Ceftizoxime sodium compound preparation

Abstract

An antibacterial compound ceftizoxime sodium is prepared from the ceftizoxime or its physiologically acceptable salt and a beta-lectamase depressant in weight ratio of (2-8):1.

Description

Technical field: [0001] The invention relates to a compound drug preparation, in particular to an antibacterial compound drug preparation containing ceftizoxime or a physiologically acceptable salt thereof and a β-lactamase inhibitor. Background technique: [0002] Ceftizoxime sodium (Ceftizoxime, czx) is a semi-synthetic third-generation cephalosporin, which is effective for most G - Bacteria, G + Both bacteria and anaerobic bacteria have antibacterial activity and have broad-spectrum antibacterial activity. Due to the increased isolation rate of β-lactamase-producing bacteria, the antibacterial activity of cephalosporin products decreased, and ceftizoxime sodium was no exception. [0003] β-lactamase inhibitors can specifically inhibit the production of β-lactamase, so that the resistant antibacterial substances can regain their antibacterial effect. Therefore, the development of compound preparations containing enzyme inhibitors is an effective measure to solve the mec...

AI Technical Summary

Problems solved by technology

[0005] There is no literature report on the combined use of ceftizoxime sodium and β-lactamase inhibitors