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328results about How to "Increase savings" patented technology

Co-delivery nano-carrier of drug and gene, preparation method and application thereof

The invention discloses a co-delivery nano-carrier of drugs and genes, a preparation method and an application thereof; and particularly relates to a co-delivery nano-carrier TCPL-siRNA-PPX which can carry a chemotherapeutic drug and a genetic drug simultaneously. The drug delivery system is composed of a polymer prodrug carrier TCPL, siRNA and a multifunctional polyanionic polyer PPX through electrostatic adsorption among the components in a self-assembly manner. The co-delivery nano-carrier can achieve targetedly delivery of the drug and the gene to the same tumor cell, release the siRNA at the cytoplasm, silence Bcl-2 protein, promote apotosis and relieve inhibition of the Bcl-2 on lonidamine, and can deliver the chemotherapeutic drug, lonidamine, which is mitochondrion-acted to mitochondria so that the chemotherapeutic drug and the gene can synergistically trigger the apotosis of a mitochondrial pathway and kill tumor cells cooperatively. Through in-vivo and in-vitro activity evaluation, the drug delivery system is proved to be better than drug delivery carriers which deliver single components respectively at the same time, can significantly improve the anti-cancer activity of the drug and the gene and has a definite synergistic treatment effect.
Owner:CHINA PHARM UNIV

Ternary complex nanometer system and preparation method and application thereof

The invention discloses a ternary complex nanometer system and a preparation method and application thereof. The system comprises an iron compound, a benzene-ring-containing micromolecule antineoplastic active compound and a polyphenol compound; a weight ratio of the iron compound to the benzene-ring-containing micromolecule antineoplastic active compound to the polyphenol compound is (1 to 4):(2to 10):(5 to 20). Relative to the prior art, according to the invention, different micromolecule compounds or medicines can be stably assembled only by a physical assembling means; the formed complexnanometer medicine not only has an antineoplastic treatment effect of the micromolecule antineoplastic active compound, but also has a ferroptosis treatment effect that the iron compound reacts with the polyphenol compound are mediated on the basis of an intracellular Fenton reaction; moreover, the novel complex nanometer medicine formed by the preparation method disclosed by the invention furtherhas an outstanding photothermal effect; chemotherapy, ferroptosis treatment and photothermal therapy can be integrated into one whole body, take a synergistic effect, beneficiate each other and achieve an all-in-one combined antineoplastic treatment effect.
Owner:CHINA PHARM UNIV

Gold-gadolinium composite nano material as well as preparation method and application of gold-gadolinium composite nano material

The invention relates to a gold-gadolinium composite nano material as well as a preparation method and application of the gold-gadolinium composite nano material. The gold-gadolinium composite nano material provided by the invention comprises an inner core of a gold nano rod modified by silicon dioxide, and a gadolinium-containing silicon dioxide layer covering the outer side of the inner core. The gold-gadolinium composite nano material is high in gadolinium contain and each nano particle contains 1.5*10<6> Gd ions; the gold-gadolinium composite nano material is good in imaging effect and small in toxic side effect and can be used for loading a plurality of types of drugs and probe molecules, and target molecules can be adsorbed on the surface of the gold-gadolinium composite nano material, so that the drugs and the molecules can be efficiently transported to focus parts and multifunctional diagnosis and treatment can be realized. After the gold-gadolinium composite nano material is used as a carrier for loading the drugs, the gold-gadolinium composite nano material has the synergistic effect of thermal therapy and chemical therapy under laser irradiation in a treatment process of tumor-bearing mice, so that the growth of tumors is effectively inhibited; the gold-gadolinium composite nano material has multiple imaging functions including CT (Computed Tomography), MRI (Magnetic Resonance Imaging), photo-acoustic imaging and the like, and is suitable for being applied to complicated need tumor diagnosis and treatment.
Owner:THE NAT CENT FOR NANOSCI & TECH NCNST OF CHINA
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