33results about How to "Reduce hypoxia" patented technology

The invention relates to the technical field of nano-drugs, in particular to an acoustic / chemical power synergistic anti-tumor nano-drug as well as a preparation method and application thereof. The invention provides an acoustic / chemical power synergistic anti-tumor nano-drug, which takes hollow mesoporous MnO2 nano-particles as a carrier, and is loaded with vitamin C and a sound-sensitive agent chlorin e6. Vc can generate abundant H2O2 to provide a raw material for CDT, and MnO2 is used as a peroxidase-like enzyme to catalyze H2O2 to generate O2, so that tumor hypoxia is effectively relieved, and the effect of sonodynamic therapy is enhanced. Besides, GSH induces MnO2 degradation, GSH consumption is caused to enhance CDT, GSH depletion can cause glutathione peroxidase 4 (GPX4) activity reduction, ROS generation and GPX4 activity reduction have a synergistic effect, lipid peroxides (LPOs) are increased, and finally ferroptosis of tumor cells is caused.

The invention belongs to the field of biological catalytic materials, particularly relates to a sound-sensitive agent based on a metal-pyridine coordination structure as well as a preparation method and application of the sound-sensitive agent, and more particularly relates to a sound-sensitive agent doped with second metal and based on the metal-pyridine coordination structure. Compared with other most reported sound-sensitive agents based on micromolecules, the sound-sensitive agent based on the metal-pyridine coordination structure and the doped second metal and based on the metal-pyridine coordination structure, especially the latter, has higher ultrasonic mediated < 1 > O2 generation activity; in addition, the effects of relieving oxygen deficit, promoting polarization of macrophages to M1 and enhancing immunotherapy are achieved, and therefore the tumor microenvironment of immunosuppression is reversed. When the sonosensitizer provided by the invention is used in combination with a PD-L1 antibody, satisfactory sonodynamic triggered synchronous immune activation is realized, and original and distant metastatic tumors are eradicated impressively.

The invention provides a photodynamic and chemotherapy synergistic antibacterial composite material, the composite material comprises an intermediate composite material and hyaluronic acid HA coating the outer side of the intermediate composite material, and the intermediate composite material takes a photosensitizer i-ZnPPOPs as a substrate and is loaded with calcium peroxide and gentamicin. The composite material has excellent bacteria targeting characteristic and antibacterial effect. Specifically, hyaluronic acid can target hyaluronidase secreted by bacteria so as to capture the bacteria, and then the intermediate composite material is transferred to the surfaces of the bacteria and interacts with negatively charged bacterial membranes. Then, the exposed biomass-based CaO2 is released and reacts with water to generate H2O2 and O2, so that oxygen deficit of the infected wound surface is relieved, generation of < 1 > O2 in the i-ZnPPOPs is effectively promoted, and the photodynamic antibacterial effect is further improved. Meanwhile, the released gentamicin can further improve the antibacterial efficiency of the chemotherapy.

The invention discloses a ternary carrier-free nanoparticle as well as a preparation method and application thereof. The ternary carrier-free nanoparticles comprise nanoparticles which are formed by the chlorine e6, the lonidamine and the RG108 through an intermolecular interaction force. The nanoparticles can improve effective absorption and accumulation of drugs in tumors, can induce tumor specific pyroptosis and immunogenic effect under laser irradiation, and can promote maturation of antigen presenting cells and recruitment and activation of cytotoxic T lymphocytes, thereby starting adaptive anti-tumor immunity.

The invention relates to a degradable double-enzyme active nano-enzyme for treating diabetic foot ulcer, and aims to provide a novel efficient treatment scheme. The nano-enzyme has peroxidase-like and catalase-like dual-enzyme activity, is prepared by a specific chemical synthesis method, has good biodegradability, and can efficiently catalyze a reaction in a physiological environment to reduce drug resistance. Compared with a traditional treatment method, the nano-enzyme disclosed by the invention can be used for remarkably improving the treatment effect of the diabetic foot ulcer, accelerating the healing process and reducing the toxic and side effects on a human body and the manufacturing cost at the same time, and a safer and more effective treatment choice is provided for a patient with the diabetic foot ulcer.

This invention relates to a pH-responsive hydrogel composite dressing, its preparation method, and its application, belonging to the field of biomedical materials and drug delivery technology. The pH-responsive hydrogel composite dressing comprises a hydrogel matrix and engineered exosomes and platelet-rich plasma uniformly loaded within the hydrogel matrix. The hydrogel matrix comprises a three-dimensional dynamic cross-linked network formed by a Schiff base reaction between an amino-containing polysaccharide derivative and an oxidized aldehyde-containing polysaccharide derivative. The engineered exosomes are derived from donor cells subjected to pathogen-associated molecular pattern stress treatment. The dressing provided by this invention possesses both toxin capture and immunometabolic regulation functions, achieving synergistic therapeutic effects against MRSA-infected diabetic wounds.

The present invention belongs to the technical field of lake and reservoir water ecology improvement and restoration, and discloses a method for suppressing thermal stratification of reservoirs by stimulating water flow oscillations through daily regulation and scheduling of reservoirs. The daily regulation and scheduling process of the reservoir causes gravity waves to form in the main stream of the reservoir, and induces high-frequency water flow oscillations in the tributary bay; the water level in the bay has high-frequency fluctuation characteristics through the water flow oscillation process, and the flow velocity of the water body in the bay is intermittently increased or reduced; the water body is intermittently mixed through the periodic high-frequency oscillation process, causing high-frequency fluctuations in water temperature, thereby achieving the effect of suppressing water temperature stratification. The present invention generates water level fluctuations in front of the dam by regulating the downstream flow of the hydropower station, triggering gravity waves in the main stream, and then inducing high-frequency water flow oscillations in the tributary bay. The present invention can effectively improve the density stratification characteristics of deepwater lakes and reservoirs. Compared with the currently commonly used engineering measures such as stratified water intake, water pumping and aeration, the present invention has the advantages of simple operation, easy implementation, and obvious effect.

The application discloses a preparation method and application of a hollow manganese dioxide nanocarrier coated with a human umbilical cord mesenchymal stem cell membrane and a transmembrane peptide TAT, and is characterized in that: hollow mesoporous manganese dioxide is synthesized through a selective etching technology, and a layer of human umbilical cord mesenchymal stem cell membrane is coated outside the manganese dioxide through a repeated extrusion method. Since the cell membrane has special tumor homing characteristics, and lacks major histocompatibility complex-II and only expresses major histocompatibility complex-I in a trace amount, the key scientific problems and difficulties such as low biological safety, strong immunogenicity and easy elimination by the body of artificially synthesized nanomaterials can be effectively solved. Finally, the cell membrane surface is modified with the transmembrane peptide TAT through a phospholipid insertion method, precise subcellular localization-nucleus targeting is realized, and tumor cells can be more effectively killed.

The invention discloses bionic MOFs of red blood cells as well as a preparation method and application of the bionic MOFs, and belongs to the technical field of biological materials. Comprising drug-loaded MOFs and an erythrocyte membrane layer coated outside the MOFs, the MOFs is selected from the group consisting of UiO-66-NH2; the UiO-66-NH2 is a particle formed by connecting an amino functional group to UiO-66; a dual epigenetic drug is loaded in the drug-loaded MOFs; and the dual epigenetic drugs are CM272 and MA. By targeting three epigenetic modifications and simultaneously regulating and controlling DNA methylation, histone methylation and RNA methylation in leukemia cells, the immune response aiming at acute myelogenous leukemia is enhanced, the hypoxia microenvironment of leukemia is overcome by using the bionic MOFs particles, the therapeutic activity of the loaded medicine is enhanced, and the application prospect is broad. And inducing death of leukemia cells and leukemia cell mesenchymal stem cells.

The invention discloses preparation and application of a novel ultrasonic-driven nano-enzyme MOF (Hf)-Pt, the novel piezoelectric nano-enzyme MOF (Hf)-Pt is composed of UIO-66-NH2 (Hf) and an ultra-small Pt nano-enzyme and presents a regular octahedron shape, and the diameter of the novel piezoelectric nano-enzyme MOF (Hf)-Pt is 180-200 nm; the piezoelectric effect is achieved, external ultrasonic stimulation is utilized, and variable electrical stimulation is provided through piezoelectric catalysis; in addition, the composite material has the advantages of being small in size and easy to prepare, has catalase-like activity and superoxide dismutase activity at the same time, and has good biocompatibility. The MOF (Hf)-Pt is used as a novel piezoelectric catalyst, and the technical effect of treating OA is achieved by improving the enzyme catalytic activity of the nano-enzyme, relieving oxygen deficit of an inflammation part, recovering the mitochondrial function, removing excessive ROS in an inflammation tissue and promoting cartilage regeneration through the piezoelectric effect.

The utility model belongs to the technical field of cultivation, and particularly relates to an oxygenation equipment fixing device which comprises a device rack. A plurality of groups of cutting grooves are formed in the side wall of the device rack; springs are fixedly connected to the side walls of the cutting grooves in the two sides. The end part of the spring is fixedly connected with a connecting block; a first connecting plate is placed on the lower connecting block; the first connecting plates slide up and down on the corresponding cutting grooves; the bottom of the first connecting plate is fixedly connected with a motor; the output end of the motor is fixedly connected with a first connecting rod; multiple groups of impellers are fixedly connected to the middle of the first connecting rod; the bottom of the first connecting plate is fixedly connected with multiple groups of buoys; by arranging a cutting groove, a spring and a connecting block, the damage of a motor and an impeller caused by rollover caused by shaking of a first connecting plate is reduced, and meanwhile the situations that the impeller cannot work normally due to rollover of the first connecting plate, the oxygenation effect of oxygenation equipment is reduced, aquatic organisms are affected by oxygen deficit, and the service life of the aquatic organisms is prolonged are reduced. And even death can be caused in severe cases.

The present invention belongs to the field of tumor immunotherapy, and specifically relates to a nano-immunomodulator F@PDA@I and its application in tumor immunotherapy, wherein the nano-immunomodulator integrates the activities of superoxide dismutase (SOD), catalase (CAT), peroxidase (POD) and glutathione oxidase (GSHOx). Photodynamic therapy (PDT) and photothermal therapy (PTT) are used to achieve tumor immunotherapy. The multi-enzyme-like activity not only contributes to the generation of oxygen to relieve hypoxia and promotes the polarization of M2 to M1 macrophages, but also consumes GSH in the TME to promote PDT and induce ferroptosis. As a result, a large amount of necrotic debris is released, which ultimately promotes the maturation of dendritic cells and the infiltration of cytotoxic T lymphocytes, thereby reversing the immunosuppressive TME. In in vivo experiments, F@PDA@I is combined with a Toll-like receptor agonist for synergistic immunotherapy against primary and distal tumors.

This invention discloses a metal thin-film capacitive vacuum gauge, comprising: a vacuum gauge body with a connector; the connector having a protection mechanism and a cleaning mechanism; the protection mechanism including: a housing, an inflation sealing assembly, a negative pressure suction assembly, an elastic reset assembly, and a stroke linkage transmission mechanism; the housing having an inflation chamber and a suction chamber; the inflation sealing assembly including a sealing airbag, an inflation piston slidably disposed in the inflation chamber, and an inflation pipe connecting the sealing airbag and the inflation chamber; the negative pressure suction assembly including a suction piston slidably disposed in the suction chamber, and an air inlet pipe connecting the inside of the connector and the suction chamber; the stroke linkage transmission mechanism connecting the inflation sealing assembly, the negative pressure suction assembly, and the elastic reset assembly; the cleaning mechanism including: a storage drive unit, a cleaning component, and a conveying unit; the cleaning mechanism and the stroke linkage transmission mechanism are linked and cooperate. This application can achieve effective protection of the connector, improve signal transmission stability and measurement accuracy, and simplify and reduce maintenance costs.

The present invention relates to the use of JWA polypeptide in the preparation of an anti-tumor drug synergist. The amino acid sequence of the polypeptide is shown in I or II: I: FPGSDRF-Z; II: X-FPGSDRF-Z; wherein the amino acid S is phosphorylated, X and Z are amino acids or amino acid sequences respectively; X is selected from one of F, (R)9, (R)9-F, 6-aminocaproic acid, 6-aminocaproic acid-F, 6-aminocaproic acid-(R)9, and 6-aminocaproic acid-(R)9-F; and Z is selected from one of (G) n ‑RGD, A‑(G) n ‑RGD, n is an integer greater than or equal to 0, and the value range of n is 0-10. The above polypeptide can improve the hypoxia state of the tumor microenvironment, promote the normalization of tumor blood vessels to inhibit the initiation and occurrence of tumor metastasis, increase the effective perfusion of drugs in the tumor, and can be used as an anti-tumor drug synergist to provide new clinical drug possibilities for the treatment of tumors.

The invention discloses a liposome composite material for enhancing breast cancer radioimmunotherapy as well as a preparation method and application of the liposome composite material. The liposome composite material is prepared by encapsulating RudZ and MnB in a lipid phase and a water phase through folic acid (FA) modified liposome (Lipo), wherein MnB refers to MnO2 nanoparticles, RudZ refers to cis-[Ru (DIP) 2dppz] < 2 + > Cl2, and the structural formula of the RudZ is as follows: # imgabs0 #. The RuII-MnIV-based liposome composite material has the advantages that under the combined irradiation of 4Gy X-rays, the RudZ is Cis-[Ru (DIP) 2dppz] < 2 + > Cl2; according to the present invention, active breast cancer targeting, fluorescence imaging tracing, active oxygen generation promotion, tumor microenvironment oxygen deficit relieving, mitochondrial DNA release caused by mitochondrial injury, and cell cycle G2 / M period retardation can be achieved, and the cGAS-STING immune signal channel can be double activated in cooperation with Mn < 2 + > release, such that the liposome composite material has the breast cancer radioimmunotherapy effect enhancing function.

The utility model discloses a matrix flowerpot for family gardening, which relates to the field of flowerpots and comprises a pot body, an annular water cavity is arranged in the side wall of the pot body and is positioned at the top of the pot body, and a plurality of uniformly distributed water outlet holes are arranged on the inner side wall of the pot body and correspond to the annular water cavity. L-shaped water inlet pipes are fixedly arranged at the positions, corresponding to the annular water cavity, of the two sides of the pot body. A base is arranged at the bottom of the pot body, a plurality of evenly-distributed stand columns are fixedly arranged between the base and the bottom of the pot body, an electric push rod is fixedly arranged at the top of the base, a fixing disc is fixedly arranged at the moving end of the electric push rod, a plurality of soil loosening rods are fixedly arranged on the upper surface of the fixing disc, and the upper ends of the soil loosening rods extend into the pot body. Through the slow flow watering structure and the automatic soil loosening mechanism, hardening inducements are reduced from the source, dynamic loosening of the matrix is achieved, and an efficient and worry-free matrix management solution is provided for family gardening.

A pillowing device for a gastroscope comprises a back cushion which is an L-shaped cushion body and comprises a lower jaw supporting part and a rear neck leaning part which are connected with each other; wherein the rear neck leaning part forms a vertical edge of the L-shaped pillow body; and the lower jaw supporting part forms the transverse edge of the L-shaped pillow body. The lower jaw of a patient can be supported in the operation process of the painless gastroscope, so that bucking is reduced, the airway of the patient is helped to be in a continuous open state, and the situation of oxygen deficit of the patient is reduced.

The utility model relates to the technical field of water conservancy emergency equipment, specifically discloses a bubble disturbance type ice melting device based on unmanned ship platform, including bubble ice melting device, temperature monitoring module and total control module, and temperature monitoring module is composed of temperature sensor fixed in the lower part of sand head air disc. The utility model discloses bubble ice melting device and temperature sensor cooperate with each other, utilize temperature sensor real -time mobile type monitoring river and lake temperature before the operation of bubble ice melting device, send data to total control module, utilize total control module to carry out unified control to bubble ice melting device, when temperature is lower than set threshold value, total controller starts bubble ice melting device, forms bubble group, and a large number of bubbles contact ice layer and collapse rapidly, and the impact and the disturbance to the water flow of generation make ice layer melt. The utility model discloses a bubble disturbance type ice melting device based on unmanned ship platform, which solves the problem of deterioration of water conservancy building structure caused by rapid freezing weather in existing rivers and lakes.

The application discloses a kind of tannin-based Mn-Fe diatomic metal polyphenol nano-carrier loaded hypocrellin B nano-assemblies and its preparation method and application.The nano-assemblies use tannin as ligand, by step coordination driven self-assembly strategy, first with Mn 2+ Forming pre-assembly template, then introducing Fe 3+ Constructing Mn-Fe diatomic metal polyphenol network with atomic level uniform dispersion, and loading traditional Chinese medicine source photosensitizer hypocrellin B to obtain nano-preparation.The preparation realizes Fe 2+ / Fe 3+ Self-circulation, and can sustainably catalyze H2O2 in tumor microenvironment to generate hydroxyl radical, realizes long-acting chemical kinetics treatment;Meanwhile, in-situ oxygen production relieves tumor hypoxia, improves photodynamic therapy effect, and consumes glutathione to amplify oxidative stress.The preparation process of the application is mild, and biocompatibility is good, and it breaks through the bottleneck of insufficient effect of traditional treatment in anoxic tumor.

The application discloses a microwave-responsive hydrogel dressing and application thereof in preparation of an anti-diabetic chronic infection wound preparation. The raw material of the hydrogel dressing disclosed by the application comprises: (A) a hydrogel matrix; (B) glucose oxidase; (C) a nano-enzyme composition, wherein the nano-enzyme composition at least comprises a luteolin-manganese dioxide composite; wherein the luteolin-manganese dioxide composite is a solid-phase product obtained by wet blending of luteolin and nano-manganese dioxide. Under microwave irradiation, the heat effect generated by the microwave causes the hydrogel dressing to heat up, the heat-enhanced glucose oxidase consumes glucose to generate hydrogen peroxide, and at the same time, the heat-enhanced luteolin-manganese dioxide composite decomposes the hydrogen peroxide to generate oxygen, thereby simultaneously relieving high glucose and hypoxia, fundamentally breaking the vicious cycle of "high glucose-hypoxia-infection-chronic inflammation" of the diabetic wound, and finally improving the antibacterial effect on the skin wound.

This invention relates to the field of targeted drug delivery systems, specifically to a glutathione-responsive iron-based nanozyme for anti-atherosclerosis, its preparation method, and its application. The iron-based nanozyme prepared by this invention uses iron oxide nanoparticles as the core, a glutathione-responsive delivery carrier as the intermediate layer, and cationic lipids and platelet membranes as the outer shell. It can effectively escape lysosomes and, in response to the action of glutathione, release the encapsulated iron oxide nanoparticles. In the cytoplasmic environment, it exerts CAT-like enzyme activity, reduces reactive oxygen species levels, and the generated oxygen can alleviate hypoxia in atherosclerotic plaques, thus helping to reduce plaque inflammation, improve plaque stability, and has a positive therapeutic effect on atherosclerosis.

The application discloses a preparation method of a multifunctional nano drug of Fe-based MOF loaded CM-272, and relates to a preparation method of an anti-cancer nano drug.The application aims at solving the problem that the CM-272 action is limited due to the internal hypoxic environment of a tumor.Method: I, preparing a Fe-based metal organic framework;II, preparing a MIL-53@CM-272 nano drug.The application is used for the preparation of the multifunctional nano drug of the Fe-based MOF loaded CM-272.

This utility model relates to the field of aquaculture technology, specifically an escape-proof leech farming cage. It includes a cage body with an opening and escape-proof door at the top. The cage body is fitted inside an outer frame, which includes multiple side rods and several connectors. A cleaning assembly is provided on the outer frame, comprising four movable sleeves. A brush plate is positioned between adjacent side rods, and several bristles are inserted into the inner surface of the brush plate, with the ends of the bristles adhering to the outer surface of the cage body. This escape-proof leech farming cage, through the cleaning assembly, allows the movable sleeves to slide along the side rods, causing the brush plate and bristles to move against the outer surface of the cage body, effectively cleaning attached suspended matter, preventing mesh blockage, maintaining water circulation within the cage, and reducing oxygen deficiency.

The utility model relates to the technical field of breeding pond cleaning, disclose a kind of aquaculture pond cleaning equipment, including support seat, the top of support seat is fixedly connected with pond body, the inside bottom wall of pond body is fixedly connected with conical disc, the inside of conical disc is connected with connecting column, the top of connecting column is fixedly connected with top ring, the inside of support seat is provided with motor, the output of motor is fixedly connected with rotating rod.The utility model is provided with connecting column, motor, rotating rod, can solve the problem that the pollution residue on the bottom and the wall of pond, long-term accumulation can influence breeding environment, the influence of equipment to aquatic organism can be reduced, by the first scraper adheres to the circumferential motion of conical disc surface, push the dirt on the bottom to edge, to effectively shorten cleaning time, ensure that cleaning effect is more uniform, avoid omission and reduce the demand of manual operation, promote the healthy growth of aquatic organism.

According to the oxygen concentration detection circuit and method, an optical oxygen sensor is adopted for oxygen concentration detection, a peripheral complex circuit is not needed, the concentration detection range is large, the precision is high, alarm signals correspond to different oxygen-containing states, a worker can know the approximate oxygen-containing condition at the first time according to an alarm, and the detection accuracy is high. Pretreatment can be carried out, further deterioration of the state is prevented, and oxygen deficit and explosion risks are reduced.

This invention belongs to the field of nanomaterials technology, and more specifically, relates to indocyanine green-stabilized CuET nanoparticles, a nanoparticle dispersion, a preparation method thereof, and its applications. The indocyanine green-stabilized CuET nanoparticles provided by this invention are nanoparticles formed by stabilizing CuET nanocrystals with indocyanine green, wherein indocyanine green binds to and stabilizes the CuET nanocrystals through hydrophobic interactions, forming the indocyanine green-stabilized CuET nanoparticles. The indocyanine green-stabilized CuET nanoparticles provided by this invention can improve the water solubility and serum stability of CuET, facilitating intravenous administration of CuET. Furthermore, the indocyanine green-stabilized CuET nanoparticles provided by this invention can disrupt mitochondrial function of tumor cells, inhibit tumor cell respiration, improve hypoxia at the tumor site, and enhance the photodynamic antitumor therapeutic effect mediated by indocyanine green.

The invention discloses a preparation method of an artificial peroxisome LOX-Ce6-Mn and an application of the artificial peroxisome LOX-Ce6-Mn. Belongs to the technical field of nano materials and tumor treatment, and is prepared by the following steps: uniformly mixing prepared DCC, NHS, Ce6 and LOX in proportion, reacting, dialyzing by using a dialysis bag, adding an aqueous solution of MnCl2, adjusting the pH value, dialyzing, and drying to obtain the LCM nanoparticles. The lactate oxidase activity, the OXD activity, the POD activity and the CAT activity of the LCM nanoparticles can form a cascade reaction to cause tumor cells to generate efficient active oxygen and consume lactic acid and glutathione in the tumor, so that autophagy and apoptosis of the tumor cells occur; in addition, H2O2 generated through LOX catalysis can be converted into high-toxicity hydroxyl free radicals through Mn < 2 + > mediated Fenton-like reaction, and oxidative damage of cancer cells is further amplified. The LCM nanoparticles have tumor specificity for killing tumor cells, can be effectively accumulated at tumor parts, have a weak killing effect on normal parts, and have good biocompatibility.

The invention relates to a biological oxygen therapy and antioxidation dual-strategy soluble microneedle as well as a preparation method and application thereof, and belongs to the technical field of medicines. The microneedle is an integrated soluble microneedle and comprises a matrix formed by a water-soluble polymer and a compound which is uniformly dispersed in the matrix and formed by microalgae and metal organic framework nano-enzyme, the compound formed by the microalgae and the metal organic framework nano-enzyme is a compound of a'core-shell 'structure, the metal organic framework nano-enzyme serving as the shell is wrapped on the surface of the microalgae serving as the core. The microneedle disclosed by the invention has the capability of rapidly resisting oxidation in situ and continuously and deeply conveying oxygen, is widely applied to preparation of medicine design or preparations for treating tumors, promoting wound healing, regulating an inflammation microenvironment, treating skin burns and scalds and removing scars, and is good in patient applicability; and the preparation process is green, environment-friendly, simple, rapid, mild in condition and suitable for large-scale production.

The application discloses a kind of red blood cell biomimetic MOFs and its preparation method and application, belong to biomaterial technical field. Including drug-loaded MOFs and the red blood cell membrane layer coated outside MOFs;The MOFs are selected from UiO-66-NH2;The UiO-66-NH2 is the microparticle that amino functional group is connected on UiO-66;The drug-loaded MOFs are loaded with double apparent genetic drugs;The double apparent genetic drugs are CM272 and MA. By targeting three kinds of epigenetic modification, simultaneously control DNA methylation in leukemia cell, histone methylation and RNA methylation to enhance the immune response to acute myeloid leukemia, and utilize biomimetic MOFs microparticle to overcome the hypoxic microenvironment of leukemia, enhance the therapeutic activity of loaded drug, and induce leukemia cell and leukemia cell mesenchymal stem cell death.

The application provides a synergistic hair growth microneedle based on active oxygen scavenging and nitric oxide delivery and a preparation method thereof. The hair growth microneedle comprises a substrate layer and a plurality of microneedles arranged on the substrate layer, and at least comprises: an active oxygen scavenging component arranged on a needle root part of the microneedle, which is used for scavenging excessive active oxygen under a pathological oxidative environment around a hair follicle; a nitric oxide delivery component arranged on a needle tip part of the microneedle, which is used for continuously releasing nitric oxide after the microneedle is inserted into the skin; a mass ratio of the active oxygen scavenging component to the nitric oxide delivery component is (0.01-10):1; and the active oxygen scavenging component and the nitric oxide delivery component in the microneedle have a synergistic effect.