Ceftizoxime sodium compound preparation

A kind of technology of ceftizoxime sodium and ceftizoxime, which is applied in the field of antibacterial compound pharmaceutical preparations

Inactive Publication Date: 2005-12-28
天津新丰制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] There is no literature report on the combined use of ceftizoxime sodium and β-lactamase inhibitors

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0065] Embodiment 1: Ceftizoxime sodium and sulbactam sodium compound preparation

[0066] Mix 1000g of ceftizoxime sodium and 1000g of sulbactam sodium, measure the content, fill, stopper and seal with an aluminum cap.

Embodiment 2

[0067] Embodiment 2: Ceftizoxime sodium and sulbactam sodium compound preparation

[0068] Mix 1000g of ceftizoxime sodium and 500g of sulbactam sodium, measure the content, fill, stopper and seal with an aluminum cap.

Embodiment 3

[0069] Embodiment 3: Ceftizoxime sodium and sulbactam sodium compound preparation

[0070] Mix 1000g of ceftizoxime sodium and 250g of sulbactam sodium, measure the content, fill, stopper and seal with an aluminum cap.

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PUM

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Abstract

An antibacterial compound ceftizoxime sodium is prepared from the ceftizoxime or its physiologically acceptable salt and a beta-lectamase depressant in weight ratio of (2-8):1.

Description

Technical field: [0001] The invention relates to a compound drug preparation, in particular to an antibacterial compound drug preparation containing ceftizoxime or a physiologically acceptable salt thereof and a β-lactamase inhibitor. Background technique: [0002] Ceftizoxime sodium (Ceftizoxime, czx) is a semi-synthetic third-generation cephalosporin, which is effective for most G - Bacteria, G + Both bacteria and anaerobic bacteria have antibacterial activity and have broad-spectrum antibacterial activity. Due to the increased isolation rate of β-lactamase-producing bacteria, the antibacterial activity of cephalosporin products decreased, and ceftizoxime sodium was no exception. [0003] β-lactamase inhibitors can specifically inhibit the production of β-lactamase, so that the resistant antibacterial substances can regain their antibacterial effect. Therefore, the development of compound preparations containing enzyme inhibitors is an effective measure to solve the mec...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/546
Inventor 李红梅
Owner 天津新丰制药有限公司
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