Ceftizoxime sodium compound
A technology of ceftizoxime sodium and its compounds, which is applied in the field of ceftizoxime sodium compounds, can solve the problems of poor sensitivity, achieve fast dissolution, easy packaging, and good clinical effects
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Embodiment 1
[0026] Example 1: Preparation of Ceftizoxime Sodium Compound
[0027] 1. Prepare 1L saturated aqueous solution of crude ceftizoxime sodium at 15°C, stir until it is completely dissolved;
[0028] 2. Under a sound field with a frequency of 12KHz and an output power of 20W, while stirring, add 10L of a mixed solvent of dimethylformamide and tetrahydrofuran at 0°C at a speed of 240 ml / min; dimethylformamide and tetrahydrofuran The volume ratio is 1:2; the stirring speed is 240 revolutions per minute;
[0029] 3. After the solution is added, in a sound field with a frequency of 25KHz and an output power of 40W, the temperature is raised to 17°C, the heating rate is 2.5°C / hour, the crystals are allowed to stand for 8 hours, washed, and dried to obtain the ceftizoxime sodium compound .
[0030] The prepared ceftizoxime sodium compound uses Cu-Kα rays to measure the X-ray powder diffraction pattern as shown in figure 1 As shown, the main particle size is 220-280 μm, and the distribution wi...
Embodiment 2
[0031] Example 2: Preparation of Ceftizoxime Sodium Compound
[0032] 1. Prepare 1L saturated aqueous solution of crude ceftizoxime sodium at 20°C and stir until it is completely dissolved;
[0033] 2. Under a sound field with a frequency of 22KHz and an output power of 30W, add 18L of a mixed solvent of dimethylformamide and tetrahydrofuran at 5°C while stirring at a speed of 600ml / min; for dimethylformamide and tetrahydrofuran The volume ratio is 1:2; the stirring speed is 480 revolutions per minute;
[0034] 3. After the solution is added, in a sound field with a frequency of 35KHz and an output power of 60W, the temperature is increased to 15°C at a rate of 2.5°C / hour; the crystals are allowed to stand for 2-8 hours, washed, and dried to obtain ceftizoxime Sodium compounds.
[0035] The prepared ceftizoxime sodium compound uses Cu-Kα rays to measure the X-ray powder diffraction pattern as shown in figure 1 As shown, the main particle size is 220-280 μm, and the distribution widt...
Embodiment 3
[0036] Example 3: Preparation of Ceftizoxime Sodium Compound
[0037] 1. Prepare 1L of saturated aqueous solution of crude ceftizoxime sodium at 15~20℃, stir until completely dissolved;
[0038] 2. Under a sound field with a frequency of 18KHz and an output power of 40W, while stirring, add 15L of a mixed solvent of dimethylformamide and tetrahydrofuran at 3°C at a rate of 400 ml / min; dimethylformamide and tetrahydrofuran The volume ratio is 1:2; the stirring speed is 120 revolutions per minute.
[0039] 3. After the solution is added, in a sound field with a frequency of 30KHz and an output power of 50W, the temperature is raised to 16°C, the heating rate is 2°C / hour, the crystals are allowed to stand for 8 hours, washed, and dried to obtain the ceftizoxime sodium compound .
[0040] The prepared ceftizoxime sodium compound uses Cu-Kα rays to measure the X-ray powder diffraction pattern as shown in figure 1 As shown, the main particle size is 220-280 μm, and the distribution widt...
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