93results about How to "Compliance" patented technology

The invention offers 3', 4', 7-troxerutin synthetic method. It uses rutin and ethylene oxide to do hydroxyethylation reaction under the catalyzing of sodium hydroxide. Its features are that in the reaction, the weight ratio of rutin and water is 1:1-1:3; optimization is 1:1-1:1.5; the weight ratio of rutin and sodium hydroxide is 100:0.82-100:0.85; adding resin when the pH value of the reaction solution is 9.0-9.5 to adjust end point pH value to 9.5-10.3. The method can make high purity and high quality troxerutin. And its 3', 4', 7-troxerutin content is more than 78%; optimization is more than 80%; and the more optimization is more than 85%.

The present invention discloses a composite Chinese medicine preparation for treating type-II diabetes, and the medicine preparation is prepared by using Radix Puerariae, trichosanthes root, atractylodes rhizome, scrophularia root, Astragalus membranaceus and other over 20 Chinese medicinal materials and through crushing, decoction, stoving, disinfecting and other steps. It can be in pill, medicine powder and other forms. The present invention has unique recipe, low cost and obvious curative effect.

The invention relates to an environmentally-friendly ultralight flame-retardant rubber sole material and a manufacturing method thereof, and particularly relates to a manufacturing method of footwear product soles with high requirements on light weight and flame retardant property. The environmentally-friendly ultralight flame-retardant rubber sole material comprises chlorosulfonated polyethylene rubbers, a reinforcing agent, an active agent, a plasticizer, a foaming agent, a synergistic foaming agent, a flame retardant, a synergistic flame retardant, a vulcanizing agent and a vulcanization accelerator. According to the invention, through the screening and optimization of a series of formulas of the reinforcing agent, the plasticizer, the vulcanizing agent, the foaming agent, the synergistic foaming agent and the synergistic flame retardant, an ultralight flame-retardant sole material with a relative density of 0.3-0.5 g / cm3 is prepared, wherein in a flame retardant property test, the limit oxygen index of the sole material is greater than or equal to 34.5%, and the UL-94 reaches level V-a. The material has the following advantages: soles are lighter in weight and excellent in flame retardant property, and abandoned soles do not release toxic nitrosamine, polybrominated dibenzo-p-dioxins (PBDD) and polybrominated diphenyl furans (PBDF) in the process of burning.

The invention relates to the technical field of analytical chemistry and discloses a method for detecting afatinib dimaleate isomer and main degradation impurities through a high performance liquid chromatography.According to the method, afatinib dimaleate raw materials or preparations are compounded into a detection solution with diluent, bonding amylose-trichlorobenzene carbamic acid ester serves as a stationary phase, a normal hexane-ethanol-organic base solution serves as a mobile phase for isocratic elution, and an HPLC spectrogram is recorded under afatinib absorption wavelength.According to the method, a chromatographic column with trichlorobenzene carbamic acid ester serving as a filling material, the normal hexane-ethanol-organic base solution serves as the mobile phase, the content of isomers existing in afatinib dimaleate and preparations thereof can be measured quantitatively, afatinib, the isomers and the main impurities can be separated completely, the peak pattern is good, the method meets the specifications in Chinese Pharmacopoeia, quality of afatinib dimaleate and afatinib dimaleate preparation products is effectively controlled, and the method is great in specificity, high in sensitivity and good in accuracy.

The invention discloses a novel synthetic method of a CDK-4 / 6 inhibitor. The method comprises the steps of mixing 1:2,4-dichloro, 5-acetyl pyrimidine and alkali in a solvent, reacting and carrying out crystallization and suction filtration to obtain a compound 2-chloro-4-cyclopentylamine-5-acetyl pyrimidine; dissolving fructone into anhydrous tetrahydrofuran, and performing recrystallization with ethyl acetate to obtain a compound 4,6-acetyl-2-chloro-8-cyclopentyl-5-methylpyridine (2,3-d) pyrimidino-7(8H)-ketone; mixing the 4,6-acetyl-2-chloro-8-cyclopentyl-5-methylpyridine (2,3-d) pyrimidino-7(8H)-ketone with alkali and a compound 5 tert-butyl4-(6-aminopyridine-3-yl) piperazine-1-carboxyl tert-butyl ester in DMF, methylbenzene and dimethylsulfoxide, heating and reacting to obtain a compound 6 4-(6-(8-cyclopentyl-5-methyl-6-(2-methyl-1,3-dioxolame-2-yl)-7-oxo-7,8-dihydropyridino-(2,3-d) pyrimidine-2-yl) amino) pyridine-3-yl) piperazine-1-carboxyl tert-butyl ester; and finally, adding the compound 6 4-(6-(8-cyclopentyl-5-methyl-6-(2-methyl-1,3-dioxolame-2-yl)-7-oxo-7,8-dihydropyridino-(2,3-d) pyrimidine-2-yl) amino) pyridine-3-yl) piperazine-1-carboxyl tert-butyl ester into acid liquid, and reacting to obtain the corresponding salt of 6-acetyl-8-cyclopentyl-5-methyl-2-((5(piperazine-1-yl) pyridine-2-yl) amino) pyridino-(2,3-d) pyrimidine-7(8H)-ketone. The synthetic process is low in cost, is simple and environment-friendly and is suitable for industrial volume production.

The invention relates to the technical field of analytical chemistry and discloses a method for detecting afatinib-dimaleate-related substances through high performance liquid chromatography. According to the method, an afatinib dimaleate raw material drug or preparation is prepared into a detection solution with diluents, octadecyl silane keys and silica gel serve as fixing phases, inorganic salt buffer liquid is adopted as a flowing phase A, an organic phase serves as a flowing phase B, gradient elution is conducted, and an HPLC spectrogram is recorded under afatinib absorption wave length. According to the method, a chromatographic column with the octadecyl silane keys and silica gel serving as filler is adopted, the inorganic salt buffering liquid-organic phase for regulating the proper pH value serves as the flowing phase, the contents of related substances existing possibly of the afatinib dimaleate and a preparation thereof can be measured quantitatively, main impurities and various impurities can be completely separated, the peak pattern is good, regulations of Chinese pharmacopoeia are satisfied, the quality of the afatinib dimaleate and a preparation product containing the afatinib dimaleate is effectively controlled, and the method is high in specificity, high in sensitivity and good in accuracy.

The invention relates to a toothpaste containing Phyllanthus emblica extract, which contains abrasives, humectants, thickeners, foamers, sweeteners, flavors, a Phyllanthus emblica extract, adjuvants and deionized water, wherein the weight percentage of the Phyllanthus emblica extract in the formula is 0.1% to 50%; and the Phyllanthus emblica extract contains vitamin C, SOD-like antioxidant components and tannin chemicals (such as phy-13, PGG) or a combination thereof. The toothpaste containing the Phyllanthus emblica extract has the nursing effects of being capable of effectively relieving bad breath, killing bacteria, alleviating inflammation, soothing the throat, making teeth white quickly, keeping the gum healthy, can improve the antibacterial and anti-inflammatory capabilities of teeth, and protects the health of oral cavity. Besides, Phyllanthus emblica plays a role of a natural antiseptic.

A method for testing safety switching in protocol conformity of network terminal includes activating safety switching in certification procedure, seizing safety switching in protocol data packet generated in certification procedure, detecting and analyzing package format and protocol flow process of safety switching in protocol data packet.

Systems and methods for operating a driveline of a hybrid vehicle are presented. In one example, the systems and methods determine a driveline disconnect boost time during vehicle operating conditions when it may be less noticeable. The driveline disconnect boost time may then be used to close a driveline disconnect clutch in a way that may reduce torque disturbances through the driveline.

An adhesive condom applicable to the male sexual organ to reduce compression and thereby reduce the difficulty of attaining and maintaining erection, improve barrier protection and prevent additional sexually transmitted diseases, to improve the efficacy of contraception (if contraception is desired) and to enhance utilization rates by enhancing sensation. Optimal production geometry and practical modes of application are also described.

The present invention discloses a medicine for preventing and curing carcinoma of esophagus and carcinoma of stomach with obvious therapeutic effect. It is made up by using 13 Chinese medicinal materials of isatis leaf, ganoderma, cordyceps, saffron, coptis root and others through a certain preparation process.

The present invention discloses one kind of Chinese medicine preparation for preventing and treating tumor and its preparation process, and belongs to the field of Chinese medicine technology. The Chinese medicine preparation is prepared with 15 kinds of Chinese medicinal materials, including cinnabar, multibanded krait, leech, barbed skullcap herb, American ginseng, etc, and through sorting and washing all the Chinese medicinal materials except cinnabar, stoving in a pot at 100-120 deg.c, crushing to 120 mesh, adding cinnabar and mixing and encapsulating. It has obvious curative effect, short treating period, no toxic side effect and other advantages.

The invention belongs to the field of chemical synthesis and provides a meclofenoxatum preparation method. The meclofenoxatum is also called as meclofenoxate and is one of widely applicable central stimulants. In the meclofenoxatum preparation method, salt is obtained by esterifying by one-step method, and the process is improved by the phase transfer catalytic method. The meclofenoxatum preparation method is few in side products, mild in reaction conditions, easy to control, low in cost, easy to realize industrialization and high in production capacity and provides an environment-friendly meclofenoxatum synthesis way, raw materials are easy to obtain, and products obtained are high in purity, stable in quality and accord with pharmacopeia provision.

The invention discloses a flame retardant experimental facility for a textile flame retardant fabric. The flame retardant experimental facility for the textile flame retardant fabric comprises a combustion testing box, wherein a base is arranged at the bottom end of the inside of the combustion testing box; a vertical placement rack is arranged on one side of the upper end of the base; a first clamping rod is fixedly mounted at the lower end of the placement rack; a second clamping rod is slidably connected to the upper end of the placement rack; a fixing nut is arranged on the other side, which is close to the second clamping rod, of the placement rack; a flame retardant fabric combustion time sensor is arranged on the second clamping rod; an ignition device is arranged on the other sideof the upper end of the base; a combustion device is arranged at the other end of the ignition device; and a flame temperature sensor is arranged on the inner wall of a combustion tube. By arrangementof the combustion testing box, the base, the placement rack, the ignition device, the combustion device, the flame temperature sensor and the flame retardant fabric combustion time sensor, the problem that the traditional flame retardant experimental facility is inaccurate in experiment, complicated in operation and inconvenient to use is solved.

The invention discloses a method for producing spectinomycin hydrochloride and lincomycin hydrochloride soluble powder comprising 550g of spectinomycin hydrochloride and 450g of lincomycin hydrochloride. The method comprises the following steps: washing, sterilizing and drying of a rubber stopper; washing, drying and sterilizing of a glass bottle; preparation; capping and outer packaging, and themethod for producing the spectinomycin hydrochloride and lincomycin hydrochloride soluble powder has comprehensive therapeutic effect, high production efficiency, low production cost, simple production process and other characteristics.

A Chinese medicine for treating epilepsy is prepared from 8 Chinese-medicinal materials including turtle shell, amber, scorpion, gastrodia tuber, etc.

The invention discloses an osmotic slow-release material in an ethyl acrylate-methyl methacrylate copolymer aqueous dispersion. The osmotic slow-release material in the ethyl acrylate-methyl methacrylate copolymer aqueous dispersion comprises the following raw materials in part by weight: 90-110 parts of ethyl acrylate, 45-65 parts of methyl methacrylate, 0.2-1.2 parts of potassium persulfate or ammonium persulfate, 1-5 parts of alkylphenol ethoxylate (OP-10) and 320-410 parts of purified water. Compared with the existing coating materials at home, slow-release tablets prepared from the osmotic slow-release material in the ethyl acrylate-methyl methacrylate copolymer aqueous dispersion has the advantages of good plasticity, easiness in film formation, no addition of a plasticizer, better slow-release effect and the like; polymerized neutral copolymer dispersed particles contained in a latex solution provided by the invention have a particle diameter range of 10-1000 nm; and due to thermal convection and Brownian motion of the particles, at the room temperature, the osmotic slow-release material in the ethyl acrylate-methyl methacrylate copolymer aqueous dispersion is stable to store, non-toxic and harmless.

The invention discloses an electrical system control cabinet for large-scale road maintenance machinery. The electrical system control cabinet comprises an electrical cabinet group which comprises two single electrical cabinet bodies, namely a front control cabinet and a rear control cabinet, wherein both the front control cabinet and the rear control cabinet are the single electrical cabinet bodies for carrying out a system integration on a plurality of main operation bodies into a whole; each of the front control cabinet and the rear control cabinet comprises a video cabinet, a brake cabinet, a walking cabinet and a data printing branch cabinet; each video cabinet is provided with a display, and can carry out real-time monitoring on an operation of the road maintenance machinery; each brake cabinet can control braking of the road maintenance machinery; each walking cabinet can control walking of the road maintenance machinery; each data printing branch cabinet is provided with a data printer and can print daily operation real-time data of the road maintenance machinery; the front control cabinet is also provided with an operation cabinet which is used for controlling the operation of the road maintenance machinery; and an operation platform is arranged on the rear control cabinet instead of the operation cabinet.

The invention relates to a pharmaceutical composition for preventing and treating lung carcinoma and process for preparation, wherein the composition is prepared from the following raw materials (by weight portion): apricot kernel 20-40, root of balloonflower 20-50, safflower 20-50, licorice root 10-30, coptis root 30-60, bletilla striata 30-70, crystal sugar 150-300, snow pear 1000-2000, dyers woad leaf 20-60, honeysuckle flower 20-50.

Belonging to the field of pharmaceutical preparation, the invention relates to cefazedone sodium frozen powder injection which comprises 45-90% of cefazedone, 5-52% of excipient, 0.02-5% of antioxygen; wherein the excipient is composed of one or more of mannitol, sorbic alcohol or lactose, the antioxygen is composed of one or more of arginine, cysteine hydrochloride or glutathione. The cefazedone sodium frozen powder injection features stable physical and chemical properties, controllable quality; in addition, polymer impurities of the cefazedone sodium frozen powder injection are obviously reduced in the process of storage, thus improving safety of using the injection.

The invention discloses a cefuroxime sodium 3 / 4-hydrate compound and a preparation method. Each mole of cefuroxime sodium 3 / 4-hydrate compound contains 3 / 4 mol of water. The cefuroxime sodium 3 / 4-hydrate compound prepared by using the method is high in stability and meets requirements for raw materials of preparations.

The invention provides a method for synthesizing 3', 4', 7-trihydroxyethyl rutin, which uses rutin and ethylene oxide to carry out hydroxyethylation reaction under the condition of sodium hydroxide as a catalyst, It is characterized in that, in the hydroxyethylation reaction, the weight ratio of rutin to water is 1:1 to 1:3, preferably 1:1 to 1:1.5; the weight ratio of rutin to sodium hydroxide is 100:0.82 ~100: 0.85; Another feature of the present invention is that when the pH value of the reaction solution is 9.0~9.5, add resin; adjust the pH value of the end point of the reaction solution by using the resin to be 9.5~10.3. The method of the present invention can prepare high-purity and high-quality troxerutin products, and the 3', 4', and 7-trihydroxyethylrutin content in the troxerutin crude product prepared by the method of the present invention can be obtained by using The HPLC test is greater than 78%, preferably greater than 80%, more preferably greater than 85%.

The invention discloses a coal mine tunnel rock wall deformation monitoring device. According to the device,a water storage cylinder is communicated with a warning cylinder through a water storage channel, a pure mechanical structure and liquid medium conduction are formed in a matched mode, electric driving is not needed; underground anti-explosion equipment regulations are met; the mechanical structure and the liquid medium conduction are unlikely to be damaged due to the influence of by downhole environment, so that the deformation monitoring device has a long service life. The deformation monitoring device is characterized in that: one ends of two vertical rods are arranged at the two ends of a semicircular rod respectively and communicated with the interior of the semicircular rod; and the other ends of the vertical rods are bent towards the interior of the semicircular plate to form bent parts; the interiors of the bent parts and the interior of the semicircular rod are matched to form a water storage channel; the two ends of a supporting rod are arranged on the semicircular rod and are close to the two ends of the semicircular rods respectively; multiple fixing pipes are arranged on the semicircular rod at equal angles and located on the inner side of the semicircular rod.

The invention discloses a cefuroxime sodium compound containing 1 / 2 of water. Each mole of cefuroxime sodium contains 1 / 2 mole of water. The cefuroxime sodium compound containing 1 / 2 of water preparedby the method has the significant advantages of having good thermal stability and good mobility and not absorbing moisture easily, and meets the requirements for serving as a preparation raw material.

The invention discloses an eye drop for treating xerophthalmus and a preparation method. The eye drop is prepared from the following raw materials and auxiliary materials in parts by weight: 130-170 parts of an extract containing bear gall powder, 1.5-3.3 parts of borneol, 1-2 parts of a bacteriostatic agent, 6-10 parts of a solubilizer, 40 parts of sodium borate and 10 parts of boric acid. According to the physical and chemical properties of chemical components contained in the medicinal material in the formula, use of volatile oil is removed; the dosage of the borneol and the bear gall powder is adjusted; the borneol and the bear gall powder are added in different manners; muddy opalescence and the like caused by a conventional bear gall powder adding method are reduced; the medicinal composition is ensured; meanwhile, the preparation directly acts on the medication part; the dosage is greatly reduced; the onset time of the medicine is quickened; and the curative effect is improved.

The invention discloses a traditional Chinese medicine preparation for treating novel coronavirus and viral diseases and a preparation method. The traditional Chinese medicine preparation is at leastprepared from the following traditional Chinese medicine raw materials: roasted ephedra, almonds, honeysuckle, gypsum, ginger, rhizoma atractylodis, oldenlandia diffusa, fructus aurantii, poria cocos,Chinese date, medicated leaven, divaricate saposhnikovia root, rheum officinale, cassia twig, platycodon grandiflorum, ligusticum wallichii, herba schizonepetae, bighead atractylodes rhizome and honey-fried licorice root. The traditional Chinese medicine preparation is reasonable in compatibility, conforms to pharmacopeia provisions, is a pure traditional Chinese medicine prescription, has the effects of eliminating evil, nourishing the stomach and not injuring the stomach, has no side effect, treats both symptoms and root causes, has a good curative effect on initial, middle and suspected patients with the novel coronavirus, has a clinical effective cure rate as high as 98%, meanwhile can prevent the novel coronavirus, has a good curative effect on treating epidemic viral infectious diseases, and has an effective cure rate as high as 98%. The prescription is convenient to take, free of peculiar smell and convenient to apply and popularize.

The invention belongs to the technical field of silicon dioxide, and particularly relates to low-RDA friction type silicon dioxide and a preparation method thereof. According to the method, a sodium silicate solution with the modulus of 3 and the concentration of 0.71-0.77 mol / L is adopted for reaction, neutralization reaction is carried out by dropwise adding alkali into acid, and a silane coupling agent KH570 is added in the process, so that the low-RDA friction type silicon dioxide is prepared. The copper consumption value of the prepared friction type silicon dioxide in 15% dispersion liquid of sorbitol with the concentration of 70% can be as low as 1.2 mg in 10000 times of brushing and grinding, the RDA value is 120-130, the water absorption capacity is 12-16 mL / 20 g, the oil absorption value is 86-101 mL / 100 g, the apparent density is 0.47-0.51 g / mL, and the friction capacity of the silicon dioxide is reduced. A toothpaste prepared from the silicon dioxide provided by the invention is suitable for the elderly, children and other people with weak dentin.

The invention provides a Chinese traditional medicine composition for treating diarrhea and a method for preparing a medicament from the Chinese traditional medicine composition. The Chinese traditional medicine composition for treating diarrhea, which is provided by the invention, comprises the following active components in parts by weight: 0.5-1.5 parts of common jujube bark, 0.3-1 part of poppy shell, 0.5-1.5 parts of dark plum, 0.5-3 parts of orange peel, 0.3-1 part of plantain seed and 0.3-1 part of costus root. The method for preparing the medicament from the Chinese traditional medicine composition for treating diarrhea, which is provided by the invention, comprises the following steps of: frying the poppy shell to be yellow by using table vinegar, and grinding the poppy shell into fine powder; directly grinding the other components into fine powder; and mixing the components which are ground into the fine powder together to prepare the medicament. The Chinese traditional medicine composition provided by the invention can be decocted in water to be taken and can also be directly taken after being ground, and the medicament can be directly taken. In the invention, more than 20000 diarrhea patients with the age of 8 months to 65 years are clinically observed through more than 40 years, and the total effective rate reaches 95%.

The invention discloses an automatic reclosing drive mechanism including a transmission turbine, an output gear, an output main shaft, a releasing linkage and a circuit board having a central control circuit; the transmission turbine is provided with a cam engaging part, a turbine driven part, a gear driving part, and a starwheel part; the outer peripheral wall of the starwheel part is provided with a toggle boss; the circuit board is provided with a circular through hole and a blade switch assembly; the circular through hole and the transmission turbine are arranged concentrically, the toggle boss is arranged in the circular through hole; the blade switch assembly comprises a first stationary blade, a first moving blade, a second stationary blade, a second moving blade and a fourth stationary blade which are arranged successively around the circular through hole clockwise; the first moving blade can be toggled by the toggle boss to be electrically connected to the first stationary blade or the second stationary blade; the second moving blade may be toggled by the toggle boss so as to be electrically connected to the fourth stationary blade. The automatic reclosing drive mechanism can simplify electric control operation and improves reliability.