14results about How to "Reduce hypoxia" patented technology

This invention relates to a pH-responsive hydrogel composite dressing, its preparation method, and its application, belonging to the field of biomedical materials and drug delivery technology. The pH-responsive hydrogel composite dressing comprises a hydrogel matrix and engineered exosomes and platelet-rich plasma uniformly loaded within the hydrogel matrix. The hydrogel matrix comprises a three-dimensional dynamic cross-linked network formed by a Schiff base reaction between an amino-containing polysaccharide derivative and an oxidized aldehyde-containing polysaccharide derivative. The engineered exosomes are derived from donor cells subjected to pathogen-associated molecular pattern stress treatment. The dressing provided by this invention possesses both toxin capture and immunometabolic regulation functions, achieving synergistic therapeutic effects against MRSA-infected diabetic wounds.

The application discloses a preparation method and application of a hollow manganese dioxide nanocarrier coated with a human umbilical cord mesenchymal stem cell membrane and a transmembrane peptide TAT, and is characterized in that: hollow mesoporous manganese dioxide is synthesized through a selective etching technology, and a layer of human umbilical cord mesenchymal stem cell membrane is coated outside the manganese dioxide through a repeated extrusion method. Since the cell membrane has special tumor homing characteristics, and lacks major histocompatibility complex-II and only expresses major histocompatibility complex-I in a trace amount, the key scientific problems and difficulties such as low biological safety, strong immunogenicity and easy elimination by the body of artificially synthesized nanomaterials can be effectively solved. Finally, the cell membrane surface is modified with the transmembrane peptide TAT through a phospholipid insertion method, precise subcellular localization-nucleus targeting is realized, and tumor cells can be more effectively killed.

This invention discloses a metal thin-film capacitive vacuum gauge, comprising: a vacuum gauge body with a connector; the connector having a protection mechanism and a cleaning mechanism; the protection mechanism including: a housing, an inflation sealing assembly, a negative pressure suction assembly, an elastic reset assembly, and a stroke linkage transmission mechanism; the housing having an inflation chamber and a suction chamber; the inflation sealing assembly including a sealing airbag, an inflation piston slidably disposed in the inflation chamber, and an inflation pipe connecting the sealing airbag and the inflation chamber; the negative pressure suction assembly including a suction piston slidably disposed in the suction chamber, and an air inlet pipe connecting the inside of the connector and the suction chamber; the stroke linkage transmission mechanism connecting the inflation sealing assembly, the negative pressure suction assembly, and the elastic reset assembly; the cleaning mechanism including: a storage drive unit, a cleaning component, and a conveying unit; the cleaning mechanism and the stroke linkage transmission mechanism are linked and cooperate. This application can achieve effective protection of the connector, improve signal transmission stability and measurement accuracy, and simplify and reduce maintenance costs.

The utility model discloses a matrix flowerpot for family gardening, which relates to the field of flowerpots and comprises a pot body, an annular water cavity is arranged in the side wall of the pot body and is positioned at the top of the pot body, and a plurality of uniformly distributed water outlet holes are arranged on the inner side wall of the pot body and correspond to the annular water cavity. L-shaped water inlet pipes are fixedly arranged at the positions, corresponding to the annular water cavity, of the two sides of the pot body. A base is arranged at the bottom of the pot body, a plurality of evenly-distributed stand columns are fixedly arranged between the base and the bottom of the pot body, an electric push rod is fixedly arranged at the top of the base, a fixing disc is fixedly arranged at the moving end of the electric push rod, a plurality of soil loosening rods are fixedly arranged on the upper surface of the fixing disc, and the upper ends of the soil loosening rods extend into the pot body. Through the slow flow watering structure and the automatic soil loosening mechanism, hardening inducements are reduced from the source, dynamic loosening of the matrix is achieved, and an efficient and worry-free matrix management solution is provided for family gardening.

The utility model relates to the technical field of water conservancy emergency equipment, specifically discloses a bubble disturbance type ice melting device based on unmanned ship platform, including bubble ice melting device, temperature monitoring module and total control module, and temperature monitoring module is composed of temperature sensor fixed in the lower part of sand head air disc. The utility model discloses bubble ice melting device and temperature sensor cooperate with each other, utilize temperature sensor real -time mobile type monitoring river and lake temperature before the operation of bubble ice melting device, send data to total control module, utilize total control module to carry out unified control to bubble ice melting device, when temperature is lower than set threshold value, total controller starts bubble ice melting device, forms bubble group, and a large number of bubbles contact ice layer and collapse rapidly, and the impact and the disturbance to the water flow of generation make ice layer melt. The utility model discloses a bubble disturbance type ice melting device based on unmanned ship platform, which solves the problem of deterioration of water conservancy building structure caused by rapid freezing weather in existing rivers and lakes.

The application discloses a kind of tannin-based Mn-Fe diatomic metal polyphenol nano-carrier loaded hypocrellin B nano-assemblies and its preparation method and application.The nano-assemblies use tannin as ligand, by step coordination driven self-assembly strategy, first with Mn 2+ Forming pre-assembly template, then introducing Fe 3+ Constructing Mn-Fe diatomic metal polyphenol network with atomic level uniform dispersion, and loading traditional Chinese medicine source photosensitizer hypocrellin B to obtain nano-preparation.The preparation realizes Fe 2+ / Fe 3+ Self-circulation, and can sustainably catalyze H2O2 in tumor microenvironment to generate hydroxyl radical, realizes long-acting chemical kinetics treatment;Meanwhile, in-situ oxygen production relieves tumor hypoxia, improves photodynamic therapy effect, and consumes glutathione to amplify oxidative stress.The preparation process of the application is mild, and biocompatibility is good, and it breaks through the bottleneck of insufficient effect of traditional treatment in anoxic tumor.

The application discloses a microwave-responsive hydrogel dressing and application thereof in preparation of an anti-diabetic chronic infection wound preparation. The raw material of the hydrogel dressing disclosed by the application comprises: (A) a hydrogel matrix; (B) glucose oxidase; (C) a nano-enzyme composition, wherein the nano-enzyme composition at least comprises a luteolin-manganese dioxide composite; wherein the luteolin-manganese dioxide composite is a solid-phase product obtained by wet blending of luteolin and nano-manganese dioxide. Under microwave irradiation, the heat effect generated by the microwave causes the hydrogel dressing to heat up, the heat-enhanced glucose oxidase consumes glucose to generate hydrogen peroxide, and at the same time, the heat-enhanced luteolin-manganese dioxide composite decomposes the hydrogen peroxide to generate oxygen, thereby simultaneously relieving high glucose and hypoxia, fundamentally breaking the vicious cycle of "high glucose-hypoxia-infection-chronic inflammation" of the diabetic wound, and finally improving the antibacterial effect on the skin wound.

The application discloses a preparation method of a multifunctional nano drug of Fe-based MOF loaded CM-272, and relates to a preparation method of an anti-cancer nano drug.The application aims at solving the problem that the CM-272 action is limited due to the internal hypoxic environment of a tumor.Method: I, preparing a Fe-based metal organic framework;II, preparing a MIL-53@CM-272 nano drug.The application is used for the preparation of the multifunctional nano drug of the Fe-based MOF loaded CM-272.

This utility model relates to the field of aquaculture technology, specifically an escape-proof leech farming cage. It includes a cage body with an opening and escape-proof door at the top. The cage body is fitted inside an outer frame, which includes multiple side rods and several connectors. A cleaning assembly is provided on the outer frame, comprising four movable sleeves. A brush plate is positioned between adjacent side rods, and several bristles are inserted into the inner surface of the brush plate, with the ends of the bristles adhering to the outer surface of the cage body. This escape-proof leech farming cage, through the cleaning assembly, allows the movable sleeves to slide along the side rods, causing the brush plate and bristles to move against the outer surface of the cage body, effectively cleaning attached suspended matter, preventing mesh blockage, maintaining water circulation within the cage, and reducing oxygen deficiency.

The utility model relates to the technical field of breeding pond cleaning, disclose a kind of aquaculture pond cleaning equipment, including support seat, the top of support seat is fixedly connected with pond body, the inside bottom wall of pond body is fixedly connected with conical disc, the inside of conical disc is connected with connecting column, the top of connecting column is fixedly connected with top ring, the inside of support seat is provided with motor, the output of motor is fixedly connected with rotating rod.The utility model is provided with connecting column, motor, rotating rod, can solve the problem that the pollution residue on the bottom and the wall of pond, long-term accumulation can influence breeding environment, the influence of equipment to aquatic organism can be reduced, by the first scraper adheres to the circumferential motion of conical disc surface, push the dirt on the bottom to edge, to effectively shorten cleaning time, ensure that cleaning effect is more uniform, avoid omission and reduce the demand of manual operation, promote the healthy growth of aquatic organism.

This invention belongs to the field of nanomaterials technology, and more specifically, relates to indocyanine green-stabilized CuET nanoparticles, a nanoparticle dispersion, a preparation method thereof, and its applications. The indocyanine green-stabilized CuET nanoparticles provided by this invention are nanoparticles formed by stabilizing CuET nanocrystals with indocyanine green, wherein indocyanine green binds to and stabilizes the CuET nanocrystals through hydrophobic interactions, forming the indocyanine green-stabilized CuET nanoparticles. The indocyanine green-stabilized CuET nanoparticles provided by this invention can improve the water solubility and serum stability of CuET, facilitating intravenous administration of CuET. Furthermore, the indocyanine green-stabilized CuET nanoparticles provided by this invention can disrupt mitochondrial function of tumor cells, inhibit tumor cell respiration, improve hypoxia at the tumor site, and enhance the photodynamic antitumor therapeutic effect mediated by indocyanine green.

The application discloses a kind of red blood cell biomimetic MOFs and its preparation method and application, belong to biomaterial technical field. Including drug-loaded MOFs and the red blood cell membrane layer coated outside MOFs;The MOFs are selected from UiO-66-NH2;The UiO-66-NH2 is the microparticle that amino functional group is connected on UiO-66;The drug-loaded MOFs are loaded with double apparent genetic drugs;The double apparent genetic drugs are CM272 and MA. By targeting three kinds of epigenetic modification, simultaneously control DNA methylation in leukemia cell, histone methylation and RNA methylation to enhance the immune response to acute myeloid leukemia, and utilize biomimetic MOFs microparticle to overcome the hypoxic microenvironment of leukemia, enhance the therapeutic activity of loaded drug, and induce leukemia cell and leukemia cell mesenchymal stem cell death.

The application provides a synergistic hair growth microneedle based on active oxygen scavenging and nitric oxide delivery and a preparation method thereof. The hair growth microneedle comprises a substrate layer and a plurality of microneedles arranged on the substrate layer, and at least comprises: an active oxygen scavenging component arranged on a needle root part of the microneedle, which is used for scavenging excessive active oxygen under a pathological oxidative environment around a hair follicle; a nitric oxide delivery component arranged on a needle tip part of the microneedle, which is used for continuously releasing nitric oxide after the microneedle is inserted into the skin; a mass ratio of the active oxygen scavenging component to the nitric oxide delivery component is (0.01-10):1; and the active oxygen scavenging component and the nitric oxide delivery component in the microneedle have a synergistic effect.

The utility model relates to the technical field of nutrient solution cultivation, provide a kind of nutrient solution oxygenation device, comprising: nutrient solution pool;Air supply device, set in the top of greenhouse, the air outlet of air supply device is towards greenhouse inside setting;Air duct, one end is connected to the air outlet of air supply device, for transporting fresh air sent by air supply device;Its other end corresponds to nutrient solution pool;Spraying device, set in air duct, spraying device is connected with nutrient solution pool by pumping pipeline, for sending the nutrient solution in nutrient solution pool to air duct interior and spraying, so that nutrient solution is fully contacted with fresh air in air duct and then falls to nutrient solution pool;The utility model by built-in air duct inside spraying device, nutrient solution sprayed by spraying device fully absorbs oxygen in air, so that the water-soluble oxygen content of nutrient solution when falling to nutrient solution pool is significantly improved, effectively alleviate the root system anoxia problem caused by high temperature in summer;And, closed loop circulation of spraying-contact-recovery can be formed.