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Ceftizoxime sodium ultrafine powder preparation and preparation method thereof

A technology of ceftizoxime sodium and ultrafine powder, which is applied in the field of medicine, can solve the problems of unfavorable drug absorption, uneven particles, poor solubility, etc., and achieve the effects of enhancing drug efficacy, uniform powder size distribution, and easy regulation

Inactive Publication Date: 2014-09-17
杭州长典老一元健康管理有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the ceftizoxime sodium preparations made by these methods often have the problems of large particles and uneven particles, and thus have poor solubility when formulated into injections, which is not conducive to drug absorption.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] In the preparation of ceftizoxime sodium ultrafine powder preparation in this embodiment, ceftizoxime acid with a mass ratio of 1:25 was dissolved in purified water, the pH value was 6.3, and the temperature was 18°C ​​to obtain the first solution; Add excess sodium carbonate and react for 2 hours in the first solution, until ceftizoxime sodium precipitation occurs; Take out the precipitation, and this precipitation is added in dehydrated alcohol and mix homogeneously, obtain the second solution and stir until crystallization; Add glacial acetic acid in the second solution, obtain the third solution, its pH value is 6.5; Carry out the crystallization cultivation of the third solution for 2 hours, obtain crystalline form ceftizoxime sodium; Suction filter, wash and wash the crystalline form ceftizoxime sodium Vacuum drying to obtain a dry product; the dried product is air-pulverized at an airflow velocity of 50-600 m / s to obtain an ultrafine powder of ceftizoxime sodium, ...

Embodiment 2

[0041] In the preparation of ceftizoxime sodium ultrafine powder preparation in this embodiment, ceftizoxime acid with a mass ratio of 1:25 was dissolved in purified water, the pH value was 6.5, and the temperature was 25° C. to obtain the first solution; Add excess sodium carbonate and react for 2 hours in the first solution, until ceftizoxime sodium precipitation occurs; Take out the precipitation, and this precipitation is added in dehydrated alcohol and mix homogeneously, obtain the second solution and stir until crystallization; Add glacial acetic acid in the second solution, obtain the third solution, its pH value is 6.5; Carry out the crystallization cultivation of the third solution for 2 hours, obtain crystalline form ceftizoxime sodium; Suction filter, wash and wash the crystalline form ceftizoxime sodium Vacuum drying to obtain a dry product; the dried product is air-pulverized at an air velocity of 400m / s to obtain an ultrafine powder of ceftizoxime sodium, which is...

Embodiment 3

[0045] In the preparation of ceftizoxime sodium ultrafine powder preparation in this embodiment, ceftizoxime acid with a mass ratio of 1:30 was dissolved in purified water, the pH value was 6.3, and the temperature was 30°C to obtain the first solution; Add excess sodium carbonate and react in the first solution for 2.5 hours, until ceftizoxime sodium precipitates; take out the precipitate, and add the precipitate to dehydrated alcohol and mix uniformly to obtain the second solution and stir until crystallization; Add glacial acetic acid in the second solution, obtain the third solution, its pH value is 6.7; Carry out the crystallization cultivation of the third solution for 3 hours, obtain crystalline form ceftizoxime sodium; Suction filter, wash and wash the crystalline form ceftizoxime sodium Vacuum drying to obtain a dry product; the dried product is air-pulverized at an air velocity of 300m / s to obtain an ultrafine powder of ceftizoxime sodium, which is measured to have a ...

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Abstract

The invention discloses a ceftizoxime sodium ultrafine powder preparation which comprises 99.0-99.9 weight percent of ceftizoxime sodium and 0.10-1.00 weight percent of sodium carbonate, wherein the granularity of the ceftizoxime sodium ultrafine powder preparation is 1.0-3.0mu m. The invention also discloses a method for preparing the ceftizoxime sodium ultrafine powder preparation. The prepared ceftizoxime sodium ultrafine powder preparation is high in purity, the granularity of powder particles can be controlled to be in a range from 1.0 to 3.0mu m by adjusting the preparation conditions, the powder is in micron-scale, uniform in size distribution and high in re-dissolubility, and active ingredients in the medicine are absorbed, so that the curative effect of the medicine is enhanced. The preparation method is mild in reaction conditions, simple in steps and process and easy to regulate, and volume production of the ceftizoxime sodium ultrafine powder preparation can be conveniently realized.

Description

technical field [0001] The invention specifically relates to a ceftizoxime sodium ultrafine powder preparation and a preparation method thereof, belonging to the technical field of medicine. Background technique [0002] Ceftizoxime sodium, also known as ceftriaxone sodium, has a strong antibacterial effect on Enterobacteriaceae bacteria such as Escherichia coli, Klebsiella pneumoniae, and Proteus mirabilis, while Pseudomonas such as Pseudomonas aeruginosa Genus and Acinetobacter have poor sensitivity to this product. Ceftizoxime has a good antibacterial effect on Haemophilus influenzae and Neisseria gonorrhoeae. The effect of this product on Staphylococcus aureus and Staphylococcus epidermidis is worse than that of the first and second-generation cephalosporins. Methicillin-resistant Staphylococcus aureus and Enterococcus are resistant to this product, and various streptococci are resistant to this product. Products are highly sensitive. Anaerobic bacteria such as Peptoc...

Claims

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Application Information

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IPC IPC(8): A61K9/00A61K9/14A61K31/546A61P31/04
Inventor 傅苗青李凤生陈宗东
Owner 杭州长典老一元健康管理有限公司
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