Ceftizoxime sodium compound

A technology of ceftizoxime sodium and its compounds, which is applied in the field of ceftizoxime sodium compounds, can solve the problems of poor sensitivity, achieve fast dissolution, easy packaging, and good clinical effects

Active Publication Date: 2014-07-09
YOUCARE PHARMA GROUP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Ceftizoxime sodium has a strong antibacterial effect on Enterobacteriaceae bacteria such as Escherichia coli, Klebsiella pneumoniae, and Proteus mirabilis. Pseudomonas such as Pseudomonas aeruginosa and Acinetobacter are less sensitive to this product

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Example 1: Preparation of Ceftizoxime Sodium Compound

[0027] 1. Prepare 1L saturated aqueous solution of crude ceftizoxime sodium at 15°C, stir until it is completely dissolved;

[0028] 2. Under a sound field with a frequency of 12KHz and an output power of 20W, while stirring, add 10L of a mixed solvent of dimethylformamide and tetrahydrofuran at 0°C at a speed of 240 ml / min; dimethylformamide and tetrahydrofuran The volume ratio is 1:2; the stirring speed is 240 revolutions per minute;

[0029] 3. After the solution is added, in a sound field with a frequency of 25KHz and an output power of 40W, the temperature is raised to 17°C, the heating rate is 2.5°C / hour, the crystals are allowed to stand for 8 hours, washed, and dried to obtain the ceftizoxime sodium compound .

[0030] The prepared ceftizoxime sodium compound uses Cu-Kα rays to measure the X-ray powder diffraction pattern as shown in figure 1 As shown, the main particle size is 220-280 μm, and the distribution wi...

Embodiment 2

[0031] Example 2: Preparation of Ceftizoxime Sodium Compound

[0032] 1. Prepare 1L saturated aqueous solution of crude ceftizoxime sodium at 20°C and stir until it is completely dissolved;

[0033] 2. Under a sound field with a frequency of 22KHz and an output power of 30W, add 18L of a mixed solvent of dimethylformamide and tetrahydrofuran at 5°C while stirring at a speed of 600ml / min; for dimethylformamide and tetrahydrofuran The volume ratio is 1:2; the stirring speed is 480 revolutions per minute;

[0034] 3. After the solution is added, in a sound field with a frequency of 35KHz and an output power of 60W, the temperature is increased to 15°C at a rate of 2.5°C / hour; the crystals are allowed to stand for 2-8 hours, washed, and dried to obtain ceftizoxime Sodium compounds.

[0035] The prepared ceftizoxime sodium compound uses Cu-Kα rays to measure the X-ray powder diffraction pattern as shown in figure 1 As shown, the main particle size is 220-280 μm, and the distribution widt...

Embodiment 3

[0036] Example 3: Preparation of Ceftizoxime Sodium Compound

[0037] 1. Prepare 1L of saturated aqueous solution of crude ceftizoxime sodium at 15~20℃, stir until completely dissolved;

[0038] 2. Under a sound field with a frequency of 18KHz and an output power of 40W, while stirring, add 15L of a mixed solvent of dimethylformamide and tetrahydrofuran at 3°C ​​at a rate of 400 ml / min; dimethylformamide and tetrahydrofuran The volume ratio is 1:2; the stirring speed is 120 revolutions per minute.

[0039] 3. After the solution is added, in a sound field with a frequency of 30KHz and an output power of 50W, the temperature is raised to 16°C, the heating rate is 2°C / hour, the crystals are allowed to stand for 8 hours, washed, and dried to obtain the ceftizoxime sodium compound .

[0040] The prepared ceftizoxime sodium compound uses Cu-Kα rays to measure the X-ray powder diffraction pattern as shown in figure 1 As shown, the main particle size is 220-280 μm, and the distribution widt...

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Abstract

The invention relates to the field of compounds, and in particular relates to a ceftizoxime sodium compound. The X-ray powder diffraction diagram of the ceftizoxime sodium compound obtained by Cu-K alpha-ray measurement is shown in figure 1, the main particle size of the ceftizoxime sodium compound is 220-280mu m, and the distribution width is 120-390mu m. The ceftizoxime sodium compound provided by the invention has good stability and liquidity, and is not easy for moisture absorption, high in dissolution rate, good in clinical effect, low in incidence of adverse reactions, and very suitable for clinical application.

Description

Technical field [0001] The present invention relates to the field of compounds, in particular to a ceftizoxime sodium compound. Background technique [0002] Ceftizoxime sodium (ceftizoxime sodium) was developed by Japan Tengze Pharmaceutical Industry Co., Ltd. and was first marketed in Japan in 1982 under the trade name ceftizox. Ceftizoxime sodium is a third-generation cephalosporin synthesized from cephalosporin and aminothiaxamic acid. It is white or light yellow crystalline powder. Ceftizoxime sodium is a third-generation cephalosporin antibiotic. It has the same broad-spectrum antibacterial effect as the mother nucleus of cephalosporin antibiotics. It has broad-spectrum lactamase (including penicillinase) produced by a variety of Gram-positive and Gram-negative bacteria. And cephalosporin enzyme) stable. [0003] Ceftizoxime sodium has a strong antibacterial effect on Enterobacteriaceae such as Escherichia coli, Klebsiella pneumoniae and Proteus mirabilis. Pseudomonas aeru...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D501/20C07D501/12
CPCC07D501/12C07D501/20
Inventor 李琦杨磊
Owner YOUCARE PHARMA GROUP
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