtain available discharge capacities of the electric vehicles at all moments, so that an electric vehicle cluster in a region is equivalent to a time-varying power supply model, and a multi-time-sequence EV equivalent power supply model is established; according to the method, by introducing a semi-Markov chain and a Monte Carlo random simulation method, available energy storage capacity distribution characteristics of an electric vehicle group in different scenes are described. The model can reflect energy storage laws of residential areas, working areas and shopping areas in different seasons and days, and dynamic quantitative evaluation of the EV available power potential is realized.

The utility model relates to the technical field of burettes, and discloses a burette capable of preventing liquid leakage, which comprises a burette, a titration valve is fixedly arranged on the surface of the burette, a movable component is arranged in the burette, a moving component is arranged in the titration valve, and the moving component comprises a control rod, a liquid inlet pipe, a liquid outlet pipe and a liquid outlet pipe, the burette capable of preventing liquid leakage comprises a titration valve, a control rod is slidably connected into the titration valve, the control rod penetrates through the right side of the titration valve, a control disc is fixedly installed on the right side of the control rod, a first movable spring is fixedly installed on the surface of the control rod, and the first movable spring is fixedly installed on the right side of the titration valve. According to the burette disclosed by the invention, the mobile assembly can be used for protecting the burette, so that liquid leakage caused by long-time use of the burette is prevented, the convenience of a worker during use is greatly improved, the practicability and the use continuity of the burette are improved, and the economic cost of maintenance and replacement caused by abrasion loss of the titration valve due to long-time use is also reduced.

The invention belongs to the technical field of biological medicines, and discloses application of brucea javanica bitter alcohol in preparation of anti-leukemia medicines. Test results show that the brucea javanica bitter alcohol can inhibit the cell activity of leukemia cells and cause apoptosis and cell cycle arrest of the leukemia cells. The brucea javanica picrol promotes leukemia cell lipid peroxidation and intracellular ferrous ion accumulation to cause ferroptosis by inhibiting protein expression of an antioxidant transcription factor Nrf2 and downstream NQO1 of the antioxidant transcription factor Nrf2, and the brucea javanica picrol and a ferroptosis inducer Erastatin exert the anti-leukemia synergistic effect. The application proves that the brucea javanica picrol has a good anti-leukemia effect on leukemia cells, prompts that a ferroptosis pathway is one of the effective anti-leukemia pathways, is used for preparing the medicine for treating leukemia, and provides a brand-new thought for developing a drug administration scheme for treating leukemia.