63 results about "Electrophilic addition" patented technology

The invention provides an industrial method for preparing chloro- alkyl- phenol. It takes alkyl- phenol and chlorizating agent for addition reaction to prepare said product. Said reaction is carried out at -10- 100 Deg. C under co-catalytic action. Said co- catalyst comprises metallic chloride, organic sulfide and alkyl ether. The invention is characterized by greatly reduced production cost and side production production, increased purity and yield.

The invention discloses a synthetic method of 6-ethylchenodeoxycholic acid. The synthetic method comprises steps as follows: chenodeoxycholic acid and an oxidizing agent are subjected to an oxidizing reaction and an esterification reaction, and a compound with a structure represented as a formula III is prepared; hydroxyl and carbonyl on rings of the compound with the structure represented as the formula III are protected with tert-butyldimethylsilyl chloride, and a compound with a structure represented as a formula IV is obtained; the compound with the structure represented as the formula IV and paraldehydeare are subjected to an electrophilic addition reaction and then are subjected to deprotection, and a compound with a structure represented as a formula V is obtained; the compound with the structure represented as the formula V is subjected to catalytic hydrogenation and is subjected to reduction and hydrolysis finally, and the compound 6-ethylchenodeoxycholic acid with a structure represented as a formula VI is obtained. The method is simple and convenient to operate, adopts mild conditions, has higher yield and is suitable for being popularized to industrial production.

The present invention provides a method for preparing 1,3-dibenzylimidazoline-2-ketone-cis-4,5- dicarboxylic acid, and is characterized by that it utilizes chlorine gas to make fumaric acid produce electrophilic addition reaction to obtain meso-2,3-dichlorosuccinic acid, in the pressence of phase transfer catalyst the meso-2,3-dichlorosuccinic acid and benzylamine are undergone the processes of benzylamination reaction in the solvent so as to synthesize cis-2,3-dibenzylamine succinic acid, the latter and solid carbonyl chloride and undergone the process of phase transfer catalytic ring-closing reaction in the potassium hydroxide solution so as to obtain the invented product. Its total yield rate is up to 74%.

The invention relates to a reaction type phosphorus-nitrogen flame retardant and in particular to a compound with a plurality of active groups and a preparation method of the compound. The preparation method comprises the following steps: (1) weighing cyanuric chloride, dissolving cyanuric chloride into a first solvent, stirring till being completely dissolved, slowly heating to be 60 DEG C, preserving heat while continuously stirring to uniformly disperse reactant; and (2) in the presence of nitrogen, adding a phosphite ester solution which is dissolved in the first solvent, reacting for 4-6 hours, and keeping stirring in the reaction process. Compared with the prior art, the compound with the plurality of active groups has the beneficial effects that the compound is prepared from raw materials, namely, cyanuric chloride, phosphite ester compounds (trimethyl phosphate or triethyl phosphate) and polyhydric alcohol compounds (neopentyl glycol, glycerol or pentaerythritol) with quaternary carbon (or secondary carbon) atoms, through Michaelis-Arbuzov electrophilic addition reaction and nucleophilic substitution reaction.

The invention relates to a nano-titanium dioxide herbal extract formaldehyde removal agent. By virtue of the mutual compatibility of various natural herbaceous plants and the compounding of nano-titanium dioxide and kaolin, the formaldehyde removal agent is wide in raw material sources, low in cost and contains multiple active groups, amino and formaldehyde generate nucleophilic addition reaction, hydroxyl and formaldehyde generate electrophilic addition reaction, aldehyde group substances and formaldehyde generate aldol condensation reaction, and irreversible chemical reactions are generated with formaldehyde, so that the formaldehyde is eliminated, the formaldehyde removal rate reaches up to 95%, and the sterilizing rate reaches 90%; nano-titanium dioxide is large in specific surface area, controllable in particle size and good in dispersity and is compounded and crosslinked with a natural herbaceous plant extracting solution, so that the adsorption, bacteriostasis and sterilization functions of the formaldehyde removal agent are enhanced; the formaldehyde removal agent has no toxicity to a human body, does not cause environmental pollution, is high in speed and good in durability, has effects of formaldehyde elimination, air purification, sterilization, disinfection and mosquito repelling and is further capable of relieving fatigue and restoring consciousness; and a production process is simple, and the production cost is low.

The invention provides a phosphorus-nitrogen flame retardant and a preparation method thereof. The phosphorus-nitrogen flame retardant is synthesized through condensation and addition and electrophilic addition reaction of the raw materials including organic amines, hypophosphorous acid and fatty aldehydes in the presence of acid catalysts, wherein the organic amines are one or more than one of primary diamines with molecular formula of NH2RNH2, wherein R is -(CH2)m<->, -[CH2CH2NH]pCH2CH2<-> or -C6H4<->, m and p are positive integers, m is not more than 6 and not less than 2, and p is not more than 4 and not less than 1; fatty aldehydes are one or more than one of formaldehyde, acetaldehyde, propionaldehyde or butyraldehyde; the adopted acid catalysts can be one or more than one of hydrochloric acid, sulfuric acid or nitric acid. The mole ratio of the organic amines to hypophosphorous acid to fatty aldehydes adopted in the preparation process is preferably 1:(2-5):(2-5), the reaction temperature is preferably 70-90 DEG C, and the reaction time is preferably 2-6 hours.

The invention discloses a preparation method of benzotriazole derivatives. According to the preparation method, under certain conditions, benzotriazole, formaldehyde and octadecyl amine carry out Mannich reactions and electrophilic addition reactions in an organic solvent to generate the benzotriazole derivatives. Mannich reactions are adopted, the optimal feed ratio and feeding sequence are determined; no catalyst is used; the reactions are not performed in a water phase; the technology is simplified, the reactions are stable, the side reactions are few, the yield is high (96% or more), the post treatment is simple, no waste gas, waste liquid, or waste solid is generated, the content of octadecyl amine in obtained oil is low, and the synthesis technology is green.

The invention discloses a Convenia synthetic method and a Convenia sodium salt synthetic method. A ceftizoxime sodium midbody is taken as the raw material and is subjected to bromination, electrophilic addition, nucleophilic substitution, deprotection, amidation and the like to obtain Convenia and Convenia sodium salt. According to the Convenia synthetic method, synthetic routes and steps are simplified through technology improvement and reaction condition improvement, and cost is saved. The Convenia synthetic method and the Convenia sodium salt synthetic method are easy to operate, mild in reaction condition, low in requirement for production equipment, and capable of creating sound conditions for industrialization. It shows through analysis and detection that a prepared product is high in quality and can meet the requirements of industrial and agricultural production.

The invention provides a nano energy-containing material prepared by functional graphene and a method thereof. The method is characterized in that a halogenation agent and graphene oxide are subjected to electrophilic addition to generate halogenated graphite, then an energy-containing compound is grafted to graphene through a substitution reaction, the functional energy-containing graphene can be formed, then nano aluminum and nano metal oxide are arranged on the energy-containing graphene through a self assembly method, so that high-performance ternary energy-containing material can be prepared. The energy-containing material increases the ordering performance of a mixture in the nano thermite component and can reduce the agglomeration of the nano particles at certain degree, the energy-containing compound grafted on the graphene contains lots of energy-containing groups such as nitro-group, and the energy-containing material has important promotion effect for increasing the heat released by the nano thermite and increasing the reactive properties.

The invention discloses a tungsten and boron-containing two-phase catalyst, a preparation method and application thereof in epoxidation. The catalyst is used in a system of preparation of cyclohexene oxide from hydrogen peroxide cyclohexene oxide. The catalyst is in an interlayer of an aqueous phase and an oil phase, the catalyst cannot be dissolved in a cyclohexene reaction medium per se, under the action of hydrogen peroxide, the catalyst and the hydrogen peroxide jointly form an active specie which is easy to perform an electrophilic addition with the olefin, and the active specie has certain solubility in the oil phase, and brings active oxygen atoms into the oil phase so as to synthesize the cyclohexene oxide with high selectivity. The conversion rate of the cyclohexene is up to 46.58%, and the selectivity of the cyclohexene oxide to the cyclohexene is up to 88.06%; after reaction, the catalyst can be recycled by simple separation operation, and little catalyst dissolved in the oil phase can be recycled in a separating-out manner by adding solvent acetone. The preparation method of the catalyst disclosed by the invention is simple, the yield of the catalyst is high, the catalyst can be used in the system of preparing the cyclohexene oxide from the hydrogen peroxide cyclohexene oxide, and the obtained product, namely the catalyst is of a single type; the catalyst is environment-friendly, low in production cost and easy for large-scale industrial application.

The invention discloses an avibactam sodium synthesis method. In the existing synthesis method, the production cost is high, the selectivity of the intermediate is low during the reducing so as to cause the reduced yield, and the large-scale production is limited by the high toxicity of the side-product generated in the reaction, no environment protection and other factors. According to the present invention, 5-hydroxy-2-pyridine ethyl formate is used as a starting raw material, and 11 steps such as reduction hydrogenation, biological lipase resolution, electrophilic addition, nucleophilic substitution, Boc removing, aminolysis, intramolecular urealysis, debenzylation, sulfonic acid esterification, salt formation and cation exchange are performed to obtain avibactam sodium; and the synthesis method has advantages of high yield, short route, mild reaction conditions, low environmental pollution, easy large-scale preparation and the like.

The invention relates to an ionic liquid catalyst and a preparing method of the ionic liquid catalyst. The ionic liquid catalyst has a chemical formula shown as a formula (I). The preparing method of the ionic liquid catalyst comprises the following steps that: (1) an intermediate product of 1-cyanoethyl-3-(3,6-dioxaheptyl)imidazolium chloride is prepared through electrophilic addition of cyanoethylated imidazole and chlorinated diethylene glycol monomethyl ether; and (2) the ionic liquid catalyst provided by the invention can be prepared through a replacement reaction of the 1-cyanoethyl-3-(3,6-dioxaheptyl)imidazolium chloride and potassium tetracyanoborate. The ionic liquid catalyst can be used for preparing methanol through CO2 electrocatalytic reduction, and has the characteristics of low overpotential and high selectivity.

The invention discloses a synthesis method of a tricyclodecenyl propionate perfume. Petroleum coking byproducts dicyclopentadiene and propionic acid are used as the raw materials, under the catalysis of loaded solid acid, the raw materials directly have acetylation through electrophilic addition to prepare crude tricyclodecenyl propionate at one step, and meanwhile, a small amount of a propionic anhydride guard catalyst is added to prevent the crude tricyclodecenyl propionate from having hydrolysis reaction with a small amount of moisture in the material; then, propionic acid is recycled for applied mechanically, and the finished tricyclodecenyl propionate product is obtained through neutralizing, washing and rectification. According to the synthesis method, the petroleum coking byproducts used as the raw materials are easily available, the reaction condition is moderate, the reaction conversion rate is high, the technology is easier to implement, the discharge capacity of three wastes generated in the production process is low, the product yield is greatly increased, and the synthesis method belongs to technology of cleaner production. In addition, the content of tricyclo[5, 2, 1, 0<2.6>]-3-decene-9-yl acetate with delicate fragrance and fragrance and sweetness of anise is more than 92%, and the product green wood is pure, fine and mild in fragrance. The invention further provides a synthesis device special for the synthesis method of a tricyclodecenyl propionate perfume.

The invention discloses a magnetic cobalt (II) complex based on a 4,4'-bipyridine-itaconic acid derivative ligand and a preparation method of the magnetic cobalt (II) complex. The molecular formula ofthe magnetic cobalt (II) complex is [[Co(HL)2(H2O)2].2NO3]n, wherein HL represents the 4,4'-bipyridine-itaconic acid derivative ligand with one hydrogen atom removed from carboxylic acid, a single-crystal structure has a one-dimensional chain structure, and an asymmetric construction unit of the single-crystal structure contains half cobalt (II) ion, one 4,4'-bipyridine-itaconic acid derivative ligand, one end coordination water molecule and one free nitrate anion; pyridine nitrogen in 4,4'-bipyridineis subjected to an electrophilic addition reaction with double bonds in itaconic acid, a semi-rigid carboxylate ligand containing N(+)-C bonds is synthesized, and the ligand and the cobalt (II) ion are subjected to an in-situ coordination reaction, and the cobalt (II) complex is synthesized;the cobalt (II) complex has slow magnetic relaxation phenomenon at the low temperature and serves as a molecule-based magnetic material to be applied to the fields of information storage, quantum computation and the like.

The invention belongs to the field of film material preparation, and particularly relates to a preparation method of a hybrid silicon film with a hydrophilically modified surface. One simple, mild andefficient hydrophilic modification method is provided, a hybrid silicon film material is left to stand in bromine vapor to be subjected to an electrophilic addition reaction, a brominated hybrid silicon film is obtained, then the brominated hybrid silicon film is left to stand in ammonia vapor, bromine atoms are enabled to be replaced with ammonia molecules, the amino-group functionalized hybridsilicon film is prepared accordingly, surface hydrophilicity of the film is improved, and water permeability in a water treatment process is increased.

The invention discloses an MFI molecular sieve and a preparation method and application thereof, two kinds of metal heteroatoms of titanium and vanadium are doped into an MFI skeleton at the same time, a structure regulator is added, and a coupled and coordinated catalytic active site structure is formed between adjacent skeleton titanium and skeleton vanadium active centers through guiding, and the titanium and vanadium doped MFI molecular sieve containing the coupled coordination structure is obtained. The prepared MFI molecular sieve is mixed with cyclohexene, acetonitrile and hydrogen peroxide, the coupling coordination active site between framework titanium and framework vanadium in the MFI molecular sieve can efficiently catalyze hydrogen peroxide molecules to form an active matter, the active matter attacks a cyclohexene C = C bond, electrophilic addition is carried out, oxygen atoms are transferred, and cyclohexene oxide is generated. In the preparation of cyclohexene oxide, the prepared MFI molecular sieve is used as a catalyst so that the conversion rate of cyclohexene and the selectivity of cyclohexene oxide can be improved, and the reaction time is shortened.

The invention discloses a trifluoroisoproanol substituted phenol strong hydrogen bond acid functional group-containing organophosphorus sensitive siloxane polymer material, which is a polymer adopting polysiloxane as a skeleton and adopting the trifluoroisoproanol substituted phenol as a functional group. The sensitive polymer material is prepared by taking hydrogen-containing silicone oil and 2-allylphenol as raw materials, performing reflux hydrosilylation on the raw materials in an organic solvent for 5 to 6 hours, and performing electrophilic addition reaction on the raw materials with trifluoroacetone. The molecule structure of the material contains a trifluoroisoproanol substituted phenol strong hydrogen bond acid functional group, so the absorbing effect on strong alkali compounds, such as organophosphorus, is increased effectively and relatively high sensitivity and selectivity are achieved. The material has the advantages of simple preparation process, low raw material toxin and mild and easily controlled reaction conditions, can be applied to a plurality of organophosphorus detecting analyzers, such as quartz crystal microbalance sensors, surface acoustic wave sensors, micro-suspending arm sensors, micro-gas chromatograms and pre-enriching devices and has wide application prospect.

The invention discloses a method for synthesizing 3-quinoline derivatives. The method comprises the following steps: based on a simple 3-nitroquinoline, with bronsted acid as a catalyst, substituting 1,4-dihydropyridine (HEH) as a reducing agent, realizing 1,4- reduction of quinoline to obtain enamine, performing electrophilic addition on the enamine intermediate and a fluorinated reagent, and then repeatedly aromatizing under an alkali condition to obtain various substituted 3-quinoline derivatives. The method for synthesizing the 3-quinoline derivatives has the advantages that the operation is simple, convenient and practical, the raw materials are easy to obtain, the reaction is quick, the post-treatment is convenient, and the yield is high.

The invention discloses a synthesis method for 2,3-dibromo-1,4-butylene glycol. The invention aims to solve the technical problems of the prior art that the synthesis method for 2,3-dibromo-1,4-butylene glycol is complex, reaction conditions are harsh and unsafe, parameters are difficult to be controlled, production cost is high, product quality is low and use is limited. The synthesis method for2,3-dibromo-1,4-butylene glycol disclosed by the invention comprises the following steps: 1) adding a catalyst tetraethyl ammonium bromide into a dichloromethane solvent, and then dropwise adding liquid bromine while stirring, thereby acquiring a brominating agent tetraethyl ammonium bromide complex bromide; 2) adding butynediol into the dichloromethane solvent, triggering electrophilic addition reaction with the brominating agent tetraethyl ammonium bromide complex bromide prepared in the step 1), thereby generating 2,3-dibromo-1,4-butylene glycol; adding water for washing, cooling, separating 2,3-dibromo-1,4-butylene glycol crystal, and performing suction filtration, thereby acquiring a crude product of 2,3-dibromo-1,4-butylene glycol; 3) purifying the crude product of 2,3-dibromo-1,4-butylene glycol. The synthesis method provided by the invention can be widely applied to the technical field of chemical synthesis.