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The application belongs to the technical field of compound synthesis, and particularly relates to a preparation method of dipyrone with controlled content of 4-N methylene sulfonic acid sodium dipyrone impurity, which comprises the following steps: dissolving 4-formylaminoantipyrine in water, and then adding dimethyl sulfate and lye to react to obtain a methylation liquor; the obtained methylation liquor is hydrolyzed and neutralized, and then is left to stand and separate into layers, the upper 4-methylaminoantipyrine oil is cooled and crystallized to obtain 4-methylaminoantipyrine solid; the obtained 4-methylaminoantipyrine solid, ethanol, sodium pyrosulfite, activated carbon and formaldehyde are mixed to react to obtain dipyrone; the mass percentage of 4-aminoantipyrine in the 4-formylaminoantipyrine is not more than 1.5%. The content of 4-N methylene sulfonic acid sodium dipyrone (unknown impurity) in the prepared dipyrone is less than or equal to 0.05%, which meets the requirements of the European Pharmacopoeia.

The invention provides a liquid liposome composition which comprises phospholipid, oligosaccharide and water, the weight ratio of the oligosaccharide to the phospholipid is 4: 1-21: 1, and further, the composition further comprises a functional component; further, the composition optionally does not contain or contains a filler. The invention further provides a method for preparing the liquid lipidosome composition, an oral product and application of the liquid lipidosome composition in food and health care products or application of the liquid lipidosome composition in preparation of drugs. The liquid liposome composition disclosed by the invention has the advantages of physical stability, functional component stability and the like.