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High-purity ceftizoxime sodium and preparation thereof

A technology of ceftizoxime and ceftizoxime acid, which is applied in the field of medicine, can solve the problems affecting the application of ceftizoxime or its salt, large side effects, poor stability, etc., and achieve the effects of low cost, improved stability, and improved solubility

Inactive Publication Date: 2009-01-21
HAINAN LINGKANG PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Most ceftizoxime sodium raw materials have problems such as low purity, poor clarity after dissolution, poor stability in aqueous solution, and relatively large side effects.
Thereby, have had a strong impact on the application of ceftizoxime or its salt

Method used

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  • High-purity ceftizoxime sodium and preparation thereof
  • High-purity ceftizoxime sodium and preparation thereof
  • High-purity ceftizoxime sodium and preparation thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] (1) Dissolve 500 g of ceftizoxime sodium crude product in 2 L of purified water, add sulfuric acid to adjust the pH value to 4;

[0044] (2) Extract with 6L n-butanol, separate the organic phase, flow the organic phase through anhydrous magnesium sulfate column for dehydration, then concentrate under reduced pressure to dryness, and get the column product;

[0045] (3) After suspending 20 kg of 800-mesh alumina with activity level II with n-hexane, remove air bubbles, evenly add it to a glass chromatography column with an effective column length of 400 cm and an internal diameter of 20 cm, and concentrate the above-mentioned ceftizole to dryness Add oxime sodium crude product to dissolve in 800ml eluent (cycloheptane and chloroform volume ratio are 1: 7), filter out the insoluble matter, put it on the column head with plunger type solvent pump, then pump into eluent (cycloheptane Alkanes and chloroform (volume ratio is 1: 7) elution, column pressure is 3MPa, collect fra...

Embodiment 2

[0050] (1) Take 800g of ceftizoxime sodium crude product and dissolve it in 3L of purified water, add phosphoric acid to adjust the pH value to 3;

[0051] (2) Extract with 10L cyclooctane, separate the organic phase, flow the organic phase through an anhydrous calcium chloride column for dehydration, then concentrate under reduced pressure to dryness to obtain a column product;

[0052] (3) After suspending 10 kg of 100-mesh aluminum oxide with activity level II with n-hexane, remove air bubbles, and evenly add it to a glass chromatography column with an effective column length of 200 cm and an internal diameter of 10 cm, and the above-mentioned concentrated to dry ceftizoxime Add 1000ml of eluent (volume ratio of 1-nonene to 1,2-dichloroethane is 1:4) to dissolve the crude sodium product, filter out the insoluble matter, put it on the column head with a plunger solvent pump, and then pump it into the eluent (1-nonene to 1,2-dichloroethane volume ratio is 1:4), the column pre...

Embodiment 3

[0057] (1) Dissolve 600g of ceftizoxime sodium crude product in 2L of purified water, add hydrochloric acid to adjust the pH value to 2.5;

[0058] (2) Extract three times with 5L chloroform, separate the organic phase, flow the organic phase through an anhydrous sodium sulfate column for dehydration, and then concentrate under reduced pressure to dryness to obtain a column product;

[0059] (3) After suspending 5kg of 50-mesh alumina with activity level II with n-hexane, remove air bubbles, and evenly add it to a glass chromatography column with an effective column length of 20cm and an internal diameter of 5cm, and the above-mentioned concentrated to dry ceftizoxime Add 600ml of eluent (normal hexane to dichloromethane volume ratio is 1:10) to dissolve the sodium crude product, filter out the insoluble matter and put it on the column head with a plunger solvent pump, then pump in the eluent (normal hexane and dichloromethane Methane (volume ratio: 1:10) was eluted, column pr...

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Abstract

The invention provides a method for preparing high purity ceftizoxime or a ceftizoxime salt, a method for preparing a powder-injection of ceftizoxime or the ceftizoxime salt, and high purity ceftizoxime or ceftizoxime salt and corresponding powder-injections prepared according the methods.

Description

technical field [0001] The invention provides a method for preparing high-purity ceftizoxime or its salt, a method for preparing ceftizoxime or its salt powder injection, and the high-purity ceftizoxime or its salt and corresponding powder injection prepared according to the method , belonging to the field of medical technology. Background technique [0002] Ceftizoxime, English name: Ceftizoxime, molecular formula: C 13 h 13 N 5 o 5 S 2 , the chemical name is: 7-[2-methoxyimino-2-(2-amino-1,3-thiazol-4-yl)-acetylamino]-3-cephem-4-carboxylic acid, belonging to the third Substitute cephalosporin, with broad-spectrum antibacterial effect, stable to broad-spectrum lactamase (including penicillinase and cephalosporinase) produced by various Gram-positive and Gram-negative bacteria. This product has a strong antibacterial effect on Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis and other Enterobacteriaceae bacteria. Pseudomonas such as Pseudomonas aeruginosa and...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D501/22A61K31/546A61K9/14A61P31/04
Inventor 陶灵刚
Owner HAINAN LINGKANG PHARMA CO LTD
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