The invention discloses a comprehensive prevention and control technology of a corn waterlogging disaster, wherein soil ridging or compartment ridging regulation and control are utilized. The comprehensive prevention and control technology comprises the following steps: sowing in a wide and narrow row spacing manner during corn sowing, carrying out intertillage ridging or ditching during the five-leaf stage of corn, ditching in wide rows of corn and ridging in narrow rods of corn, or ditching in wide rows on the two sides of a compartment consisting of four or six rows, additionally applying nitrogen-oxygen mixed fertilizer instantly after the corn waterlogging disaster occurs, and spraying spermidine chemical modifier on leaf surfaces at the same time, wherein spraying is carried out once in the morning and night for 2-3 days continuously; other steps are the same as that during normal management, corn is harvested until bracts of corn clusters are dried up, corn grain milk lines disappear, and a black layer appears, namely when grains are completely and physiologically matured. According to the comprehensive prevention and control technology, through comprehensive precontrol advantages of prevention in advance and remedy after the disaster, the root oxygen deficiency after waterlogging can be effectively reduced and retarded, accumulated toxic effect of hazardous substances of soil is reduced, and the root growth and absorption capacity is strengthened, so that the symplastic growth of overground part and root system is promoted, and the yield is improved.